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| 1 | 纳米定位测量机操作测量结果(英文)显示文摘伊尔梅瑙工业大学过程测量和传感技术研究所研制了三维纳米定位和测量机 (NPMM ) .阿贝无偏设计使得该机器异常精确 .在整个 2 5mm× 2 5mm× 5mm的定位和测量域内 ,干涉测长系统分辨力可达 0 .1nm ,不确定度达 5~ 10nm .提供了纳米定位测量机的基本信息 ,介绍其操作模式 。 | JAGER Gerd GRUNWALD Rainer MANSKE Eberhard HAUSOTTE Tino FUβL Roland | 2004 | 纳米技术与精密工程2004，2，2： | 14 |
| 2 | Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype显示文摘AIM: To investigate the effects of ZK1916784, a low calcemic analog of calcitriol on intestinal inflammation. METHODS: Acute and chronic colitis was induced by dextran sodium sulfate (DSS) according to standard procedures. Mice were treated intraperitoneally with ZK1916784 or placebo and colonic inflammation was evaluated. Cytokine production by mesenterial lymph node (MLN) cells was measured by ELISA. Immunohistochemistry was performed to detect intestinal dendritic cells (DCs) within the colonic tissue, and the effect of the calcitriol analog on DCs was investigated. RESULTS: Treatment with ZK191784 resulted in significant amelioration of disease with a reduced histological score in acute and chronic intestinal inflammation. In animals with acute DSS colitis, down- regulation of colonic inflammation was associated with a dramatic reduction in the secretion of the proinflammatory cytokine interferon (IFN)-γ and a significant increase in intereleukin (IL)-10 by MLN cells. Similarly, in chronic colitis, IL-10 expression in colonic tissue increased 1.4-fold when mice were treated with ZK191784, whereas expression of the Th1-specific transcription factor T-beta decreased by 81.6%. Lower numbers of infiltrating activated CD11c+ DCs were found in the colon in ZK191784-treated mice with acute DSScolitis, and secretion of proinflammatory cytokines by primary mucosal DCs was inhibited in the presence of the calcitriol analog. CONCLUSION: The calcitriol analog ZK191784 demonstrated significant anti-inflammatory properties in experimental colitis that were at least partially mediated by the immunosuppressive effects of the derivate on mucosal DCs. | Ulrike G Strauch Florian Obermeier Nicole Grunwald Nadja Dunger Heiko C Rath Jürgen Schlmerich A Steinmeyer U Zügel HH Herfarth | 2007 | World Journal of Gastroenterology2007，13，48： | 4 |
| 3 | Ranibizumab and Bevacizumab for Treatment of Neovascular Age-related Macular Degeneration显示文摘 | Daniel F. Martin Maureen G. Maguire Stuart L. Fine Gui-shuang Ying Glenn J. Jaffe Juan E. Grunwald Cynthia Toth Maryann Redford Frederick L. Ferris | 2012 | Ophthalmology2012，，7： | 3 |
| 4 | Spatial/temporal indexing and information visualization genre for environmental digital libraries显示文摘Protecting and preserving our environmental systems require the ability to understand the spatio-temporal distri- bution of soils, parent material, topography, and land cover as well as the effects of human activities on ecosystems. Space-time modelling of ecosystems in an environmental digital library is essential for visualizing past, present, and future impacts of changes occurring within such landscapes (e.g., shift in land use practices). In this paper, we describe three novel features, spa- tio-temporal indexing, visualization, and geostatistical genre, for the environmental digital library, Environmental Visualization and Geographic Enterprise System (ENVISAGE), currently in progress at the University of Florida. | CHEN Su-shing GRUNWALD Sabine | 2005 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2005，6，11： | 3 |
| 5 | A WebGIS and geodatabase for Florida’s wetlands显示文摘 | V. Mathiyalagan S. Grunwald K.R. Reddy S.A. Bloom | 2004 | Computers and Electronics in Agriculture2004，，1： | 3 |
