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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Visible-light-driven enhanced antibacterial and biofilm elimination activity of graphitic carbon nitride by embedded Ag nanoparticles显示文摘有 photocatalytic 活动的半导体 nanomaterials 为许多应用有潜力。支持 photocatalytic 活动的一个有效方法在一个半导体上正在扔高贵金属 nanoparticles (NP ) ,自从 NP 作为禁止 photoexcited 电子洞对的快再结合并且从而提高反应的氧种类(ROS ) 的产生的优秀电子领受人扮演的高贵金属。此处,一个高度有效的平台, graphitic 碳氮化物( g-C <潜水艇class=“ a-plus-plus ”> 3 N <潜水艇class=“ a-plus-plus ”>有嵌入的 Ag nanoparticles 的 4 ) nanosheets ( Ag/g-C <潜水艇class=“ a-plus-plus ”> 3 N <潜水艇class=“ a-plus-plus ”> 4 ),被综合由一灵巧的线路。在可见轻照耀下面, Ag/g-C 的 ROS 生产<潜水艇class=“ a-plus-plus ”> 3 N <潜水艇class=“ a-plus-plus ”> 4 nanohybrids 极大地与太古的 g-C 相比被改进<潜水艇class=“ a-plus-plus ”> 3 N <潜水艇class=“ a-plus-plus ”> 4 nanosheets ,并且而且, nanohybrids 显示出驱散细菌的 biofilms 的提高的抗菌剂功效和能力。我们第一次证明 Ag/g-C < 潜水艇 class= “ a-plus-plus ” > 3 N < 潜水艇 class= “ a-plus-plus ” > 4 nanohybrids 是在可见的光下面的有效杀菌代理人照耀,和罐头也为 biofilm 提供一个新方法消除。Ag/g-C 的提高的抗菌剂性质和破坏 biofilm 能力 < 潜水艇 class= “ a-plus-plus ” > 3 N < 潜水艇 class= “ a-plus-plus ” > 4 nanohybrids 可以为许多提供生物医学的应用。 | Wei Bing Zhaowei Chen Hanjun Sun Peng Shi Nao Gao Jinsong Ren Xiaogang Qu | 2015 | Nano Research2015，8，5： | 7 |
| 3 | Two-dimensional optical spatial differentiation and high-contrast imaging显示文摘Optical analog signal processing technology has been widely studied and applied in a variety of science and engineering fields, with the advantages of overcoming the low-speed and high-power consumption associated with its digital counterparts. Much attention has been given to emerging metasurface technology in the field of optical imaging and processing systems. Here, we demonstrate, for the first time, broadband two-dimensional spatial differentiation and high-contrast edge imaging based on a dielectric metasurface across the whole visible spectrum. This edge detection method works for both intensity and phase objects simply by inserting the metasurface into a commercial optical microscope. This highly efficient metasurface performing a basic optical differentiation operation opens up new opportunities in applications of fast,compactible and power-efficient ultrathin devices for data processing and biological imaging. | Junxiao Zhou Haoliang Qian Junxiang Zhao Min Tang Qianyi Wu Ming Lei Hailu Luo Shuangchun Wen Shaochen Chen Zhaowei Liu | 2021 | National Science Review2021，8，6： | 6 |
| 4 | Cargo-encapsulated cells for drug delivery显示文摘Synthetic micro-/nanoparticle(MNP)carriers,either organic or inorganic ones,have advanced considerably in recent years for drug delivery with the aim of enhancing drug solubility/stability,reducing systemic toxicity and increasing dosing at pathological sites(Chen and Liang,2018;Xiang et al.,2018).Specially,the properties of MNPs,such as size,morphology,or surface groups,can be easily modulated to maximize their potency in delivering drugs to the targeted areas(Ran and Xue,2018).Nevertheless,till now,only a handful of MNPs have been approved by the US Food and Drug Administration for clinical application.Although numerous proof-of-concept studies of MNPs in animal models are in progress or are being clinically evaluated,synthetic MNPs are still struggling to reach the clinical expectations. | Zhaowei Chen Di Wen Zhen Gu | 2020 | Science China(Life Sciences)2020，63，4： | 4 |
