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| 1 | Dysregulation of gastric H,K-ATPase by cigarette smoke extract显示文摘AIM:To test whether the expression and activity of H,K-ATPase in parietal cells would be affected by cigarette smoke extract.METHODS: Extracts of cigarette smoke were administered into mice by gastric gavage (5 mg/kg body weight/day) for 3 d or in drinking water for 7 or 14 d. For the latter, each day a mouse consumed 5 mL water containing extracts of two cigarettes, on average. Control littermate mice received only vehicle. To compare the amount of H,K-ATPase in control and smoke-treated mice, the stomach was processed for Western blotting and immunohistochemical analysis using monoclonal antibodies specific for α- or β-subunits of H,K-ATPase. The p-nitrophenylphospatase activity assay was used as a measurement for K-dependent H,K-ATPase activity.RESULTS: Probed transblots showed an increase in the amount of H,K-ATPase in smoke-treated mice which was confirmed by immunohistochemistry and was found to be due to increased amounts of protein per parietal cell rather than an increased parietal cell number. The increase in the amount of H,K-ATPase was associated with an enhancement of its enzymatic activity. K-dependent activity in control and smoke-treated mice was significantly different (respectively, 0.12 μmol/mg vs 0.27 μmol/mg per minute, P<0.05).CONCLUSION: Administration of cigarette smoke extract is associated with an increase in the amount and activity of H,K-ATPase and hence, smokers are susceptible to development of peptic ulcer. | Muna Hammadi Mohamed Adi Rony John Ghalia AK Khoder Sherif M Karam | 2009 | World Journal of Gastroenterology2009，15，32： | 7 |
| 2 | Laparoscopic versus open distal pancreatectomy: a single-institution case-control study显示文摘 | Sanket Sharad Mehta Ghalia Doumane Thibault Mura David Nocca Jean-Michel Fabre | 2012 | Surgical Endoscopy2012，，2： | 2 |
| 3 | 添加Si/Ti对粉末冶金FiNiCrCo高熵合金物理力学和化学性能的影响显示文摘用粉末冶金法制备FiNiCrCoSi_(x)和FiNiCrCoTi_(x)高熵合金(HEAs)。其中x为0、0.3%、0.6%和0.9%(质量分数)。所有合金中均形成均匀分布的固溶体。与FiNiCrCo高熵合金相比,加入Si和Ti后,合金的密度和硬度提高,研究合金在不同载荷下的磨损率。结果表明,含0.3%Si和0.9%Ti的高熵合金磨损率最低。用XRD、SEM和EDX研究HEAs的相组或、晶粒尺寸和显微组织。通过H_(2)SO_(4)、HNO_(3)和HCl溶液浸泡实验,研究Si和Ti含量对烧结态FiNiCrCoSi_(x)和FiNiCrCoTi_(x) HEAs腐蚀行为和表面形貌的影响。在样品表面观察到不同尺寸的均匀腐蚀和局部点烛,且FiNiCrCoSi0.3合金具有更小,更少的蚀坑,和优异的显微组织。 | Sarah HEDYA Lamiaa MOHAMED Ghalia GABER Omayma ELKADY Hassan MEGAHED Shimaa ABOLKASSEM | 2022 | Transactions of Nonferrous Metals Society of China2022，32，8： | 2 |
| 4 | Intelligent system to support judgmental business forecasting: The case of estimating hotel room demand显示文摘 | Ghalia M B Wang P P | 2000 | IEEE Transactions on Fuzzy Systems2000，8，4： | 2 |
| 5 | Serum leptin as an additional possible pathogenic factor in polycystic ovary syndrome显示文摘 | El Orabi H Ghalia AA Khalifa A | 1999 | Clin Biochem1999，32，1： | 1 |
| 6 | Serum leptin as additional possible pathogenic factor in polycystic ovarian syndrome显示文摘 | Rabi H Ghalia AA Khalifa A | 1999 | Clin Biochem1999，32，1： | 1 |
| 7 | A fuzzy variable structure ap- proach to feedback regulation of uncertain dynamical systems, with application to robotics 显示文摘 | Ghalia M B Alouani A T | 1995 | Information Sciences1995，85，4： | 1 |
| 8 | Intelligent system to support judgmental business forecasting: The case of estimating hotel room demand显示文摘 | Wang P P | 2000 | IEEE Transactions on Fuzzy Systems2000，8，4： | 1 |
| 9 | Estimation of glutathione S-transferase and its Pi isoenzyme in tumor tissues and sera of patients with ovarian cancer显示文摘 | Rabboh NA el Shalakani A | 2000 | Anticancer Res2000，20，2： | 1 |
| 10 | Serum leptin as an additional possible pathogenic factor in polycystic ovary syndrome 显示文摘 | Elorabi H Ghalia AA Khalifa A | 1999 | Clin Biochem1999，32，： | 1 |
| 11 | Laparoscopic versus open distal pancreatectomy: a single-institution case-control study显示文摘 | Sanket SM Ghalia D Thibault M | 2012 | Surg Endosc2012，26，2： | 1 |
| 12 | Tourism and Economic Growth: An Empirical Study 显示文摘 | GhaliA | 1976 | EconomicDevelopment and Cultural Change1976，，24： | 1 |
| 13 | Laparoscopic versus open distal pancreatectomy: a single-institution case-control study显示文摘 | Sanket Sharad Mehta Ghalia Doumane Thibault Mura David Nocca Jean-Michel Fabre | 2012 | Surgical Endoscopy2012，，2： | 1 |
| 14 | Serum leptin as an additional possible pathogenic factor in polycystic ovary syndrome显示文摘 | Orabi H Ghalia AA Khalifa A | 1999 | Clin Biochem1999，32，1： | 1 |
| 15 | Proteomic Helicobacter pylori biomarkers discriminating between duodenal ulcer and gastric cancer显示文摘 | Ghalia Khoder Yoshio Yamaoka Jean-Louis Fauchère Christophe Burucoa Christo Atanassov | 2009 | Journal of Chromatography B2009，，11： | 1 |
| 16 | Dexmedetomidine versus propofol for sedation in patients undergoing vitreoretinal surgery under sub-Tenon's anesthesia显示文摘 | GhaliA MahfouzAK Ihanamǎki T | | 0，，01： | 1 |
| 17 | Chromosome-selective sequencing of maternal plasma cell–free DNA for first-trimester detection of trisomy 21 and trisomy 18显示文摘 | Ghalia Ashoor Argyro Syngelaki Marion Wagner Cahit Birdir Kypros H. Nicolaides | 2012 | American Journal of Obstetrics and Gynecology2012，，4： | 1 |
| 18 | Design for punching shear with ACI 318 - 95 显示文摘 | GHALIA A MEGALLY S | 1999 | ACI Structure Journal1999，96，4： | 1 |
| 19 | Upregulation and inhibition of the nuclear translocation of Oct4 duringmultistep gastric carcinogenesis显示文摘 | Fathyia Al-Marzoqee Ghalia Khoder Haifa Al-Awadhi Rony John Azam Beg Aron Vincze Frank Branicki Sherif Karam | 2012 | International Journal of Oncology2012，，5： | 1 |
| 20 | Upregulation and inhibition of the nuclear translocation of Oct4 duringmultistep gastric carcinogenesis显示文摘 | Fathyia Al-Marzoqee Ghalia Khoder Haifa Al-Awadhi Rony John Azam Beg Aron Vincze Frank Branicki Sherif Karam | 2012 | International Journal of Oncology2012，，5： | 1 |
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