|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Evaluation of VEGF gene polymorphisms and proliferative diabetic retinopathy in Mexican population显示文摘● AIM: To assess if the included vascular endothelial growth factor(VEGF) polymorphisms rs3025035, rs3025021 and rs2010963 are associated to proliferative retinopathy in a Mexican population with type 2 diabetes mellitus(T2DM).● METHODS: A case-control study was conducted in adult individuals with T2 DM associated to proliferative retinopathy or non-proliferative retinopathy from Oct. 2014 to Jun. 2015 from the Retina Department of the Asociation to Prevent Blindness in Mexico. The selected patients were adults with a diagnosis of T2 DM ≥5y. All subjects had a comprehensive ocular examination and the classification of the retinopathy severity was made considering the Early Treatment Diabetic Retinopathy Study(ETDRS) standardization protocols. Genomic DNA was extracted from whole fresh blood. All samples were genotyped by q PCR for selected VEGF polymorphisms. Hardy-Weinberg equilibrium was calculated by comparing Chi-square values between the expected and the observed values for genotype counts.● RESULTS: In total 142 individuals were enrolled, 71 individuals with T2 DM and associated proliferative retinopathy and 71 individuals with non-proliferative retinopathy. One-sided Fisher's exact test was performed for rs3025021[OR(95% CI)=0.44(0.08-2.2); P=0.25] and rs2010963 [OR(95% CI)=0.63(0.25-1.6); P=0.23]. The minor allelic frequencies obtained were 26% for rs3025021, 10% for rs3025035 and 61% for rs2010963. The pairwise linkage disequilibrium between the three SNP was assessed, and was as follows: rs3025021 vs rs3025035: D'=1.0, r^2=0.1043, P≤0.0001; rs3025021 vs rs2010963: D'=0.442, r^2=0.0446, P=0.149; rs3025035 vs rs2010963: D'=0.505, r^2=0.0214, P=0.142.● CONCLUSION: This is the first analysis involving VEGFA polymorphisms and proliferative diabetic retinopathy in a Mexican population. A major finding of the present study is that none of the polymorphisms studied was significantly associated with proliferative retinopathy. Based on these results, we can infer that different populations have different associations for the same polymorphisms. | Roberto Gonzalez-Salinas Maria C Garcia-Gutierrez Gerardo Garcia-Aguirre Virgilio Morales-Canton Raul Velez-Montoya Vidal R Soberon-Ventura Victoria Gonzalez Rodrigo Lechuga Pablo Garcia-Solis David G Garcia-Gutierrez Marco Vinicio Garcia-Solis Manuel Saenz de Viteri Juan C Solis-S | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 12 |
| 2 | Transcystic Common Bile Duct Exploration in the Management of Patients With Choledocholithiasis显示文摘 | Sergio Rojas-Ortega Daniel Arizpe-Bravo Eduardo R Mar??n López Rachid Cesin-Sánchez Gerardo Reed-San Roman Crispina Gómez | 2003 | Journal of Gastrointestinal Surgery2003，，4： | 3 |
| 3 | Carbon nanotubes as reinforcement of styrene-butadiene rubber 显示文摘 | Alejandro D F Silvia G Gerardo H R | 2007 | Applied Surface Science2007，254，1： | 1 |
| 4 | Aero- monas hydrophila clinical and environmental ecotypes as revealed by genetic diversity and virulence genes 显示文摘 | MaGuadalupe A A Cesar H R Gerardo Z | 2005 | FEMS Microbiol Lett2005，，10： | 1 |
