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| 1 | Animal models of portal hypertension显示文摘Animal models have allowed detailed study of hemodynamic alterations typical of portal hypertension and the molecular mechanisms involved in abnormalities in splanchnic and systemic circulation associated with this syndrome. Models of prehepatic portal hypertension can be used to study alterations in the splanchnic circulation and the pathophysiology of the hyperdynamic circulation. Models of cirrhosis allow study of the alterations in intrahepatic microcirculation that lead to increased resistance to portal ? ow. This review summarizes the currently available literature on animal models of portal hypertension and analyzes their relative utility. The criteria for choosing a particular model, depending on the specific objectives of the study, are also discussed. | Juan G Abraldes Marcos Pasarín Juan Carlos García-Pagán | 2006 | World Journal of Gastroenterology2006，12，41： | 14 |
| 2 | Intrahepatic vascular changes in non-alcoholic fatty liver disease: potential role of insulin-resistance and endothelial dysfunction显示文摘Metabolic syndrome is a cluster of several clinical conditions characterized by insulin-resistance and high cardiovascular risk. Non-alcoholic fatty liver disease is the liver expression of the metabolic syndrome, and insulin resistance can be a frequent comorbidity in several chronic liver diseases, in particular hepatitis C virus infection and/or cirrhosis. Several studies have demonstrated that insulin action is not only relevant for glucose control, but also for vascular homeostasis. Insulin regulates nitric oxide production, which mediates to a large degree the vasodilating, antiinflammatory and antithrombotic properties of a healthy endothelium, guaranteeing organ perfusion. The effects of insulin on the liver microvasculature and the effects of IR on sinusoidal endothelial cells have been studied in animal models of non-alcoholic fatty liver disease. The hypotheses derived from these studies and the potential translation of these results into humans are critically discussed in this review. | Marcos Pasarín Juan G Abraldes Eleonora Liguori Beverley Kok Vincenzo La Mura | 2017 | World Journal of Gastroenterology2017，23，37： | 6 |
| 3 | The management of portal hypertension: Rational basis, available treatments and future options显示文摘 | Jaime Bosch Annalisa Berzigotti Juan Carlos Garcia-Pagan Juan G. Abraldes | 2008 | Journal of Hepatology2008，，： | 3 |
| 4 | Efficacy and Safety of Anticoagulation on Patients With Cirrhosis and Portal Vein Thrombosis显示文摘 | María Gabriela Delgado Susana Seijo Ismael Yepes Linette Achécar Maria Vega Catalina ángeles García–Criado Juan G. Abraldes Joaquín de la Pe?a Rafael Ba?ares Agustín Albillos Jaume Bosch Juan Carlos García–Pagán | 2012 | Clinical Gastroenterology and Hepatology2012，，7： | 3 |
| 5 | 预防静脉曲张再出血的标准治疗方案联合辛伐他汀不能降低再出血率但可增加肝硬化患者的生存率显示文摘【据《Gastroenterology》2016年1月报道】题:预防静脉曲张再出血的标准治疗方案联合辛伐他汀不能降低再出血率但可增加肝硬化患者的生存率(作者Abraldes JG等)β-受体阻滞剂联合套扎是预防静脉曲张再出血的标准治疗措施,但治疗后再出血率及病死率较高。降脂药物辛伐他汀可降低门静脉压力、改善肝功能、延缓肝纤维化。 | Abraldes JG 莫雪 王中锋 | 2016 | 临床肝胆病杂志2016，32，3： | 3 |
| 6 | 661 USE OF EARLY-TIPS FOR HIGH-RISK VARICEAL BLEEDING. RESULTS OF A POST-RCT SURVEILLANCE STUDY显示文摘 | M. Di Pascoli J.C. García-Pagan K. Caca W. Laleman C. Bureau B. Appenrodt A. Luca A. Zipprich J.G. Abraldes F. Nevens J.P. Vinel J. Bosch | 2012 | Journal of Hepatology2012，，： | 3 |
