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| 1 | Coking wastewater increases micronucleus frequency in mouse in vivo via oxidative stress显示文摘Coking wastewater has caused serious health risk in coal-producing areas of China, however its toxic efects have not been well understood. The genotoxicity induced by coking wastewater on mice in vivo and its possible oxidative mechanisms were investigated via observing the induction of micronuclei in polychromatic erythrocytes of mouse bone marrow, and subsequently determining the antioxidative enzyme activities(superoxide dismutase Cu, Zn-SOD, Se-dependent glutathione peroxidase, and catalase), thiobarbituric acid reactive substance contents and protein carbonyl levels in brains and livers of mice. Results showed that the tested coking wastewater caused a significant increase of micronucleus frequencies in a concentration-dependent manner. Also, the sample increased lipid peroxidation and protein oxidation levels, which was accompanied by changes in antioxidative status. Interestingly, pre-treatment with an antioxidant(vitamin C) led to a statistical reduction in the micronucleus frequency caused by coking wastewater. This implies that coking wastewater induces evident genetic damage in mammalian cells, and exposure to polluted areas might pose a potential genotoxic risk to human beings; in the process, oxidative stress played a crucial role. | Na Zhu Hongyan Li Guangke Li Nan Sang | 2013 | Journal of Environmental Sciences2013，25，10： | 8 |
| 2 | Effects of nitrogen dioxide and its acid mist on reactive oxygen species production and antioxidant enzyme activity in Arabidopsis plants显示文摘Nitrogen dioxide(NO2) is one of the most common and harmful air pollutants. To analyze the response of plants to NO2 stress, we investigated the morphological change, reactive oxygen species(ROS) production and antioxidant enzyme activity in Arabidopsis thaliana(Col-0) exposed to 1.7, 4, 8.5, and 18.8 mg/m3NO2. The results indicate that NO2 exposure affected plant growth and chlorophyll(Chl) content, and increased oxygen free radical(O2-)production rate in Arabidopsis shoots. Furthermore, NO2 elevated the levels of lipid peroxidation and protein oxidation, accompanied by the induction of antioxidant enzyme activities and change of ascorbate(As A) and glutathione(GSH) contents. Following this, we mimicked nitric acid mist under experimental conditions, and confirmed the antioxidant mechanism of the plant to the stress. Our results imply that NO2 and its acid mist caused pollution risk to plant systems. During the process, increased ROS acted as a signal to induce a defense response, and antioxidant status played an important role in plant protection against NO2/nitric acid mist-caused oxidative damage. | Xiaofang Liu Fen Hou Guangke Li Nan Sang | 2015 | Journal of Environmental Sciences2015，27，8： | 7 |
| 3 | Abnormal energy metabolism and tau phosphorylation in the brains of middle-aged mice in response to atmospheric PM2.5 exposure显示文摘In light of the accelerated aging of the global population and the deterioration of the atmosphere pollution, we sought to clarify the potential mechanisms by which fine particulate matter(PM_(2.5)) can cause cognitive impairment and neurodegeneration through the alteration of mitochondrial structure and function. The results indicate that PM_(2.5) inhalation reduces ATP production by disrupting the aerobic tricarboxylic acid cycle and oxidative phosphorylation, thereby causing the hypophosphorylation of tau in the cortices of middle-aged mice. Furthermore, excessive reactive oxygen species generation was involved in the impairment. Interestingly, these alterations were partially reversed after exposure to PM_(2.5) ended. These findings clarify the mechanism involved in mitochondrial abnormality-related neuropathological dysfunction in response to atmospheric PM_(2.5) inhalation and provide an optimistic sight for alleviating the adverse health outcomes in polluted areas. | Rui Gao Tingting Ku Xiaotong Ji Yingying Zhang Guangke Li Nan Sang | 2017 | Journal of Environmental Sciences2017，29，12： | 7 |
