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| 1 | New insights into the associations among feed efficiency, metabolizable efficiency traits and related QTL regions in broiler chickens显示文摘Background: Improving the feed efficiency would increase profitability for producers while also reducing the environmental footprint of livestock production. This study was conducted to investigate the relationships among feed efficiency traits and metabolizable efficiency traits in 180 male broilers. Significant loci and genes affecting the metabolizable efficiency traits were explored with an imputation-based genome-wide association study. The traits measured or calculated comprised three growth traits, five feed efficiency related traits, and nine metabolizable efficiency traits.Results: The residual feed intake(RFI) showed moderate to high and positive phenotypic correlations with eight other traits measured, including average daily feed intake(ADFI), dry excreta weight(DEW), gross energy excretion(GEE), crude protein excretion(CPE), metabolizable dry matter(MDM), nitrogen corrected apparent metabolizable energy(AMEn), abdominal fat weight(Ab F), and percentage of abdominal fat(Ab P). Greater correlations were observed between growth traits and the feed conversion ratio(FCR) than RFI. In addition, the RFI, FCR, ADFI, DEW,GEE, CPE, MDM, AMEn, Ab F, and Ab P were lower in low-RFI birds than high-RFI birds(P < 0.01 or P < 0.05), whereas the coefficients of MDM and MCP of low-RFI birds were greater than those of high-RFI birds(P < 0.01). Five narrow QTLs for metabolizable efficiency traits were detected, including one 82.46-kb region for DEW and GEE on Gallus gallus chromosome(GGA) 26, one 120.13-kb region for MDM and AMEn on GGA1, one 691.25-kb region for the coefficients of MDM and AMEn on GGA5, one region for the coefficients of MDM and MCP on GGA2(103.45–103.53 Mb), and one 690.50-kb region for the coefficient of MCP on GGA14. Linkage disequilibrium(LD) analysis indicated that the five regions contained high LD blocks, as well as the genes chromosome 26 C6 orf106 homolog(C26 H6 orf106), LOC396098, SH3 and multiple ankyrin repeat domains 2(SHANK2), ETS homologous factor(EHF), and histamine receptor H3-like(HRH3 L), which are known to be involved in the regulation of neurodevelopment, cell proliferation and differentiation, and food intake.Conclusions: Selection for low RFI significantly decreased chicken feed intake, excreta output, and abdominal fat deposition, and increased nutrient digestibility without changing the weight gain. Five novel QTL regions involved in the control of metabolizable efficiency in chickens were identified. These results, combined through nutritional and genetic approaches, should facilitate novel insights into improving feed efficiency in poultry and other species. | Wei Li Ranran Liu Maiqing Zheng Furong Feng Dawei Liu Yuming Guo Guiping Zhao Jie Wen | 2020 | Journal of Animal Science and Biotechnology2020，11，4： | 4 |
| 2 | Characterization of codon usage bias in the dUTPase gene of duck enteritis virus显示文摘A comparative analysis of the codon usage bias in the newly discovered dUTPase gene (Assigned Accession No.:DQ486149) of the duck enteritis virus (DEV) and the dUTPase gene of 32 reference herpesviruses was performed.The results indicated that the DEV dUT-Pase gene encodes a protein of 477 amino acids, which includes five conserved motifs with a 3-1-2-4-5 arrangement.The codon adap-tation index (CAI), efiective number of codons (ENC), and GC3S values indicated synonymous codon usage bias in the dUTPase gene of herpesviruses, and this synonymous bias was correlated with host evolution.The codon usage patterns of the DEV dUTPase gene were phylogenetically conserved and similar to that of the dUTPase genes of the avian alphaherpesvirus.Although codon usage in each micro-organism was difierent, there were no strain-specific difierences among them.Sixty-one codons in the predicted polypeptide, with a strong bias towards A and T at the third codon position, were used.Comparison of the codon usage in the dUTPase gene of difierent organisms revealed that there were 19 codons showing distinct codon usage difierences between the DEV and Escherichia coli dUTPase genes;16 between the DEV and yeast dUTPase genes;and 15 between the DEV and human dUTPase genes.Analysis of variance (ANOVA) showed significant difierences between the DEV and yeast dUTPase genes (r = 0.536, P < 0.01).The extent of codon usage bias in the DEV dUTPase gene was highly correlated with the gene expression level, therefore the results may provide useful information for gene classification and functional studies. | Lichan Zhao Anchun Cheng Mingshu Wang Guiping Yuan Mingsheng Cai | 2008 | Progress in Natural Science:Materials International2008，18，9： | 4 |
