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您的检索式：作者名="Guangli Suo"
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| 1 | Expression of Nanog gene promotes NIH3T3 cell proliferation显示文摘 | Jingyu Zhang Xia Wang Bing Chen Guangli Suo Yanhong Zhao Ziyuan Duan Jianwu Dai | 2005 | Biochemical and Biophysical Research Communications2005，，： | 1 |
| 2 | Expression of Nanog gene promotes NIH3T3 cell proliferation显示文摘 | Jingyu Zhang Xia Wang Bing Chen Guangli Suo Yanhong Zhao Ziyuan Duan Jianwu Dai | 2005 | Biochemical and Biophysical Research Communications2005，，2： | 1 |
| 3 | A human monoclonal antibody neutralizes SARS-CoV-2 Omicron variants bytargeting the upstream region of spikeprotein HR2 motif显示文摘The continuous emergence of new severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants meansthere is a need to explore additional strategies to develop broad-spectrum vaccines or therapeutics for individuals remaining at risk of coronavirus disease 2019(COVID-19).Neutralizing monoclonal antibody(mAb)that binds to theconserved S2 subunit of the SARS-CoV-2 spike(S)protein alone,or in combination with mAb that binds to the receptor-binding domain(RBD)of S protein,might be effective in eliciting protection from infection by a variety of SARS-CoV2 variants.Using high-throughput single-cell immunoglobulin sequencing of B cells from COVID-19-convalescent donors,we identified a high-affinity S2-specific mAb-39,that could inhibit original SARS-CoV-2 strain,Omicron BA.1,BA.2.86,BA.4,BA.5,and EG.5.1 S protein-mediated membrane fusion,leading to the neutralization of these pseudoviralinfections.Moreover,mAb-39 could also improve the neutralizing activity of anti-RBD antibody against the highlyneutralization-resistant Omicron variants.Molecular docking and point mutation analyses revealed that mAb-39 recognized epitopes within the conserved upstream region of the heptad repeat 2(HR2)motif of the S2 subunit.Collectively,these findings demonstrate that targeting the conserved upstream region of the HR2 motif(e.g.,using mAbs)provides anovel strategy for preventing the infection of SARS-CoV-2 and its variants. | Hang Su Jun Zhang Zhenfei Yi Sajid Khan Mian Peng Liang Ye Alan Bao Han Zhang Guangli Suo Qian Li Housheng Zheng Dandan Wu Thomas J.Kipps Lanfeng Wang Zhenghong Lin Suping Zhang | 2024 | hLife2024，2，3： | 0 |
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