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| 1 | Colorectal cancer carcinogenesis:a review of mechanisms显示文摘Colorectal cancer(CRC) is the second most common cancer in women and the third most common in men globally. CRC arises from one or a combination of chromosomal instability, Cp G island methylator phenotype, and microsatellite instability. Genetic instability is usually caused by aneuploidy and loss of heterozygosity. Mutations in the tumor suppressor or cell cycle genes may also lead to cellular transformation. Similarly, epigenetic and/or genetic alterations resulting in impaired cellular pathways, such as DNA repair mechanism, may lead to microsatellite instability and mutator phenotype. Non-coding RNAs, more importantly micro RNAs and long non-coding RNAs have also been implicated at various CRC stages. Understanding the specific mechanisms of tumorigenesis and the underlying genetic and epigenetic traits is critical in comprehending the disease phenotype. This paper reviews these mechanisms along with the roles of various non-coding RNAs in CRCs. | Kanwal Tariq Kulsoom Ghias | 2016 | Cancer Biology & Medicine2016，13，1： | 15 |
| 2 | Eltrombopag Increases Platelet Numbers in Thrombocytopenic Patients With HCV Infection and Cirrhosis, Allowing for Effective Antiviral Therapy显示文摘 | Nezam H. Afdhal Geoffrey M. Dusheiko Edoardo G. Giannini Pei–Jer Chen Kwang–Hyub Han Aftab Mohsin Maribel Rodriguez–Torres Sorin Rugina Igor Bakulin Eric Lawitz Mitchell L. Shiffman Ghias–Un–Nabi Tayyab Fred Poordad Yasser Mostafa Kamel Andres Brainsky Ja | 2014 | Gastroenterology2014，，2： | 2 |
| 3 | 1,8-Naphthyridines IV. 9-Substituted N , N -dialkyl-5-(alkylamino or cycloalkylamino) [1,2,4]triazolo[4,3- a ][1,8]naphthyridine-6-carboxamides, new compounds with anti-aggressive and potent anti-inflammatory activities显示文摘 | Giorgio Roma Mario Di Braccio Giancarlo Grossi Francesca Mattioli Marco Ghia | 2000 | European Journal of Medicinal Chemistry2000，，11： | 2 |
| 4 | Bioassay-guided isolation of novel and selective urease inhibitors from Diospyros lotus显示文摘Two new dimeric naphthoquinones, 5′,8′-dihydroxy-6,6′-dimethyl-7,3′-binaphthyl-1,4,1′,4′-tetraone(1; Di-naphthodiospyrol D) and 5′,8′-dihydroxy-5,8-dimethoxy-6,6′-dimethyl-7,3′-binaphthyl-1,4,1′,4′-tetraone(2; Di-naphthodiospyrol E), along with known naphthoquinones diospyrin(3) and 8-hydroxy diospyrin(4) were isolated from the chloroform fraction of extract of Diospyros lotus roots. Their structures were elucidated by advanced spectroscopic analyses, including HSQC, HMBC, NOESY, and J-resolved NMR experiments. The fractions and compounds 1-4 were evaluated for urease activity and phosphodiesterase-Ⅰ, carbonic anhydrase-Ⅱ and α-chymotrypsin enzyme inhibitory activities. Compounds 1 and 2 and their corresponding fractions showed significant and selective inhibitory effects on urease activities. The IC_(50) values of 1 and 2 were 260.4 ± 6.37 and 381.4 ± 4.80 μmol·L-1, respectively, using thiourea(IC_(50) = 21 ± 0.11 μmol·L^(-1)) as the standard inhibitor. This was the first report demonstrating that the naphthoquinones class showed urease inhibition. | Abdur Rauf Ghias Uddin Bina S. Siddiqui Ajmal Khan Umar Farooq Farhan A. Khan Syed Majid Bukhari Sher Bahadar Khan | 2017 | Chinese Journal of Natural Medicines2017，15，11： | 2 |
