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| 1 | DRISPR/Cas9 Platforms for Genome Editing in Plants: Developments and Applications显示文摘 | Xingliang Ma Qinlong Zhu Yuanling Ghen Yao-Guang Liu | 2016 | Molecular Plant2016，9，7： | 39 |
| 2 | Lung transplantation in China between 2015 and 2018显示文摘Background:Lung transplantation(LT)has been demonstrated as the only effective therapy for patients with end-stage lung diseases.Increasing listed lung transplant candidates and expanding volumes of lung transplant centers across China require wellorganized programs and registry data collection based on the large population.This study aimed to summarize and analyze the data of LT development in China.Methods:We retrospectively collected and analyzed data from the China Lung Transplantation Registry(CLuTR).Key data were reported from the registry with transplant types,indications,donor and recipient characteristics,outcomes and survival.The survival<30 days,1-year and 3-year survival rates were estimated with risk factors identified.Results:CLuTR contained data from 1053 lung transplants performed through January 1st,2015 to December 31st,2018 reported by 18 registered transplant centers.The largest category of diagnosis before transplantation was idiopathic interstitial pneumonitis.The total<30 days,1-year and 3-year survival rates in CLuTR were 81.45%,70.11%,and 61.16%with discrepancy by indications.Large proportion of recipients who were more than 60 years old required higher standard of care.Infection-related complications resulted in more death events in the early post-surgery periods.New York Heart Association grading at listing,extra-corporeal membrane oxygenation usage peri-transplantation,allograft dysfunction(primary graft dysfunction>Grade 0),renal insufficiency(estimated glomerular filtration rate<60 mL min_11.73 m^2),were independently associated with a higher risk for 3-year mortality in the entire cohort.Conclusions:Facing more end-stage of lung diseases and comorbidities,this study analyzed the outcomes and survival of LT recipients in China.Further prospectively stratified analyses with longer follow-up will be needed. | Chun-Xiao Hu Wen-Hui Ghen Jian-Xing He Ge-Ning Jiang Xiao-Shan Li Dong Wei Bo Wu Ji Zhang Chen Wang Jing-Yu Chen | 2019 | Chinese Medical Journal2019，，23： | 25 |
| 3 | 中国成人糖尿病、血糖与结直肠癌发病率:针对50万人的前瞻性研究显示文摘背景糖尿病可致结直肠癌(CRC)的发病风险升高。糖尿病病程和非糖尿病患者的血糖与CRC发病风险之间的相关性仍不清楚。方法2004至2008年前瞻性中国Kadoofe Biobank研究从10个不同地区纳入了512 713名受试者。在10年随访期间,在基线无癌症史的510 136名受试者中共记录有3 024例新发CRC病例(1 745例结肠癌,1 716例直肠癌)。应用Cox回归分析对糖尿病(入组前诊断或筛查发现的)或无糖尿病病史者随机血糖(RPG)水平与CRC发病相关性的校正风险比(HR)进行估计。结果基线时,共有5.8%的受试者患有糖尿病。糖尿病患者发生CRC的校正HR为1.18(95%可信区间1.04~1.33),且发生结肠癌与直肠癌的风险相当[1.19(1.01~1.39)比1.14(0.96~1135)]。这些患者发生CRC的HR随糖尿病病程的延长而下降(趋势P值为0.03)。在入组前无糖尿病的受试者中,其RPG水平与CRC发病呈正相关,基线RPG每升高1 mmol/L其发生CRC的校正HR为1.04(1.02~1.05),且发生结肠癌与直肠癌的风险亦相当[1.03(1.01~1.05)比1.04(1.02~1.06)]。在男性中,糖尿病和RPG与CRC发病风险的相关性高于女性,但其差异无统计学意义(异质性检验的P值分别为0.3和0.2)。讨论在中国成年人中,未诊断糖尿病者其糖尿病和升高的血糖水平与CRC发病风险升高相关。 | Yuanjie Pang Christiana Kartsonak yu Guo Yiping Chen Ling Yang Zheng Bian Fiona Bragg Iona Y Millwood Leijia Shen Songgen Zhou Jiben Liu Junshi Chen Liming Li Michael V Holmes Zhengming Ghen 霍永丰(译) | 2019 | 英国医学杂志中文版2019，22，1： | 6 |
