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12篇 您的检索式：作者名="Guanciale"

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		题名	作者	年代	出处	被引量
	1	Role of copper transporters in platinum resistance显示文摘Platinum(Pt)-based antitumor agents are effective in the treatment of many solid malignancies. However, their efficacy is limited by toxicity and drug resistance. Reduced intracellular Pt accumulation has been consistently shown to correlate with resistance in tumors. Proteins involved in copper homeostasis have been identified as Pt transporters. In particular, copper transporter receptor 1(CTR1), the major copper influx transporter, has been shown to play a significant role in Pt resistance. Clinical studies demonstrated that expression of CTR1 correlated with intratumoral Pt concentration and outcomes following Pt-based therapy. Other CTRs such as CTR2, ATP7 A and ATP7 B, may also play a role in Pt resistance. Recent clinical studies attempting to modulate CTR1 to overcome Pt resistance may provide novel strategies. This review discusses the role of CTR1 as a potential predictive biomarker of Pt sensitivity and a therapeutic target for overcoming Pt resistance.	Deepak Kilari Elizabeth Guancial Eric S Kim	2016	World Journal of Clinical Oncology2016，7，1：	3
	2	CAIR-1/BAG-3 modulates cell adhesion and migration by downregulating activity of focal adhesion proteins 显示文摘	Kassis JN Guancial EA Doong H	2006	Exp Cell Res2006，312，15：	1
	3	CAIR-1/BAG-3 modulates cell adhesion and migration by downregulating activity of focal adhesion proteins显示文摘	Kassis JN Guancial EA Doong H		0，，15：	1
	4	CAIR-I/BAG-3 modulates cell adhesion and migration by downregulating activity of focal adhesion proteins显示文摘	Kassis J N Guancial E A Doong H	2006	Exp Cell Res2006，312，15：	1
	5	The evolving understand-ing of microRNA in bladder cancer显示文摘	Guancial E A Be丨Imunt J Yeh S	2014	Urol Oncol2014，32，1：	1
	6	Genomic and phenotypic analysis reveals a key role for ccn1(cyr61)in bag3-modulated adhension and invasion显示文摘	Kassis JN Virador VM Guancial EA		0，，04：	1
	7	The evolving understanding of mieroRNA in bladder cancer显示文摘	Guancial E A Bellmunt J Yeh S	2014	Urol Oncol2014，32，1：	1
	8	Operations improvement and reengineering atOhio State University Medical Center显示文摘	Marsh G Guanciale T Simon M		0，，01：	1
	9	The evolving understanding of microRNA in bladder cancer 显示文摘	Guancial EA Bellmunt J Yeh S	2013	Urol Oncol2013，32，1：	1
	10	The evolving understanding of microRNA in bladder cancer显示文摘	Guancial EA Bellmunt J Yeh SY		0，，：	1
	11	The evolving understanding of microRNA in bladder cancer 显示文摘	Guancial EA Bellmunt J Yeh S	2013	Urol Oneal2013，32，1：	1
	12	Expression levels of DNA damage repair proteins are associated with overall survival in platinum-treated advanced urothelial carcinoma显示文摘	Mullane SA Werner L Guancial EA	2016	Clin Genitourin Cancer2016，14，4：	1

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