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| 1 | Appropriateness of outpatient gastrointestinal endoscopy in a non-academic hospital显示文摘AIM:To assess the appropriate use and the diagnostic yield of upper gastrointestinal endoscopy and colonoscopy in this subgroup of patients.METHODS:In total,789 consecutive outpatients referred for gastrointestinal(GI) endoscopy [381 for esophagogastroduodenoscopy(EGD) and 408 for colonoscopy] were prospectively enrolled in the study.The American Society for Gastrointestinal Endoscopy(ASGE) guidelines were used to assess the relationship between appropriateness and the presence of relevant endoscopic f indings.RESULTS:The overall inappropriate rate was 13.3%.The indications for EGD and colonoscopy were,respectively,appropriate in 82.7% and 82.6% of the exams,uncertain in 5.8% and 2.4% and inappropriate in 11.5% and 15%.The diagnostic yield was signif icant higher forEGDs and colonoscopies judged appropriate and uncertain when compared with those considered inappropriate(EGD:36.6% vs 36.4% vs 11.4%,P = 0.004;Colonoscopy:24.3% vs 20.0% vs 3.3%,P = 0.001).Of the 25 malignant lesions detected,all but one was detected in exams judged appropriate or uncertain.CONCLUSION:This study shows a good adherence to ASGE guidelines by the referring physicians and a significant increase of the diagnostic yield in appropriate examinations,namely in detecting neoplastic lesions.It underscores the importance that the appropriateness of the indication assumes in assuring high-quality GI endoscopic procedures. | Joo Mangualde Marie I Cremers Ana M Vieira Ricardo Freire lia Gamito Cristina Lobato Ana L Alves Fátima Augusto Ana P Oliveira | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，10： | 2 |
| 2 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 3 | Interictal scalp fast oscillations as a marker of the seizure onset zone显示文摘 | Andrade-Valenca L P Dubeau F Mari F | 2011 | Neurology2011，77，6： | 1 |
| 4 | Maternal antibody inhibits both cellular and humoral immunity in response to measles vaccination at hirth显示文摘 | Mary P L Gregory H Paul R | 2006 | Virology2006，350，2： | 1 |
| 5 | Spinal fracture throgh the neurocentral synchondrosis in battered children:a report for three cases显示文摘 | Vialle R Mary P Schmider L | 2006 | Spine2006，31，11： | 1 |
| 6 | Interictal scalp fast oscillations as a marker of the seizure onset zone显示文摘 | Andrade-Valenca L P Dubeau F Mari F | 2011 | Neurology2011，77，6： | 1 |
| 7 | Hierarchical GUI Test Case Generation Using Automated Planning 显示文摘 | Atif M M Martha E P Mary L S | 2001 | IEEE Transaction on Software Engineering2001，27，29： | 1 |
| 8 | High-resolution analysis of chromosomal breakpoints and genomic instability identifies PTPRD as a candidate tumor suppressor gene in neuroblastoma显示文摘 | Stallings R L Nair P Maris J M | 2006 | Cancer Res2006，66，7： | 1 |
| 9 | Using the chlorite ion tocontrol nitrification显示文摘 | MICHAEL J M NANCY I L MARIE S P | 1999 | American Water Works Association Journal1999，91，10： | 1 |
| 10 | Prediction of Pulmonary Embol-ism in the Emergency Department:The Revised Geneva Score显示文摘 | Gal L Righini M Marie P | 2006 | annals of internal medicine2006，144，3： | 1 |
| 11 | Chemother apy versus support cancer treatment in advanced gas- tric cancer: a meta-analysis显示文摘 | CASARETTO L SOUSA P L MARI J J | 2006 | Braz J Med Biol Res2006，39，4： | 1 |
| 12 | Maternal trait anxiety,depression and life event stress in pregnancy:Relationships with infant temperament显示文摘 | Dusan H P Leo L | 2005 | Early Human Development2005，81，2： | 1 |
| 13 | The innate immune system is activated by stimulation of vaginal epithelial cells with Staphylococcus aureus and toxic shock syndrome toxin 1 显示文摘 | MARNIE L P KEVIN A MARY J K | 2005 | Infection and Immunity2005，73，4： | 1 |
| 14 | Prenatal stress,the hypothalamic pituitary adrenal axis,and fetal and infant neurobehaviour显示文摘 | Leo R L Nicole R | 2005 | Early Human Development2005，81，11： | 1 |
| 15 | Cosmeceutical peptides显示文摘 | Mary P L Anna L | | 0，，05： | 1 |
| 16 | Determination of the mineral fraction and rheological properties of microwave modified starch from canna edulis plant显示文摘 | Mary L Elevina P | 2006 | Food Human Nntri2006，61，3： | 1 |
| 17 | Interstitial lung disease in polymyosiris and dermatomyositis 显示文摘 | Marie L Hachulia E Chem P | 2002 | Arthritis Rheum2002，47，： | 1 |
| 18 | Diagnosis and management of ectopic pregnancy 显示文摘 | Anne - marie L Beth P | 2005 | Am Fam Physician2005，72，9： | 1 |
| 19 | Mitochondrial H^sub 2^O^sub 2^ emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans显示文摘 | Anderson Ethan J Lustig Mary E Boyle Kristen E Woodlief Tracey L Kane Daniel A Lin Chien-Te Rice Jesse W Kang Li Rabinovitch Peter S Szeto Hazel H Houmard Joseph A Cortright Ronald N Wasserman David H Neufer P Darrell | 2009 | Journal of Clinical Investigation2009，，3： | 1 |
| 20 | Core stability and its relationship to lower extremity function and injury显示文摘 | WILLSON J D DOUGHERTY C P MARY L I | 2005 | journal of the American Academy of Orthopaedic Surgeons2005，13，5： | 1 |
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