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| 1 | Update on pathogenesis and clinical management of acute pancreatitis显示文摘Acute pancreatitis (AP), defined as the acute nonbacterial inflammatory condition of the pancreas, is derived from the early activation of digestive enzymes found inside the acinar cells, with variable compromise of the gland itself, nearby tissues and other organs. So, it is an event that begins with pancreatic injury, elicits an acute inflammatory response, encompasses a variety of complications and generally resolves over time. Different conditions are known to induce this disorder, although the innermost mechanisms and how they act to develop the disease are still unknown. We summarize some well established aspects. A phase sequence has been proposed: etiology factors generate other conditions inside acinar cells that favor the AP development with some systemic events; genetic factors could be involved as susceptibility and modifying elements. AP is a disease with extremely different clinical expressions. Most patients suffer a mild and limited disease, but about one fifth of cases develop multi organ failure, accompanied by high mortality. This great variability in presentation, clinical course and complications has given rise to the confusion related to AP related terminology. However, consensus meetings have provided uniform definitions, including the severity of the illness. The clinical management is mainly based on the disease′s severity and must be directed to correct the underlying predisposing factors and control the inflammatory process itself. The first step is to determine if it is mild or severe. We review the principal aspects to be considered in this treatment, as reflected in several clinical practice guidelines. For the last 25 years, there has been a global increase in incidence of AP, along with many advances in diagnosis and treatment. However, progress in knowledge of its pathogenesis is scarce. | Dulce M Cruz-Santamaría Carlos Taxonera Manuel Giner | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，3： | 16 |
| 2 | In vivo anti-inflammatory activity of saponins from Bupleurum rotundifolium 显示文摘 | Navarro P Giner R M Recio M C | 2001 | Life Sci2001，68，10： | 2 |
| 3 | Effect of temperature on hot-air drying rate and on retention of antioxidant capacity in apple leathers显示文摘 | Silvana M. Demarchi Natalia A. Quintero Ruiz Analía Concellón Sergio A. Giner | 2012 | Food and Bioproducts Processing2012，，： | 2 |
| 4 | Inactivation of peach polyphenoloxidase by exposure to pulsed electric fields显示文摘 | Giner J Gimeno V Ortega M | 2002 | Journal of Food Science2002，67，4： | 1 |
| 5 | Developing mobile business processes for the Internet of Things显示文摘 | GINER P CETINA C FONS J | 2010 | IEEE Pervasive Computing2010，9，2： | 1 |
| 6 | Direction of crack propagation in a complete contact fretting-fatigue problem显示文摘 | GINER E SABSABI M RODENAS J J | 2014 | International Journal of Fatigue2014，58，： | 1 |
| 7 | Tension-free vaginal tape versus tension-free vaginal tape obturator in women with stress urinary incontinence显示文摘 | Liapis A Bakas P Giner M | 2006 | Gynecol Obstet Invest2006，62，3： | 1 |
| 8 | Two fungal lanostane derivatives as phospholipase A2 inhibitors 显示文摘 | Culla M J Giner R M Recio M C | 1996 | J Nat Prod1996，59，10： | 1 |
| 9 | Variations in landscape patterns and vegetation cover between 1957 and 1994 in a semiarid Mediterranean ecosystem显示文摘 | C.L. Alodos Y. Pueyo O. Barrantes J. Escós L. Giner A.B. Robles | 2004 | Landscape Ecology2004，，5： | 1 |
| 10 | Testing the safety-net role of hedgerow tree roots by 15N placement different soil depths显示文摘 | Rowe E C Hairaih K Giner K E | 1999 | Agroforestry System1999，43，： | 1 |
| 11 | Influence of traditional Chinese anti-inflammatory medicinal plants on leukocyte and platelet functions显示文摘 | Prieto JM Recio MC Giner RiM | 2003 | J Pharm Pharmacol2003，55，： | 1 |
| 12 | Non-enzymatic browning in peach puree during heating显示文摘 | GARZA S IBARZ A GINER J | | 0，，5： | 1 |
| 13 | RANKL/OPG in primary cultures of osteoblasts from post-menopausal women. Differences between osteoporotic hip fractures and osteoarthritis显示文摘 | Mercè Giner M a José Rios M a José Montoya M a Angeles Vázquez Latifa Naji Ramón Pérez-Cano | 2008 | Journal of Steroid Biochemistry and Molecular Biology2008，，1： | 1 |
| 14 | Tension-free vaginal tape versue tension-free vaginal tape obturator in women with stress urinary in-continence显示文摘 | Liapis A Bakas P Giner M et a1 | 2006 | Gyneeol Obstet Invest2006，62，3： | 1 |
| 15 | Protein growth performance, amino acid utilization and somatotropic axis responsiveness to fish meal replacement by plant protein sources in gilthead seabream (Sparus aurata) 显示文摘 | GOMEZ-REQUENI P MINGARRO M CALDUCH- GINER J A | 2004 | Aquaculture2004，232，1234： | 1 |
| 16 | Non-enzymatic browning inpeach puree during heating显示文摘 | Garaz S Ibarz A Giner J | 1999 | Food Researcher International1999，32，： | 1 |
| 17 | Assessment of the anti-inflammatory activity and free radical scavenger activity of tiliroside显示文摘 | Araceli Sala M.Carmen Recio Guillermo R Schinella Salvador Má?ez Rosa M Giner Miguel Cerdá-Nicolás José-Luis R??os | 2003 | European Journal of Pharmacology2003，，1： | 1 |
| 18 | Phase IItrial of oxaliplatin and capecitabine after progression to firet-linechemotherapy in androgen-independent prostate cancer patients显示文摘 | Gasent Blesa JM Giner Marco V Giner-Bosch V | 2011 | Am J Clin Oncol2011，34，2： | 1 |
| 19 | Inhibition of xanthine oxidase by phenolic conjugates of methylated quinic acid 显示文摘 | Gongora L Manez S Giner RM | 2003 | Planta Med2003，69，5： | 1 |
| 20 | Rheology of clarified cher- ry juices 显示文摘 | Giner J Ibarz A Garza S | 1996 | Journal of Food Engineering1996，30，1： | 1 |
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