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| 1 | Effect of Lepidium meyenii (maca) roots on spermatogenesis of male rats显示文摘Aim: To determine the effect of oral administration of an aqueous extract from the roots of Lepidium meyenii (maca)on spermatogenesis in adult male rats. Methods: Male rats received an aqueous extract of the root (66.7 mg in one mL) twice a day for 14 consecutive days. Results: Treatment with Lepidium meyenii resulted in an increase in the weights of testis and epididymis but not the seminal vesicle weight. The length and frequency of stages IX-XIV seminiferous tubules, where mitosis occurred, were increased and stages Ⅰ-Ⅵ were reduced in rats treated with Lepidium meyenii. Conclusion: The Lepidium meyenii root invigorates spermatogenesis in male rats by acting on its initial stages (IX-XIV). | Gustavo F.Gonzales Ana Ruiz Carla Gonzales León Villegas Amanda Cordova | 2001 | Asian Journal of Andrology2001，3，3： | 22 |
| 2 | Lepidium meyenii (Maca) improved semen parameters in adult men显示文摘Aim: The present study was designed to determine the effect of a 4-month oral treatment with tablets of Lepidium meyenii (Maca) on seminal analysis in nine adult normal men aged 24 - 44 years old. Methods: Nine men received tablets of Maca (1500 or 3000 mg/day) for 4 months. Seminal analysis was performed according to guidelines of the World Health Organization (WHO). Serum luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin (PRL), testosterone (T) and estradiol (E2) were measured before and after treatment. Results: Treatment with Maca resulted in increased seminal volume, sperm count per ejaculum, motile sperm count, and sperm motility. Serum hormone levels were not modified with Maca treatment. Increase of sperm count was not related to dose of Maca.Conclusion: Maca improved sperm production and sperm motility by mechanisms not related to LH, FSH, PRL, T and E2 . | Gustavo F.Gonzales Amanda Cordova Carla Gonzales Arturo Chung Karla Vega Arturo Villena | 2001 | Asian Journal of Andrology2001，3，4： | 23 |
| 3 | Glutamine is highly effective in preventing in vivo cobalt-induced oxidative stress in rat liver显示文摘AIM: To evaluate the in vivo effect of glutamine on cobaltgenerated oxidative stress and (HO-1) induction in rat liver.METHODS: Fasted female Wistar rats received a single injection of cobalt chloride (375 μmol/kg body weight) and then were killed at different times. Lipid peroxidation and soluble and enzymatic antioxidant defense system (reduced glutathione (GSH), catalase (CAT), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD)) were measured in liver homogenates. Ferritin and ferritin iron contents as well as heme oxygenase-1 (HO-1) activity and expression were also determined. The antioxidant properties of glutamine (Gin) were also evaluated. RESULTS: Cobalt chloride increased lipid peroxidation (50% over control values) 1 h after treatment. GSH reached a minimum at 3 h (40%) increasing thereafter. Twelve hours after CoCl2 injection, the antioxidant enzymes CAT, GSH-Px and