| 4 | Synergistic effects of particulate matter(PM_10) and SO_2 on human non-small cell lung cancer A549 via ROS-mediated NF-κB activation显示文摘Since a real atmospheric scenario usually represents a system involving multiple pollutants, air pollution studies typically focused on describing adverse effects associated with exposure to individual pollutants cannot reflect actual health risk. Particulate matter(PM10) and sulfur dioxide(SO2) are two major pollutants derived from coal combustion processes and co-existing in coal-smoke air pollution, but their potentially synergistic toxicity remains elusive thus far. In this study, we investigated the cytotoxic responses of PM10 and SO2, singly and in binary mixtures, using human non-small cell lung cancer A549 cells, followed by clarifying the possible mechanisms for their interaction. The results indicated that the concomitant treatment of PM10 and SO2 at low concentrations led to synergistic injury in terms of cell survival and apoptosis occurrence, while PM10 and SO2 alone at the same concentrations did not cause damage to the cells. Also, radical oxygen species(ROS) production followed by nuclear factor kappa B(NF-κB) activation was involved in the above synergistic cytotoxicity, which was confirmed by the repression of the actions by an ROS inhibitor(NAC). This implies that assessment of health risk should consider the interactions between ambient PM and gaseous copollutants. | Yang Yun Rui Gao Huifeng Yue Guangke Li Na Zhu Nan Sang | 2015 | Journal of Environmental Sciences2015，27，5： | 3 |
| 5 | Manufacturing-oriented BOM Reconfiguration Method显示文摘Bill of material (BOM) structures describe the component structure of a product.It is used and processed in the whole product lifecycle,and is the bridge for the product data integration among enterprise application.In the process of product development,product model is evolving and BOM is also changed.To keep the data among BOM views integrate,accurate and consistent,a general model of weighted diagraph of product BOM is developed.By establishing BOM structure model and defining the mapping rules of Virtual Component,Successive Component,Middle Component and Collaborative Component,an algorithm for BOM structure mapping is proposed based on single source of product data (SSPD).According to BOM multi-view mapping and SSPD,an integration model and application framework of the product design and the manufacturing process is given.Final- ly,a BOM management system named BomMan is provided,which indicates the validity and feasibility of this method.Thus, the reconfiguration from EBOM to MBOM could be realized. | YAN Hui WANG Zhongqi HAO Guangke YIN Junqing (Institute of Mechanical Engineering,Northwestern Polytechnical University,Xi’an 710072,China | 2006 | 武汉理工大学学报2006，28，S2： | 2 |
| 6 | A comparison of the toxicity of landfill leachate exposure at the seed soaking and germination stages on Zea mays L.(maize)显示文摘To compare the toxicity of landfill leachate exposure at the early stages of seed soaking and germination on maize,a field experiment was conducted to evaluate the physiological aspects of growth,yield and potential clastogenicity of root-tip cells. The maizes were treated with leachate at levels of 2%,10%,20%,30% or 50%(V/V). First,the change of physiological indexes,including chlorophyll(Chl),Malondialdehyde(MDA)and Reactive oxygen species(ROS)levels,combined with yield all showed that soaking with leachate,but not germination,generated a greater ecological risk on maize. After a soaking treatment of maize with 50% leachate,the Chl,MDA and ROS levels during a vigorous growth period were 47.3%,149.8% and 309.7%,respectively,of the control,whereas the yield decreased to 68.6% of the control. In addition,our results demonstrated that the leachate at lower levels could promote growth. This is mainly embodied in that the yield of maize treated with 10%leachate at the soaking stage increased to 116.0% of the control. Moreover,the cytological analysis experiment also demonstrated that the ecological risk of leachate still exists in both cases. Furthermore,the gray relational analysis showed that the ear row number and tassel branch number were the major factors affecting the yield of maize treated with 50%leachate at the stages of soaking and germination,respectively. In general,these results are helpful in understanding the phytotoxicity of leachate,which provides additional reference data for risk assessment and management of leachate. | Guangke Li Junyan Chen Wei Yan Nan Sang | 2017 | Journal of Environmental Sciences2017，29，5： | 2 |
