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| 1 | Live cell screening platform identifies PPAR6 as a regulator of cardiomyocyte proliferation and cardiac repair显示文摘Zebrafish 能高效地通过 cardiomyocyte 增长改革他们的心。相反,哺乳动物的 cardiomyocytes 站立即在出生以后增殖,限制出生后的哺乳动物的心的再生能力。因此,如果出生后的 cardiomyocyte 增长的内长的潜力能被提高,它能为心失败病人提供有希望的未来治疗。这里,我们开始系统地识别触发出生后的 cardiomyocyte 增长的小分子。由屏蔽为估计房间周期阶段利用一个基于 Fucci 的系统的化学复合图书馆,我们作为出生后的 cardiomyocyte 增长的 inducer 识别了 carbacyclin。在 vitro, carbacyclin 经由 peroxisome 导致了新生、成年的 mononuclear 老鼠 cardiomyocytes 的增长激活 proliferator 的受体(PPAR )/PDK1/p308Akt/GSK3/-catenin 小径。PPAR 的抑制在 zebrafish 心新生期间减少了 cardiomyocyte 增长。尤其是,象有在在老鼠的心肌的梗塞以后的 PPAR 收缩筋的治疗一样的组成地活跃的 PPAR 的可诱导的 cardiomyocyte 特定的 overexpression 在 cardiomyocytes 导致了房间周期前进,减少了结疤,并且改进了心脏的功能。一起,我们建立了屏蔽系统和礼品的 cardiomyocyte 增长有为心脏的病理的治疗的诺言的一个新 drugable 目标由 cardiomyocyte 损失引起了。 | Ajit Magadum Yishu Ding Lan He Teayoun Kim Mohankrishna Dalvoy Vasudevarao Qinqiang Long Kevin Yang Nadeera Wickramasinghe Harsha V Renikunta Nicole Dubois Gilbert Weidinger Qinglin Yang Felix B Engel | 2017 | Cell Research2017，27，8： | 6 |
| 2 | Gold and trace element zonation in pyrite using a laser imaging technique: Implications for the timing of gold in orogenic and Carlin- style sediment- hosted deposits 显示文摘 | R R Large L Danyushevsky C Hollit V Maslennikov S Meffer S Gilbert S Bull R Scott P Emsbo H Thomas B Singh J Foster | 2009 | Economic Geology2009，104，5： | 1 |
| 3 | Strategize commitment to price to stimulate downstream innovation in a supply chain显示文摘 | Gilbert S M Cvsa V | 2003 | European Journal of Operational Research2003，，150： | 1 |
| 4 | Strategic commitment versus postponement in a two-tier supply chain显示文摘 | Cvsa V Gilbert SM | 2002 | European Journal of Operational Research2002，141，： | 1 |
| 5 | Recurrent and novel LDL receptor gene mutations causing heterozygous familial hypercholesterolemia in La Habana显示文摘 | Erasmo Pereira Raoul Ferreira Brigitte Hermelin Ginette Thomas Chantal Bernard Véronique Bertrand Hadad Nassiff Dora Mendez Castillo Gilbert Bereziat Pascale Benlian | 1995 | Human Genetics1995，，3： | 1 |
| 6 | Strategic commitment versus postponement in a two-tier supply chain显示文摘 | Cvsa V Gilbert S M | 2002 | European Journal of Opera- tional Research2002，141，3： | 1 |
| 7 | Developing an appropriate strategy to assess genetic variability in plant germplasm collections 显示文摘 | Gilbert J E levis R V Wilkinson M J | 1999 | Theor Appl Genet1999，98，： | 1 |
| 8 | Quantitative estima- tion of the stability of' methicillin resistant Staphylococcus aureus strain-typing systems by use of Kaplan-Meier survival analysis显示文摘 | OSullivan MVN Sintchenko V Gilbert | 2013 | JCM2013，51，1： | 1 |
| 9 | Strategic commitment to price to stimulate downstream innovation in a supply chain 显示文摘 | Gilbert S M Cvsa V | 2003 | European Journal of Operations Research2003，15，3： | 1 |
| 10 | Improved respiratory delivery of the anticancer drugs, camptothecin and paclitaxel with 5% CO2-enriched air:pharmacokinetic studies 显示文摘 | Koshkina NV Kinght V Gilbert BE | 2001 | Cancer Chemother Pharmacol2001，47，： | 1 |
| 11 | Mechanisms for fracture and fatigue-crack propagation in a bulk metallic glass显示文摘 | Gilbert C L Schroeder V Ritchie R O | 1999 | Metallurgical and Materials Transactions A1999，30，： | 1 |
| 12 | Developing an appropriate strategy to assess genetic variability in plant germplasm collection 显示文摘 | Gilbert J E Lewis R V Wikinson M L | 1999 | Theoretical and Applied Genetics1999，98，： | 1 |
| 13 | Strategic Commitment to Price to Stimulate Downstream Innovation in a Supply Chain 显示文摘 | Gilbert S M Cvsa V | 2003 | European Journal of Operational Research2003，150，3： | 1 |
| 14 | Strategic commitment to price to stimulate downstream innovation in a supply chain显示文摘 | Gilbert M S Cvsa V | 2003 | European Journal of Operational Research2003，150，： | 1 |
| 15 | Culture-Inde-pendent Characterization of Archaeal Biodiversity in Swine Con-finement Building Bioaerosols显示文摘 | NEHME B GILBERT Y LETOURNEAU V | 2009 | Applied and Environmental Mi-crobiology2009，75，17： | 1 |
| 16 | Devel- oping an appropriate strategy to assess genetic variability in- plant germplasm collections 显示文摘 | GILBERT J E LEWIS R V WILKINSON M J | 1999 | Theor Appl Genet1999，98，： | 1 |
| 17 | Distribution of cammptothecin after delivery as liposome aerlsol or following intramuscular injection in mice显示文摘 | Koshkina N V Gilbert B E Waldrep J C | 1999 | Cancer Chemother Pharmacol1999，44，3： | 1 |
| 18 | Developing an appropriate strategy to assess genetic variability in plant germ- plasm collections显示文摘 | GILBERT J E LEWIS R V WILKINSON M J | 1999 | Theor Appl Genet1999，98，： | 1 |
| 19 | Effect of aqueous environment on fatigue-crack propagation behavior in a Zr-based bulk amorphous metal?显示文摘 | V Schroeder C.J Gilbert R.O Ritchie | 1999 | Scripta Materialia1999，，9： | 1 |
| 20 | Developing an appropriate strategy to assess genetic variability in plant germplasm collecaions显示文摘 | Gilbert J E Lewis R V Wilkinson M J | 1999 | Theoretical and Applied Genetics1999，98，： | 1 |
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