SOD also diminished by about 30%. Heme oxygenase-1 induction was observed 6 h after treatment reaching a maximum value of 14-fold over the controls, 12 h after cobalt treatment. A 1.7-fold increase in ferritin and ferritin-bound iron 24 h after treatment were also obtained. Administration of glutamine (300 mg/kg body weight) by gavage 24 h before CoCl2 treatment entirely prevented the increase in thiobarbituric acid reactive substances (TBARS) content, the decrease in GSH levels, and partially reverted heme oxygenase-1 induction. CONCLUSION: These results suggested that a natural product such as glutamine prevents glutathione depletion and consequently heme oxygenase induction. | Soledad Gonzales Ariel H.Polizio María A.Erario María L.Tomaro | 2005 | World Journal of Gastroenterology2005，11，23： | 16 |
| 4 | Effect of two different extracts of red maca in male rats with testosterone-induced prostatic hyperplasia显示文摘瞄准:在更男的 ats 决定红 maca 的二篇不同摘录的效果。方法:Prostatic 增生与睾丸激素 enanthate (TE ) 在雄的老鼠被导致。Thestudy 包括了六个组:一个控制组(组 1 ),与 TE (组 2 )对待的一个组,与 TE 对待的二个组和红 maca 的水的摘录(组织 3 和 4 ),一个组对待红 maca (组 5 )的 withhydroalcoholic 摘录,一个组与 finasteride 对待( 0.1 mg , group6 )。在沸腾的时间的长度上的水的摘录依赖者的差别,是否为 2 个 or3 小时,为组, 3 和 4 被估计。红 maca 的摘录包含了 0.1 mg ofbenzylglucosinolate。此后,在红 maca 摘录的 benzylglucosinolates (0.02-0.08 mg ) 的不同剂量的剂量反应效果被估计。结果:前列腺重量在与红 maca 的水的摘录在沸腾的 2 和 3 个小时以后准备了的 freeze-dried 对待的老鼠是类似的。红 maca 的 Freeze-dried 水的摘录,红 maca 和 finasteride 的水疗院酒鬼摘录与职业人员静电干扰增生在老鼠减少了前列腺重量。没有差别在从水的摘录或红 maca 的水疗院酒鬼摘录获得的数据之间被观察。前列腺重量的剂量依赖者减小随红 macaextracts 的 benzylglucosinolates 的剂量的增加被观察。结论:现在的学习在 prostatichyperplasia 被 TE 在导致了的雄的老鼠给那个水疗院酒鬼或红 macacontaining 的水的摘录看了 benzylglucosinolate 罐头还原剂前列腺尺寸的 0.1 mg。 | Gustavo F. Gonzales Vanessa Vasquez Daniella Rodriguez Carmen Maldonado Juliet Mormontoy Jimmy Portella Monica Pajuelo León Villegas Manuel Gasco | 2007 | Asian Journal of Andrology2007，9，2： | 14 |
| 5 | Serum testosterone levels and excessive erythrocytosis during the process of adaptation to high altitudes显示文摘人口生活在高高度()特别地在秘鲁的安第斯山脉,被题目的混合物与红血球增多描绘( 16 g dl −1<haemoglobin ( Hb ) ≤ ; 21 ;有过多的红血球增多( EE )的 g dl −1)和其它( Hb> ; 21 ; g dl −1)。提高的血色素价值(EE ) 与长期的高山病被联系,反映改编的缺乏到的一个条件哈。根据当前的数据,从区域的本国的男人哈如果他们提高了浆液睾丸激素层次,足够地没被改编生活在如此的高度。这似乎由于 dehydroepiandrosterone 硫酸盐(DHEAS ) 的增加的变换到睾丸激素。有红血球增多在的男人与 EE 比男人举办更高的浆液 androstenedione 铺平的表演和更低的 testosterone/androstenedione 比率,建议减少的 17beta-hydroxysteroid 脱氢酶(17beta-HSD ) 活动。经由 Δ 的更低的 17beta-HSD 活动;在有红血球增多在的男人的 4 类固醇生产哈可以免于提高的浆液睾丸激素层次,因此阻止 EE。到在有 EE 的题目的睾丸激素的 DHEAS 的更高的变换经由 Δ 显示增加的 17beta-HSD 活动; 5 小径。当前,与低或高的血色素层次在有人们在过的各种各样的状况(人的生物多样性) 哈。古代能是为生活在的一个重要改编部件哈,并且睾丸激素似乎参予这个过程。 | Gustavo F Gonzales | 2013 | Asian Journal of Andrology2013，15，3： | 8 |