| 3 | Effects of Structural Parameters on the Poisson’s Ratio and Compressive Modulus of 2D Pentamode Structures Fabricated by Selective Laser Melting显示文摘Metamaterials have been receiving an increasing amount of interest in recent years. As a type of metamaterial, pentamode materials (PMs) approximate the elastic properties of liquids. In this study, a finite-element analysis was conducted to predict the mechanical properties of PM structures by altering the thin wall thicknesses and layer numbers to obtain an outstanding load-bearing capacity. It was found that as the thin wall thickness increased from 0.15 to 0.45 mm, the compressive modulus of the PM structures increased and the Poisson’s ratio decreased. As the layer number increased, the Poisson’s ratio of the PM structures increased rapidly and reaches a stable value ranging from 0.50 to 0.55. Simulation results of the stress distribution in the PM structures confirmed that stress concentrations exist at the junctions of the thin walls and weights. For validation, Ti–6Al–4V specimens were fabricated by selective laser melting (SLM), and the mechanical properties of these specimens (i.e., Poisson’s ratio and elastic modulus) were experimentally studied. Good consistency was achieved between the numerical and experimental results. This work is beneficial for the design and development of PM structures with simultaneous load-bearing capacity and pentamodal properties. | Lei Zhang Bo Song Ruijie Liu Aiguo Zhao Jinliang Zhang Linrong Zhuo Guiping Tang Yusheng Shi | 2020 | Engineering2020，6，1： | 4 |
| 4 | Recent studies in satellite observations of three-dimensional magnetic reconnection显示文摘Magnetic reconnection is a main process converting the magnetic energy into thermal and kinetic energy in plasmas. It is one of the fundamental problems of crucial importance not only to space plasmas physics and space weather studies,such as the solar flare,coronal mass ejections and magnetospheric substorms,but also to the stability analysis in magnetically confined fusion. In general,except for cases with periodical boundary conditions,three-dimensional(3D) magnetic re-connection occurs on magnetic separatrices generated by magnetic nulls. Here we briefly introduce/review the theories and some recent satellite observations of 3D magnetic reconnection. Topics to be further studied are also discussed. | XIAO ChiJie WANG XiaoGang PU ZuYin MA ZhiWei ZHAO Hui ZHOU GuiPing WANG JingXiu LIU ZhenXing | 2007 | Science China(Technological Sciences)2007，50，3： | 4 |
| 5 | Low strain rate compressive behavior of high porosity closed-cell aluminum foams显示文摘The impact of a rigid body(protected structure) together with cushion material(cellular metal foam) on hard ground from a fixed height was investigated.An analytical one-degree-of-freedom colliding model(ODF-CM) was established to analyze the protection ability and energy absorption by the foam under low velocity impact conditions.For validation,drop hammer experiments were carried out for high porosity closed-cell aluminum foam specimens subjected to low velocity impact loading.The dynamic deformation behavior of the specimen was observed and the velocity attenuation of the drop hammer was measured.The results demonstrated that the aluminum foam had excellent energy absorption capabilities,with its dynamic compressive behavior similar to that obtained under quasi-static loading conditions.Finite element method(FEM) was subsequently employed to obtain stress distributions in the foam specimen.As the propagating period of stress in the specimen was far less than the duration of attenuation,the evolution of the stress was similar to that under quasi-static loading conditions and no obvious stress wave effect was observed,which agreed with the experimental observation.Finally,the predicted velocity attenuation by the ODF-CM was compared with both the experimental measurements and FEM simulation,and good agreements were achieved when the stress distribution was considered to be uniform and the 'quasi-static' compressive properties are employed. | LI BinChao ZHAO GuiPing LU TianJian | 2012 | Science China(Technological Sciences)2012，55，2： | 3 |
