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| 1 | Development of a CLDN18.2-targeting immuno-PET probe for non-invasive imaging in gastrointestinal tumors显示文摘Claudin18.2(CLDN18.2)is a tight junction protein that is overexpressed in a variety of solid tumors such as gastrointestinal cancer and oesophageal cancer.It has been identified as a promising target and a potential biomarker to diagnose tumor,evaluate efficacy,and determine patient prognosis.TST001 is a recombinant humanized CLDN18.2 antibody that selectively binds to the extracellular loop of human Claudin18.2.In this study,we constructed a solid target radionuclide zirconium-^(89)(^(89)Zr)labled-TST001 to detect the expression of in the human stomach cancer BGC823CLDN18.2 cell lines.The[^(89)Zr]Zr-desferrioxamine(DFO)-TST001 showed high radiochemical purity(RCP,>99%)and specific activity(24.15±1.34 GBq/mmol),and was stable in 5%human serum albumin,and phosphate buffer saline(>85%RCP at 96 h).The EC_(50) values of TST001 and DFO-TST001 were as high as 0.413±0.055 and 0.361±0.058 nM(P>0.05),respectively.The radiotracer had a significantly higher average standard uptake values in CLDN18.2-positive tumors than in CLDN18.2-negative tumors(1.11±0.02 vs.0.49±0.03,P=0.0016)2 days post injection(p.i.).BGC823CLDN18.2 mice models showed high tumor/muscle ratios 96 h p.i.with[^(89)Zr]Zr-DFO-TST001 was much higher than those of the other imaging groups.Immunohistochemistry results showed that BGC823CLDN18.2 tumors were highly positive(+++)for CLDN18.2,while those in the BGC823 group did not express CLDN18.2().The results of ex vivo biodistribution studies showed that there was a higher distribution in the BGC823CLDN18.2 tumor bearing mice(2.05±0.16%ID/g)than BGC823 mice(0.69±0.02%ID/g)and blocking group(0.72±0.02%ID/g).A dosimetry estimation study showed that the effective dose of[^(89)Zr]Zr-DFO-TST001 was 0.0705 mSv/MBq,which is within the range of acceptable doses for nuclear medicine research.Taken together,these results suggest that Good Manufacturing Practices produced by this immuno-positron emission tomography probe can detect CLDN18.2-overexpressing tumors. | Yan Chen Xingguo Hou Dapeng Li Jin Ding Jiayue Liu Zilei Wang Fei Teng Hongjun Li Fan Zhang Yi Gu Steven Yu Xueming Qian Zhi Yang Hua Zhu | 2023 | Journal of Pharmaceutical Analysis2023，13，4： | 2 |
| 2 | Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy显示文摘Chimeric antigen receptor T cell(CAR T) therapy was a milestone in the treatment of relapsed and refractory B cell malignancies. However, beneficial effects of CAR T cells have not been obtained in solid tumors yet. Herein, we implement a porous microneedle patch that accommodates CAR T cells and allows in situ penetration-mediated seeding of CAR T cells when implanted in the tumor bed or in the post-surgical resection cavity. CAR T cells loaded in the pores of the microneedle tips were readily escorted to the tumor in an evenly scattered manner without losing their activity. Such microneedle-mediated local delivery enhanced infiltration and immunostimulation of CAR T cells as compared to direct intratumoral injection. This tailorable patch offers a transformative platform for scattered seeding of living cells for treating a variety of tumors. | Hongjun Li Zejun Wang Edikan A.Ogunnaike Qing Wu Guojun Chen Quanyin Hu Tianyuan Ci Zhaowei Chen Jinqiang Wang Di Wen Hongwei Du Jie Jiang Jie Sun Xingcai Zhang Gianpietro Dotti Zhen Gu | 2022 | National Science Review2022，9，3： | 2 |