| 5 | Platinum-coordinated graphitic carbon nitride nanosheet used for targeted inhibition of amyloid β-peptide aggregation显示文摘淀粉的肽(A) 聚集是在 Alzheimers 疾病(广告) 的致病的关键步。生产的抑制, A 的存在总数和清理的溶解对广告代表有效治疗学的策略。此处,新奇的铂(II ) 协调了 graphitic 碳氮化物(g-C 3 N 4) nanosheet (g-C 3 N 4@Pt) 被设计了 covalently 绑在 A 并且调制肽聚集和毒性。而且, g-C 3 N 4@Pt nanosheets 拥有高 photocatalytic 活动并且能氧化在可见轻照耀之上的 A,显著地 attenuating 聚集力量和 A 的 neurotoxicity。由于它穿过血大脑障碍(BBB ) 和它的好 biocompatibility 的能力, g-C 3 N 4@Pt nanosheet 是聚集的一个有希望的禁止者。这研究可以为为广告的处理使用的新奇多功能的 nanomaterials 的工程担任一个模型。 | Meng Li Yijia Guan Zhaowei Chen Nan Gao Jinsong Ren Kai Dong Xiaogang Qu | 2016 | Nano Research2016，9，8： | 3 |
| 6 | In situ fabrication of organic electrochemical transistors on a microfluidic chip显示文摘Microfluid chips integrating with organic electrochemical transistors (OECTs) are useful for manufacturing biosensors with high throughput and large-scale analyses. We report here the utilization of alternating current (AC) electrodeposition to fabricate OECTs in situ on a microfiuid chip. With this method, the organic semiconductor (OS) layer with a channel length of 8μm was readily prepared without requiring the postbonding process in the conventional construction of microfluidic chips. Poly(3,4-ethylenedioxythiophene):poly(4-styrenesulfonate)/graphene quantum dots (PEDOT:PSS/GQDs) composites with different morphologies, such as microfilms, nanodendrites and nanowires were electropolymerized. The mass transfer process of the electropolymerization reaction was evidenced to be diffusion limited. Morphologies, growth directions, and chemical structures of OS layers could be tuned by the amplitude and the frequency of the AC voltage. Transfer and output characteristic curves of OECTs were measured on the microfluidic chip. The maximum transconductance, on/off current ratio and threshold voltage measured in the experiment was 1.58 mS, 246, and 0.120 V, respectively. | Jianlong Ji Mangmang Li Zhaowei Chen Hongwang Wang Xiaoning Jiang Kai Zhuo Ying Liu Xing Yang Zhen Gu Shengbo Sang Yang Shu | 2019 | Nano Research2019，12，8： | 3 |
| 7 | Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy显示文摘Chimeric antigen receptor T cell(CAR T) therapy was a milestone in the treatment of relapsed and refractory B cell malignancies. However, beneficial effects of CAR T cells have not been obtained in solid tumors yet. Herein, we implement a porous microneedle patch that accommodates CAR T cells and allows in situ penetration-mediated seeding of CAR T cells when implanted in the tumor bed or in the post-surgical resection cavity. CAR T cells loaded in the pores of the microneedle tips were readily escorted to the tumor in an evenly scattered manner without losing their activity. Such microneedle-mediated local delivery enhanced infiltration and immunostimulation of CAR T cells as compared to direct intratumoral injection. This tailorable patch offers a transformative platform for scattered seeding of living cells for treating a variety of tumors. | Hongjun Li Zejun Wang Edikan A.Ogunnaike Qing Wu Guojun Chen Quanyin Hu Tianyuan Ci Zhaowei Chen Jinqiang Wang Di Wen Hongwei Du Jie Jiang Jie Sun Xingcai Zhang Gianpietro Dotti Zhen Gu | 2022 | National Science Review2022，9，3： | 2 |
| 8 | OsbZIP72 Is Involved in Transcriptional Gene-Regulation Pathway of Abscisic Acid Signal Transduction by Activating Rice High-Affinity Potassium Transporter OsHKT1;1显示文摘We created CRISPR-Cas9 knock-out and overexpressing OsbZIP72 transgenic rice plants to gain a better understanding of the role and molecular mechanism of OsbZIP72 gene in stress tolerance,which has remained largely elusive.OsbZIP72 was expressed and integrated into rice transgenic plant genomes,and the OsbZIP72 transcript in overexpression lines was elicited by salinity,abscisic acid(ABA)and drought stresses.OsbZIP72 overexpressing plants showed higher tolerance to drought and salinity stresses,while knock-out transgenic lines showed higher sensitivity to these stresses.The differentially expressed