| 6 | Internal carotid artery agenesis with stenosed intercavernous anastomosis:a case report显示文摘We report a rare case of internal carotid artery agenesis with stenosed intercavernous anastomosis.A 59-yearold male patient presented with a new infarction in the left basal ganglia.Magnetic resonance angiography and cerebral angiography showed that the right internal carotid artery disappeared from the origin to the foramen lacerum segment,and there was an anastomotic artery with severe stenosis passed through the floor of the sella and in front of the cavernous sinus.The right A1 segment of the anterior cerebral artery was absent and A2 segment was supplied by the normal contralateral internal carotid artery via the anterior communicating artery. | Hongzhou Duan Liang Li Guiping Zhao Yang Zhang Jiayong Zhang | 2016 | The Journal of Biomedical Research2016，30，4： | 3 |
| 7 | A selected population study reveals the biochemical mechanism of intramuscular fat deposition in chicken meat显示文摘Background:Increasing intramuscular fat(IMF)is an important strategy to improve meat quality,but the regulation mechanism of IMF deposition needs to be systematically clarified.Results:A total of 520 chickens from a selected line with improved IMF content and a control line were used to investigate the biochemical mechanism of IMF deposition in chickens.The results showed that the increased IMF would improve the flavor and tenderness quality of chicken meat.IMF content was mainly determined both by measuring triglyceride(TG)and phospholipid(PLIP)in muscle tissue,but only TG content was found to be decisive for IMF deposition.Furthermore,the increase in major fatty acid(FA)components in IMF is mainly derived from TGs(including C16:0,C16:1,C18:1n9c,and C18:2n6c,etc.),and the inhibition of certain very-long-chain FAs would help to IMF/TG deposition.Conclusions:Our study elucidated the underlying biochemical mechanism of IMF deposition in chicken:Prevalent accumulation of long-chain FAs and inhibitions of medium-chain FAs and very long chain FA would jointly result in the increase of TGs with the FA biosynthesis and cellular uptake ways.Our findings will guide the production of high-quality chicken meat. | Huanxian Cui Lu Liu Xiaojing Liu Yongli Wang Na Luo Xiaodong Tan Yuting Zhu Ranran Liu Guiping Zhao Jie Wen | 2022 | Journal of Animal Science and Biotechnology2022，13，5： | 2 |
| 8 | Computational mechanics of laser cladding process显示文摘 | Chongdu Cho Guiping Zhao Kwak Si-Young | 2004 | Journal of Materials Processing Technology2004，，11： | 1 |
| 9 | Up-regulation of the MyD88-dependent pathway of TLR signaling in spleen and caecum of young chickens infected with Salmonella serovar Pullorum显示文摘 | Peng Li Pingan Xia Jie Wen Maiqing Zheng Jilan Chen Jingpeng Zhao Ruirui Jiang Ranran Liu Guiping Zhao | 2009 | Veterinary Microbiology2009，，2： | 1 |
| 10 | The regulation of IMF deposition in pectoralis major of fast-and slow-growing chickens at hatching显示文摘Background: The lipid from egg yolk is largely consumed in supplying the energy for embryonic growth until hatching. The remaining lipid in the yolk sac is transported into the hatchling's tissues. The gene expression profiles of fast-and slow-growing chickens, Arbor Acres(AA) and Beijing-You(BJY), were determined to identify global differentially expressed genes and enriched pathways related to lipid metabolism in the pectoralis major at hatching.Results: Between these two breeds, the absolute and weight-specific amounts of total yolk energy(TYE) and intramuscular fat(IMF) content in pectoralis major of fast-growing chickens were significantly higher(P < 0.01,P < 0.01, P < 0.05, respectively) than those of the slow-growing breed. IMF content and u-TYE were significantly related(r = 0.9047, P < 0.01). Microarray analysis revealed that gene transcripts related to lipogenesis, including PPARG, RBP7, LPL, FABP4, THRSP, ACACA, ACSS1, DGAT2, and GK, were significantly more abundant in breast muscle of fast-growing chickens than in slow-growing chickens. Conversely, the abundance of transcripts of genes involved in fatty acid degradation and glycometabolism, including ACAT1, ACOX2, ACOX3, CPT1 A, CPT2, DAK, APOO, FUT9, GCNT1,and