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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Parallel Itoh-Tsujii multiplicative inversion algorithm for a special class of trinomials 显示文摘 | Francisco R H Guillermo M L Nazar A | 2007 | Designs Codes and Cryptography2007，45，1： | 1 |
| 3 | Chromenes of polyketide oridin from Peperomia villipetiola 显示文摘 | KARINA J M S GUILLERMO E D P LI5IS R L | 2005 | Phytochemistry2005，66，5： | 1 |
| 4 | Chromenes of polyketide oridin from Peperomia villipetiola 显示文摘 | Karina J M S Guillermo E D P Luis R L | 2005 | Phytochemistry2005，66，： | 1 |
| 5 | Assessment of the anti-inflammatory activity and free radical scavenger activity of tiliroside显示文摘 | Araceli Sala M.Carmen Recio Guillermo R Schinella Salvador Má?ez Rosa M Giner Miguel Cerdá-Nicolás José-Luis R??os | 2003 | European Journal of Pharmacology2003，，1： | 1 |
| 6 | Human milk glycans protect infants against enteric pathogens显示文摘 | David S N Guillermo M R Ardythe L M | 2005 | Ann Rev Nutr2005，25，： | 1 |
| 7 | Modeling of VOC mass transfer in two-liquid phase stirred tank,biotrickling filter and airlift reactors显示文摘 | Hernándeza M Guillermo Q Mu(n)oz R | 2011 | Chem Eng J2011，172，23： | 1 |
| 8 | Optimization of power management in an hybrid electric vehicle using dynamic programming显示文摘 | LAURA V P GUILLERMO R B DIEGO M | 2006 | Mathematics and Computers in Simulation2006，73，1： | 1 |
| 9 | Prediction of bending strength in oak beams on the basis of elasticity,density,and wood defects显示文摘 | Guillermo R M Gete A R | | 0，，06： | 1 |
| 10 | An empirical model to predict yield of rainfed dry bean with multi-year data 显示文摘 | MARIO D A R Efrain A D Guillermo M G | 2007 | Rev Fotptec Mex2007，30，3： | 1 |
| 11 | Optimization of power management in an hybrid electric vehicle using dynamic programming显示文摘 | Laura V P Guillermo R B Diego M | | 0，，： | 1 |
| 12 | Chromenes of polyketide oridin from Peperomia villipetiola显示文摘 | KARINA J M S GUILLERMO E D P LUIS R L | 2005 | Phytochemistry2005，66，： | 1 |
| 13 | Chromenes of polyketide oridin from Peperomia villipetiola 显示文摘 | KARINA J M S GUILLERMO E D P LUIS R L | 2005 | Phytochemistry2005，66，5： | 1 |
| 14 | Chromenes of polyketide oridin from Peperomia villipetiola显示文摘 | KARINA J M S GUILLERMO E D P LUIS R L | 2005 | Phytochemistry2005，66，： | 1 |
| 15 | Exploring QSAR of anti- amoebic agents of isolated natural products by MLR, ANN, and RTO 显示文摘 | Guillermo R G Heidy M P Ramon G J | 2011 | Med Chem Res2011，，9： | 1 |
| 16 | Chromenes of polyketide oridin from Peperomia villipetiola 显示文摘 | Karina J M S Guillermo E D P Luis R L | 2005 | Phytochemistry2005，66，5： | 1 |
| 17 | Phase Ⅰ trial of intratumoral injection of an adenovirus encoding interleukin-12 for advanced digestive tumors显示文摘 | Bruno S Guillermo M Juan R et el | 2004 | Journel of Clinical Oncology2004，22，： | 1 |
| 18 | Chromenes of polyketide oridin fromPeperomia villipetiola 显示文摘 | Karina J M S Guillermo E D P Luis R L | 2005 | Phytochemistry2005，66，： | 1 |
| 19 | Association between lifestyle factors and thyroid function in young euthyroid adults显示文摘Purpose:The present work examines the associations of dietary habits,sedentarism,physical activity(PA)levels and sleep habits,with thyroid function in young euthyroid adults.Methods:A total of 105 young euthyroid adults participated in this cross-sectional study.Thyroid function was determined in fasting conditions(>6 h).Dietary habits were measured by a food frequency questionnaire and three non-consecutive 24 h recalls,and different dietary intake and patterns were then estimated.The time spent in sedentary,PA levels and sleep habits were objectively measured using a wrist-worn accelerometer.Results:Energy and carbohydrate intake were positively associated with thyroid stimulating hormone(TSH)(β=0.222;R^(2)=0.102;P=0.022 andβ=0.425;R^(2)=0.129;P=0.007,respectively)whereas fat intake was negatively associated with TSH(β=-0.428;R^(2)=0.137;P=0.004).Energy intake was also positively associated with free triiodothyronine(β=0.277;R^(2)=0.137;P=0.004).Further,adherence to the Mediterranean diet was negatively related to TSH and free thyroxine(FT4)(β=-0.221;R^(2)=0.113;P=0.020 andβ=-0.268;R^(2)=0.071;P=0.007,respectively).Vigorous-intensity and overall PA were negatively associated with FT4(β=-0.227;R^(2)=0.052;P=0.022 andβ=-0.204;R^(2)=0.042;P=0.041,respectively).In contrast,no associations were found between sleep parameters and thyroid function.Conclusions:Lifestyle factors such as dietary intake and PA levels seems to be related to thyroid function even in young euthyroid adults. | Elisa Merchan-Ramirez Guillermo Sanchez-Delgado Lucas Jurado-Fasoli Francisco M Acosta Manuel Munoz-Torres Jose M.Llamas-Elvira Jonatan R Ruiz | 2024 | Food Science and Human Wellness2024，13，1： | 0 |
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