| 6 | Loss of CD103^+ intestinal dendritic cells during colonic inflammation显示文摘AIM:To investigate possible differences in dendritic cells(DC)within intestinal tissue of mice before and after induction of colitis. METHODS:Mucosal DC derived from intestinal tissue,as well as from mesenteric lymph nodes and spleen,were analyzed by fluorescence activated cell sorting(FACS) analysis.Supernatants of these cells were analyzed for secretion of different pro-and anti-inflammatory cytokines. Immunohistochemistry and immunofluorescence were performed on cryosections of mucosal tissue derived from animals with colitis as well as from healthy mice. RESULTS:It was shown that DC derived from healthy intestinal lamina propria(LP)represented an immature phenotype as characterized by low-level expression of costimulatory cytokines.In contrast to DC from spleen and mesenteric lymph nodes(MLN)that secreted proinflammatory cytokines,LP-DC produced high levels of the anti-inflammatory cytokine IL-10.After induction of mu-rine colitis in a CD4 + CD62L + transfer model or in chronic Dextran sulfate sodium-colitis,a marked increase of activated CD80 + DC could be observed within the inflamed colonic tissue.Interestingly,in contrast to splenic DC,a significant population of DC within MLN and colonic LP expressed the mucosal integrin CD103 which was lost during colitis. CONCLUSION:The constitutive secretion of antiinflammatory cytokines by immature DC within the intestinal LP might regulate the homeostatic balance between mucosal immunity and tolerance.CD103 + DC could mediate this important function. | Ulrike G Strauch Nicole Grunwald Florian Obermeier Sonja Gürster Heiko C Rath | 2010 | World Journal of Gastroenterology2010，16，1： | 2 |
| 7 | Calibration and validation of a non-point source pollution model显示文摘 | S Grunwald L.D Norton | 2000 | Agricultural Water Management2000，，1： | 2 |
| 8 | Using the modified agricultural non-point source pollution model in German watersheds显示文摘 | S. Grunwald H.-G. Frede | 1999 | Catena1999，，3： | 2 |
| 9 | Ranibizumab and Bevacizumab for Treatment of Neovascular Age-related Macular Degeneration显示文摘 | Daniel F. Martin Maureen G. Maguire Stuart L. Fine Gui-shuang Ying Glenn J. Jaffe Juan E. Grunwald Cynthia Toth Maryann Redford Frederick L. Ferris | 2012 | Ophthalmology2012，，7： | 2 |
| 10 | Design of a magnetostrictive (MS) actuator显示文摘 | Grunwald A Olabi A G | 2008 | Sensors and Actuators2008，144，1： | 1 |
| 11 | I-131-1ipiodol therapy in liver neoplasms 显示文摘 | Risse JH Grunwald F Strunk H | 1999 | Hybridoma1999，18，1： | 1 |
| 12 | Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic properties 显示文摘 | Emaus RK Grunwald R Lemasters JJ | 1986 | Biochim Biophy Acta1986，850，3： | 1 |
| 13 | Neuronal substrates of sensory gating within the human brain显示文摘 | Grunwald T Boutros NN Pezer N | 2003 | Bid Psychiatry2003，53，： | 1 |
| 14 | Influenee of carotid artery stenting on cognitive function 显示文摘 | Grunwald IQ Papanagiotou P Reith W | 2010 | Neuroradio- logy2010，52，1： | 1 |
| 15 | Developing inhibitors of the ep iderreal growth factor receptor for cancer treatment 显示文摘 | Grunwald V Hidalgo M | 2003 | J Natl Cancer Inst2003，95，8： | 1 |
| 16 | Molecular cloning and expression in insect cells of honeybee venom allergen aeidphosphatase (Apim 3) 显示文摘 | Grunwald T Bockisch B Spiuner E | 2006 | J Allergy Clin Immunol2006，117，4： | 1 |
| 17 | Monocytes can phagocytose Gram-negative bacteria by a CD14-dependent mechanism显示文摘 | Grunwald U Fan X Jack RS | 1996 | J Immunol1996，157，9： | 1 |
| 18 | Rhodamin 123 as a probe of transmembrane potential in isolated rat-liver mitoehondria: spec- tral and metabolic properties 显示文摘 | Emaus R K Grunwald Lemasters J J | 1986 | Biocbim Biophys Aeta1986，850，3： | 1 |
| 19 | Fluorine-18 fluorodeoxyglucose positron emission tomography in thyroid cancer: results of a multicenter study显示文摘 | Grunwald F Kalicke T Feine U et al | 1999 | Eur J Nucl Med1999，26，： | 1 |
| 20 | Sterol changes during germination of Nicotiana tabacum seeds 显示文摘 | BUSH P B GRUNWALD C | 1972 | Plant Physiology1972，50，1： | 1 |
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