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| 1 | Engineered three-dimensional scaffolds for enhanced bone regeneration in osteonecrosis显示文摘Osteonecrosis,which is typically induced by trauma,glucocorticoid abuse,or alcoholism,is one of the most severe diseases in clinical orthopedics.Osteonecrosis often leads to joint destruction,and arthroplasty is eventually required.Enhancement of bone regeneration is a critical management strategy employed in osteonecrosis therapy.Bone tissue engineering based on engineered three-dimensional(3D)scaffolds with appropriate architecture and osteoconductive activity,alone or functionalized with bioactive factors,have been developed to enhance bone regeneration in osteonecrosis.In this review,we elaborate on the ideal properties of 3D scaffolds for enhanced bone regeneration in osteonecrosis,including biocompatibility,degradability,porosity,and mechanical performance.In addition,we summarize the development of 3D scaffolds alone or functionalized with bioactive factors for accelerating bone regeneration in osteonecrosis and discuss their prospects for translation to clinical practice. | Tongtong Zhu Yutao Cui Mingran Zhang Duoyi Zhao Guangyao Liu Jianxun Ding | 2020 | Bioactive Materials2020，5，3： | 14 |
| 2 | Effect of drag reducing riblet surface on coherent structure in turbulent boundary layer显示文摘The characteristics of turbulent boundary layer over streamwise aligned drag reducing riblet surface under zero-pressure gradient are investigated using particle image velocimetry. The formation and distribution of large-scale coherent structures and their effect on momentum partition are analyzed using two-point correlation and probability density function. Compared with smooth surface, the streamwise riblets reduce the friction velocity and Reynolds stress in the turbulent boundary layer, indicating the drag reduction effect. Strong correlation has been found between the occurrence of hairpin vortices and the momentum distribution. The number and streamwise length scale of hairpin vortices decrease over streamwise riblet surface. The correlation between number of uniform momentum zones and Reynolds number remains the same as smooth surface. | Guangyao CUI Chong PAN Di WU Qingqing YE Jinjun WANG | 2019 | Chinese Journal of Aeronautics2019，32，11： | 6 |
| 3 | Effects of surface shapes on properties of turbulent/non-turbulent interface in turbulent boundary layers显示文摘The effects of directional riblets surfaces on the turbulent/non-turbulent(T/NT) interface in turbulent boundary layers are experimentally investigated using two-dimensional time-resolved particle image velocimetry(PIV). The velocity field of streamwise-wall-normal plane for the smooth surface, converging and diverging riblets surfaces are measured. The interface is detected using the criterion of local kinetic energy. The statistical properties of interface height and conditional averaged velocity for different surfaces are analyzed. It is shown that, the converging and diverging riblets surfaces have little effect on the fractal dimension of the T/NT interface, but they cause the intermittency profile deviate from error function and the probability distribution of interface height deviate from Gaussian function. To be specific, the distribution of interface height for the converging riblets surface shows a positive skewness while it shows a negative skewness for the diverging riblets surface.Moreover, the conditional averaged streamwise velocity and spanwise vorticity across the interface are analyzed, and it is found that their self-similarities are preserved for different surfaces when normalized with respective friction velocity. The correlation analysis reveals that near-wall streamwise velocity fluctuation and interface height show a negative correlation. | WU Di WANG JinJun CUI GuangYao PAN Chong | 2020 | Science China(Technological Sciences)2020，63，2： | 4 |
| 4 | Effects of Standoff Distance on Magnetic Pulse Welded Joints Between Aluminum and Steel Elements in Automobile Body显示文摘In industrial production,the standoff distance of magnetic pulse welding(MPW)is a critical parameter as it directly affects welding quality.However,the effects of standoff distance on the physical properties of MPW joints have not been investi-gated.Therefore,in this study,aluminum alloy(AA5182)sheets and high-strength low-alloy steel(HC340LA)sheets were welded through MPW at a discharge energy of 20 kJ,under various standoff distances.Thereafter,mechanical tests were performed on the MPW joints,and the results indicate that there is a significant change in the shear strength of the AA5182/HC340LA-welded joints with respect to the standoff distance.When the standoff distance ranges from 0.8 to 1.4 mm,the strength of the joint is higher than that of the base AA5182 sheet.Microscopic observations were conducted to analyze the interfacial morphology,element diffusion behavior,and microdefects on the welding interface of the AA5182/HC340LA joints.The AA5182/HC340LA joint with a standoff distance of 1.4 mm possesses the longest welded region and the largest interfacial wave.This interfacial wave pattern is suitable for achieving MPW joints with high shear strengths. | Junjia Cui Shaoluo Wang Wei Yuan Guangyao Li | 2020 | Automotive Innovation2020，3，3： | 3 |