| 3 | Spectroscopic characterization of the structural and functional properties of natural organic matter fractions显示文摘 | Jie Chen Baohua Gu Eugene J. LeBoeuf Hongjun Pan Sheng Dai | 2002 | Chemosphere2002，，1： | 1 |
| 4 | A Comparative Study of Genetic Algorithm Parameters for the Inverse Problem-based Fault Diagnosis of Liquid Rocket Propulsion Systems显示文摘当有人驾驶的空间使命被伴随时,液体火箭推进系统(LRPS ) 的差错诊断特别地是在太空发射活动的一个很重要的问题,自从安全和可靠性能被利用一个有效差错诊断系统显著地提高。当前,反的基于问题的诊断在差错诊断领域吸引了很多研究注意。这方法论为监视推进系统的健康提供新策略给基于模型的差错诊断。解决从 LRPS 的差错诊断产生的反的问题,气体是在最近的年里被采用了第一并且可得到的数字优化工具的有效选择。然而, GA 有许多控制参数预先被选并且仍然在那里缺乏健全理论工具在诊断性能经分解上分析这些参数的效果。在这篇论文,诊断结果上的 GA 参数的影响的比较研究被执行一系列数字实验进行。这研究的目的是调查最后的诊断结果的单个算法参数的贡献并且为在 LRPS 的反的基于问题的差错诊断选择 GA 参数提供合理估计。一些建设性的评论在结论被做并且以后将对到 LRPS 的差错诊断实践的 GA 的实现有用。关键词液体火箭推进系统-反的问题-差错诊断-基因算法-比较学习这个工作被杨尔富收到了的中国(号码 50106005 )的国家自然科学基础支持他来自空间技术的学校的 B.E , M.E ,和博士学位,航空学和航天学的北京大学,中国在 1994 , 1996 ,和 1999 ,分别地。从 1999 年 9 月到 2001 年 9 月,他是在在清华大学的自动化的系的一个博士后的研究人员,中国。在 2001 年 9 月,他作为一个副教授加入了航空学和航天学的北京大学。作为 JSPS (为科学的提升的日本协会) 博士后的研究家伙,从 2001 年 11 月,到 2003 年 12 月,他在系工作了机械并且在东京工学院的控制系统工程,东京,日本。他的研究兴趣包括非线性的控制理论和应用程序,机器人学,多代理人系统,进程控制,机器学习,和差错诊断。他是 IEEE 的一个成员。项洪军从空间技术的学院收到了他的 B.E, M.E,和博士学位,航空学和航天学的北京大学,中国在 1994, 1997,和 2000,分别地。从 2000 ~ 2002,他是在在航空学和航天学的北京大学的液体动力学的研究所的一个博士后的研究人员。他现在是空间技术的学院里的一个副教授。他的主要研究兴趣为火箭引擎,二阶段的液体动力学,和新推进技术的内部流动包括数字模拟,等等。Dongbing Gu 收到了学士在 1985 的度和在从北京工学院的自动控制的在 1988 两个的硕士学位,中国。他从艾塞克斯大学在 2004 在计算机科学收到了博士学位,英国。他在艾塞克斯大学在 2000 成为了计算机科学的一个讲师。他是在设计科学的系的一个访问学者,牛津大学,英国,从 1996 年 10 月到 1997 年 9 月,财政上从英国委员会由 SBFSS 的奖学金支持了。从 1988 ~ 2000,他在科技的长春大学在电子工程的系工作了,中国。他在杂志和会议出版了超过 40 篇论文,并且在中国收到了几件研究奖品。他的当前的研究兴趣包括预兆的控制,分布式的控制,机器学习,并且统计图象处理。他是 IEEE 的一个成员。张振鹏是空间技术的学院里的一个教授,航空学和航天学的北京大学,中国。从 1987 ~ 1989,他是在在乔治亚工学院的太空工程的系的一个访问学者,美国。他是空间技术的学院的负责人,航空学和航天学的北京大学。他在杂志并且在会议出版了超过 3 本书和许多论文。他的研究兴趣包括液体和稳固的火箭引擎,二阶段的液体动力学,气体动力学,健康监视和差错为火箭推进系统的诊断,和新推进技术,等等。 | Erfu Yang Hongjun Xiang Dongbing Gu Zhenpeng Zhang | 2007 | International Journal of Automation and computing2007，4，3： | 1 |
| 5 | Study on Reservoir Engineering: ASP Flooding Pilot Test in Karamay Oilfield 显示文摘 | Gu Hongjun Yang Ruiqi Guo Shuanggeng | 1998 | SPE509181998，，： | 1 |
| 6 | Tunable spin textures in polar antiferromagnetic hybrid organic–inorganic perovskites by electric and magnetic fields显示文摘The hybrid organic–inorganic perovskites(HOIPs)have attracted much attention for their potential applications as novel optoelectronic devices.Remarkably,the Rashba band splitting,together with specific spin orientations in k-space(i.e.,spin texture),has been found to be relevant for the optoelectronic performances.In this work,by using first-principles calculations and symmetry analysis,we study the electric polarization,magnetism. | Feng Lou Teng Gu Junyi Ji Junsheng Feng Hongjun Xiang Alessandro Stroppa | 2020 | npj Computational Materials2020，，1： | 0 |
| 7 | Discovery of Majorana Bound State in Fe-based Superconductor显示文摘In 1937, Italian theoretical physicist Ettore Majorana published a paper, in which he made a brilliant discovery by decomposing Dirac equation into the real and imaginary parts. That is the famous equation describing the motion of a Majorana fermion whose antiparticle is itself. | WANG Dongfei KONG Lingyuan FAN Pen GAO Hongjun DING Hong Genda Gu Liang Fu | 2018 | Bulletin of the Chinese Academy of Sciences2018，32，4： | 0 |