| 7 | Improved clinical outcome using polytetrafluoroethylene-coated stents for tips: Results of a randomized study显示文摘 | Christophe Bureau Juan carlos Garcia-Pagan Philippe Otal Gilles Pomier-Layrargues Valérie Chabbert Carlos Cortez Pierre Perreault Jean marie Péron Juan G. Abraldes Louis Bouchard José Ignacio Bilbao Jaume Bosch Hervé Rousseau Jean pierre Vinel | 2004 | Gastroenterology2004，，2： | 3 |
| 8 | Portal Hypertension and Gastrointestinal Bleeding显示文摘 | Jaime Bosch Juan Abraldes Annalisa Berzigotti Juan Garcia-Pagan | 2008 | Semin Liver Dis2008，，01： | 3 |
| 9 | TIPS for Budd-Chiari Syndrome: Long-Term Results and Prognostics Factors in 124 Patients显示文摘 | Juan Carlos Garcia–Pagán Mathis Heydtmann Sebastian Raffa Aurélie Plessier Sarwa Murad Federica Fabris Giovanni Vizzini Juan Gonzales Abraldes Simon Olliff Antonio Nicolini Angelo Luca Massimo Primignani Harry L.A. Janssen Dominique Valla Elwyn Elias Jaum | 2008 | Gastroenterology2008，，3： | 3 |
| 10 | Hemodynamic response to pharmacological treatment of portal hypertension and long-term prognosis of cirrhosis显示文摘 | Juan G. Abraldes Ilaria Tarantino Juan Turnes Juan Carlos Garcia-Pagan Juan Rodés Jaime Bosch | 2003 | Hepatology2003，，4： | 3 |
| 11 | Real-time shear-wave elastography: applicability, reliability and accuracy for clinically significant portal hypertension显示文摘 | Bogdan Procopet Annalisa Berzigotti Juan G. Abraldes Fanny Turon Virginia Hernandez-Gea Juan Carlos García-Pagán Jaime Bosch | 2014 | Journal of Hepatology2014，，： | 2 |
| 12 | Hepatic endothelial dysfunction and abnormal angiogenesis: New targets in the treatment of portal hypertension显示文摘 | Jaume Bosch Juan G. Abraldes Mercedes Fernández Juan Carlos García-Pagán | 2010 | Journal of Hepatology2010，，3： | 2 |
| 13 | Ultrasonographic evaluation of liver surface and transient elastography in clinically doubtful cirrhosis显示文摘 | Annalisa Berzigotti Juan G. Abraldes Puneeta Tandon Eva Erice Rosa Gilabert Juan Carlos García-Pagan Jaime Bosch | 2010 | Journal of Hepatology2010，，6： | 2 |
| 14 | Impact of deepsedation on the accuracy of hepatic and portal venous pressuremeasurements in patients with cirrhosis显示文摘 | Reverter E Blasi A Abraldes JG | 2014 | Liver Int2014，34，： | 1 |
| 15 | Simvastatin lowersportal pressure in patients with cirrhosis and portal hypertension :a randomized controlled trial 显示文摘 | Abraldes JG Albillos A Bariares R | 2009 | Gastroenterology2009，136，： | 1 |
| 16 | Hemodynamic response to pharmacological treatment of portal hypertension and long-term prognosis of cirrhosis显示文摘 | Abraldes JG Tarantino I Turnes J | 2003 | Hepatology2003，37，4： | 1 |
| 17 | Variceal bleeding: pharmacological therapy显示文摘 | BOSCH J ABRALDES JG | 2005 | Dig Dis2005，23，1： | 1 |
| 18 | Acute Variceal Bleeding显示文摘 | Juan García-Pagán Enric Reverter Juan Abraldes Jaime Bosch | 2012 | Semin Respir Crit Care Med2012，，01： | 1 |
| 19 | Simvastatin enhances hepatic nitric oxide production and decreases the hepatic vascular tone in patients with cirrhosis显示文摘 | Zafra C Abraldes J G Turnes J | 2004 | Gastroenterology2004，126，3： | 1 |
| 20 | FBXW7/hCDC4 controls glioma cell proliferation in vitro and is a prognostic marker for survival in gioblastoma patients显示文摘 | Hoedowm M Delugin M Abraldes I | 2007 | Cell Div2007，2，： | 1 |
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