| 5 | Analysis of plates and shells using an edge-based smoothed finite ele- ment method显示文摘 | CUI Xiangyang LIU Guirong LI Guangyao | 2010 | Comput Mech2010，45，： | 1 |
| 6 | NS-FEM/ES-FEM for contact problems in metal forming analysis显示文摘 | CUI Xiangyang LI Guangyao ZHENG Gang | 2010 | Int J Mater Form2010，3，： | 1 |
| 7 | Biofunctionalized composite scaffold to potentiate osteoconduction,angiogenesis,and favorable metabolic microenvironment for osteonecrosis therapy显示文摘Osteonecrosis is a common orthopedic disease in clinic,resulting in joint collapse if no appropriate treatment is performed in time.Core decompression is a general treatment modality for early osteonecrosis.However,effective bone regeneration in the necrotic area is still a significant challenge.This study developed a biofunctionalized composite scaffold(PLGA/nHA30VEGF)for osteonecrosis therapy through potentiation of osteoconduction,angiogenesis,and a favorable metabolic microenvironment.The composite scaffold had a porosity of 87.7%and compressive strength of 8.9 MPa.PLGA/nHA30VEGF had an average pore size of 227.6μm and a water contact angle of 56.5◦with a sustained release profile of vascular endothelial growth factor(VEGF).After the implantation of PLGA/nHA30VEGF,various osteogenic and angiogenic biomarkers were upregulated by 2-9 fold compared with no treatment.Additionally,the metabolomic and lipidomic profiling studies demonstrated that PLGA/nHA30VEGF effectively regulated the multiple metabolites and more than 20 inordinate metabolic pathways in osteonecrosis.The excellent performances reveal that the biofunctionalized composite scaffold provides an advanced adjuvant therapy modality for osteonecrosis. | Tongtong Zhu Mengyang Jiang Mingran Zhang Liguo Cui Xiaoyu Yang Xukai Wang Guangyao Liu Jianxun Ding Xuesi Chen | 2022 | Bioactive Materials2022，7，3： | 1 |
| 8 | A smoothed finite element method (SFEM) for linear and geometrically nonlinear analysis of plates and shells 显示文摘 | CUI Xiangyang LIU Guirong LI Guangyao | 2008 | Computer Methods Applied Mechanics and Engineering2008，28，2： | 1 |
| 9 | Novel thin plate element theory based on a continuity re-relaxed technique显示文摘Thin plate problem has been receiving much interest due to its wide application in engineering.In this paper,a novel thin plate element theory is proposed based on a continuity re-relaxed technique to avoid the high continuity requirement for thin plate formulation which needs the high computation cost.The problem is first discretized into a set of background cells with field nodes,and only deflection field is treated as the field variable.On top of the background cells,the integration domains are further formed.The curvatures over integration domains are restructured through the divergence theorem,and the continuity requirement of the trial deflection function for thin plate problems can be re-relaxed.The Galerkin weak form is then used to create the discretized system equations.The curvatures in the integration domains are constant,and the stiffness matrix of the system can be computed directly without numerical integration.The rotational essential boundary conditions are imposed in the process of curvature field construction.Some numerical examples are computed using the RPIM approximation function.The excellent results demonstrate the efficiency of the proposed method. | CUI XiangYang,LI GuangYao & ZHENG Gang State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body,Hunan University,Changsha 410082,China | 2010 | Science China(Technological Sciences)2010，53，9： | 0 |
| 10 | Analysis and Optimization of the Electrohydraulic Forming Process of Sinusoidal Corrugation Tubes显示文摘Aluminum alloy thin-walled structures are widely used in the automotive industry due to their advantages related to light weight and crashworthiness.They can be produced at room temperature by the electrohydraulic forming process.In the present study,the influence of the related parameters on the forming quality of a 6063 aluminum alloy sinusoidal corrugation tube has been assessed.In particular,the orthogonal experimental design(OED)and central composite design(CCD)methods have been used.Through the range analysis and variance analysis of the experimental data,the influence degree of wire diameter(WD)and discharge energy(DE)on the forming quality was determined.Multiple regression analysis was performed using the response surface methodology.A prediction model for the attaching-die state coefficient was established accordingly.The following optimal arrangement of parameters was obtained(WD=0.759 mm,DE=2.926 kJ).The attaching-die state coefficient reached the peak value of 0.001.Better optimized wire diameter and discharge energy for a better attaching-die state could be screened by CCD compared with OED.The response surface method in CCD was more suitable for the design and optimization of the considered process parameters. | Da Cai Yinlong Song Hao Jiang Guangyao Li Junjia Cui | 2024 | Fluid Dynamics & Materials Processing2024，20，4： | 0 |