genes(DEGs)from RNA-sequencing data encompassed several abiotic stress genes,and the functional classification of these DEGs demonstrated the robust transcriptome diversity in OsbZIP72.Yeast one-hybrid,along with luciferase assay,indicated that OsbZIP72 acted as a transcriptional initiator.Remarkably,electrophoresis mobility assay revealed that OsbZIP72 bound directly to the ABAresponsive element in the OsHKT1;1 promoter region and activated its transcription.Overall,our findings revealed that OsbZIP72 can act as a transcriptional modulator with the ability to induce the expression of OsHKT1;1 in response to environmental stress through an ABA-dependent regulatory pathway,indicating that OsbZIP72 can play a crucial role in the ABA-mediated salt and drought tolerance pathway in rice. | WANG Baoxiang LIU Yan WANG Yifeng LI Jingfang SUN Zhiguang CHI Ming XING Yungao XU Bo YANG Bo LI Jian LIU Jinbo CHEN Tingmu FANG Zhaowei LU Baiguan XU Dayong Babatunde Kazeem BELLO | 2021 | Rice science2021，28，3： | 2 |
| 9 | Three Gorge runner blade design counted in the effect of limited blades number 显示文摘 | Chen Naixiang Liu Zhaowei Lin Ruchang | 1998 | Journal of' Tsinghua University1998，38，10： | 1 |
| 10 | Mesoporous silica-encapsulated gold nanoparticles as artificial enzymes for self-activated cascade catalysis显示文摘 | Youhui Lin Zhenhua Li Zhaowei Chen | 2013 | Biomaterials2013，34，： | 1 |
| 11 | Fullerenes and derivatives as electron transport materials in perovskite solar cells显示文摘In this study,two fullerenes(C60,C70)and their methano-substitutions(PC61BM,PC71BM),as electron transport materials(ETMs)in perovskite solar cells(Pero-SCs),were systematically studied.As being used as ETMs,methanofullerenes,though with lower electron mobility compared to the counterpart pristine fullerenes,lead to higher power conversion efficiencies(PCEs)of Pero-SCs.The difference is likely caused by the fill-out vacancies and smoother morphology of the interfaces between ETM and perovskite layers,as they were prepared by different methods.In addition,compared to C60 and PC61BM,C70 and PC71BM showed priority in terms of short-circuit current density,which should be attributed to fast free charge extraction abilities. | Kaicheng Zhang Hao Yu Xiaodong Liu Qingqing Dong Zhaowei Wang Yaofeng Wang Ning Chen Yi Zhou Bo Song | 2017 | Science China Chemistry2017，60，1： | 1 |
| 12 | Three Gorge Runner Blade Design Ounted in theEffect of Limited Blades Number显示文摘 | Chen Naixiang Liu Zhaowei Lin Ruchang | 1998 | Journal of Ts-inghua University1998，38，1： | 1 |
| 13 | Immunotherapy in leukaemia显示文摘Leukaemia is the common name for a group of malignant diseases of the haematopoietic system with complex classifications and characteristics.Remarkable progress has been made in basic research and preclinical studies for acute leukaemia compared to that of the many other types/subtypes of leukaemia,especially the exploration of the biological basis and application of immunotherapy in acute myeloid leukaemia(AML)and B-cell acute lympho-blastic leukaemia(B-ALL).In this review,we summarize the basic approaches to immunotherapy for leukaemia and focus on the research progress made in immunotherapy development for AML and ALL.Importantly,despite the advances made to date,big challenges still exist in the effectiveness of leukaemia immunotherapy,especially in AML.Therefore,we use AML as an example and summarize the mechanisms of tumour cell immune evasion,describe recently reported data and known therapeutic targets,and discuss the obstacles in finding suitabie treatment targets and the results obtained in recent clinical trials for several types of single and combination immunotherapies,such as bispecific antibodies,cell therapies(CAR-T-cell treatment),and checkpoint blockade.Finally,we summarize novel immunotherapy strategies for treating lymphocytic leukaemia and clinical trial results. | Xingmei Mu Chumao Chen Loujie Dong Zhaowei Kang Zhixian Sun Xijie Chen Junke Zheng Yaping Zhang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，6： | 1 |