| 7 | Genotoxicity of municipal landfill leaehate on root tips of vicia faba显示文摘 | Nan Sang Guangke Li | 2004 | Mutation Research2004，560，2： | 1 |
| 8 | Characterization of pLP18, a novel cryptic plasmid of Lactobacillus plantarum PC518 isolated from Chinese pickle显示文摘 | Qu Pan Lin Zhang JinChuan Li Tian Chen Wei Chen GuangKe Wang JianHua Yin | 2011 | Plasmid2011，，3： | 1 |
| 9 | 1,8-Naphthalimide-based 'turn-on' fluorescent sensor for the detection of zinc ion in aqueous media and its applications for bioimaging显示文摘 | Zhao Liyun Mi Qili Wang Guangke | 2013 | Tetrahedron Letters2013，54，26： | 1 |
| 10 | A highly efficient and selective turn-on fluorescent sensor for Cu2+ ion based oncalixarene bearing four iminoquinoline subunits on the upper rim显示文摘 | Li Guangke Xu Zhenxiang Chen Chuanfeng | 2008 | Chem Commun2008，，： | 1 |
| 11 | Micronuclei induced by municipal landfill leachate in mouse bone marrow cells in vivo显示文摘 | Guangke Li Nan Sang Youcai Zhao | 2003 | Environmental Research2003，，1： | 1 |
| 12 | Dynamics of a three-species ratio-dependent diffusive model显示文摘 | Hu Zhixing Gao Guangke Ma Wanbiao | 2010 | Nonlinear Analysis: Real World Applications2010，11，3： | 1 |
| 13 | The fate of antibiotic resistance genes in the coastal lagoon with multiple functional zones显示文摘Coastal lagoons provide many important services to human society,but their year-round use for aquaculture introduces large amounts of sewage.The contamination of antibiotic resistance genes(ARGs)is therefore of great concern.In this study,50 ARGs subtypes,two integrase genes(intl1,intl2),and 16S rRNA genes were detected by high-throughput quantitative PCR,and standard curves of all target genes were prepared for quantification.The occurrence and distribution of ARGs in a typical coastal lagoon(XinCun lagoon,China)were comprehensively explored.We detected 44 and 38 subtypes of ARGs in the water and sediment,respectively,and discuss the various factors influencing the fate of ARGs in the coastal lagoon.Macrolides-lincosamides-streptogramins B was the primary ARG type,and macB was the predominant subtype.Antibiotic efflux and antibiotic inactivation were the main ARG resistance mechanisms.The XinCun lagoon was divided into eight functional zones.The ARGs showed a distinct spatial distribution owing to the influence of microbial biomass and anthropogenic activity in different functional zones.Fishing rafts,abandoned fish ponds,the town sewage zone,and mangrove wetlands provided a large quantity of ARGs to the XinCun lagoon.Nutrients and heavy metals also significantly correlated with the fate of the ARGs,especially NO_(2)^(−)-N and Cu,which cannot be ignored.It is noteworthy that lagoon-barrier systems coupled with persistent pollutant inputs result in coastal lagoons acting as a“buffer pool”for ARGs,which can then accumulate and threaten the offshore environment. | Shisheng Li Hui Gao Haibo Zhang Guangke Wei Qin Shu Ruijing Li Shuaichen Jin Guangshui Na Yali Shi | 2023 | Journal of Environmental Sciences2023，，6： | 0 |
| 14 | Cardiac energy metabolism disorder mediated by energy substrate imbalance and mitochondrial damage upon tebuconazole exposure显示文摘Tebuconazole exposure has been described as an increasing hazard to human health.An increasing number of recent studies have shown a positive association between tebuconazole exposure and cardiovascular disease risk,which is characterized by the reduction of adenosine triphosphate(ATP)synthesis.However,researches on the damage of tebuconazole exposure to energy metabolism and the related molecular mechanisms are limited.In the present study,male C57BL/6 mice were treated with tebuconazole at different low concentrations for 4 weeks.The results indicated that tebuconazole could accumulate in the heart and further induce the decrease of ATP content in the mouse heart.Importantly,tebuconazole induced an obvious shift in substrate utilization of fatty acid and glucose by disrupting their corresponding transporters(GLUT1,GLUT4,CD36,FABP3 and FATP1)expression,and significantly repressed the expression of mitochondrial biogenesis(Gabpa and Tfam)and oxidative phosphorylation(CS,Ndufa4,Sdhb,Cox5a and Atp5b)related genes in a dosedependent manner.Further investigation revealed that these alterations were related to the IRS1/AKT and PPARγ/RXRαpathways.These findings contribute to a better understanding of triazole fungicide-induced cardiovascular disease by revealing the key indicators associated with this phenomenon. | Tingting Ku Jindong Hu Mengmeng Zhou Yuanyuan Xie Yutong Liu Xin Tan Lin Guo Guangke Li Nan Sang | 2024 | Journal of Environmental Sciences2024，，2： | 0 |