| 11 | An element decomposition method with variance strain stabilization显示文摘An element decomposition method with variance strain stabilization(EDM-VSS) is proposed. In the present EDM-VSS, the quadrilateral element is first divided into four sub-triangular cells, and the local strains in sub-triangular cells are obtained using linear interpolation function. For each quadrilateral element, the strain of the whole quadrilateral is the weighted average value of the local strains, which means only one integration point is adopted to construct the stiffness matrix. The stabilization item of the stiffness matrix is constructed by variance of the local strains, which can eliminate the instability of the one-point integration formulation and largely increase the accuracy of the element. Compared with conventional full integration quadrilateral element, the EDM-VSS achieves more accurate results and expends much lower computational cost. More importantly, as no mapping or coordinate transformation is involved in the present EDM-VSS, the restriction on the conventional quadrilateral elements can be removed and problem domain can be discretized in more flexible ways. To verify the accuracy and stability of the present formulation, a number of numerical examples are studied to demonstrate the efficiency of the present EDM-VSS. | CUI XiangYang LIU PengWei LI GuangYao | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，7： | 0 |
| 12 | Genome sequencing of Sitopsis species provides insights into their contribution to the B subgenome of bread wheat显示文摘Wheat(Triticum aestivum,BBAADD)is an allohexaploid species that originated from two polyploidization events.The progenitors of the A and D subgenomes have been identified as Triticum urartu and Aegilops tauschii,respectively.Current research suggests that Aegilops speltoides is the closest but not the direct ancestor of the B subgenome.However,whether Ae.speltoides has contributed genomically to the wheat B subgenome and which chromosome regions are conserved between Ae.speltoides and the B subgenome remain unclear.Here,we assembled a high-quality reference genome for Ae.speltoides,resequenced 53 accessions from seven species(Aegilops bicornis,Aegilops longissima,Aegilops searsii,Aegilops sharonensis,Ae.speltoides,Aegilops mutica[syn.Amblyopyrum muticum],and Triticumdicoccoides)and revealed their genomic contributions to the wheat B subgenome.Our results showed that centromeric regions were particularly conserved between Aegilops and Triticum and revealed 0.17 Gb of conserved blocks between Ae.speltoides and the B subgenome.We classified five groups of conserved and non-conserved genes between Aegilops and Triticum,revealing their biological characteristics,differentiation in gene expression patterns,and collinear relationships between Ae.speltoides and the wheat B subgenome.We also identified gene families that expanded in Ae.speltoides during its evolution and 789 genes specific to Ae.speltoides.These genes can serve as genetic resources for improvement of adaptability to biotic and abiotic stress.The newly constructed reference genome and large-scale resequencing data for Sitopsis species will provide a valuable genomic resource for wheat genetic improvement and genomic studies. | Yuxin Yang Licao Cui Zefu Lu Guangrong Li Zujun Yang Guangyao Zhao Chuizheng Kong Danping Li Yaoyu Chen Zhencheng Xie Zhongxu Chen Lichao Zhang Chuan Xia Xu Liu Jizeng Jia Xiuying Kong | 2023 | Plant Communications2023，4，4： | 0 |
| 13 | Genome resources for the elite bread wheat cultivar Aikang 58 and mining of elite homeologous haplotypes for accelerating wheat improvement显示文摘Despite recent progress in crop genomics studies,the genomic changes brought about by modern breeding selection are still poorly understood,thus hampering genomics-assisted breeding,especially in polyploid crops with compound genomes such as common wheat(Triticum aestivum).In this work,we constructed genome resources for the modern elite common wheat variety Aikang 58(AK58).Comparative genomics between AK58 and the landrace cultivar Chinese Spring(CS)shed light on genomic changes that occurred through recent varietal improvement.We also explored subgenome diploidization and divergence in common wheat and developed a homoeologous locus-based genome-wide association study(HGWAS)approach,which was more effective than single homoeolog-based GWAS in unraveling agronomic trait-associated loci.A total of 123 major HGWAs loci were detected using a genetic population derived from AK58 and cs.Elite homoeologous haplotypes(HHs),formed by combinations of subgenomic homoeologs of the associated loci,were found in both parents and progeny,and many could substantially improve wheat yield and related traits.We built a website where users can download genome assembly sequence and annotation data for AK58,perform blast analysis,and run JBrowse.Our work enriches genome resources for wheat,provides new insights into genomic changes during modern wheat improve-.ment,and suggests that efficientmining of elite HHs can make a substantial contribuutionto genomics-assisted breeding in common wheat and other polyploid crops. | Jizeng Jia Guangyao Zhao Danping Li Kai Wang Chuizheng Kong Pingchuan Deng Xueqing Yan Xueyong Zhang Zefu Lu Shujuan Xu Yuannian Jiao Kang Chong Xu Liu Dangqun Cui Guangwei Li Yijing Zhang Chunguang Du Liang Wu Tianbao Li Dong Yan Kehui Zhan Feng Chen Zhiyong Wang Lichao Zhang Xiuying Kong Zhengang Ru Daowen Wang Lifeng Gao | 2023 | Molecular Plant2023，16，12： | 0 |
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