| 8 | Wireless Self-Powered Vibration Sensor System for Intelligent Spindle Monitoring显示文摘In recent years,high-end equipment is widely used in industry and the accuracy requirements of the equipment have been risen year by year.During the machining process,the high-end equipment failure may have a great impact on the product quality.It is necessary to monitor the status of equipment and to predict fault diagnosis.At present,most of the condition monitoring devices for mechanical equipment have problems of large size,low precision and low energy utilization.A wireless self-powered intelligent spindle vibration acceleration sensor system based on piezoelectric energy harvesting is proposed.Based on rotor sensing technology,a sensor is made to mount on the tool holder and build the related circuit.Firstly,the energy management module collects the mechanical energy in the environment and converts the piezoelectric vibration energy into electric energy to provide 3.3 Vfor the subsequent circuit.The lithium battery supplies the system with additional power and monitors’the power of the energy storage circuit in real-time.Secondly,a three-axis acceleration sensor is used to collect,analyze and filter a series of signal processing operations of the vibration signal in the environment.The signal is sent to the upper computer by wireless transmission.The host computer outputs the corresponding X,Y,and Z channel waveforms and data under the condition of the spindle speed of 50∼2500 r/min with real-time monitoring.The KEIL5 platform is used to develop the system software.The small-size piezoelectric vibration sensor with high-speed,high-energy utilization,high accuracy,and easy installation is used for spindle monitoring.The experiment results show that the sensor system is available and practical. | Lei Yu Hongjun Wang Yubin Yue Shucong Liu Xiangxiang Mao Fengshou Gu | 2023 | Structural Durability & Health Monitoring2023，17，4： | 0 |
| 9 | Recent advances of bioresponsive polymeric nanomedicine for cancer therapy显示文摘A bioresponsive polymeric nanocarrier for drug delivery is able to alter its physical and physicochemical properties in response to a variety of biological signals and pathological changes,and can exert its therapeutic efficacy within a confined space.These nanosystems can optimize the biodistribution and subcellular location of therapeutics by exploiting the differences in biochemical properties between tumors and normal tissues.Moreover,bioresponsive polymer-based nanosystems could be rationally designed as precision therapeutic platforms by optimizing the combination of responsive elements and therapeutic components according to the patient-specific disease type and stage.In this review,recent advances in smart bioresponsive polymeric nanosystems for cancer chemotherapy and immunotherapy will be summarized.We mainly discuss three categories,including acidity-sensitive,redox-responsive,and enzyme-triggered polymeric nanosystems.The important issues regarding clinical translation such as reproducibility,manufacture,and probable toxicity,are also commented. | Tu Hong Xinyuan Shen Madiha Zahra Syeda Yang Zhang Haonan Sheng Yipeng Zhou JinMing Xu Chaojie Zhu Hongjun Li Zhen Gu Longguang Tang | 2023 | Nano Research2023，16，2： | 0 |
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