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| 1 | Hepatitis C virus genotypes distribution and transmission risk factors in Luxembourg from 1991 to 2006显示文摘AIM:To analyze the Hepatitis C virus (HCV) genotype distribution and transmission risk factors in a population of unselected patients in Luxembourg. METHODS:Epidemiological information (gender, age and transmission risks) were collected from 802 patients newly diagnosed for hepatitis C and living in Luxembourg, among whom 228 patients referred from prison. Genotyping using 5'noncoding (5'NC) sequencing was performed. We compared categorical data using the Fisher's exact F-test and odds ratios (OR) were calculated for evaluating association of HCV genotype and risk factors. RESULTS:The sex ratio was predominantly male (2.2) and individuals aged less than 40 years represented 49.6% of the population. Genotype 1 was predominant (53.4%) followed by genotype 3 (33%). Among risk factors, intravenous drug usage (IVDU) was the most frequently reported (71.4%) followed by medical-related transmission (17.6%) including haemophilia, transfusion recipients and other nosocomial reasons. Genotype 3 was significantly associated to IVDU (OR = 4.84, P < 0.0001) whereas genotype 1 was significantly associated with a medical procedure (OR = 2.42, P < 0.001). The HCV genotype distribution from inmate patients differed significantly from the rest of the population (Chi-square test with four degrees of freedom, P < 0.0001) with a higher frequency of genotype 3 (46.5% vs 27.5%) and a lower frequency of genotype 1 and 4 (44.7% vs 56.8% and 5.3% vs 9.6%, respectively). IVDU was nearly exclusively reported as a risk factor in prison. CONCLUSION:We report the first description of the HCV genotype distribution in Luxembourg. The repartition is similar to other European countries, with one of the highest European prevalence rates of genotype 3 (33%). Since serology screening became available in 1991, IVDU remains the most common way of HCV transmission in Luxembourg. | Francois Roman Karin Hawotte Daniel Struck Anne-Marie Ternes Jean-Yves Servais Vic Arendt Patrick Hoffman Robert Hemmer Thérèse Staub Carole Seguin-Devaux Jean-Claude Schmit | 2008 | World Journal of Gastroenterology2008，14，8： | 3 |
| 2 | Infuence of maternal and perinatal factors on subsequent hospitalization for asthma in children : Evidence from the oxford record linkage study 显示文摘 | Davidson R Roberts SE Wotton C J | 2010 | BMC Pulm Med2010，1610，： | 1 |
| 3 | Trends in mortality after hospital admission for liver cirrhosis in an English population from 1968 to 1999 显示文摘 | Roberts SE Goldacre M J Yeates D | 2005 | Gut2005，54，11： | 1 |
| 4 | Time trends and demography of mortality after fractures neck of femur in an English population 1968-1998 : database study显示文摘 | Roberts SE Goldacre MJ | 2003 | BMJ2003，，327： | 1 |
| 5 | Witness of intimate partner violence in childhood and perpetration of intimate parmer violence in adulthood显示文摘 | Roberts AL Gilman SE Fitzmaurice G | | 0，，6： | 1 |
| 6 | Loss of red cell A, B, and H antigens is frequent in myeloid malignancies显示文摘 | Tina B Belinda FJ Robert SE | 2001 | Blood2001，97，11： | 1 |
| 7 | The expression of androgen- regulated genes before and after a resistance exercise bout in younger and older men显示文摘 | Roberts MD Dalbo VJ Hassell SE | 2009 | J Strength Cond Res2009，23，4： | 1 |
| 8 | Topical penetration of commercial salicylate esters and salts using human isolated skin and clinical microdialysis studies显示文摘 | CROSS SE ANDERSON C ROBERTS MS | 1998 | Br J Clin Pharmacol1998，46，1： | 1 |
| 9 | Liver failurc with marked hyper ferritinenia:‘ironing out' the diagnosis显示文摘 | Natsheh SE Robert FA Ngan B | 2001 | Can J Gastroenterol2001，15，： | 1 |
| 10 | C-erbB-3 in human breast carcinoma: expression and related to prognosis and established prognostic indicators 显示文摘 | Travis A Pinder SE Robert JFR | 1996 | Br J Cancer1996，74，2： | 1 |
| 11 | A genome - wide screen identifies 27 genes involved in transposon silencing in elegans显示文摘 | Vastenhouw NL Fischer SE Robert VJ | 2003 | Curr Biol2003，13，15： | 1 |
| 12 | Intersession repeatability of macular thickness measurements with the Humphrey,2000 OCT显示文摘 | Koozekanani D Roberts C Katz SE | | 0，，06： | 1 |
| 13 | Mortality after admission tohospital with Fracture dneck of femar:data base study显示文摘 | Goldacre MJ Roberts SE Yeates D | 2002 | BMJ2002，325，： | 1 |
| 14 | The independence of intrinsic radiosensitivity as a prognostic factor for patient re- sponse to radiotherapy of carcinoma of the cervix显示文摘 | West CML Davidson SE Roberts SA | 1997 | British Journal of Cancer1997，76，： | 1 |
| 15 | The independence of intrinsic radiosensitivity as a prognostic factor for patient response to radiotherapy of carcinoma of the cervix 显示文摘 | Davidson SE Roberts SA | 1997 | Br J Cancer1997，76，9： | 1 |
| 16 | effect of exercise training on pulmonary function in children with thermal injury 显示文摘 | Oscar SE Robert MP David HN | 2002 | J Bum Care Rehabil Clin N Am2002，23，： | 1 |
| 17 | Apoptosis as predictor of response to radiotherapy in cervical carcinoma 显示文摘 | Levine EL Davidson SE Robert SA | 1994 | Lancet1994，344，： | 1 |
| 18 | Prostatitis as a risk factor for prostate cancer显示文摘 | ROBERTS RO BERGSTRALH EJ BASS SE | 2004 | Epidemiology2004，15，1： | 1 |
| 19 | Time trends and demography of mortality after fractured neck of fenmr in English population, 1968 - 98: database study 显示文摘 | Roberts SE Goldacre MJ | 2003 | BMJ2003，327，7148： | 1 |
| 20 | Time trends and demography of mortality after fractured neck of femur in an English population, 1969-98: Database study显示文摘 | Roberts SE Goldaere MJ | 2003 | BMJ2003，327，： | 1 |
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