| 4 | Analysis of potential factors contributing to refusal of invasive strategy after ST-segment elevation myocardial infarction in China显示文摘Background:Reduced application of percutaneous coronary intervention(PCI)is associated with higher mortality rates after STsegment elevation myocardial infarction(STEMI).We aimed to evaluate potential factors contributing to the refusal of PCI in STEMI patients in China.Methods:We studied 957 patients diagnosed with STEMI in the emergency departments(EDs)of six public hospitals in China.The differences in baseline characteristics and 30-day outcome were investigated between patients who refused PCI and those who underwent PCI.Multivariable logistic regression was used to evaluate the potential factors associated with refusing PCI.Results:The potential factors contributing to refusing PCI were older than 65 years(odds ratio[OR]2.66,95%confidence interval[Cl]1.56-4.52,P<0.001),low body mass index(BMI)(OR 0.91,95%Cl 0.84-0.98,P=0.013),not being married(OR 0.29,95%Cl 0.17-0.49,P<0.001),history of myocardial infarction(MI)(OR 2.59,95%Cl 1.33-5.04,P=0.005),higher heart rate(HR)(OR 1.02,95%Cl 1.01-1.03,P=0.002),cardiac shock in the ED(OR 5.03,95%Cl 1.48-17.08,P=0.010),pre-hospital delay(>12 h)(OR 3.31,95%Cl 1.83-6.02,P<0.001)and not being hospitalized in a tertiary hospital(OR 0.45,95%Cl 0.27-0.75,P=0.002).Compared to men,women were older,were less often married,had a lower BMI and were less often hospitalized in tertiary hospitals.Conclusions:Patients who were older,had lower economic or social status,and had poorer health status were more likely to refuse PCI after STEMI.There was a sex difference in the potential predictors of refusing PCI.Targeted efforts should be made to improve the acceptance of PCI among patients with STEMI in China. | He Zhang Wen Zheng Shuo Wu Jing-Jing Ma Guang-Mei Wang Yong Li Jia-Qi Zheng Yuan Lyu Meng-Yang Xue Feng Xu Jia-Li Wang Yu-Guo Ghen | 2021 | Chinese Medical Journal2021，，5： | 6 |
| 5 | Effect of intraarterial chemotherapy on vascular endothelial growth factor expression and microvessel density in carcinoma of the cervix显示文摘Objective: To clarify the effect of intraarterial chemotherapy on vascular endothelial growth factor (VEGF) expres- sion and microvessel density (MVD) count in carcinoma of the cervix. Methods: Before intraarterial chemotherapy and after 2–3 weeks of therapy, the expression of VEGF and MVD count in 36 carcinoma tissues of locally advanced cervical cancer were determined by CD34. Results: Before intraarterial chemotherapy and after 2–3 weeks, the expression of VEGF were 75% (27/36) and 30.6% (11/36) respectively, and MVD were reduced obviously (P<0.001). Conclusion:?The intraarterial chemotherapy can reduce the expression of VEGF and MVD, and adjust malignancy of cervical cancer, and cut down the postoperative metastasis. | Yongxiu Qiu Ghunlin Ghen Ping Liu Yili Wei | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，1： | 5 |
| 6 | Surface removal of a copper thin film in an ultrathin water environment by a molecular dynamics study显示文摘The surface planarity and asperity removal behavior on atomic scale in an ultrathin water environment were studied for a nanoscale process by molecular dynamics simulation.Monolayer atomic removal is achieved under both noncontact and monoatomic layer contact conditions with different water film thicknesses.The newly formed surface is relatively smooth without deformed layers,and no plastic defects are present in the subsurface.The nanoscale processing is governed by the interatomic adhering action