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| 1 | Interaction between autophagy and the NLRP3 inflammasome显示文摘Autophagy,a metabolic pathway that plays an important role in maintaining the dynamic balance of cells,has two types,i.e.non-selective autophagy and selective autophagy.The role of nonselective autophagy is primarily to allow cells to circulate nutrients in an energy-limited environment,while selective autophagy primarily cleans up the organelles inside the cells to maintain the cell structure.The NLRP3 inflammasome is an innate immune response produced by the organism that can promote the secretion of interleukin-1f3 and interleukin-18 through caspase-1 activation and resist the damage of some pathogens.However,when the NLRP3 inflammasome is overactivated,it can cause various inflammatory diseases,such as inflammatory liver disease and inflammatory bowel disease.Many previous studies have shown that autophagy can inhibit the NLRP3 inflammasome,while in recent years,new studies have found that autophagy can also promote the NLRP3 inflammasome in some cases,and the NLRP3 inflammasome can,in turn,affect autophagy.In this review,the interaction between autophagy and the NLRP3 inflammasome is explored,and then the application of this interaction in disease treatment is discussed. | Zhenrui Cao Yanhao Wang Zhimin Long Guiqiong He | 2019 | Acta Biochimica et Biophysica Sinica2019，51，11： | 14 |
| 2 | ELASTIC BEHAVIOR ANALYSIS OF 3D ANGLE-INTERLOCK WOVEN CERAMIC COMPOSITES显示文摘为 angle-interlockwoven 的有弹性的行为分析的一个微机械模型陶器的 composites 在这篇论文被建议。这个模型由在空间,在邻近的纱之间的洞和纱的实际剖面图几何学认为纤维是波动和连续性考虑实际织物结构。基于 laminate 理论,编织的 3D 角度联锁的有弹性的性质陶器的 composites 被预言。交叉的纬的不同数字几乎有一样的有弹性的 moduli。陶器的矩阵的厚度在有弹性的 moduli 上有小效果。当波动比率增加纵的模量减少和另外的幼仔的 moduli 增加时。在理论预言和试验性的结果之间的好同意在分析编织的 3Dangle-interlock 的有弹性的性质表明建议模型的可行性陶器的 composites。这篇论文的结果验证分析聚酯矩阵 composites 的方法对编织陶器的 composites 合适的事实。 | Chang Yanjun Jiao Guiqiong Wang Bo Liu Wei | 2006 | Acta Mechanica Solida Sinica2006，19，2： | 11 |
| 3 | Damage characteristics and constitutive modeling of the 2D C/Si C composite: Part I – Experiment and analysis显示文摘This paper reports an experimental investigation on the macroscopic mechanical behaviors and damage mechanisms of the plain-woven(2D) C/Si C composite under in-plane on- and offaxis loading conditions. Specimens with 15, 30, and 45 off-axis angles were prepared and tested under monotonic and incremental cyclic tension and compression loads. The obtained results were compared with those of uniaxial tension, compression, and shear specimens. The relationships between the damage modes and the stress state were analyzed based on scanning electronic microscopy(SEM) observations and acoustic emission(AE) data. The test results reveal the remarkable axial anisotropy and unilateral behavior of the material. The off-axis tension test results show that the material is fiber-dominant and the evolution rate of damage and inelastic strain is accelerated under the corresponding combined biaxial tension and shear loads. Due to the damage impediment effect of compression stress, compression specimens show higher mechanical properties and lower damage evolution rates than tension specimens with the same off-axis angle. Under cyclic tension–compression loadings, both on-axis and off-axis specimens exhibit progressive damage deactivation behaviors in the compression range, but with different deactivation rates. | Li Jun Jiao Guiqiong Wang Bo Yang Chengpeng Wang Gang | 2014 | Chinese Journal of Aeronautics2014，27，6： | 10 |
| 4 | Damage characteristics and constitutive modeling of the 2D C/SiC composite: Part Ⅱ–Material model and numerical implementation显示文摘In this work, a macroscopic non-linear constitutive model accounting for damage, inelastic strain and unilateral behavior is proposed for the 2D plain-woven C/Si C composite. A set of scalar damage variables and a new thermodynamic potential expression are introduced in the framework of continuum damage mechanics. In the deduced constitutive equations, the material's progressive damage deactivation behavior during the compression loading is described by a continuous function, and different