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| 1 | Ibutilide and novel indexes of ventricular repolarization in persistent atrial fibrillation patients显示文摘AIM: To examine the effect of ibutilide on novel indexes of repolarization in patients with persistent atrial fibrillation (AF). METHODS: We studied consecutive patients scheduled for elective electrical cardioversion. Intravenous ibutilide (1+1mg) was administered before the electrical cardioversion while close electrocardiographic (ECG) monitoring was performed. ECG indexes such as corrected QT interval (QTc), the interval from the peak until the end of T wave (Tpe), and the Tpe/QT ratio were measured before ibutilide infusion and 10 min after the end of infusion. RESULTS: The final study population consisted of 20 patients (mean age: 67.1±9.9 years, 10 men). Six patients were cardioverted pharmacologically and did not proceed to electrical cardioversion. Two patientsdeveloped short non-sustained episodes of torsades de pointes ventricular tachycardia. All but one of the aforementioned ECG indexes increased significantly after ibutilide administration. In specific, the QTc interval increased from 442 ± 29 to 471 ± 37 ms (P=0.037), the Tpe interval in precordial leads from 96 ms (range 80-108 ms) to 101 ms (range 91-119 ms) (P=0.021), the Tpe interval in lead Ⅱ from 79 ms (range 70-88 ms) to 100 ms (range 87-104 ms) (P<0.001), the Tpe/QT ratio in precordial leads from 0.23 ms (range 0.18-0.26 ms) to 0.26 ms (range 0.23-0.28 ms) (P=0.028), and the Tpe interval dispersion from 25 ms (range 23-30 ms) to 35 ms (range 27-39 ms) (P=0.012). However, the Tpe/QT ratio in lead II did not change significantly. CONCLUSION: Ibutilide increases the duration and dispersion of ventricular repolarization. The prognostic value of Tpe and Tpe/QT in the setting of drug-induced proarrhythmia needs further study. | Panagiotis Korantzopoulos Konstantinos P Letsas Anna Kotsia Giannis Baltogiannis Kallirroi Kalantzi Konstantinos Kyrlas John A Goudevenos | 2013 | World Journal of Cardiology2013，5，7： | 3 |
| 2 | PLateler - asmciated and secreted PAF aeetylhydrnlase activity in patients with stable angina: sequen tial changes of the enzyme activity after angioplasty 显示文摘 | Goudevenos J TseLepis A D Vini M P | 2001 | Eur JC Linic Invest2001，31，1： | 1 |
| 3 | Eosinophilic responses to stent implantation and the risk of Kounis hypersensitivity associated coronary syndrome显示文摘 | Nicholas G. Kounis Sotiris Giannopoulos Grigorios G. Tsigkas John Goudevenos | 2011 | International Journal of Cardiology2011，，2： | 1 |
| 4 | Components of the Metabolic Syndrome and Risk for First-Ever Acute Ischemic Nonembolic Stroke in Elderly Subjects显示文摘 | Rizos E Goudevenos J | 2005 | Stroke2005，36，： | 1 |
| 5 | The role of oxidative stress in the pathogenesis and perpetuation of atrial fibrillation显示文摘 | Korantzopoulos P Kolettis TM Galaris D Goudevenos JA | 2007 | Int J Cardio12007，115，2： | 1 |
| 6 | Therapeutic modulation of lipoprotein-associated phospholipase A2 (Lp-PLA2)显示文摘 | Tselepis AF Rizzo M Goudevenos IA | 2011 | Curr Pharm Des2011，17，33： | 1 |
| 7 | Meta-Analysis of Association Between C-Reactive Protein and Immediate Success of Electrical Cardioversion in Persistent Atrial Fibrillation显示文摘 | Tong Liu Lijian Li Panagiotis Korantzopoulos John A. Goudevenos Guangping Li | 2008 | The American Journal of Cardiology2008，，12： | 1 |
| 8 | The platelet hyporesponsiveness to clopidogrel in acute coronary syndrome patients treated with 75 mg/day ciopidogrel may be overcome within 1 month of treatment显示文摘 | Kalantzi KI Dimitriou AA Goudevenos JA | 2012 | Platelets2012，23，2： | 1 |
| 9 | Avoiding and managingbleeding complications in patients with non-ST-segment elevationacute coronary syndromes显示文摘 | Potsis TZ Katsouras C Goudevenos JA | 2009 | Angiology2009，60，2： | 1 |
| 10 | The antiplatelet and antithrombotic actions of statins显示文摘 | Mitsios JV Papathanasiou AI Goudevenos JA | 2010 | Curt Pharm Des2010，16，34： | 1 |
| 11 | The platelet hyporesponsiveness to clopidogrel in acute coronary syn- drome patients treated with 75 mg/day clopidogrel may be overcome within 1 month of treatment显示文摘 | Kalantzi KI Dimitriou AA Goudevenos JA | 2012 | Platelets2012，23，2： | 1 |
| 12 | Kounis syndrome: a new twist on an old disease显示文摘 | Nicholas G Kounis Andreas Mazarakis Grigorios Tsigkas Sotiris Giannopoulos John Goudevenos | 2011 | Future Cardiol2011，，6： | 1 |
| 13 | Serum uric acid levels and risk for acute ishaemic non-embolic stroke in elderly subjects显示文摘 | Milionis H J Kalantzi K J Goudevenos JA | 2005 | J Intern Med2005，258，5： | 1 |
| 14 | Risk factors for first-ever acute ischemie nonembolie stroke in elderly individuals显示文摘 | Milionis HJ Liberopoulos E Goudevenos J | 2005 | IntJ Cardiol2005，99，2： | 1 |
| 15 | Serum uricacid levels and risk for acute ischemic non - emboilc strokein elderly subjects显示文摘 | Milionis HJ Kalnatzi KJ Goudevenos JA | 2005 | J Intern Med2005，258，5： | 1 |
| 16 | Risk factros for first-ever acute ischemic non-embolic stroke in elderly in-dividuals显示文摘 | Milionis HJ Liberopoulos E Goudevenos J | 2005 | Int J Cardiol2005，99，： | 1 |
| 17 | Therapeuticmodulation of lipoprotein-associated phospholipase A2 (Lp-PLA2)显示文摘 | TSELEPIS A F RIZZO M GOUDEVENOS i A | 2011 | Curr Pharm Des2011，17，33： | 1 |
| 18 | Serum uric acid levels and risk for acute ischaemic non-embolic stroke in elderly sujects显示文摘 | Milionis HJ Kalantzi KJ Goudevenos JA | | 0，，： | 1 |
| 19 | Platelet-associated and secreted PAF-acetylhydrolase activity in patients with stable angina: sequential changes of the enzyme activity after angioplasty显示文摘 | Goudevenos J Tselepis AD Vini MP | 2001 | Eur J Clinic Invest2001，31，1： | 1 |
| 20 | The effect of atorvastatin on serum lipids, lipoprotein (a) and plasma brinogen levels in primary dyslipidaemia:apilot study involving serial sampling 显示文摘 | GOUDEVENOS J A BAIRAKTARI E T CHATZIDIMOU K G | 2001 | Curt Med Res Opin2001，16，4： | 1 |
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