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| 1 | When sepsis affects the heart: A case report and literature review显示文摘A 59-year-old nursing home patient with Down syndrome was brought to the internal medicine department of our hospital due to fever, cough without expectorate, and dyspnea. A thoracic computed tomography revealed the presence of bilateral basal parenchymal opacities. Her condition deteriorated after admission and troponin reached a peak serum concentration of 16.9 ng/m L. The patient was in cardiogenic shock. In addition to fluid resuscitation, vaso-active amine infusion was administered to achieve hemodynamic stabilization. The differential diagnosis investigated possible pulmonary embolism, myocardial infarction, and myocarditis. Furthermore, a second transthoracic echocardiogram suggested Tako-Tsubo syndrome. This is a septic patient. The purpose of this manuscript is to review studies which formerly examined the possible association between high levels of troponin and mortality to see if it can be considered a positive predictive factor of fatal prognosis as the case of thrombocytopenia, already a positive independent predictive factor of multiple organ failure syndrome, and generally to characterize risk profile in a septic patient. | Giuseppe Clemente Antonino Tuttolomondo Daniela Colomba Rosaria Pecoraro Chiara Renda Vittoriano Della Corte Carlo Maida Irene Simonetta Antonio Pinto | 2015 | World Journal of Clinical Cases2015，3，8： | 5 |
| 2 | The Yin-Yang of osteopontin in nervous system diseases: damage versus repair显示文摘Osteopontin is a broadly expressed pleiotropic protein,and is attracting increased attention because of its role in the pathophysiology of several inflammatory,degenerative,autoimmune,and oncologic diseases.In fact,in the last decade,several studies have shown that osteopontin contributes to tissue damage not only by recruiting harmful inflammatory cells to the site of lesion,but also increasing their survival.The detrimental role of osteopontin has been indeed well documented in the context of different neurological conditions(i.e.,multiple sclerosis,Parkinson’s,and Alzheimer’s diseases).Intriguingly,recent findings show that osteopontin is involved not only in promoting tissue damage(the Yin),but also in repair/regenerative mechanisms(the Yang),mostly triggered by the inflammatory response.These two apparently discordant roles are partly related to the presence of different functional domains in the osteopontin molecule,which are exposed after thrombin or metalloproteases cleavages.Such functional domains may in turn activate intracellular signaling pathways and mediate cell-cell and cell-matrix interactions.This review describes the current knowledge on the Yin and Yang features of osteopontin in nervous system diseases.Understanding the mechanisms behind the Yin/Yang would be relevant to develop highly specific tools targeting this multifunctional protein. | Giuseppe Cappellano Domizia Vecchio Luca Magistrelli Nausicaa Clemente Davide Raineri Camilla Barbero Mazzucca Eleonora Virgilio Umberto Dianzani Annalisa Chiocchetti Cristoforo Comi | 2021 | Neural Regeneration Research2021，16，6： | 2 |
| 3 | SmartArc-Based Volumetric Modulated Arc Therapy for Oropharyngeal Cancer: A Dosimetric Comparison With Both Intensity-Modulated Radiation Therapy and Helical Tomotherapy显示文摘 | Stefania Clemente BinBin Wu Giuseppe Sanguineti Vincenzo Fusco Francesco Ricchetti John Wong Todd McNutt | 2011 | International Journal of Radiation Oncology, Biology, Physics2011，，： | 1 |
| 4 | Unexpected Gallbladder Cancer after Laparoscopic Cholecystectomy for Acute Cholecystitis: A Worrisome Picture显示文摘 | Gennaro Clemente Gennaro Nuzzo Agostino Rose Ivo Giovannini Giuseppe Torre Francesco Ardito Felice Giuliante | 2012 | Journal of Gastrointestinal Surgery2012，，8： | 1 |
| 5 | Gastric emptying and orocecal transit time in pregnancy显示文摘 | Marisa Chiloiro Giuseppe Darconza Elettra Piccioli Massimo De Carne Caterina Clemente Giuseppe Riezzo | 2001 | Journal of Gastroenterology2001，，8： | 1 |
| 6 | Unexpected Gallbladder Cancer after Laparoscopic Cholecystectomy for Acute Cholecystitis: A Worrisome Picture显示文摘 | Gennaro Clemente Gennaro Nuzzo Agostino Rose Ivo Giovannini Giuseppe Torre Francesco Ardito Felice Giuliante | 2012 | Journal of Gastrointestinal Surgery2012，，8： | 1 |
| 7 | Stroke Subtypes and their Possible Implication in Stroke Prevention Drug Strategies显示文摘 | Antonino Tuttolomondo Rosaria Pecoraro Domenico Di Raimondo Valentina Arnao Giuseppe Clemente Vittoriano Della Corte Carlo Maida Irene Simonetta Giuseppe Licata Antonio Pinto | 2013 | Current Vascular Pharmacology2013，，6： | 1 |
| 8 | Direct Costs of Schizophrenia and Related Disorders in Italian Community Mental Health Services: A Multicenter, Prospective 1-Year Followup Study显示文摘 | Livio Garattini Corrado Barbui Rosa Clemente Dante Cornago Fabio Parazzini Study Qroup SCORE Adele Bono Giuseppe Bonomo Giampiero Covelli Alfredo Dama Andrea Fiorillo Pier Maria Furlan Patricia Gatta Roberto Laneri Emanuele Lo Monaco Giuseppe Marra Gianfr | 2004 | Schizophrenia Bulletin2004，，2： | 1 |
| 9 | Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines显示文摘 | Sandro Drago Ramzi El Asmar Mariarosaria Di Pierro Maria Grazia Clemente Amit Tripathi Anna Sapone Manjusha Thakar Giuseppe Iacono Antonio Carroccio Cinzia D’Agate Tarcisio Not Lucia Zampini Carlo Catassi Alessio Fasano | 2006 | Scandinavian Journal of Gastroenterology2006，，4： | 1 |
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