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| 1 | Heavy Oil and Oil Sands:Global Distribution and Resource Assessment显示文摘Global recoverable resources of heavy oil and oil sands have been assessed by CNPC using a geology-based assessment method combined with the traditional volumetric method, spatial interpolation method, parametric-probability method etc. The most favourable areas for exploration have been selected in accordance with a comprehensive scoring system. The results show:(1) For geological resources, CNPC estimate 991.18 billion tonnes of heavy oil and 501.26 billion tonnes of oil sands globally, of which technically recoverable resources of heavy oil and oil sands comprise 126.74 billion tonnes and 64.13 billion tonnes respectively. More than 80% of the resources occur within Tertiary and Cretaceous reservoirs distributed across 69 heavy oil basins and 32 oil sands basins. 99% of recoverable resources of heavy oil and oil sands occur within foreland basins, passive continental-margin basins and cratonic basins.(2) Since residual hydrocarbon resources remain following large-scale hydrocarbon migration and destruction, heavy oil and oil sands are characterized most commonly by late hydrocarbon accumulation, the same basin types and source-reservoir conditions as for conventional hydrocarbon resources, shallow burial depth and stratabound reservoirs.(3) Three accumulation models are recognised, depending on basin type: degradation along slope; destruction by uplift; and migration along faults.(4) In addition to mature exploration regions such as Canada and Venezuela, the Volga-Ural Basin and the Pre-Caspian Basin are less well-explored and have good potential for oil-sand discoveries, and it is predicted that the Middle East will be an important region for heavy oil development. | LIU Zuodong WANG Hongjun Graham BLACKBOURN MA Feng HE Zhengjun WEN Zhixing WANG Zhaoming YANG Zi LUAN Tiansi WU Zhenzhen | 2019 | Acta Geologica Sinica(English Edition)2019，93，1： | 9 |
| 2 | p21-activated kinase signalling in pancreatic cancer: New insights into tumour biology and immune modulation显示文摘Pancreatic cancer is one of the most aggressive and lethal malignancies worldwide, with a very poor prognosis and a five-year survival rate less than 8%. This dismal outcome is largely due to delayed diagnosis, early distant dissemination and resistance to conventional chemotherapies. Kras mutation is a well-defined hallmark of pancreatic cancer, with over 95% of cases harbouring Kras mutations that give rise to constitutively active forms of Kras. As important down-stream effectors of Kras, p21-activated kinases(PAKs) are involved in regulating cell proliferation, apoptosis, invasion/migration and chemo-resistance. Immunotherapy is now emerging as a promising treatment modality in the era of personalized anti-cancer therapeutics. In this review, basic knowledge of PAK structure and regulation is briefly summarised and the pivotal role of PAKs in Kras-driven pancreatic cancer is highlighted in terms of tumour biology and chemoresistance. Finally, the involvement of PAKs in immune modulation in the tumour microenvironment is discussed and the potential advantages of targeting PAKs are explored. | Kai Wang Graham S Baldwin Mehrdad Nikfarjam Hong He | 2018 | World Journal of Gastroenterology2018，24，33： | 7 |
| 3 | 基于学校儿童及其家庭的减盐干预研究(School-EduSalt):一项整群随机对照试验显示文摘摘要 目标研究基于学校的小学生减盐干预能否有效减少儿童及其家庭的摄盐量。设计整群随机对照试验,学校被随机分为干预组或对照组。实施现场中国北方城市长治市区的28所小学。研究对象小学五年级的279名学生,平均年龄为10.1岁;553名成年家长,平均年龄43.8岁。 | Feng J He 武阳丰 冯向先 马军 马媛 王海俊 张京 原建慧 Ching-Ping Lin Caryl Nowson Graham A MacGregor | 2015 | 英国医学杂志中文版2015，18，6： | 6 |
| 4 | 基于智能手机应用的中国学龄儿童及其家庭成员减盐健康教育(AppSalt):平行、整群随机对照研究显示文摘目的探讨基于智能手机应用的健康教育能否降低学龄儿童及其家庭成员的盐摄入量。设计平行、整群随机对照试验,将学校随机分配到干预组或对照组(1∶1)。背景从2018年9月15日至2019年12月27日,在中国北部、中部和南部3个省份纳入54所小学。参与者592名小学3年级儿童[每所学校约11名儿童,其中308名(52.0%)男孩;平均年龄8.58岁(标准差0.41)],以及1184名成年家庭成员[其中551名(46.5%)男性;平均年龄45.80岁(12.87)]。干预在手机应用程序的支持下,对干预组中的儿童进行关于减盐的健康教育,并布置家庭作业,以带动全家参与减盐的相关活动。主要结局测量干预组和对照组在第12个月随访时盐摄入量(通过24小时尿钠排泄量测量)改变值的差值。结果基线调查后,来自27所学校的297名儿童和594名成年家庭成员被分配到干预组,另外27所学校的295名儿童和590名成年家庭成员被分配到对照组。在试验期间,由于儿童转到另一所学校或成年家庭成员无法参加随访评估,27名(4.6%)儿童和112名(9.5%)成年人失去随访。干预组其余287名儿童和546名成人,以及对照组的278名儿童和526名成人完成了12个月的随访评估。干预组儿童基线时的平均盐摄入量为5.5[标准差(SD)1.9]g/天,干预组成人10.0(SD 3.5)g/天,对照组儿童5.6(SD 2.1)g/天,成人10.0(SD 3.6)g/天。在研究期间,干预组和对照组儿童的盐摄入量均有所增加,但干预组增加的幅度较小[调整混杂偏倚变量后平均干预效果为-0.25 g/天,95%可信区间(CI):-0.61~0.12;P=0.18]。干预组和对照组成人的盐摄入量均有所下降,但干预组的盐摄入量变化更大(平均效果-0.82 g/天,-1.24~-0.40;P<0.001)。对儿童收缩压的平均效果为-0.76 mmHg(-2.37~0.86;P=0.36),成人为-1.64 mmHg(-3.01~-0.27;P=0.02)。结论采用儿童带动家长的方式,基于手机应用程序的健康教育可有效降低成人的盐摄入量和收缩压,但对儿童的效果并不显著。这种新颖的方法有可能被更大规模地推广,但在此之前方案需要进一步加强,才能减少包括学童在内的人群盐摄入量。试验注册中国临床试验注册ChiCTR1800017553。 | Feng J He 张普洪 骆蓉 李园 孙悦文 陈凤格 赵昱红 赵伟 李道西 陈航 吴田勇 周思远 刘宇 李贤 何静 Changqiong Wang Monique Tan Jing Song Graham A MacGregor | 2022 | 英国医学杂志中文版2022，25，9： | 5 |