deactivation rates under uniaxial and biaxial compression loadings are also considered. In damage evolution laws, the coupling effect among the damage modes and impediment effect of compression stress on the development of shear damage in different plane stress states are taken into account. Besides, the general plasticity theory is applied to describing the evolution of inelastic strain in tension and/or shear stress state. The Tsai–Wu failure criterion is adopted for strength analysis. Additionally, the material model is implemented as a user-defined material subroutine(UMAT) and linked to the ABAQUS finite element software, and its performance is demonstrated through several numerical examples. | Li Jun Jiao Guiqiong Wang Bo Li Liang Yang Chengpeng | 2015 | Chinese Journal of Aeronautics2015，28，1： | 10 |
| 5 | Cellular apoptosis and Caspase-12 expression in a rat model of progressive spinal cord compression显示文摘BACKGROUND:Studies have demonstrated that the mechanisms underlying cellular apoptosis signal transduction focus on two pathways:intracellular mitochondria and extracellular death receptor.The current evidence supports that signal transduction of cellular apoptosis also includes endoplasmic reticulum stress signal transduction. OBJECTIVE:To observe Caspase-12 expression and cellular apoptosis following ischemia in rats with progressive spinal cord compression,and to verify the influence of endoplasmic reticulum stress on the apoptosis induced by spinal cord injury. DESIGN,TIME AND SETTING:A randomized,controlled,animal trial was performed at the Institute of Neuroscience in Chongqing Medical University between January and October in 2006. MATERIALS:Immunohistochemical kit,diaminobenzidine,and TUNEL kit were purchased from Beijing Zhongshan Biotechnology,China;rabbit anti-rat Caspase-12 monoclonal antibody was provided by Santa Cruz,USA. METHODS:Sixty Wistar rats,aged 3-4 months,were randomly assigned to a model group(n=50), which underwent spinal cord compression in the L_1 segment following L_1 laminectomy and articular process excision to establish a model of progressive spinal cord compression,and a sham-surgery group(n=10),which underwent only laminectomy.Starting with the first day after surgery,the rats were locally anesthetized,the skin was opened,and the screw was rotated by 1/4 of a cycle,twice weekly. MAIN OUTCOME MEASURES:At 3,7,14,21,and 28 days after surgery,rats from each group were anesthetized,and the spinal cords were resected.Pathological changes following spinal cord compression were determined using hematoxylin-eosin staining,Nissl dye,and transmission electron microscopy.The TUNEL method was used to observe neuronal apoptosis in the compressed spinal cord segments.Immunohistochemistry and Western blot were utilized to detect Caspase-12 expression in the compressed segments. RESULTS:Cellular swelling,neural degeneration,and altered endoplasmic reticulum structures were observed at 3 days following compression.Symptoms became gradually aggravated with increasing compression time.Compared with the sham-surgery group,the number of apoptotic neurons was remarkably increased in compressed segments of the model group(P<0.05),and Caspase-12 expression was also shown to increase(P<0.05). CONCLUSION:Neuronal apoptosis was a predominant pathological factor resulting in secondary spinal cord injury during progressive spinal cord compression,and Caspase-12 was shown to be possibly involved in neuronal apoptosis induced by progressive spinal cord compression. | Yijian Liang Kejian Wang Shanquan Sun Wei Li Jianhua Ran Guiqiong He | 2009 | Neural Regeneration Research2009，4，8： | 4 |
