|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effect of glycyrrhizin on traumatic brain injury in rats and its mechanism显示文摘ObjectiveTo 在创伤的大脑损害(TBI ) MethodsMale Sprague-Dawley 老鼠随机被划分成三个组以后,在老鼠在高活动性的组盒子 1 的表示(HMGB1 ) 上象它的效果一样调查 glycyrrhizin (Gly ) 的 neuroprotective 效果:假冒的组 TBI 组和 TBI + Gly 组(n = 36 每组) 。老鼠 TBI 模型被使用修改 Feeney’s 方法做。在 TBI + Gly 组 Gly 在 10 的剂量静脉内地被管理; mg/kg 30 在 TBI 以后的 min。在 24 在 TBI 马达功能和大脑水内容以后的 h 被评估。同时包括像使用费的受体的 HMGB1/HMGB1 受体 4 (TLR4 ) 并且为先进 glycation 结束产品(愤怒) 的受体 /nuclear 因素 -- 在受伤大脑纸巾表明小径和煽动性的 cytokines 的 B (NF- B ) 用量的即时聚合酶链反应被检测西方的污点 electrophoretic 活动性移动试金和连接酶的 immunosorbent 试金。而且 HMGB1 愤怒和 TLR4 immunohistochemistry 和 apoptosis 是走表演缺陷和大脑浮肿的 analyzedResultsBeam 显著地在 TBI 被减少; + Gly 组与 TBI 相比组;同时, HMGB1/HMGB1 受体(TLR4 和愤怒) 的在表示上 /NF-B DNA 有约束力的活动和煽动性的 cytokines 被禁止。 HMGB1 ,愤怒和TLR4积极的房间和 apoptotic 房间的百分比是分别地58.37% ; ± ;5.06%,54.15% ; ± ;4.65%,65.50% ; ± ;4.83%,52.02% ; ± ;4.63%在 TBI 组和39.99% ; ± ;4.99%,34.87% ; ± ;5.02%,43.33% ; ± ;4.54%,37.84% ; ± ;5.16%在 TBI ;+ ; Gly 组(所有 P ;< ; 0.01 与 TBI 相比组织)能 .ConclusionGly | Gu Xiangjin Xu Jin Ma Banyou Chen Gong Gu Peiyuan Wei Dong Hu Weixing | 2014 | Chinese Journal of Traumatology2014，17，1： | 4 |
| 2 | Converter Placement in Wavelength - routed Networks with Dynamic Traffic Demand 显示文摘 | Peiyuan Lee Xianzhong Wang Wangyi Gu Minli Zhou | 2007 | Journal of Optical Communications2007，28，1： | 1 |
| 3 | Adaptive routing and wavelength assignment algorithm for WDM networks with uniform and non-uniform traffic model 显示文摘 | Lee Peiyuan Gong Yongtao Gu Wanyi | 2004 | Communications Letters IEEE Volume: 20042004，8，6： | 1 |
| 4 | A facile strategy of in-situ anchoring of Co_(3)O_(4) on N doped carbon cloth for an ultrahigh electrochemical performance显示文摘Enhancement of supercapacitors(SCs)with high-energy density and high-power density is still a great challenge.In this paper,a facile strategy for in situ anchoring of Co_(3)O_(4) particles on N doped carbon cloth(pCoNCC)is reported.Due to the interaction of the doped N and Co_(3)O_(4),the electrochemical performance improves significantly,reaching 1,940.13 mF·cm^(−2) at 1 mA·cm^(−2) and energy density of 172.46μWh·cm^(−2) at the power density of 400μW·cm^(−2),much larger than that without N doping electrode of 28.5 mF·cm^(−2).An aqueous symmetric supercapacitor(ASSC)assembled by two pCoNCC electrodes achieves a maximum energy density of 447.42μWh·cm^(−2) and a highest power density of 8,000μW·cm^(−2).Utilizing such a high-energy storage ASSC,a digital watch and a temperature-humidity detector are powered for nearly 1 and 2 h,respectively.Moreover,the ASSC displays a superb electrochemical stability of 87.7%retention after 10,000 cycles at 40 mA·cm^(−2).This work would provide a new sight to enhance active materials performance and be beneficial for the future energy storage and supply systems. | Junlin Lu Jien Li Jing Wan Xiangyu Han Peiyuan Ji Shuang Luo Mingxin Gu Dapeng Wei Chenguo Hu | 2021 | Nano Research2021，14，7： | 0 |
| 5 | Chiral N-triflylphosphoramide-catalyzed asymmetric hydroamination of unactivated alkenes: a hetero-ene reaction mechanism显示文摘A highly enantioselective intramolecular hydroamination reaction catalyzed by chiralN-triflylphosphoramide (NTPA) that features an exceptionally broad substrate scope of isolated unactivated alkenes was recently reported by some of us. Herein we report a detailed density functional theory(DFT) study that unveil an uncommon hetero-ene reaction mechanism for this transformation. The reaction changes from a stepwise mechanism involving discrete tertiary carbocation formation to a concertedmechanism to avoid the generation of energetically unfavorable secondary carbocation species for distinctly substituted alkene substrates. The reactivity of this reaction is primarily affected by the substituentson the internal carbon of the alkene, with the carbocation-stabilizing ones promoting the reaction. Inaddition, the reaction is also influenced by the substituents on the terminal alkene carbons: those diminishing the innate alkene polarization of the starting alkenes retard the reaction by disfavoring the formation of related transition states featuring highly polarized alkene residues. The steric effect of all thesealkene substituents was found to be largely unimportant due to the unique arrangement of the heteroene reaction complex that keeps the reacting alkene away from the sterically congested core region ofthe catalyst pocket. The lower acidity of chiral phosphoric acids than that of chiral NTPAs renders the protonated precomplex along the hetero-ene reaction pathway greatly thermodynamically disfavored. Thisindirectly results in a greater relative distortion in the corresponding transition state, which in turn causesreaction retardation. Our results demonstrate the use of intramolecular pericyclic reactions as an alternative strategy for alkene activation by chiral Brønsted acid catalysis and provide insights into the furtherdevelopment of asymmetric hydrofunctionalization of unactivated alkenes. | Na Wang Li-Wen Fan Jin Zhang Qiang-Shuai Gu Jin-Shun Lin Guo-Qiang Chen Xin-Yuan Liu Peiyuan Yu | 2022 | Organic Chemistry Frontiers2022，9，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员