| 6 | Tooth-derived stem cells: Update and perspectives显示文摘Tissue engineering is an emerging field of science that focuses on creating suitable conditions for the regeneration of tissues. The basic components for tissue engineering involve an interactive triad of scaffolds, signaling molecules, and cells. In this context,stem cells(SCs) present the characteristics of selfrenewal and differentiation capacity, which make them promising candidates for tissue engineering. Although they present some common markers, such as cluster of differentiation(CD)105, CD146 and STRO-1, SCs derived from various tissues have different patterns in relation to proliferation, clonogenicity, and differentiation abilities in vitro and in vivo. Tooth-derived tissues have been proposed as an accessible source to obtain SCs with limited morbidity, and various tooth-derived SCs(TDSCs) have been isolated and characterized, such as dental pulp SCs, SCs from human exfoliated deciduous teeth, periodontal ligament SCs, dental follicle progenitor cells, SCs from apical papilla, and periodontal ligament of deciduous teeth SCs. However, heterogeneity among these populations has been observed, and the best method to select the most appropriate TDSCs for regeneration approaches has not yet been established. The objective of this review is to outline the current knowledge concerning the various types of TDSCs, and discuss the perspectives for their use in regenerative approaches. | Miki Taketomi Saito Karina Gonzales Silvério Márcio Zaffalon Casati Enilson Antonio Sallum Francisco Humberto Nociti Jr | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 7 | Antioxidant role of heme oxygenase-1 in prehepatic portal hypertensive rats显示文摘瞄准:在氧化的肝地位和这项活动和表示上学习胆红素的效果他我在老鼠肝损伤的 oxygenase-1 (HO-1 ) 由 prehepatic 门静脉高血压导致了。方法:Wistar 雄的老鼠,称 200-250 g,在随机被划分成二个组:有调整 prehepatic 门静脉结扎(PPVL ) 导致的 prehepatic 门静脉高血压(PH ) 的一个组和另外的组对应于假冒的操作老鼠。门压力,氧化压力参数,抗氧化剂酶, HO-1 活动和表示和肝的正弦曲线血管舒张被测量。结果:在 PPVL 老鼠,氧化应力被在减少的谷胱甘肽(GSH ) 的反应物质(TBARS ) 内容和减少铺平的 thiobarbituric 酸的显著增加证实。当 HO-1 的活动和表示被提高时,肝抗氧化剂酶,超级氧化物歧化酶(草皮) ,过氧化氢酶(猫) 和谷胱甘肽过氧化物酶(GSH-Px ) 的活动也被减少。胆红素(5 mumol/kg 体重) 的管理在实验的结束前的 24 h 完全阻止了所有这些效果。有 Sn-protoporphyrin IX (Sn-PPIX ) 的预告的处理(100 mug/kg 体重, i.p ) ,一个有势力禁止者惊讶,完全废除了氧化压力并且每氧化象类脂化合物的增加一样在肝 GSH 层次挑起了细微减少。而且,一氧化碳,另一他我分解代谢的产品,在在 PPVL 的肝的区域组织的正弦曲线导致了重要增加。有 Sn-PPIX 的 PPVL 老鼠的预告的处理完全阻止了这效果。结论:这些结果在 prehepatic 门 hypertensive 老鼠在表示上建议 HO-1 的一个有益的角色。 | Soledad Gonzales María Julia Pérez Juan C Perazzo María Luján Tomaro | 2006 | World Journal of Gastroenterology2006，12，26： | 6 |
| 8 | Effect of alcoholic extract of Lepidium meyenii (Maca) on testicular function in male rats显示文摘Aim: To evaluate the effect of the alcoholic extract of Lepidium meyenii (Maca) on the spermatogenesisin male rats. Methods: In Holtzman rats, Maca alcoholic extract (5 %) was given by oral route at doses of 48 mg/day or 96 mg/day for 7 days, 14 days and 21 days. Testicular function was assessed by measurements of lengths of different stages of seminiferous epithelia and by epididymal sperm count. Results: Ethanolic extract of Maca increased the length of stages IX-XI of seminiferous epithelium at treatment day 7, day 14 and day 21. Progression of spermatogenesis was evident only after day 21 when lengths of stages XII-XIV of seminiferous epithelium were increased; at day 7 and day 14, no important change in spermatogenesis was observed. Epididymal sperm count was increased with 48 mg/day at all times. With 96 mg/day an increase in sperm count was observed at day 7, but it was reduced at day 14 and day 21 of treatment. Serum testosterone levels were not affected. Conclusion: The alcoholic extract of Maca activates onset ant progression of spermatogenesis at 48 mg/day or 96 mg/day in rats. | Gustavo F. Gonzales Julio Rubio Arturo Chung Manuel Gasco León Villegas | 2003 | Asian Journal of Andrology2003，5，4： | 6 |
