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| 1 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 2 | New insights into liver regeneration 显示文摘 | Gilgenkrantz H Collin de l'Hortet A | 2011 | Clin Res in Hepat Gast2011，35，： | 1 |
| 3 | Effect of dystrophin gene deletions on mRNA levels and processing in Duchenne and Becker muscular dystrophies 显示文摘 | Chelly J Gilgenkrantz H Lambert M | 1990 | Cell1990，63，6： | 1 |
| 4 | Bri(c)f communication:the relationship of regression of cirrhosis to outcome in chronic hepatitis C显示文摘 | Mallet V Gilgenkrantz H Serpaggi J | | 0，，： | 1 |
| 5 | Mesenchymal stem cells:an alternative source of hepatocytes?显示文摘 | Gilgenkrantz H | 2004 | Hepatology2004，40，6： | 1 |
| 6 | New insights into liver regeneration 显示文摘 | Gilgenkrantz H Collin de l'Hortet A | 2011 | Clin Res Hepatol Gastroenterol2011，35，10： | 1 |
| 7 | Dual Role of CCR2 in the Constitution and the Resolution of Liver Fibrosis in Mice显示文摘 | Claudia Mitchell Dominique Couton Jean-Pierre Couty Marie Anson Anne-Marie Crain Vinciane Bizet Laurent Rénia Stanislas Pol Vincent Mallet Hélène Gilgenkrantz | 2009 | The American Journal of Pathology2009，，5： | 1 |
| 8 | Transient expression of genes transferred in vivo into heart using firstgeneration adenoviral vectors:role of the immune response显示文摘 | Gilgenkrantz H Duboc D Juillard V | 1995 | Hum Gene Ther1995，6，10： | 1 |
| 9 | Climatologic parameters and myocardial infarction显示文摘 | Larcan A Gilgenkrantz JM Stoltz JF | 1983 | Ann Cardiol Angeiol (Paris)1983，32，2： | 1 |
| 10 | 3M dwarfism:a study of two further sibs显示文摘 | Feldmann M Gilgenkrantz S Parisot S | 1989 | J Med Genet1989，26，9： | 1 |
| 11 | New insights into liver regen- eration显示文摘 | Gilgenkrantz H Collin de l'Hortet A | 2011 | Clin Res Hepatol Gastroenterol2011，35，10： | 1 |
| 12 | Bone marrow transplantation in mice leads to a minor population of hepatocytes that can be selectively amplified in vivo显示文摘 | Vincent O. Mallet Claudia Mitchell Eva Mezey Monique Fabre Jacques-Emmanuel Guidotti Laurent Renia Laure Coulombel Axel Kahn Hélène Gilgenkrantz | 2002 | Hepatology2002，，4： | 1 |
| 13 | Transient expression of genes transferred in vivo into heart using first-generation adenoviral vectors:role of the immune response显示文摘 | Gilgenkrantz H Dubc D Juillard V | 1995 | Hum Gene Ther1995，6，： | 1 |
| 14 | Mosaictetrasomy 12p显示文摘 | Gilgenkrantz S Droulle P Schweitzer M | 1985 | Clin Genet1985，28，1： | 1 |
| 15 | New insights into liver regeneration 显示文摘 | Gilgenkrantz H deHortet A C | 2011 | Clinics and Research in Hepatology and Gastroenterology2011，35，10： | 1 |
| 16 | 肝脏手术后动员干细胞进行修复:梦想还是现实?显示文摘当令人惊讶的数据显示成人千细胞可以从干细胞库迁移到受伤器官,跨越组织谱系的界限参与修复时,对肝脏干细胞的研究进入了一个充满争议和希望的新领域。例如,在啮齿类动物中已经证实,循环中的干细胞在粒细胞集落刺激因子(G-CSF)的动员下,可以定殖到心肌梗死灶并且参与心肌的重塑和功能改建。在骨髓移植后,已经发现肝脏中有供体衍生的肝细胞存在,但最近有人对这种“可塑性”提出了质疑。在啮齿类动物和人类中。 | Vincent Olivier Mallet Helene Gilgenkrantz 姚勤伟(编译) 杨月(审校) | 2006 | 传染病网络动态2006，，3： | 0 |
| 17 | 脆性X研究新进展显示文摘自1991年应用分子生物学技术分析伴有智力低下的脆性X获得结果以来,该领域研究进展很快。Mandel小组对一些智力低下患者的研究证实了位于脆性X位点的CpG岛的特异甲基化作用。通过对包含一脆性位点区域的人工酵母染色体克隆、类似标记物的分离表明脆性X细胞遗传学和临床表型与甲基化的CpG岛下游的DNA长度的增加有关。与正常基因相比。 | Gilgenkrantz H 高小平 | 1993 | 国外医学(遗传学分册)1993，16，1： | 0 |
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