B4 GALT3, was significantly lower in fast-growing chickens. The results further indicated that the PPAR signaling pathway was directly involved in fat deposition in pectoralis major, and other upstream pathways(Hedgehog, TGFbeta, and cytokine–cytokine receptor interaction signaling pathways) play roles in its regulation of the expression of related genes.Conclusions: Additional energy from the yolk sac is transported and deposited as IMF in the pectoralis major of chickens at hatching. Genes and pathways related to lipid metabolism(such as PPAR, Hedgehog, TGF-beta, and cytokine–cytokine receptor interaction signaling pathways) promote the deposition of IMF in the pectoralis major of fast-growing chickens compared with those that grow more slowly. These findings provide new insights into the molecular mechanisms underlying lipid metabolism and deposition in hatchling chickens. | Lu Liu Huanxian Cui Ruiqi Fu Maiqing Zheng Ranran Liu Guiping Zhao Jie Wen | 2018 | Journal of Animal Science and Biotechnology2018，9，1： | 1 |
| 11 | Application of 3 D finite element method using Lagrangian formulation to dilution control in laser cladding process显示文摘 | Guiping Zhao Chongdu Cho Jae-Do Kim | 2003 | Mechanical Sciences2003，45，5： | 1 |
| 12 | Dominant changes in the breast muscle lipid profiles of broiler chickens with wooden breast syndrome revealed by lipidomics analyses显示文摘Background: Chicken is the most consumed meat worldwide and the industry has been facing challenging myopathies. Wooden breast(WB), which is often accompanied by white striping(WS), is a serious myopathy adversely affecting meat quality of breast muscles. The underlying lipid metabolic mechanism of WB affected broilers is not fully understood.Results: A total of 150 chickens of a white-feathered, fast-growing pure line were raised and used for the selection of WB, WB + WS and control chickens. The lipids of the breast muscle, liver, and serum from different chickens were extracted and measured using ultra performance liquid chromatography(UPLC) plus Q-Exactive Orbitrap tandem mass spectrometry. In the breast, 560 lipid molecules were identified. Compared to controls, 225/225 of 560 lipid molecules(40.2%) were identified with differential abundance(DA), including 92/100 significantly increased neutral lipids and 107/98 decreased phospholipids in the WB/WB + WS groups, respectively. The content of monounsaturated fatty acids(MUFA) was significantly higher, and the polyunsaturated fatty acids(PUFA) and saturated fatty acids(SFA) were significantly lower in the affected breasts. In the liver, 434 lipid molecules were identified, and 39/61 DA lipid molecules(6.7%/14.1%) were detected in the WB and WB + WS groups, respectively. In the serum, a total of 529 lipid molecules were identified and 4/44 DA lipid molecules(0.8%/8.3%) were detected in WB and WB + WS group, respectively. Compared to controls, the content of MUFAs in the serum and breast of the WB + WS group were both significantly increased, and the content of SFAs in two tissues were both significantly decreased. Only five lipid molecules were consistently increased in both liver and serum in WB + WS group.Conclusions: We have found for the first time that the dominant lipid profile alterations occurred in the affected breast muscle. The relative abundance of 40.2% of lipid molecules were changed and is characteristic of increased neutral lipids and decreased phospholipids in the affected breasts. Minor changes of lipid profiles in the liver and serum of the affected groups were founded. Comprehensive analysis of body lipid metabolism indicated that the abnormal lipid profile of WB breast may be independent of the liver metabolism. | Ranran Liu Fuli Kong Siyuan Xing Zhengxiao He Lu Bai Jiahong Sun Xiaodong Tan Di Zhao Guiping Zhao Jie Wen | 2022 | Journal of Animal Science and Biotechnology2022，13，6： | 1 |
| 13 | Dynamic responses of sandwich beams with gradient-density aluminum foam cores显示文摘 | ZHANG Jian ZHAO Guiping LU Tianjian | 2011 | International Journal of Protective Structures2011，2，4： | 1 |