| 9 | Antiviral activity of maca ( Lepidium meyenii ) against human influenza virus显示文摘 | Juana del Valle Mendoza Tomàs Pumarola Libertad Alzamora Gonzales Luis J. del Valle | 2014 | Asian Pacific Journal of Tropical Medicine2014，，： | 3 |
| 10 | TIPS for Budd-Chiari Syndrome: Long-Term Results and Prognostics Factors in 124 Patients显示文摘 | Juan Carlos Garcia–Pagán Mathis Heydtmann Sebastian Raffa Aurélie Plessier Sarwa Murad Federica Fabris Giovanni Vizzini Juan Gonzales Abraldes Simon Olliff Antonio Nicolini Angelo Luca Massimo Primignani Harry L.A. Janssen Dominique Valla Elwyn Elias Jaum | 2008 | Gastroenterology2008，，3： | 3 |
| 11 | Hepatoprotection and Lethality Rescue by Histone Deacetylase Inhibitor Valproic Acid in Fatal Hemorrhagic Shock显示文摘 | Earl R. Gonzales Huazhen Chen Richard M. Munuve Tina Mehrani Amal Nadel Elena Koustova | 2008 | The Journal of Trauma: Injury, Infection, and Critical Care2008，，3： | 2 |
| 12 | The Spectrum of Liver Diseases Related to ABCB4 Gene Mutations: Pathophysiology and Clinical Aspects显示文摘 | Anne Davit-Spraul Emmanuel Gonzales Christiane Baussan Emmanuel Jacquemin | 2010 | Semin Liver Dis2010，，02： | 2 |
| 13 | Value of microscopy in the diagnosis of dysentery associated with invasive Entamoeba histolytica 显示文摘 | Gonzale RA Haque R Aguirre A | 1994 | J Clin Pathol1994，47，： | 2 |
| 14 | Biogenesis of mitochondrial c-type cytochromes显示文摘 | Gonzales D H Neupert W | 2000 | Bioenerg Biomembr2000，22，： | 1 |
| 15 | Liver transplantasion in pations with non- biliary cirrhosis:prognostic valuc of preoperative factors显示文摘 | Gonzale EE Rimola A Navasa M ct al | 1998 | J Hepatol1998，28，： | 1 |
| 16 | Thrombin activity and platelet microparticle fommtion are increased in type 2 diabetic platelets: a potential correlation with caspase activation显示文摘 | Cohen Z Gonzales RF Davis-Gorman GF | 2002 | Thromb Res2002，107，5： | 1 |
| 17 | Pitfalls associated with Fast-Fix meniscal repair 显示文摘 | MILLER MD KLINE AJ GONZALES J | 2002 | Arthroscopy2002，18，8： | 1 |
| 18 | Angiogen-sis and angiogenic growth factors in middle ear chol-esteatoma显示文摘 | SUDHOFF H DAZERT S GONZALES AM | 2000 | Am J Otol2000，21，6： | 1 |
| 19 | Benefit of heparin in peripheral venous and arterial catheters: systematic review and meta-analysis of randomized controlled trials显示文摘 | Randolph AG Cook DJ Gonzales CA | 1998 | BMJ1998，316，7136： | 1 |
| 20 | Testosterone suppresses endothelium-dependent dilation of rat middle cerebral arteries显示文摘 | Gonzales RJ Krause DN Duckles SP | 2004 | Am J Physiol Heart Circ Physiol2004，286，2： | 1 |
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