| 5 | Robust model predictive control:reflections and opportunities显示文摘The past three decades have witnessed important developments in the theory and practice of model predictive control(MPC).In particular,considerable effort has been devoted to robust MPC theory.There have also been many successful applications.This paper will give a brief overview of existing results and summarise experience gained in two real-world applications.We also present some reflections on issues which,in the authors’opinion,deserve further attention. | Graham C.Goodwin He Kong Galina Mirzaeva María M.Seron | 2014 | Journal of Control and Decision2014，1，2： | 5 |
| 6 | Detection of chlamydial antibody by fetal serology-an aid to the diagnosis of ovine abortion显示文摘 | Kennedy HE MeCullough SJ Graham D | 2001 | J Vet Diagn Invest2001，13，1： | 1 |
| 7 | Influence oflikelihood function choice foe estimating crop model parameters usingthe generalized likelihood uncertainty estimation method显示文摘 | Jianqiang He James W Jones Wendy D Graham | 2010 | Agricul-tural Systems2010，103，： | 1 |
| 8 | Outward-growth of the Tibetan Plateau during the Cenozoic: A review显示文摘 | Chengshan Wang Jingen Dai Xixi Zhao Yalin Li Stephan A. Graham Dengfa He Bo Ran Jun Meng | 2014 | Tectonophysics2014，，： | 1 |
| 9 | Influence of likelihood function choice for estimating crop model parameters using the generalized likelihood uncertainty estimation method显示文摘 | He J Jones J W Graham W D | 2010 | Agricultural Systems2010，103，： | 1 |
| 10 | Insulin-like growth factor-I-dependent up-regulation of ZEB1 drives epithe- lial-to-mesenchymal transition in human prostate cancer cells 显示文摘 | Graham TR Zhau HE Odero-Marah VA | 2008 | Cancer Res2008，68，7： | 1 |
| 11 | A systematic review of the role of intrapartum hypoxic-ischemia in the causation of neonatal encephalopathy显示文摘 | Graham EM Ruis KA Hartman AL Northington FJ Fox HE | 2008 | Am J Obstet Gynecol2008，1999，6： | 1 |
| 12 | Importance of the renin system for determining blood pressure fall with acute salt restriction in hypertensive and normotensive whites显示文摘 | He FJ Nirmala D Graham M | 2001 | Hypertension2001，38，： | 1 |
| 13 | Influence of likelihood function choice for estimating crop model parameters using the generalized likelihood uncertainty estimation method显示文摘 | He J Jones J W Graham W D | 2010 | Agricultural Systems2010，103，5： | 1 |
| 14 | Insulin-like growth factor-I-dependent up-regulation of ZEBl drives epithelial-to-mesenchymal transition in human prostate cancer cells显示文摘 | GRAHAM TR ZHAU HE ODERO-MARAH VA | 2008 | Cancer Res2008，68，7： | 1 |
| 15 | In- sulin-like growth factor-l-dependent up-regulation of ZEB1 drives epithelial-to-mesenchymal transition in human pros- tate cancer cells显示文摘 | GRAHAM TR ZHAU HE ODERO-MARAH VA | 2008 | Cancer Res2008，68，7： | 1 |
| 16 | Are parents in the UK equipped to provide adequate bums first aid? 显示文摘 | Graham HE Bache SE Muthayya P | 2012 | Burns2012，38，3： | 1 |
| 17 | Preparation of TiO2/ITO and TiO2/Ti photoelectrodes by magnetron sputtering for photocatalytic application显示文摘 | He C Li X Z Graham N | 2006 | Applied Catalysis A: General2006，305，1： | 1 |
| 18 | Differential control of seed primary dormancy in Arabidopsis ecotypes by the transcription factor SPATULA显示文摘 | Vaistij F E Gan Y Penfield S Gilday A D Dave A He Z Josse E M Choi G Halliday K J Graham I A | 2013 | Proceedings of the National Academy of Sciences2013，110，10： | 1 |
| 19 | Photoelectrocatalytic degradation of bisphenol A in aqueous solution using a Au- TiOz/ITOfilm显示文摘 | LI X Z HE C GRAHAM N | 2005 | J Appl Electroehem2005，35，： | 1 |
| 20 | Characterisation of virus- specific peripheral blood cell cytokine responses following vaccination or infection with classical swine fever viruses 显示文摘 | Graham SP Everctt HE Johns HL | 2010 | Vet Microbiol2010，142，12： | 1 |
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