during which the water film transmits the loading forces to the Cu surface and thereby results in the migration and removal of the surface atoms.When the scratching depth≥0.5 nm,the abrasive particle squeezes out the water film from the scratching region and scratches the Cu surface directly.This leads to the formation of trenches and ridges,accumulation of chips ahead of the particles,and generation of dislocations within the Cu substrate.This process is mainly governed by the plowing action,leading to the deterioration of the surface quality.This study makes the'0 nm planarity,0 residual defects,and 0 polishing pressure'in a nanoscale process more achievable and is helpful in understanding the nanoscale removal of materials for developing an ultra-precision manufacture technology. | Junqin SHI Liang FANG Kun SUN Weixiang PENG Juan GHEN Meng ZHANG | 2020 | Friction2020，8，2： | 3 |
| 7 | Gene cloning and expression of aminopeptidase N and cadherin from midgut of the rice stem borer, Chilo suppressalis显示文摘 | Hong-Kun Yu Hao Ghen Yong-Jun Zhang Kong-Ming Wu Ge-Mei Liang Ze-Wen Liu Yu-Yuan Guo | 2010 | Insect Science2010，17，5： | 3 |
| 8 | Chkl mediates S and G2arrests through CDC25A degradation inresponse to DNA-damaging agents显示文摘 | Xiao Z Ghen Z Gunasekera AH | 2003 | J Biol Chem2003，278，21： | 1 |
| 9 | Extfirtic regulation of eardiomyoeyte differentiation of embryonic stem cells显示文摘 | Ghen K Wu I Wang | 2008 | J Cell Biochem2008，104，1： | 1 |
| 10 | High -level expression of a sika deer (Cervus nippon) Cu/Zn superoxide dismutase in Pichia pastoris and its characterization 显示文摘 | Li RK Fu CL Ghen P et aL | 2013 | Environ Toxicol Pharmacol2013，35，2： | 1 |
| 11 | The critical role of 15-1ipoxygeng ase-I in coloreetal epithelial cell terminal differentiation and htmorigenesis 显示文摘 | Shureiqi l Wu Y Ghen D | 2005 | Cancer Res2005，65，11： | 1 |
| 12 | Impact of residual and intrafractional errors on strategy of correction for image-guided accelerated partial breast irradiation显示文摘 | CAI G HU W G GHEN J Y | 2010 | Radiat Oncol2010，5，： | 1 |
| 13 | A two - stage quality measure for mobile phone captured 2D barcode images 显示文摘 | Ghen C Kot A G Yang H | 2013 | Pattern Recognition2013，46，9： | 1 |
| 14 | Programmed death-ligand 1 and programmed death--1 inhibiting molecular pathways: next generation immunotherapy显示文摘 | Ghen DS Irving BA Hodi FS | 2012 | Glin Gancer Res2012，18，24： | 1 |
| 15 | A new series of LA-groups 显示文摘 | Ban Guining Ghen Liying Zhou Yu | 2007 | J Guangxi Teachers Education University2007，24，4： | 1 |
| 16 | A Predator-prey System with Stage Structure for Predator显示文摘 | WANG W GHEN L | 1994 | Computers Math Applic(S0898-1221)1994，33，8： | 1 |
| 17 | Brain-derived neurotrophic factor stimulates proliferation and differentiation of neural stem cells, possibly by triggering the Wnt/13-catenin signaling pathway 显示文摘 | Ghen B Y Wang X Wang Z Y | 2013 | J Neurosci Res2013，91，1： | 1 |
| 18 | Prediction of ice shapes and their effect on airfoil drag显示文摘 | SHIN J BERKOWITZ B GHEN H H | 1994 | Journal of Aircral1994，31，2： | 1 |
| 19 | Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia显示文摘 | Zhao C Ghen A Jamieson CH | 2009 | Nature2009，458，7239： | 1 |
| 20 | Potential clinical applications using stem cel s derived from human umbilical cord blood显示文摘 | Ghen MJ Roshan R Roshan RO | | 0，，04： | 1 |
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