| 15 | Investigation of the mechanical performance of Al-coated DI steel sheets prepared by DC magnetron sputtering显示文摘Aluminum films coated on DI steel sheets were prepared by direct current(DC)magnetron sputtering. The influence of the deposition conditions and film thickness on the formability of coated steel sheets was studied. The results of the cupping test and drawing test show that the substrate temperature and thickness of Al films are the key factors that affect Al adhesion and formability of coated steel sheets.Adhesion became worse when the thickness of Al sheets was more than 2μm.And formability was improved remarkably when the substrate temperature was increased to 200℃. | QIAO Zhaohui TIAN Guangke | 2014 | Baosteel Technical Research2014，8，1： | 0 |
| 16 | Endocannabinoid 2-arachidonoylglycerol protects inflammatory insults from sulfur dioxide inhalation via cannabinoid receptors in the brain显示文摘Sulfur dioxide(SO_2) pollution in the atmospheric environment causes brain inflammatory insult and inflammatory-related microvasculature dysfunction.However,there are currently no effective medications targeting the harmful outcomes from chemical inhalation.Endocannabinoids(eCBs) are involved in neuronal protection against inflammation-induced neuronal injury.The 2-arachidonoylglycerol(2-AG),the most abundant eCBs and a full agonist for cannabinoid receptors(CB1 and CB2),is also capable of suppressing proinflammatory stimuli and improving microvasculature dysfunction.Here,we indicated that endogenous 2-AG protected against neuroinflammation in response to SO_2 inhalation by inhibiting the activation of microglia and astrocytes and attenuating the overexpression of inflammatory cytokines,including tumor necrosis factor alpha(TNF-a),interleukin(IL)-1β,and inducible nitric oxide synthase(iNOS).In addition,endogenous 2-AG prevented cerebral vasculature dysfunction following SO_2 inhalation by inhibiting endothelin 1(ET-1),vascular cell adhesion molecule-1(VCAM-1) and intercellular adhesion molecule 1(ICAM-1) expression,elevating endothelial nitric oxide synthase(eNOS) level,and restoring the imbalance between thromboxane A2(TXA2) and prostaglandin 12(PGI2).In addition,the action of endogenous 2-AG on the suppression of inflammatory insult and inflammatory-related microvasculature dysfunction appeared to be mainly mediated by CB1 and CB2 receptors.Our results provided a mechanistic basis for the development of new therapeutic approaches for protecting brain injuries from SO_2 inhalation. | Ben Li Minjun Chen Lin Guo Yang Yun Guangke Li Nan Sang | 2017 | Journal of Environmental Sciences2017，29，1： | 0 |
| 17 | Tidal Response Characteristics of the Well Water Level in the Sichuan-Yunnan Region显示文摘In this paper,the long time series data of the well water-level data of 12 wells in the Sichuan and Yunnan area is analyzed by the Baytap-G tidal analysis software,and well water level tidal response characteristic parameters( amplitude ratio and phase change)are extracted. We analyzed the features of the shape and stage change,and characteristic parameters of the tidal response of well water level before and after the earthquakes,which can provide a new method and approach to analyzing the response relationships between well water level and earth tide and barometric pressure. The results show that Luguhu Well and 9 other wells are affected by earth tides,and their well water level amplitude ratios and phases are relatively stable; the Nanxi Well and Dayao Well water level changes are affected by the barometric pressure combined with tide force,and their well water level amplitude ratios and phases are more discrete. The water level amplitude ratios and phases of Jiangyou Well,Luguhu Well and Dongchuan Well are significant to large earthquakes,and the relationship between seismic energy density and water level amplitude ratios and phases of M_2 wave of the three wells are presented. | Gong Haobo Li Guangke Liao Xin Guo Weiying Chen Min | 2017 | Earthquake Research in China2017，31，2： | 0 |
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