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| 1 | Sclerosing cholangitis following severe trauma: Description of a remarkable disease entity with emphasis on possible pathophysiologic mechanisms显示文摘AIM: Persistent cholestasis is a rare complication of severe trauma or infections, Little is known about the possible pathomechanisms and the clinical course,METHODS: Secondary sclerosing cholangitis was diagnosed in five patients with persistent jaundice after severe trauma (one burn injury, three accidents, one power current injury). Medical charts were retrospectively reviewed with regard to possible trigger mechanisms for cholestasis, and the clinical course was recorded.RESULTS: Diagnosis of secondary sclerosing cholangitis was based in all patients on the primary sclerosing cholangitis (PSC)-like destruction of the intrahepatic bile ducts at cholangiography after exclusion of PSC. In four patients, arterial hypotension with subsequent ischemia may have caused the bile duct damage, whereas in the case of power current injury direct thermal damage was assumed to be the trigger mechanism. The course of secondary liver fibrosis was rapidly progressive and proceeded to liver cirrhosis in all four patients with a follow-up >2 years. Therapeutic possibilities were limited.CONCLUSION: Posttraumatic sclerosing cholangitis is a rare but rapidly progressive disease, probably caused by ischemia of the intrahepatic bile ducts via the peribiliary capillary plexus due to arterial hypotension. Gastroenterologists should be aware of this disease in patients with persistent cholestasis after severe trauma. | Johannes Benninger Rainer Grobholz Yurdaguel Oeztuerk Christoph H.Antoni Eckhart G.Hahn Manfred V.Singer Richard Strauss | 2005 | World Journal of Gastroenterology2005，11，27： | 10 |
| 2 | Loss of pro-grammed cel death 4 expression marks adenoma-carcinoma transition,correlates inversely with phosphory-lated protein ki-nase B,and is an independent prognostic factor in resected colorectal cancer显示文摘 | Mudduluru G Medved F Grobholz R | | 0，，08： | 1 |
| 3 | Simple models improve the discrimination of prostate cancers from the peripheral gland by T1-weighted dynamic MRI显示文摘 | Kiessling F Lichy M Grobholz R | 2004 | Eur Radiol2004，14，10： | 1 |
| 4 | Expression of the mutated transketolase TKTL 1 , a molecular marker in gastric cancer 显示文摘 | Staiger WI Coy JF Grobholz R | 2006 | Oncol Rep2006，16，4： | 1 |
| 5 | Can pro-operative contrast-enhanced dynamic MR imaging for prostate can cer predict microvessel density in prostatectomy specimens显示文摘 | Schlemmer HP Merkle J Grobholze R | 2004 | Eur Radiol2004，14，： | 1 |
| 6 | Loss of programmed cell death 4 expression marks adenoma-carcinoma transition, correlates inversely with phosphorylated protein kinase B, and is an independent prognostic factor in resected colorectal cancer显示文摘 | Mudduluru G Medved F Grobholz R | 2007 | Cancer2007，110，8： | 1 |
| 7 | Phase I trial of cetuximab in combination with capecitabine, weekly irinotecan, and radiotherapy as neoadjuvant therapy for rectal cancer显示文摘 | Ralf-Dieter Hofheinz Karoline Horisberger Christoph Woernle Frederik Wenz Uta Kraus-Tiefenbacher Georg K?hler Dietmar Dinter Rainer Grobholz Steffen Heeger Stefan Post Andreas Hochhaus Frank Willeke | 2006 | International Journal of Radiation Oncology Biology Physics2006，，5： | 1 |
| 8 | A new technique of endoscopic full thickness resection using a flexible stapler显示文摘 | Kaehler G Grobholz R Langner C Suchan K Post S | 2006 | Endoscopy2006，38，： | 1 |
| 9 | Expression of the mutated transketolase TKTL1, a molecular marker in gastric cancer显示文摘 | Staiger WI Coy JF Grobholz R | 2006 | Oneol Rep2006，16，4： | 1 |
| 10 | HIV-related and Epstein-Barr virus-associated anal Burkitt's lymphoma: report of a case显示文摘 | Freudenberg S Palma P Grobholz R | 2005 | Dis Colon Rectum2005，48，8： | 1 |
| 11 | Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulate aortic valve calcification显示文摘 | Kaden JJ Bickelhaupt S Grobholz R | 2004 | J Mol Cell Cardiol2004，36，1： | 1 |
| 12 | Preva- lence and determinants of osteoporosis in patients with type 1 and type 2 diabetes mellitus显示文摘 | Leidig-- Bruckner G Grobholz S Bruekner T | 2014 | Bme Endocrine Disorders2014，14，12： | 1 |
| 13 | Increase of AKT/PKB expression correlates with gleason pattern in human prostate cancer 显示文摘 | Liao Y Grobholz R Abel U | 2003 | Int J Cancer2003，107，4： | 1 |
| 14 | Continuous low dose chemotherapy plus inhibition of cyclooxygenase-2 as an antiangiogenic therapy of glioblastoma multiforme显示文摘 | Tuettenberg J Grobholz R Korn T | 2005 | J Cancer Res Clin 0ncol2005，131，1： | 1 |
| 15 | A new technique of endoscopic ful-thickness resection using a flexible stapler显示文摘 | Kaehler G Grobholz R Langner C | 2006 | Endoscopy2006，38，1： | 1 |
| 16 | Preva- lence and determinants of osteoporosis in patients with type 1 and type 2 diabetes mellitus 显示文摘 | Leidig-Bruckner G Grobholz S Bruckner T | 2014 | BMC Endocr Disord2014，14，1： | 1 |
| 17 | Prevalence and determinants of osteoporosis in patients with type 1 and type 2 diabetes mellitus 显示文摘 | Leidig-Bruckner G Grobholz S Bruckner T | 2014 | BMC Endocr Disord2014，14，： | 1 |
| 18 | Inflammatory regulation of extracellular matrix remodeling in calcific aortic valve stenosis显示文摘 | Kaden JJ Dempfle CE Grobholz R | 2005 | Cardiovasc Pathol2005，14，2： | 1 |
| 19 | Loss of programmed cell death 4 expression marks adenoma-carcinoma transition,correlates inversely with phosphorylated protein kinase B,and is an independent prognostic factor in resected colorectal cancer显示文摘 | Mudduluru G Medved F Grobholz R | 2007 | Cancer2007，110，8： | 1 |
| 20 | Inflammatory regulation of extracellular matrix remodeling in calcific aortic valve stenosis显示文摘 | Dempfle CE Grobholz R | 2005 | Cardovasc Pathol2005，14，2： | 1 |
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