| 5 | Anti-nociceptive, anti-inflammatory and sedative activities of the extracts and chemical constituents of Diospyros lotus L.显示文摘 | Ghias Uddin Abdur Rauf Bina S. Siddiqui Naveed Muhammad Ajmal Khan Syed Uzair Ali Shah | 2014 | Phytomedicine2014，，： | 1 |
| 6 | High-re solutions for incompressible flow using the navier-stokes equations and a multigrid method显示文摘 | Ghia U Ghia K N Shin C T | 1982 | Journal of Computational Physics1982，48，： | 1 |
| 7 | Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B- cell chronic lymphocytic leukemia显示文摘 | GRANZIERO L GHIA P CIRCOSTA P | 2001 | Blood2001，97，9： | 1 |
| 8 | High-/?e Solutions for Incom-pressible Flow Using the Navier-Stokes Equations and aMultigrid Method 显示文摘 | Ghia U Ghia KN Shin CT | 1982 | Journal of Computational Physics1982，48，3： | 1 |
| 9 | The role of ganglionated plexi in apnea-re- lated atrial fibrillation显示文摘 | Ghias M Scherlag B J Lu Z | 2009 | J Am Coll Cardiol2009，54，： | 1 |
| 10 | Tropisetron upregulates cannabinoid CB 1 receptors in cerebellar granule cells: Possible involvement of calcineurin显示文摘 | Reza Rahimian Ahmad Reza Dehpour Gohar Fakhfouri Mohammad Reza Khorramizadeh Jean-Eric Ghia Mohammad Seyedabadi Antonio Caldarelli Kazem Mousavizadeh Mehdi Forouzandeh Shahram Ejtemaei Mehr | 2011 | Brain Research2011，，： | 1 |
| 11 | Reprogramming cell death: BCL2 family inhibition in hematological malignancies显示文摘 | Scarfo L Ghia P | 2013 | Immunol Lett2013，155，12： | 1 |
| 12 | Primary vaginal cancer and chemoradiotherapy a patterns-of care analysis 显示文摘 | Ghia AJ Gonzalez VJ Tward JD | 2011 | Int J Gy- necol Cancer2011，21，： | 1 |
| 13 | The microenviron- ment in mature B-cell malignancies: a target for new treat- ment strategies显示文摘 | Burger JA Ghia P Rosenwald A | 2009 | Blood2009，114，16： | 1 |
| 14 | Vagus nerve integrity and experimental colitis 显示文摘 | Ghia JE Blennerhassett P Collins SM | 2007 | Am J Physiol Gastrointest Liver Physiol2007，293，3： | 1 |
| 15 | High-Re solutions for incompressible flow using the Navier-Stokes equations and a multigrid method显示文摘 | Ghia U Ghia K N Shin C T | 1982 | J Comput Phys1982，48，3： | 1 |
| 16 | High-Re solutions for incompressibleow using the navier-stokes equations and multigrid method显示文摘 | GHIA U GHIA K N SHIN C T | 1982 | J Comput Phys1982，48，： | 1 |
| 17 | Alternate Day versus Once Daily Atorvastatin for Primary Prevention of (CHD) in Naive Patients of Dyslipidemia显示文摘 | Ghia C J Panda AS Khobragade LR | 2014 | J Clin Diagn Res2014，8，3： | 1 |
| 18 | Effect of acetic acid or trypsin application on rat colonic motility in vitro and modulation by two synthetic: fragments of chromogranin A显示文摘 | Ghia JE Pradaud I Crenner F | 2005 | Regul Pept2005，124，13： | 1 |
| 19 | High - Re Solutions for Incompressible ow Using the Navier Stokes Equations and Multigrid Method 显示文摘 | Ghia U Ghla KN Shin CT | 1982 | Journal of Computational Physics1982，48，： | 1 |
| 20 | High-Re solutions for incompressible flow using the Navier-Stokes equations and a multigrid method 显示文摘 | Ghia U Ghia K N Shin C T | 1982 | J Comput Phys1982，48，3： | 1 |
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