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| 1 | Convergent genomic signatures of high-altitude adaptation among domestic mammals显示文摘Abundant and diverse domestic mammals living on the Tibetan Plateau provide useful materials for investigating adaptive evolution and genetic convergence.Here,we used 327 genomes from horses,sheep,goats,cattle,pigs and dogs living at both high and low altitudes,including 73 genomes generated for this study,to disentangle the genetic mechanisms underlying local adaptation of domestic mammals.Although molecular convergence is comparatively rare at the DNA sequence level,we found convergent signature of positive selection at the gene level,particularly the EPAS1 gene in these Tibetan domestic mammals.We also reported a potential function in response to hypoxia for the gene C10 orf67,which underwent positive selection in three of the domestic mammals.Our data provide an insight into adaptive evolution of high-altitude domestic mammals,and should facilitate the search for additional novel genes involved in the hypoxia response pathway. | Dong-Dong Wu Cui-Ping Yang Ming-Shan Wang Kun-Zhe Dong Da-Wei Yan Zi-Qian Hao Song-Qing Fan Shu-Zhou Chu Qiu-Shuo Shen Li-Ping Jiang Yan Li Lin Zeng He-Qun Liu Hai-Bing Xie Yun-Fei Ma Xiao-Yan Kong Shu-Li Yang Xin-Xing Dong Ali Esmailizadeh David M Irwin Xiao Xiao Ming Li Yang Dong Wen Wang Peng Shi Hai-Peng Li Yue-Hui Ma Xiao Gou Yong-Bin Chen Ya-Ping Zhang | 2020 | National Science Review2020，7，6： | 7 |
| 2 | A NEW FLAVONE C-GLYCOSIDE FROM SCUTELLARIA BAICALENSIS显示文摘ANEWFLAVONEC-GLYCOSIDEFROMSCUTELLARIABAICALENSIS￥YongYuZHANG;XianLI;YunZhenGOU(ShenyangPharmaceuticalUniversity,Shenyang11001... | Yong Yu ZHANG Xian LI Yun Zhen GOU(Shenyang Pharmaceutical University, Shenyang 110015)Yoshihiro HARIGAYA, Masayuki ONDASchool of Pharmaceutical Sciences, Kitasato University, Tokyo 108 ,JapanKadsunort H^SHIMO’rO, yukinobu iK EYA, Minoru OKAD^, cacao M^ | 1994 | Chinese Chemical Letters1994，5，10： | 3 |
| 3 | Heterotrimeric G proteins regulate nitrogen-use efficiency in rice 显示文摘 | Sun H Y Qian Q Wu K Luo J J Wang S S Zhang C W Ma Y F Liu Q Huang X Z Yuan Q B Han R X Zhao M Dong G J Guo L B Zhu X D Gou Z H Wang W Wu Y J Lin H X Fu X D | 2014 | Nature Genetics2014，46，4： | 1 |
| 4 | MicroRNA: Past and present 显示文摘 | Wang Y Stricker H M Gou D M | 2007 | Frontiers in Bioscienee2007，12，： | 1 |
| 5 | An analysis of the hypothesis that amino acid requirements for chicks should be stated as a proportion of the dietary protein显示文摘 | Morris T R Gous R M Fisher C | 1999 | World Poult Sci1999，55，： | 1 |
| 6 | Enantioselective addition of diethylzinc to aromatic aldehydes catalyzed by Ti (IV) complexes of Cz-symmetrical chiral BINOL derivatives 显示文摘 | Gou S H Zaher M A Judeh | 2008 | Tetrahedron Letters2008，50，： | 1 |
| 7 | Preparation of CuAlO2 nanocrystalline transparent thin films with high conductivity显示文摘 | Gao S M Zhao Y Gou P P | 2003 | Nanotechnology2003，，14： | 1 |
| 8 | Nanostructured sensors for de tection of heavy metals: a review 显示文摘 | Li M Gou H A1-Ogaidi 1 | 2013 | ACS Sustainable Chem Eng2013，1，7： | 1 |
| 9 | MicroRNA: past and present显示文摘 | Wang Y Stricker H M Gou O | 2007 | Front Biosci2007，12，： | 1 |
| 10 | On the properties of reflexive g-inverses of a bordered matrix显示文摘 | Gou W B Wei M S | 2003 | Journal of East China Normal University2003，1，： | 1 |
| 11 | Regulation of cell prolifera- tion by smad proteins显示文摘 | Ten Dijke P Gou roans M J Itnh F el al | 2002 | J Cell Physiol2002，191，1： | 1 |
| 12 | Biodegradable poly(epsilon-caprolactone)-poly(ethylene glycol)copolymers as drug delivery system显示文摘 | Wei X Gong C Gou M | 2009 | Int J Pharm2009，381，1： | 1 |
| 13 | An overview of the Namakwa Sands ilmenite smelting oper- ations 显示文摘 | Gous M | 2006 | The South African Institute of Mining and Metallurgy2006，106，： | 1 |
| 14 | Efficienl inhibition of an intraperitoneal xenograft model of human ovarian cancer by HSulf-1 gene delivered by biodegradable cationic heparin-polyethylencimine nanogels显示文摘 | Liu P Gou M Yi T etal | 2012 | Oncol Rep2012，27，2： | 1 |
| 15 | Role of metallic absorption on enhancing the light emitting efficiency by plasmonic gratings显示文摘 | GOU Y XUAN Y M | 2013 | Journal of Applied Physics2013，114，11： | 1 |
| 16 | Antiemetic activity of megestrol acetate in patients receiving chemotherapy 显示文摘 | Zang J Hou M Gou HF | 2011 | Support Care Cancer2011，19，5： | 1 |
| 17 | Research on plastic deformation behaviour in cold ring by FEM numerical simulation显示文摘 | Gou L G Yang H Zhan M | 2005 | Modeling and Simulation in Materials Science and Engineering2005，13，7： | 1 |
| 18 | On feasibility of interferencealignment in MIMO interference networks显示文摘 | YETIS C M GOU T JAFAR S A | 2010 | IEEE Transaction onSignal Processing2010，58，9： | 1 |
| 19 | Evaluation of the parameters needed to describe the overall growth,the chemical growth,and the growth of feathers and breast muscles of broilers显示文摘 | Gous R M Moran E T Stilborn H R | 1999 | Poultry Science1999，78，： | 1 |
| 20 | Tissue-specific expression ofPopulus C19 GA 2-oxidases differentially regulate above-and below-ground biomass growth through control of bioactive GAconcentrations 显示文摘 | GOU J MA C KADMIEL M | 2011 | New Phytol2011，192，3： | 1 |
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