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| 1 | Autoantibody to MOG suggests two distinct clinical subtypes of NMOSD显示文摘We characterized a unique group of patients with neuromyelitis optica spectrum disorder(NMOSD) who carried autoantibodies of aquaporin-4(AQP4) and myelin-oligodendrocyte glycoprotein(MOG). Among the 125 NMOSD patients, 10(8.0%) were AQP4- and MOG-ab double positive, and 14(11.2%) were MOG-ab single positive. The double-positive patients had a multiphase disease course with a high annual relapse rate(P=0.0431), and severe residual disability(P<0.0001). Of the double-positive patients, 70% had MS-like brain lesions, more severe edematous, multifocal regions on spinal magnetic resonance imaging(MRI), pronounced decreases of retinal nerve fiber layer thickness and atrophy of optic nerves. In contrast, patients with only MOG-ab had a higher ratio of monophasic disease course and mild residual disability. Spinal cord MRI illustrated multifocal cord lesions with mild edema, and brain MRIs showed more lesions around lateral ventricles. NMOSD patients carrying both autoantibodies to AQP4 and MOG existed and exhibited combined features of prototypic NMO and relapsing-remitting form of MS, whereas NMOSD with antibodies to MOG only exhibited an 'intermediate' phenotype between NMOSD and MS. Our study suggests that antibodies against MOG might be pathogenic in NMOSD patients and that determination of anti-MOG antibodies maybe instructive for management of NMOSD patients. | Yaping Yan Yujing Li Ying Fu Li Yang Lei Su Kaibin Shi Minshu Li Qiang Liu Aimee Borazanci Yaou Liu Yong He Jeffrey L Bennett Timothy L Vollmer Fu-Dong Shi | 2016 | Science China(Life Sciences)2016，59，12： | 20 |
| 2 | Energy-discriminative performance of a spectral micro-CT system显示文摘 | He P Yu HY Bennett J | | 0，，： | 1 |
| 3 | Automaiedmutation detection using universal conditions direct sequencing :application to ten muscular dystrophy genes 显示文摘 | Bennett RR* Schneider HE Estrella E | 2009 | BMC Genet2009，10，： | 1 |
| 4 | Archival analysis of p53 genetic and protein alterations in Chinese esophageal cancer显示文摘 | Bennett WP Hollstein MC He A | 1991 | Oncogene1991，6，10： | 1 |
| 5 | Sevoflurane general anesthesia:An ahemative technique in the petiatric oral and maxill of aeial surgery patient显示文摘 | Lee MS Bennett HE Goon N | 2003 | J Oral Mmaxillofac Surg2003，61，6： | 1 |
| 6 | The characteristics of technology transfer into the Chinese steel industry and the valuation problem 显示文摘 | He Jinsheng Wang Xingming Bennett D J | 1998 | Proceedings of the Second International Symposium on Management of Technology1998，11，98： | 1 |
| 7 | Alterations in osteoclastmorphology following long-term 17beta-estradiol administration inthe mouse显示文摘 | Gruber HE Puzanov IJ Bennett M | 2001 | BMC Cell Bio2001，2，： | 1 |
| 8 | Sevoflurane general anesthesia: an alternative technique in the pediatric oral and maxillofacial surgery patient 显示文摘 | Lee M Bennett HE Gordon N | 2003 | J Oral Maxillofac Surg2003，61，11： | 1 |
| 9 | In situ testing of metallic iron nanoparticle mobility and reactivity in a shallow granular aquifer显示文摘 | Peter Bennett Feng He Dongye Zhao Brian Aiken Lester Feldman | 2010 | Journal of Contaminant Hydrology2010，，1： | 1 |
| 10 | A heuristic bidding strategy for buying multiple goods in multiple English auetions显示文摘 | M He N R Jennings and A Prugel - Bennett | 2006 | ACM Trans on Intemet Technology2006，6，4： | 1 |
| 11 | Sevoflurane General Anesthesia: An alternative technique in the petiatric oral and maxill ofaeial surgery patient显示文摘 | LeeM S Bennett HE Gordon N | 2003 | J Oral Mmaxillofac Surg2003，61，6： | 1 |
| 12 | Alterations in osteoclast morphology following long-term 17beta-estradiol administration in the mouse显示文摘 | Gruber HE Puzanov IJ Bennett M | 2001 | BMC Cell Biol2001，2，： | 1 |
| 13 | Validation of screening measures for assessing mood in stroke patients 显示文摘 | Bennett HE Thomas SA Austen R | 2006 | Br J Clin Psychol2006，45，3： | 1 |
| 14 | Sevoflurane general anesthesia : An alternative technique in the pediatric oral and maxillofacial surgery patient显示文摘 | Lee M Bennett HE Gordon N | 2003 | J Oral Maxillofac Surg2003，61，11： | 1 |
| 15 | TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth显示文摘 | Ken Inoki Hongjiao Ouyang Tianqing Zhu Charlotta Lindvall Yian Wang Xiaojie Zhang Qian Yang Christina Bennett Yuko Harada Kryn Stankunas Cun-yu Wang Xi He Ormond A. MacDougald Ming You Bart O. Williams Kun-Liang Guan | 2006 | Cell2006，，5： | 1 |
| 16 | Sevoflurane General Anesthesia: An al- ternative technique in the petiatric oral and maxill ofacial surgery pa- tient显示文摘 | Lee MS Bennett HE Gordon N | 2003 | J Oral Mmaxillofac Surg2003，61，6： | 1 |
| 17 | Insitu testing of metallic iron nanoparticle mobility and reactivity in a shallow granular aquifer显示文摘 | Bennett P He Feng Zhao Dong-ye | | 0，，1： | 1 |
| 18 | Sevoflurane general anesthesia:an alternative technique in the pediatric oral and maxillofacial surgery patient显示文摘 | Bennett HE Gordon N | 2003 | J Oral Maxillofac Surg2003，61，11： | 1 |
| 19 | Sevoflurane General Anesthesia: an altemative technique in the petiatric oral and maxillofaeial surgery patient 显示文摘 | Lee MS Bennett HE Gordon N | 2003 | J Oral Mmaxillofae Surg2003，61，11： | 1 |
| 20 | Sevoflurane general anesthesia: an alternative technique in the pediatric oral and maxillofacial surgery patient显示文摘 | LEE M BENNETT HE GORDON N | 2005 | J Oral Maxillofac Surg2005，61，11： | 1 |
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