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| 1 | 3D-printed gelatin methacrylate (GelMA)/ silanated silica scaffold assisted by two-stage cooling system for hard tissue regeneration显示文摘Among many biomaterials,gelatin methacrylate(GelMA),a photocurable protein,has been widely used in 3D bioprinting process owing to its excellent cellular responses,biocompatibility and biodegradability.However,GelMA still shows a low processability due to the severe temperature dependence of viscosity.To overcome this obstacle,we propose a two-stage temperature control system to effectively control the viscosity of GelMA.To optimize the process conditions,we evaluated the temperature of the cooling system(jacket and stage).Using the established system,three GelMA scaffolds were fabricated in which different concentrations(0,3 and 10 wt%)of silanated silica particles were embedded.To evaluate the performances of the prepared scaffolds suitable for hard tissue regeneration,we analyzed the physical(viscoelasticity,surface roughness,compressive modulus and wettability)and biological(human mesenchymal stem cells growth,western blotting and osteogenic differentiation)properties.Consequently,the composite scaffold with greater silica contents(10 wt%)showed enhanced physical and biological performances including mechanical strength,cell initial attachment,cell proliferation and osteogenic differentiation compared with those of the controls.Our results indicate that the GelMA/silanated silica composite scaffold can be potentially used for hard tissue regeneration. | Eunjeong Choi Dongyun Kim Donggu Kang Gi Hoon Yang Bongsu Jung MyungGu Yeo Min-Jeong Park SangHyun An KyoungHo Lee Jun Sik Kim Jong Chul Kim Woonhyeok Jeong Hye Hyun Yoo Hojun Jeon | 2021 | Regenerative Biomaterials2021，8，2： | 2 |
| 2 | Reappraisal of serum alpha‐foetoprotein as a surveillance test for hepatocellular carcinoma during entecavir treatment显示文摘 | Gi‐Ae Kim Chang Hyeon Seock Jang Won Park Jihyun An Kwang‐Sun Lee Jee Eun Yang Young‐Suk Lim Kang Mo Kim Ju Hyun Shim Danbi Lee Han Chu Lee | 2015 | Liver Int2015，，1： | 2 |
| 3 | Evidence for the association of peroxidases with the antioxidant effect of p-eoumaric acid in endo- thelial cells exposed to high glucose plus araehidonie acid 显示文摘 | Lee SJ Mun GI An SM | 2009 | BMB Rep2009，42，9： | 1 |
| 4 | Evidence for the associa- tion of peroxidases with the antioxidant effect of p - cou- marie acid in endothelial cells exposed to high glucose plus arachidonic acid 显示文摘 | Lee SJ Mun GI An SM | 2009 | BMP Rep2009，42，9： | 1 |
| 5 | Development of SSR markers for studies of diversity in the genus Fagopyrmn显示文摘 | Kyung Ho Ma Nam Soo Kim Gi An Lee | 2009 | The- or Appl Genet2009，119，7： | 1 |
| 6 | Synthesis and evaluation of a radioio-dinated bladder cancer specific peptide显示文摘 | Ha YS Lee HY An GI | | 0，，14： | 1 |
| 7 | Preparation of 3'-deoxy-3'fluorothymidine(FLT in ionic liquid显示文摘 | Moon BS Lee KC An GI | 2006 | J Label Compd Radiophann2006，49，： | 1 |
| 8 | Long-Term Outcome and Risk Factor Analysis of Surgical Pulmonary Valve Replacement in Congenital Heart Disease显示文摘Objectives:To establish long-term outcome of surgical pulmonary valve replacement(PVR)in congenital heart disease(CHD)and to identify risk factors for overall mortality,operative mortality,and repetitive PVR.Methods:This is a retrospective study of 375 surgical PVR in 293 patients who underwent surgical PVR for CHD between January 2000 and May 2020.We only included patients with index PVR with previous open-heart surgery regardless of the number of PVRs.The previous surgical history of patients who underwent PVR during the study period was also included.Patients who underwent the Rastelli operation,and those who underwent single PVR without previous open-heart surgery were excluded.Results:The median age of the patients at the time of surgical PVR was 14.9 years(Interquartile range,IQR,11.0–22.0).The median follow-up duration was 10.5 years(IQR,5.5–14.8 years).There were 3 patients with operative mortality(1.0%)and 15 patients with overall mortality(5.1%).The survival rate was 95.1%over 20 years follow-up period.Multivariate analysis demonstrated that more than 3 times of previous open-heart surgeries before surgical PVR,older age at the first operation,longer cardiopulmonary bypass(CPB)time and longer intensive care unit(ICU)stay were predictors for overall mortality.Patients who underwent surgical PVR after more than 3 times of previous open-heart surgeries had significantly higher mortality than those who underwent open-heart surgeries less than 3 times(P<0.001).Age younger than 10 years,male,multiple valve problems and longer ICU stay were significant predictors for repetitive PVR by multivariate analysis.Conclusions:Though surgical PVR has excellent long-term outcome,it should be performed with caution for those who previously underwent multiple open-heart surgeries,especially if patient received more than 3 times of open-heart surgeries. | Woo Young Park Gi Beom Kim Sang Yun Lee Mi Kyoung Song Hye Won Kwon Hyo Soon An Eun Jung Bae Sungkyu Cho Jae Gun Kwak Woong-Han Kim | 2022 | Congenital Heart Disease2022，17，3： | 0 |
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