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| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | Formation velocity and density-The diagnostic basis for stratigraphic traps 显示文摘 | Gardner G H F Gardner L W Gregory A R | 1974 | Geophysics1974，39，6： | 1 |
| 3 | Oxygen isotope exchange kinetics of mineral pairs in closed and open systems: applications to problems of hydrothermal alteration of igneous rocks and Precambrian iron formations显示文摘 | GREGORY R T CRISS R E TAYLOR H P Jr | 1989 | Chem Geol1989，75，： | 1 |
| 4 | Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013显示文摘 | Meijer A Rebelo-de-Andrade H Correia V Besselaar T Drager-Dayal R Fry A Gregory V Gubareva L Kageyama T Laekenby A Lo J Odagiri T Pere- yaslov D Siqueira M M Takashita E Tashiro M Wang D Wong S Zhang W Daniels R S Hurt A C | 2014 | An- tiviral Research2014，110，： | 1 |
| 5 | Formation velocity and density: the diagnostic basics for stratigraphic traps 显示文摘 | Gardner G H F Gardner L W Gregory A R | 1974 | Geophysics1974，39，： | 1 |
| 6 | Maternal antibody inhibits both cellular and humoral immunity in response to measles vaccination at hirth显示文摘 | Mary P L Gregory H Paul R | 2006 | Virology2006，350，2： | 1 |
| 7 | Formation velocity and density-the diagnostic basis for stratigraphic traps 显示文摘 | Gardner G H F Gardner L W Gregory A R | 1974 | Geophysics1974，39，6： | 1 |
| 8 | Polymorphicvariations in the expression of the chemical detoxifying UDPglucuronosyltransferases显示文摘 | Mackenzie P I Gregory P A Lewinsky R H ei al | 2005 | Toxicol Appl Pharmacol2005，207，2： | 1 |
| 9 | Histidine availability alters glucagons gene expression in murine αTC6 cells显示文摘 | Gregory L Waegner A Gaskins H R | 1998 | J Nutr1998，128，： | 1 |
| 10 | MR imaging evaluation of endometrial carcinoma:results of an NCI cooperative study显示文摘 | Hedvig H Lawrence V R Gregory M G | 1991 | Radiology1991，179，6： | 1 |
| 11 | An experimental investigation of factors affecting elastic wave velocities in porous media显示文摘 | Wyllie M R J Gregory A R Gardner G H F | 1958 | Geophysics1958，23，： | 1 |
| 12 | Three-dimensional developing flow model for photocatalytic monolith reactors显示文摘 | Moazzem H Gregory B R | 1999 | AIChE Journal1999，45，： | 1 |
| 13 | 显示文摘 | Kuhn H Gregory R Kimbrell W | 1989 | Int Sampe Electron Conf1989，3，： | 1 |
| 14 | Comparing images using the Hausdorff distance显示文摘 | Daniel P H Gregory A K William J R | 1993 | IEEE Transactions on Pattern Analysis and Machine Intelligence1993，15，9： | 1 |
| 15 | Incentives policies to site hazardous waste facilities显示文摘 | Gregory R Kunreuther H | 1991 | Risk Analysis1991，，11： | 1 |
| 16 | Operation drivers of customer loyahy in electronic retailing: an empirical analysis of electronic food retailers 显示文摘 | GREGORY R H KINGSHUK K S | 2001 | Manufacturing & Service Operations Management2001，3，3： | 1 |
| 17 | The constitution and properties of two gastrins extracted from hog antral mucosa显示文摘 | Gregory R A Tracy H J | 1964 | Gut1964，5，2： | 1 |
| 18 | Origins and progressing of organic matter in the Ama- zon River as indicated by carbohydrates and amino acids显示文摘 | JOHN I H GREGORY L C JEFFREY E R | 1994 | LimnolOeeanogr1994，39，4： | 1 |
| 19 | Effects of agriculture and wetland restoration on hydrology,soils,and water quality of a Carolina Bay complex显示文摘 | GREGORY L B MATTHEW F H CURTIS J R | 2003 | Wetlands Ecology and Management2003，，11： | 1 |
| 20 | Kinetic theory of oxygen isotopic exchange between minerals and water显示文摘 | CRISS R E GREGORY R T TAYLOR H P Jr | 1987 | Geochim Cosmochim Acta1987，51，： | 1 |
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