| 5 | Spanish-Latin American Multicenter Study of Attitudes Toward Organ Donation Among Personnel From Hospital Healthcare Centers显示文摘 | Antonio Ríos Ana López-Navas Marco Antonio Ayala-García María José Sebastián Anselmo Abdo-Cuza Jeannina Alán Laura Martínez-Alarcón Ector Jaime Ramírez Gerardo Mu?oz Juliette Suárez-López Roberto Castellanos Ricardo Ramírez Beatriz González Miguel Angel M | 2013 | Cirugía Espa?ola (English Edition)2013，，： | 1 |
| 6 | Community structure of polypores (Basid-iomycota) in Andean alder wood in Argentina: Functional groups among wood-decay fungi?显示文摘 | CARLOS U GERARDO R | 2004 | Austr Ecoi2004，29，4： | 1 |
| 7 | Retinal Microvascular Abnormalities and MRI-Defined Subclinical Cerebral Infarction: The Atherosclerosis Risk in Communities Study显示文摘 | Lawton S. Cooper Tien Y. Wong Ronald Klein A Richey Sharrett R Nick Bryan Larry D. Hubbard David J. Couper Gerardo Heiss Paul D. Sorlie | 2006 | Stroke2006，，1： | 1 |
| 8 | Influence of tungsten on the carbon nanotubes growth by CVD process显示文摘 | MARIANO E GERARDO H R MORENO M S SILVIA G ROBERTO C | 2009 | Journal of Alloys and Compounds2009，479，12： | 1 |
| 9 | More Than a Decade of Conflict Between Hazardous Waste Management and Public Resistance: A Case Study of NIMBY Syndrome in Souselas (Portugal)显示文摘 | Kikuchi R Gerardo R | 2009 | Journal of HazardousMaterials2009，172，23： | 1 |
| 10 | Carbon nanotubes as reinforcement of styrene-butadiene rubber显示文摘 | Alejandro D F Silvia G Gerardo H R | 2007 | Applied Sur- face Science2007，254，1： | 1 |
| 11 | Production and characteristics of the lipase from Yarrowia lipolytica 681显示文摘 | Gerardo C Sergio R | 1999 | Bioresource Technology1999，70，： | 1 |
| 12 | Biosensor immunoassays for the detection of bisphenol A 显示文摘 | Marchesini Gerardo R Meulenberg Eline Haasnoot Willem | 2005 | Analytica Chimica Acta2005，528，1： | 1 |
| 13 | Microbial enzymes involved in polyurethane biodegradation: a review显示文摘 | ARACELI L T GERARDO G S RAUL R H | 2012 | Journal of Polymers and the Environment2012，20，： | 1 |
| 14 | β-Tricalcium phosphate 3D scaffold promote alone osteogenic differentia- tion of human adipose stem ceils : in vitro study 显示文摘 | Gerardo M Francesco R Gennaro C | 2010 | J Ma- ter Sci: Mater Med2010，21，： | 1 |
| 15 | A Repetitive-based Controller for the Compens- ation of 6/:l Harmonic Components 显示文摘 | Gerardo Es Cobar Perla G Hernandez- Briones PanFilo R Martinez et a/ | 2008 | IEEE Transactions on Industrial Electronics2008，55，8： | 1 |
| 16 | Fractal analysis of tidal channels in the Bahia Blanca estuary (Argentina) 显示文摘 | Angeles GuiUermo R Perillo Gerardo M E Cintia Piccolo M | 2004 | Geomorphology2004，57，34： | 1 |
| 17 | vascular endothelial growth factor,nitric oxide,and lepin follicular fluid levels correlate negatively with embryo quality in ivf patients显示文摘 | Gerardo B Marcelo B Papineni R | 1999 | Fertil and steril1999，72，6： | 1 |
| 18 | Loss of PPARγ in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein - 1 expression and macrophage infiltration into white adipose tissue 显示文摘 | GURI A J HONTECILLAS R GERARDO F | 2008 | J Nutr Biochem2008，19，： | 1 |
| 19 | Global observability analysis of sensorless induction motors显示文摘 | Sebastian I R Jaime M Gerardo E P | 2004 | Automatica2004，40，： | 1 |
| 20 | Microbial enzymes involved in polyurethane biodegradation: a review显示文摘 | ARACELI L T GERARDO G S RAUL R H | 2012 | Journal of Polymers and the Environment2012，20，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员