|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The nematode resistance gene Mi of tomato confers resistance against the potato aphid显示文摘 | Rossi M Goggin F L Milligan S B | 1995 | Proceedings of the National Academy of Sciences USA1995，95，： | 1 |
| 2 | Experimental cyclic response of cold-formed hollow steel bracing members 显示文摘 | Goggins J M Broderick B M | 2005 | Engineering Structures2005，27，： | 1 |
| 3 | The nematode resistance gene Mi of tomato confers resistance against the potato aphid显示文摘 | ROSSI M GOGGIN F L MILLIGAN S B | 1998 | Agricultural Sciences1998，95，17： | 1 |
| 4 | Risk factors for oral mucositis in children undergoing chemotherapy: A matched case-control study显示文摘 | Cheng K K Goggins W B Lee V W | 2008 | Oral Oncol2008，44，11： | 1 |
| 5 | The nematode resistance gene Mi of tomato confers resistance against the potato aphid 显示文摘 | Rossi M Goggin F L Milligan S B | 1998 | Proc Natl Acad Sci USA1998，95，： | 1 |
| 6 | Effects of 17-allylamino-17-demethoxygeldanamycin (17-AAG) in transgenic mouse models of frontotemporal lobar degeneration and Alzheimer’s disease显示文摘Alzheimer’s disease(AD),the most common dementia,is characterized by potentially neurotoxic aggregation of Aβ peptide and tau protein,and their deposition as amyloid plaques and neurofibrillary tangles(NFTs).Tau aggregation also occurs in other common neurodegenerative diseases.Frontotemporal dementia(FTD)can be caused by tau mutations that increase the susceptibility of tau to hyperphosphorylation and aggregation,which may cause neuronal dysfunction and deposition of NFTs.17-allylamino-17-demethoxygeldanamycin(17-AAG)is a potent inhibitor of heat shock protein 90(Hsp90),a cytosolic chaperone implicated in the proper folding and functions of a repertoire of client proteins.17-AAG binds to Hsp90 and enhances degradation of Hsp90 client protein.We sought to determine whether 17-AAG can reduce Aβ and tau pathology in the brains of AD and FTD model mice expressing Aβ or P301L mutant tau,respectively.Mice were randomized to receive 25,5,or 0 mg/kg 17-AAG thrice weekly from age eight to 11 months.Analysis was performed by rotarod test on motor function,on the area occupied by plaques in hippocampus or NFTs in medulla tissue sections,and on mortality.A high dose of 17-AAG tended to decrease NFTs in male mice(p=0.08).Further studies are required to confirm the effect of 17-AAG in diseases of tau aggregation. | Shuk Wai Ho Yuk Tung Chanel Tsui Ting Ting Wong Stanley Kwok-Kuen Cheung William B Goggins Lau Ming Yi Kwok Kin Cheng Larry Baum | 2013 | Translational Neurodegeneration2013，2，1： | 1 |
| 7 | The nematode resistance gene Mi of tomato confers resistance against the potato aphid显示文摘 | ROSSI M GOGGIN F L MILLIGAN S B | | 0，，： | 1 |
| 8 | Experimental cyclic response of cold-formed hollow steel bracing members 显示文摘 | Goggins J Broderick B Elghazouli A | 2005 | Engineering Structures2005，27，7： | 1 |
| 9 | Cross-protection against four species of chicken coccidia with a single recombinant antigen显示文摘 | Crane M S Goggin B Pellegrino R M | 1991 | Infect Immun1991，59，4： | 1 |
| 10 | The nematode resistance gene Mi of tomato confers resistance against thepotato aphid显示文摘 | Rossi M Goggin F L Milligan S B | 1998 | Proc Natl Acad Sci USA1998，95，17： | 1 |
| 11 | Cross-protection against four species of chicken coccidia with a single recombinant antigen 显示文摘 | GRANE M S GOGGIN B PELLEGRINO R M | 1991 | Infect Immun1991，59，4： | 1 |
| 12 | Experimental cyclic response of cold-formed hollow steel bracing members显示文摘 | Goggins J M Broderick B M Elghazouli A Y | | 0，，： | 1 |
| 13 | Behaviour of tubular steel members under cyclic axial loading显示文摘 | Goggins J M Broderick B M Elghazouli A Y | | 0，，： | 1 |
| 14 | Frailty index as a measure of biological age in a Chinese population 显示文摘 | GOGGINS W B WOO J SHAM A | 2005 | The Journals of Gerontology Series A: Biological Sciences and Medical Sciences2005，60，8： | 1 |
| 15 | Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields 显示文摘 | Owen M J Goggin D E Powles S B | 2012 | Pest Management Science2012，68，： | 1 |
| 16 | Cross-protection against four species of chicken coccidia with a single recombinant antigen 显示文摘 | Grane M S Goggin B Pellegrino R M | 1991 | Infect Immun1991，59，： | 1 |
| 17 | Cross-Protection against four species of chicken coccidia with a single recombinant antigen显示文摘 | Goggin B Pellegrino R M | 1991 | Infect Immun1991，59，： | 1 |
| 18 | Cost-effectiveness of High-risk Human Papillomavirus Testing for Cervical Cancer Screening in Québec, Canada显示文摘 | Vijayaraghavan Arthi Efrusy Molly B Mayrand Marie-Hélène Santas Christopher C Goggin Patricia | 2010 | Canadian Journal of Public Health2010，，3： | 1 |
| 19 | Willingness of Hong Kong healthcare workers to accept pre - pandemic influenza vaccination at different WHO alert levels: two questionnaire surveys显示文摘 | CHOR J S NGAI K L GOGGINS W B | 2009 | BMJ2009，339，： | 1 |
| 20 | Analysis of functional renal allograft tolerance with single-dose rapamycin based induction immunosuppression 显示文摘 | Goggins W C Fisher R A Dattilo J B | 1997 | Transplantation1997，63，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员