| 14 | An analytical poroelastic model for laboratorial mechanical testing of the articular cartilage (AC)显示文摘The articular cartilage(AC) can be seen as a biphasic poroelastic material.The cartilage deformation under compression mainly leads to an interstitial fluid flow in the porous solid phase.In this paper,an analytical poroelastic model for the AC under laboratorial mechanical testing is developed.The solutions of interstitial fluid pressure and velocity are obtained.The results show the following facts.(i) Both the pressure and fluid velocity amplitudes are proportional to the strain loading amplitude.(ii) Both the amplitudes of pore fluid pressure and velocity in the AC depend more on the loading amplitude than on the frequency.Thus,in order to obtain the considerable fluid stimulus for the AC cell responses,the most effective way is to increase the loading amplitude rather than the frequency.(iii) Both the interstitial fluid pressure and velocity are strongly affected by permeability variations.This model can be used in experimental tests of the parameters of AC or other poroelastic materials,and in research of mechanotransduction and injury mechanism involved interstitial fluid flow. | Xiaogang WU Kuijun CHEN Zhaowei WANG Ningning WANG Teng ZHAO Yanan XUE Yanqin WANG Weiyi CHEN | 2018 | Applied Mathematics and Mechanics(English Edition)2018，39，6： | 1 |
| 15 | Effect of Random Inclusion of Wheat Straw Fibers on Shear Strength Characteristics of Shanghai Cohesive Soil显示文摘 | Jili Qu Chencai Li Baoshi Liu Xinxing Chen Ming Li Zhaowei Yao | 2013 | Geotechnical and Geological Engineering2013，，2： | 1 |
| 16 | FAILURE ANALYSIS AND INSPECTION OF CRACKING OF IN-SERVICE CATALYTIC REGENERATOR显示文摘The special subject'research on life prediction technology of important in-service pressure vessels' mainly analyzes the failure mechanism of large-sized important and critical in-service pressure vessels under the action of working medium and investigates safety assessment and life prediction technology with a view to enhance the operation reliability of in-service pressure vessels in China. Based on a series of accident investigation and test & measuring research, the cause of cracking of catalytic regenerator is analyzed and the in-line non-destructive examination method and failure prevention measures for the cracking of catalytic regenerator are proposed. | Chen Xuedong Guan Weihe Chen Wenhu Yao Zuoquan Hefei General Machinery Research Institute, Hefei 230031, ChinaGu Xuedong Wang Zhaowei Shanghai Gaoqiao Petrochemical Company | 2002 | Chinese Journal of Mechanical Engineering2002，15，2： | 1 |
| 17 | Full-scale multi-functional test platform for investigating mechanical performance of track–subgrade systems of high-speed railways显示文摘Motivated by the huge practical engineering demand for the fundamental understanding of mechanical characteristics of high-speed railway infrastructure,a fullscale multi-functional test platform for high-speed railway track–subgrade system is developed in this paper,and its main functions for investigating the mechanical performance of track–subgrade systems are elaborated with three typical experimental examples.Comprising the full-scale subgrade structure and all the five types of track structures adopted in Chinese high-speed railways,namely the