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| 1 | Hospitalized prevalence and 5-year mortality for IBD:Record linkage study显示文摘AIM:To establish the hospitalized prevalence of severe Crohn's disease(CD) and ulcerative colitis(UC) in Wales from 1999 to 2007;and to investigate long-term mortality after hospitalization and associations with social deprivation and other socio-demographic factors.METHODS:Record linkage of administrative inpatient and mortality data for 1467 and 1482 people hospitalised as emergencies for ≥ 3d for CD and UC,respectively.The main outcome measures were hospitalized prevalence,mortality rates and standardized mortality ratios for up to 5 years follow-up after hospitalization.RESULTS:Hospitalized prevalence was 50.1 per 100 000 population for CD and 50.6 for UC.The hospitalized prevalence of CD was significantly higher(P < 0.05) in females(57.4) than in males(42.2),and was highest in people aged 16-29 years,but the prevalence of UC was similar in males(51.0) and females(50.1),and increased continuously with age.The hospital-ized prevalence of CD was slightly higher in the most deprived areas,but there was no association between social deprivation and hospitalized prevalence of UC.Mortality was 6.8% and 14.6% after 1 and 5 years follow-up for CD,and 9.2% and 20.8% after 1 and 5 years for UC.For both CD and UC,there was little discernible association between mortality and social deprivation,distance from hospital,urban/rural residence and geography.CONCLUSION:CD and UC have distinct demographic profiles.The higher prevalence of hospitalized CD in more deprived areas may reflect higher prevalence and higher hospital dependency. | Lori A Button Stephen E Roberts Michael J Goldacre Ashley Akbari Sarah E Rodgers John G Williams | 2010 | World Journal of Gastroenterology2010，16，4： | 3 |
| 2 | Perinatal and early life risk factors for inflammatory bowel disease显示文摘AIM:To investigate associations between perinatal risk factors and subsequent inflammatory bowel disease (IBD) in children and young adults.METHODS:Record linked abstracts of birth registrations,maternity,day case and inpatient admissions in a defined population of southern England.Investigation of 20 perinatal factors relating to the maternity or the birth:maternal age,Crohn's disease (CD) or ulcerative colitis (UC) in the mother,maternal social class,marital status,smoking in pregnancy,ABO blood group and rhesus status,pre-eclampsia,parity,the infant's presentation at birth,caesarean delivery,forceps delivery,sex,number of babies delivered,gestational age,birthweight,head circumference,breastfeeding and Apgar scores at one and five minutes.RESULTS:Maternity records were present for 180 children who subsequently developed IBD.Univariate analysis showed increased risks of CD among children of mothers with CD (P=0.011,based on two cases of CD in both mother and child) and children of mothers who smoked during pregnancy.Multivariate analysis confirmed increased risks of CD among children of mothers who smoked (odds ratio=2.04,95% CI=1.06-3.92) and for older mothers aged 35+ years (4.81,2.32-9.98).Multivariate analysis showed that there were no significant associations between CD and 17 other perinatal risk factors investigated.It also showed that,for UC,there were no significant associations with the perinatal factors studied.CONCLUSION:This study shows an association between CD in mother and child;and elevated risks of CD in children of older mothers and of mothers who smoked. | Stephen E Roberts Clare J Wotton John G Williams Myfanwy Griffith Michael J Goldacre | 2011 | World Journal of Gastroenterology2011，17，6： | 2 |
| 3 | Interpretive bias in acupuncture research: A ease study 显示文摘 | O'Connell NE Wand BM Goldacre B | 2009 | Eval Health Prof2009，32，4： | 1 |
| 4 | Trends in mortality after hospital admission for liver cirrhosis in an English population from 1968 to 1999 显示文摘 | Roberts SE Goldacre M J Yeates D | 2005 | Gut2005，54，11： | 1 |
| 5 | Cancer after cholecystectomy: record-linkage cohort study显示文摘 | Goldacre MJ Abisgold JD Seagroatt V | 2005 | Br J Cancer2005，92，7： | 1 |
| 6 | What proportion of symptomatic side effects in patients taking statins are genuinely caused by the drug? Systematic review of randomized placebocontrolled trials to aid individual patient choice显示文摘 | Finegold JA Manisty CH Goldacre B | 2014 | Eur J Prev Cardiol2014，21，： | 1 |
| 7 | Liver cirrhosis, other liver diseases, pancreatitis and subsequent cancer: record linkage study显示文摘 | Goldacre MJ Wotton CJ Yeates D | 2008 | Eur J Gastroenterol Hepatol2008，20，5： | 1 |
| 8 | Increase in emergency admissions to hospital for children aged under 15 in England, 1999-- 2010: national database analysis显示文摘 | Gill PJ Goldacre MJ Martt D | 2013 | Arch Dis Child2013，98，5： | 1 |
| 9 | Time trends and demography of mortality after fractures neck of femur in an English population 1968-1998 : database study显示文摘 | Roberts SE Goldacre MJ | 2003 | BMJ2003，，327： | 1 |
| 10 | Inguinal hernia repair:incidence of elective and emergency surgery,readmissinn and mortality显示文摘 | Primatesta P Goldacre MJ | 1996 | Int J Epidemiol1996，25，4： | 1 |
| 11 | Cancer in people with depressionor anxiety:record-linkage study显示文摘 | Goldacre MJ Woon CJ Yeates D | 2007 | Soc Psychiatry Psychiatr Epidemiol2007，42，9： | 1 |
| 12 | Mortality after hospital discharge for people with schizophrenia or bipolar disorder: retrospective study of linked English hospital episode statistics, 1999-2006显示文摘 | Hoang U Stewart R Goldacre MJ | 2011 | BMJ2011，343，： | 1 |
| 13 | Depression and anxiety in people with inflammatory bowel disease显示文摘 | Kurina L M Goldacre M J Yeates D | 2001 | J Epidemiol Community Health2001，55，10： | 1 |
| 14 | The ionization of basic triphenylmethane dyes 显示文摘 | Goldacre R J Philips J N | 1949 | Physical Chemistry of Polymer Solutions1949，，： | 1 |
| 15 | Incidence and 30-day case fatality for acute myocardial infarction in England in 2010: national-linked database study显示文摘 | Kate Smolina Frances L. Wright Mike Rayner Michael J. Goldacre | 2012 | The European Journal of Public Health2012，，6： | 1 |
| 16 | Trends in mor-tality from appendicitis and from gallstone disease in Englishpopulations,1979-2006:study of multiple-cause coding ofdeaths显示文摘 | Goldacre MJ Duncan ME Griffith M | 2011 | Postgrad Med J2011，87，1026： | 1 |
| 17 | 显示文摘 | Goldacre M J Wotton C J Yeates D Cancer in patients with ulcerative colitis Crohn’s disease and coeliac disease | 2008 | Eur J Gastroenterol Hepatol2008，20，4： | 1 |
| 18 | Liver cirrhosis, other liver diseases,pancreatitis and subsequent cancer: record linkage study显示文摘 | Goldacre M J Wotton C J Yeates D | 2008 | Eur J Gastroenterol Hepatol2008，20，5： | 1 |
| 19 | Mortality after admission tohospital with Fracture dneck of femar:data base study显示文摘 | Goldacre MJ Roberts SE Yeates D | 2002 | BMJ2002，325，： | 1 |
| 20 | Mortality after hospital discharge for people with schizophrenia or bipolar disorder:retrospective study of linked English hospital episode statistic s显示文摘 | Hoang U Stewart R Goldacre MJ | 2011 | British Medical Journal2011，343，： | 1 |
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