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| 1 | 原发性开角型青光眼患者Myocilin基因的单核苷酸多态性显示文摘目的 探讨 Myocilin(MYOC)基因的单核苷酸多态性 (single nucleotide polymorphisms,SNPs)及其与原发性开角型青光眼 (primary open- angle glaucoma,POAG)发病的关系。方法 应用高通量构象敏感性凝胶电泳和荧光标记自动测序法筛选和鉴定香港 15 7例 POAG散发患者和 15 5名对照 MYOC基因的 SNPs。结果 在 MYOC基因所有 3个外显子及邻近的非编码区共检出 17种 SNPs:1- 83G→ A、G12 R、P16 L、A17S、R4 6 X、R76 K、R91X、T12 3T、D2 0 8E、L 2 15 P、730 +35 A→ G、A2 6 0 A、I2 88I、E30 0 K、T35 3I、Y4 71C和 15 15 +73G→ C。其中 ,R91X、E30 0 K和 Y4 71C仅在 POAG患者中检测到。此外 ,15 15 +73G→ C各基因型在 POAG患者与对照人群中的分布差异具有显著意义 ,POAG患者中 CG型频率为 0 .6 % ,低于对照组的 4 .5 % (P=0 .0 36 )。其余 16种 SNPs各基因型在两组人群中的分布差异均无显著意义。结论 MYOC基因多态性可能与中国人 POAG发病有关 ,提示 MYOC基因是 POAG的相关基因。 | 范宝剑 梁旭辉 彭智培 Larry Baum 谭霭仙 汪宁 林顺潮 | 2004 | 中华医学遗传学杂志2004，21，1： | 5 |
| 2 | More than anti-malarial agents: therapeutic potential of artemisinins in neurodegeneration显示文摘Artemisinin,also called qinghaosu,is originally derived from the sweet wormwood plant(Artemisia annua),which is used in traditional Chinese medicine.Artemisinin and its derivatives(artemisinins)have been widely used for many years as anti-malarial agents,with few adverse side effects.Interestingly,evidence has recently shown that artemisinins might have a therapeutic value for several other diseases beyond malaria,including cancers,inflammatory diseases,and autoimmune disorders.Neurodegeneration is a challenging age-associated neurological disorder characterized by deterioration of neuronal structures as well as functions,whereas neuroinflammation has been considered to be an underlying factor in the development of various neurodegenerative disorders,including Alzheimer’s disease.Recently discovered properties of artemisinins suggested that they might be used to treat neurodegenerative disorders by decreasing oxidation,inflammation,and amyloid beta protein(Aβ).In this review,we will introduce artemisinins and highlight the possible mechanisms of their neuroprotective activities,suggesting that artemisinins might have therapeutic potential in neurodegenerative disorders. | Bing-Wen Lu Larry Baum Kwok-Fai So Kin Chiu Li-Ke Xie | 2019 | Neural Regeneration Research2019，14，9： | 4 |
| 3 | Polymorphisms and vascular cognitive impairment after isehemic stroke显示文摘 | Larry Baum Xiangyan Chen Wing Sze Cheung | 2007 | Geriatr Psychiatry Neurol2007，20，2： | 1 |
| 4 | Low - density Lipoprotein Receptor - Related Protein 8 ( apolipoprotein E receptor 2) Gene Polymorphisms in Alzheimer's Disease 显示文摘 | Suk Ling Ma Ho Keung Ng Larry Baum | 2002 | Neuroscience Letters2002，，332： | 1 |
| 5 | Effects of 17-allylamino-17-demethoxygeldanamycin (17-AAG) in transgenic mouse models of frontotemporal lobar degeneration and Alzheimer’s disease显示文摘Alzheimer’s disease(AD),the most common dementia,is characterized by potentially neurotoxic aggregation of Aβ peptide and tau protein,and their deposition as amyloid plaques and neurofibrillary tangles(NFTs).Tau aggregation also occurs in other common neurodegenerative diseases.Frontotemporal dementia(FTD)can be caused by tau mutations that increase the susceptibility of tau to hyperphosphorylation and aggregation,which may cause neuronal dysfunction and deposition of NFTs.17-allylamino-17-demethoxygeldanamycin(17-AAG)is a potent inhibitor of heat shock protein 90(Hsp90),a cytosolic chaperone implicated in the proper folding and functions of a repertoire of client proteins.17-AAG binds to Hsp90 and enhances degradation of Hsp90 client protein.We sought to determine whether 17-AAG can reduce Aβ and tau pathology in the brains of AD and FTD model mice expressing Aβ or P301L mutant tau,respectively.Mice were randomized to receive 25,5,or 0 mg/kg 17-AAG thrice weekly from age eight to 11 months.Analysis was performed by rotarod test on motor function,on the area occupied by plaques in hippocampus or NFTs in medulla tissue sections,and on mortality.A high dose of 17-AAG tended to decrease NFTs in male mice(p=0.08).Further studies are required to confirm the effect of 17-AAG in diseases of tau aggregation. | Shuk Wai Ho Yuk Tung Chanel Tsui Ting Ting Wong Stanley Kwok-Kuen Cheung William B Goggins Lau Ming Yi Kwok Kin Cheng Larry Baum | 2013 | Translational Neurodegeneration2013，2，1： | 1 |
| 6 | Association between ABCB1 C3435T polymorphism and drug-resistant epilepsy in Han Chinese显示文摘 | Kwan P Larry Baum L Wong V | 2007 | Epilepsy Behav2007，11，1： | 1 |
| 7 | Neuroprotective effect of honokiol and magnolol, compounds from Magnolia offici- nalis,on beta-amyloid-induced toxicity in PCI2 cells显示文摘 | Hoi Chu Peng Ho Yee Ping Baum Larry | 2010 | Phyto- ther Res2010，24，10： | 1 |
| 8 | Associations of polymorphisms in the apolipoproteinA1/C3/A4/A5 gene cluster with familial combined hyperlipidaemia in Hong Kong Chinese 显示文摘 | Zhi-Kai Liu Miao Hu Larry Baum | 2010 | Atherosclerosis2010，208，2： | 1 |
| 9 | Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer’s disease animal models显示文摘 | Larry Baum Alex Ng | 2004 | Journal of Alzheimer’s Disease2004，，4： | 1 |
| 10 | Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression显示文摘 | Patrick Kwan Wai Sang Poon Ho-Keung Ng David E. Kang Virginia Wong Ping Wing Ng Colin H.T. Lui Ngai Chuen Sin Ka S. Wong Larry Baum | 2008 | Pharmacogenetics and Genomics2008，，11： | 1 |
| 11 | 结膜延展法 :一种简单而有效的翼状胬肉治疗方法(英文)显示文摘目的 :改进一种翼状胬肉治疗方法。方法 :对翼状胬肉患者 5 3例 5 7只眼 ,其中 5 2只眼为原发 ,5只眼为复发性胬肉 ,施行一种新的胬肉切除手术 ,即结膜延展法 ,其源自结膜瓣转位法并进行了改进 ,其实质是拉伸角巩膜缘处的结膜缘并覆盖裸露的巩膜。观察新术式的手术时间、并发症及胬肉的复发情况。结果 :所有病例随访了至少 5个月 ,手术时间较常规结膜瓣转位术明显缩短 ,胬肉复发率低 (7% ) ,没有观察到其他并发症。结论 :此种新方法简单、有效 ,复发率低。 | 刘瑶 王爱莲 LARRY Baum | 2005 | 东南大学学报(医学版)2005，24，1： | 0 |
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