CRTS I,the CRTS II and the CRTS III ballastless tracks,the double-block ballastless track and the ballasted track,the test platform is established strictly according to the construction standard of Chinese high-speed railways.Three kinds of effective loading methods are employed,including the real bogie loading,multi-point loading and the impact loading.Various types of sensors are adopted in different components of the five types of track–subgrade systems to measure the displacement,acceleration,pressure,structural strain and deformation,etc.Utilizing this test platform,both dynamic characteristics and long-term performance evolution of high-speed railway track–subgrade systems can be investigated,being able to satisfy the actual demand for large-scale operation of Chinese high-speed railways.As examples,three typical experimental studies are presented to elucidate the comprehensive functionalities of the full-scale multi-functional test platform for exploring the dynamic performance and its long-term evolution of ballastless track systems and for studying the long-term accumulative settlement of the ballasted track–subgrade system in high-speed railways.Some interesting phenomena and meaningful results are captured by the developed test platform,which provide a useful guidance for the scientific operation and maintenance of high-speed railway infrastructure. | Wanming Zhai Kaiyun Wang Zhaowei Chen Shengyang Zhu Chengbiao Cai Gang Liu | 2020 | Railway Engineering Science2020，28，3： | 1 |
| 18 | Mesoporous silica-encapsulated gold nanopartieles as artificial enzymes for self-activated cascade catalysis 显示文摘 | Lin Youhui Li Zhenhua Chen Zhaowei | 2013 | Biomaterials2013，34，11： | 1 |
| 19 | Aqueous Synthesis of Covalent Organic Frameworks as Photocatalysts for Hydrogen Peroxide Production显示文摘Covalent organic frameworks(COFs)are crystalline porous polymers with designable structures and properties.Their crystallization typically relies on trialand-error experimentation involving harsh conditions,including organic solvents,presenting significant obstacles for rational design and large-scale production.Herein,we present a liquid crystal-directed synthesis methodology and its implementation for up to gram-scale production of highly crystalline COFs in water and air.It is compatible with monomers of different structures,shape,size,length of side chains,and electron-donating,electron-accepting,and heterocyclic substitutions near reactive sites.Seventeen types of donor-acceptor two-dimensional COFs including four types of new ones and a three-dimensional COF with a yield of up to 94%were demonstrated,showing great generality of the method.The as-synthesized donor-acceptor COFs are organic semiconductors and contain macropores besides intrinsic mesopores which make them attractive catalysts.The production of H_(2)O_(2)under visible light in water was studied and the structure-property relationships were revealed.The production rate reached 4347μmol h^(−1)gcat^(−1),which is about 467%better than that of the benchmark photocatalyst g-C_(3)N_(4).This study will inspire the mild synthesis and scale-up of a wide spectrum of COFs and organic semiconductors as efficient catalysts,promote their structure-property investigation,and boost their applications. | Fanglin Tan Yuanyuan Zheng Zhipeng Zhou Honglei Wang Xin Dong Jing Yang Zhaowei Ou Haoyuan Qi Wei Liu Zhikun Zheng Xudong Chen | 2022 | CCS Chemistry2022，4，12： | 1 |
| 20 | Negative samples reduction in cross-company software defects prediction显示文摘 | Chen Lin Fang Bin Shang Zhaowei | 2015 | Information and Software Technology2015，62，1： | 1 |
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