| 14 | Study on Surface Sterilization Method for Tissue Culture of Haloxylon ammodendron(C.A.Mey.) Bunge Seeds显示文摘[Objective] The aim was to select appropriate sterilization methods and explants for tissue culture of Haloxylon ammodendron(C.A.Mey.).[Method] H.ammodendron(C.A.Mey.) seeds were used as experimental materials to investigate the sterilization results of different sterilization treatments and the effect of different seed sizes on the survival rate of aseptic seedlings.[Result] Sterilization of H.ammodendron(C.A.Mey.) seeds achieved the best result by using 75% alcohol for 15 min and 0.1% mercuric chloride for 8 min.Seeds with diameter >2.0 mm were used as explants and achieved relatively high survival rate of aseptic seedlings,which reached above 65%.[Conclusion] This study established a surface sterilization method for tissue culture of H.ammodendron(C.A.Mey.) Bunge seeds. | Dong WANG Guiping ZHAO | 2012 | Agricultural Biotechnology2012，1，3： | 1 |
| 15 | Chicken gga-miR-1306-5p targets Tollip and plays an important role in host response against Salmonella enteritidis infection显示文摘Background: Increasing evidence indicates that micro RNAs(mi RNAs) are involved in inflammatory response and immune regulation following pathogen invasion. The purpose of this study was to elucidate the roles played by Gallus gallus micro RNA-1306-5 p(gga-mi R-1306-5 p) in host responses against potential invasion by Salmonella enteritidis(SE) in chickens and the underlying mechanisms.Results: In present study, the expression levels of gga-mi R-1306-5 p were determined in both tissues and HD11 cells. The results showed that gga-mi R-1306-5 p was significantly increased following SE infection or lipopolysaccharide(LPS) stimulation. The dual luciferase reporter assay further validated that gga-mi R-1306-5 p targeted the Toll-interacting protein(Tollip), and thereby participated in the regulation of immune response against SE or LPS stimulation through binding with the 3′-untranslated region(3’UTR) of Tollip. Additionally, the expression of Tollip was significantly blocked by over-expressed gga-mi R-1306-5 p. The underlying mechanisms by which ggami R-1306-5 p modulated the production of pro-inflammatory cytokines were also investigated. Molecular biological assays demonstrated that overexpression of gga-mi R-1306-5 p promoted the production of pro-inflammatory mediators, including NF-κB, TNF-α, IL-6, and IL-1β, which produced effects similar to those of Tollip knockdown.Conclusions: Taken together, gga-mi R-1306-5 p induced by SE or LPS, regulates the immune response by inhibiting Tollip, which activates the production of inflammatory cytokines. This study has provided the first direct evidence that gga-mi R-1306-5 p targets Tollip, and is involved in the host response against SE. | Weiwei Sun Ranran Liu Peng Li Qinghe Li Huanxian Cui Maiqing Zheng Jie Wen Guiping Zhao | 2019 | Journal of Animal Science and Biotechnology2019，10，4： | 1 |
| 16 | Application of 3-D finite element method using Lagrangian formulation to dilution control in laser cladding process显示文摘 | Zhao Guiping Cho Chongdu Kim Jae-Do | 2003 | International Journal of Mechanical Science A2003，45，： | 1 |
| 17 | Expression analysis and antiviral properties of the Beijing - Yon and White Leghorn myxovirus resistance gene with different ami- no acids at position 631 显示文摘 | Chunguang Yin Chuansheng Zhang Aimin Zhang Hongwei Qin Xiaoqiang Wang GuiPing Zhao Lixin Du | 2010 | Poultry Science2010，89，： | 1 |
| 18 | Composite quantile regression estimation for P-GARCH processes显示文摘We consider the periodic generalized autoregressive conditional heteroskedasticity(P-GARCH) process and propose a robust estimator by composite quantile regression. We study some useful properties about the P-GARCH model. Under some mild conditions, we establish the asymptotic results of proposed estimator.The Monte Carlo simulation is presented to assess the performance of proposed estimator. Numerical study results show that our proposed estimation outperforms other existing methods for heavy tailed distributions.The proposed methodology is also illustrated by Va R on stock price data. | ZHAO Biao CHEN Zhao TAO GuiPing CHEN Min | 2016 | Science China Mathematics2016，59，5： | 1 |
| 19 | Effects of the 6VS.6AL translocation on agronomic traits and dough properties of wheat显示文摘 | Guiping Li Peidu Chen Shouzhong Zhang Xiue Wang Zhonghu He Yan Zhang He Zhao Huiyao Huang Xiangchun Zhou | 2007 | Euphytica2007，，3： | 1 |
| 20 | Computational Mechanics of Laser Cladding Process显示文摘 | Chongdu Cho Guiping Zhao Si-Yong Kwak | 2004 | Materials Processing Technology2004，153，： | 1 |
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