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| 1 | Importance of fatigue and its measurement in chronic liver disease显示文摘The mechanisms of fatigue in the group of people with non-alcoholic fatty liver disease and non-alcoholic steatohepatitis are protean. The liver is central in the pathogenesis of fatigue because it uniquely regulates much of the storage, release and production of substrate for energy generation. It is exquisitely sensitive to the feedback controlling the uptake and release of these energy generation substrates. Metabolic contributors to fatigue, beginning with the uptake of substrate from the gut, the passage through the portal system to hepatic storage and release of energy to target organs (muscle and brain) are central to understanding fatigue in patients with chronic liver disease. Inflammation either causing or resulting from chronic liver disease contributes to fatigue, although inflammation has not been demonstrated to be causal. It is this unique combination of factors, the nexus of metabolic abnormality and the inflammatory burden of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis that creates pathways to different types of fatigue. Many use the terms central and peripheral fatigue. Central fatigue is characterized by a lack of self-motivation and can manifest both in physical and mental activities. Peripheral fatigue is classically manifested by neuromuscular dysfunction and muscle weakness. Therefore, the distinction is often seen as a difference between intention (central fatigue) versus ability (peripheral fatigue). New approaches to measuring fatigue include the use of objective measures as well as patient reported outcomes. These measures have improved the precision with which we are able to describe fatigue. The measures of fatigue severity and its impact on usual daily routines in this population have also been improved, and they are more generally accepted as reliable and sensitive. Several approaches to evaluating fatigue and developing endpoints for treatment have relied of biosignatures associated with fatigue. These have been used singly or in combination and include: physical performance measures, cognitive performance measures, mood/behavioral measures, brain imaging and serological measures. Treatment with non-pharmacological agents have been shown to be effective in symptom reduction, whereas pharmacological agents have not been shown effective. | Lynn H Gerber Ali A Weinstein Rohini Mehta Zobair M Younossi | 2019 | World Journal of Gastroenterology2019，25，28： | 7 |
| 2 | Cancer-related fatigue: Implications for breast cancer survivors显示文摘 | Berger A M Gerber L H Mayer D K | 2012 | Cancer2012，118，8： | 1 |
| 3 | VEGF is required for growth and survival in neonatal mice显示文摘 | Gerber H P Hillan K J Ryan A M | 1999 | Development1999，126，6： | 1 |
| 4 | VEGF is required for growth and survival in neonatal mice显示文摘 | GERBER H P HILLAN K J RYAN A M | 1999 | Development1999，126，6： | 1 |
| 5 | Three-dimensional video analysis of facial movements:a new method to assess the quantity and quality of the smile显示文摘 | Frey M Giovanoli P Gerber H | | 0，，： | 1 |
| 6 | Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association 显示文摘 | Newburger J W Takahashi M Gerber M A Gewitz M H Tani L Y Burns J C | 2004 | Circulation2004，110，： | 1 |
| 7 | VEGF couples hypertrophic cartilage remodeling,ossification and angiogenesis during endochondral bone formation显示文摘 | Gerber H P Vu T H Ryan A M | 1999 | Nat Med1999，5，： | 1 |
| 8 | Simultaneous immunohistochemical detection of tumor cells in lymph nodes and bone marrow aspirates in breast cancer and its correlation with other prognostic factors显示文摘 | Krause A Müller H | 2001 | J Clin Oncol2001，19，： | 1 |
| 9 | On the probability and severity of ruin显示文摘 | Gerber H U Goovaerts M J Kass R | 1987 | ASTIN Bulletin1987，，17： | 1 |
| 10 | Classification of chronic hepatitis diagnosis, grading and staging显示文摘 | DESMET V J GERBER M HOOTMAGLE J H | 1994 | Heoatology1994，19，6： | 1 |
| 11 | Classification of chronic hepatitis :diagnosis, grading and staging显示文摘 | DESMET V J GERBER M HOOFNAGLE J H | 1994 | Hepatology1994，19，： | 1 |
| 12 | Methods of infesting sheep with gastro-intestinal nematodes after Oryopreservaltion:dosing of larval in gelatin capsules compared to dosing of larvae in water suspersion显示文摘 | Gerber H M Alves R M R | 1984 | Onderstepoort Journal of Veterinary Research1984，51，： | 1 |
| 13 | On the probability and se-verity of ruin显示文摘 | Gerber H U Goovaerts M J | 1987 | ASTIN Bulletin1987，17，2： | 1 |
| 14 | Recovery of nematodes from ruminants by migration from gastro-intestinal ingesta and mucosa gelled in agar:Perliminary report显示文摘 | Gerber H M | 1978 | Onderstepoort Journal of Veterinary Research1978，45，： | 1 |
| 15 | A technique for recovery of nematodes from ruminants by migration from gastro-intestinal ingesta gelled inagar:large-scale application显示文摘 | Gerber H M Groeneveld H T | 1980 | Onderstepoort Journal of Veterinary Research1980，47，： | 1 |
| 16 | Ambr-isentan has no clinically relevant effect on the pharmacokinetics or pharmacodynamics of warfarin显示文摘 | GERBER M J DUFTON C PENTIKIS H | 2006 | Chest2006，130，4： | 1 |
| 17 | Effects of age,egg development,and mating on calling behavior of the bertha armyworm,Mamestra config- urata Walker (Lepidoptera: Noetuidae)显示文摘 | Howlader M A Gerber G H | 1986 | Can Entomol1986，118，： | 1 |
| 18 | Classification of chronic hepatitis: diagnosis, grading and staging显示文摘 | Desmet V] Gerber M Hoofnagle]H | 1994 | Hepatology1994，19，6： | 1 |
| 19 | Three-Dimensional video analysis of facial movements : A New method to assess the quantity and quality of the smile 显示文摘 | Frey M Giovanoli P Gerber H | 1999 | Plastic and Reconstructive Surgery1999，104，7： | 1 |
| 20 | Cantilever array sensors显示文摘 | LANG H P HEGNER M GERBER C | 2005 | Materials Today2005，8，4： | 1 |
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