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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis显示文摘 | Rayner Katey J Sheedy Frederick J Esau Christine C Hussain Farah N Temel Ryan E Parathath Saj van Gils Janine M Rayner Alistair J Chang Aaron N Suarez Yajaira Fernandez-Hernando Carlos Fisher Edward A Moore Kathryn J | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 3 | Influence of age in estimating maximal oxygen uptake显示文摘ObjectiveTo 在最大的氧举起的估计( EE )的错误上估计年龄的影响( VO 2最大)用性别和在自从估计,测试的周期测力计锻练特定方程的人口, VO 2最大与实质的 EE 被联系,经常超过20%, 18~91 年,可能,由于机械 efficiency.Methods1850 的内在的可变性,成年人(68%人)经历了最大的周期测力计测试的心肺的锻练。心和肺的健康(CRF ) 相对性别和年龄被估计[更年轻(18 ~ 35 年) ,中年(36 ~ 60 年) 并且更旧(>60 年)] 。VO 2 最大[mL·(kg· min )−1] 被对煤气的交换的评价直接测量并且估计了使用性别和人口特定方程。VO 2 最大和相关 EE 在三年龄特定、性特定的 groups.ResultsDirectly 测量的 VO 2 男人和女人的最大是 29.5 ±10.5 mL·(kg· min )−1 和 24.2 ±9.0 mL·(kg· min )−1(P <0.01 ) 。EE [mL·(kg· min ) 为男人和女人的 −1] 和百分比错误(% E ) 有类似的价值, 0.5 ±3.2 和 0.4 ±2.9 mL·(kg· min )−1, 和 − 0.8 ±13.1% 并且 − 1.7 ±15.4%(P >0.05 ) 分别地。分别地,为每个年龄组的 EE 和 % E 为男人:更年轻的 = 1.9 ±4.1 mL·(kg· min )−1 和 3.8 ±10.5% ,中年的 = 0.6 ±3.1 mL·(kg· min )−1 和 0.4 ±10.3% ,更旧的 =− 0.2 ±2.7 mL·(kg· min )−1 和 − 4.2 ±16.6%(P <0.01 ) ;并且为女人:更年轻的 = 1.2 ±3.1 mL·(kg· min )−1 和 2.7 ±10.0% ,中年的 = 0.7 ±2.8 mL·(kg· min )−1 和 0.5 ±11.1% ,更旧的 =-0.8 ±2.3 mL·(kg· min )−1 和 − 9.5 ±22.4%(P <0.01 ).ConclusionVO 2 最大在更年轻的年龄组被低估并且在老年组被过高估计。年龄显著地影响 VO 2 在男人和女人的最大并且当 CRF 用人口被估计时,应该被认为特定方程,而非直接测量了。 | Christina G de Souza Silva Barry A Franklin Daniel E Forman Claudio Gil S Araujo | 2016 | Journal of Geriatric Cardiology2016，13，2： | 2 |
| 4 | A study of the abrasive resistance of metal alloys with applications in dental prosthetic fixators显示文摘 | GIL F J FERNNDEZ E MANNERO J M | 1995 | Biomedical Materials Engineering1995，5，3： | 1 |
| 5 | Stimuli-responsive polymers and their bioconjugates 显示文摘 | GIL E S HUDSON S M | 2004 | Prog Polym Sci2004，29，： | 1 |
| 6 | Method of DNA extraction and application of multiplex polymerase chain reaction to detect toxigenic Vibrio cholerae O1 and O139 from aquatic ecosystems 显示文摘 | Rivera I N Lipp E K Gil A | 2003 | Environ Microbiol2003，5，7： | 1 |
| 7 | Effect of feed deprivation and lairage time on carcass and meat quality traits on pigs under minimal stressful conditions显示文摘 | Panella-Riera N Gispert M Gil M Soler J Tibau J Oliver M A Velarde A Fàbrega E | | 0，，01： | 1 |
| 8 | Lower-limb robotic rehabilitation: literature review and challenges显示文摘 | DAZ I GIL J J SNCHEZ E | 2011 | Journal of Robotics2011，2011，75： | 1 |
| 9 | Effects of Pollutants on Laccase Activities of Marasmius Quercophilus, a White-rot Fungus Imlated from a Mediterranean Schlerophyllous Litter 显示文摘 | Famet A M Gil G Ferre E | 2008 | Chemosphere2008，，70： | 1 |
| 10 | Translocation of soils to stimulate climate change: CO2 emissions and modifications to soil organic matter 显示文摘 | Rey M Guntinas E Gil - sotres F | 2007 | European Journal of Soil Science2007，10，： | 1 |
| 11 | Prostaglandin E2-bisphosphonate conjugates:potential agents for treatment of osteoporosis显示文摘 | Gil L Han Y Opas E E | 1999 | Bioorg Med Chem1999，7，： | 1 |
| 12 | Transmission Network Expansion Planning under an Improved Genetic Algorithm显示文摘 | Silva E L Gil H A Areiza J M | 2000 | IEEE Trans on Power Systems2000，15，3： | 1 |
| 13 | A comparative study of boartaint in cooked and dry-cured meat显示文摘 | Ban6n S Costa E Gil MD e( al | 2003 | Meat Science2003，63，3： | 1 |
| 14 | Quality changes and nutrient retention in fresh-cut versus whole fruits during storage 显示文摘 | GIL M I AGUAYO E | 2006 | J Agric Food Chem2006，54，： | 1 |
| 15 | Colloidal carriers and blood-brain barrier(BBB)translocation: a way to deliver drugs to the brain? 显示文摘 | GARCIA-GARCIA E ANDRIEUX K GIL S | 2005 | Int J Pharm2005，298，2： | 1 |
| 16 | Quantitative assessment with intracoronany ultrosund of the mechanisms of resenosis after percutaneous transluminal coronary angioplasty and directional coronary atherectomy 显示文摘 | Di Mario Gil R Camen Zind E | 1995 | Am J Cardiol1995，75，： | 1 |
| 17 | Paraquat induced Fanconi syn-drome显示文摘 | Gil H W Yang JO Lee E Y | 2005 | Nephrology (Carlton)2005，10，5： | 1 |
| 18 | Ingrowth of human mesenchymal stem cells into porous silk particle reinforced silk composite scaffolds:An in vitro study显示文摘 | Rockwood D N Gil E S Park S H | 2011 | Acta biomaterialia2011，7，1： | 1 |
| 19 | Antagonism of perpheral 5-HT4 receptors reduces visceral and cutaneous pain in mice,and induces visceral analgesia after simultaneous inactivation of 5-HT3 receptors显示文摘 | Espejo EF Gil E | 1998 | Brain Res1998，788，12： | 1 |
| 20 | High temperature soldering of SiC particulate aluminium matrix composites (series 2000) using Zn-A1 filler alloys显示文摘 | URENA A GIL L ESCRICHE E SALAZAR J M G ESCALERA M D | 2001 | Science and Technology of Welding and Joining2001，6，1： | 1 |
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