| 6 | EFFECT OF Z-PINS’ DIAMETER,SPACING AND OVERLAP LENGTH ON CONNECTING PERFORMANCE OF CMC SINGLE LAP JOINT显示文摘The effect of through-thickness reinforcement by composite pins (Z-pins) on the static tensile strength and failure mechanisms of the joints made from ceramic matrix composite (CMC) is investigated. Overlap length of the single lap joint is 15 mm, 20 mm, 23 mm, 37 mm, and 60 mm, respectively. The experimental results indicate that the final failure modes of the joints can be divided into two groups, (a) the bond-line stops debonding until crack encounters Z-pins; and then the adherends break at the location of Z-pins, when overlap length is more than 20 mm; (b) the bond-line detaches entirely and Z-pins are drawn from adherends, when overlap length is equal to 15 mm. A simple effcient computational approach is presented for analyzing the benefit of through-thickness pins for restricting failure in the single lap joints. Here, the mechanics problem is simplified by representing the effect of the pins by tractions acting on the fracture surfaces of the cracked bond-line. The tractions are prescribed as functions of the crack displacement, which are available in simple forms that summarize the complex deformations to a reasonable accuracy. The resulting model can be used to track the evolution of complete failure mechanisms, for example, bond-line initial delamination and ultimate failure associated with Z-pin pullout, ultimate failure of the adherends. The paper simulates connecting performance of the single lap joints with different Z-pins’ diameter, spacing and overlap length; the numerical results agree with the experimental results; the numerical results indicate enlarging diameter and decreasing spacing of Z-pins are in favor of improving the connecting performance of the joints. By numerical analysis method, the critical overlap length that lies between two final failure modes is between 18 mm and 19 mm, when Z-pins’ diameter and spacing are 0.4 mm, 5 mm, respectively. | Yongqiang Tao Guiqiong Jiao Bo Wang Yanjun Chang | 2008 | Acta Mechanica Solida Sinica2008，21，5： | 3 |
| 7 | APPLICATION AND THEORETICAL ANALYSIS OF C/SiC COMPOSITES BASED ON CONTINUUM DAMAGE MECHANICS显示文摘Based on the thermodynamic theory,an orthotropic damage constitutive model was developed to describe the nonlinear mechanical behavior of C/SiC composites.The diferent nonlinear kinematic and isotropic hardening functions were adopted to describe accurately the damage evolution processes.The damage variables were defined with the damaged modulus and the initial undamaged modulus on energy equivalence principle.The initial orthotropy and damage coupling were presented in the damage yield function.Tensile and in-plane shear loading and unloading tests were performed,and a good agreement between the model and the experimental results was achieved. | Yanjun Chang Guiqiong Jiao Keshi Zhang Bo Wang Jiannwen Ju | 2013 | Acta Mechanica Solida Sinica2013，26，5： | 3 |
| 8 | The effect of interference fit size on the fatigue life of bolted joints in composite laminates显示文摘 | Jingchao Wei Guiqiong Jiao Purong Jia Tao Huang | 2013 | Composites Part B2013，，： | 2 |
| 9 | Effects of ovarian hormone loss on neuritic plaques and autophagic flux in the brains of adult female APP/PS1 double-transgenic mice显示文摘流行病的研究证明了女人们说明疾病(广告) 案例,在传播 gonadal 荷尔蒙的衰落为被认为是专业之一冒险的三分之二 Alzheimers 因素。另外,卵巢的荷尔蒙缺乏可以影响淀粉的(A) 免职,它与 autophagic 流动有一种靠近的关系。在这研究,我们在二个老鼠模型,上调查了短期或长期的卵巢的荷尔蒙剥夺的影响非转基因(野类型) 并且 APP/PS1 双 transgenic | Qiuhui Yao Min Feng Bo Yang Zhimin Long Shifang Luo Min Luo Guiqiong He Kejian Wang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，5： | 2 |
| 10 | MKP-1 reduces Aβ generation and alleviates cognitive impairments in Alzheimer’s disease models显示文摘Mitogen-activated protein kinase(MAPK)phosphatase 1(MKP-1)is an essential negative regulator of MAPKs by dephosphorylating MAPKs at both tyrosine and threonine residues.Dysregulation of the MAPK signaling pathway has been associated with Alzheimer’s disease(AD).However,the role of MKP-1 in AD pathogenesis remains elusive.Here,we report that MKP-1 levels were decreased in the brain tissues of patients with AD and an AD mouse model.The reduction in MKP-1 gene expression appeared to be a result of transcriptional inhibition via transcription factor specificity protein 1(Sp1)cis-acting binding elements in the MKP-1 gene promoter.Amyloid-β(Aβ)-induced Sp1 activation decreased MKP-1 expression.However,upregulation of MKP-1 inhibited the expression of both Aβprecursor protein(APP)andβ-site APP-cleaving enzyme 1 by inactivating the extracellular signal-regulated kinase 1/2(ERK)/MAPK signaling pathway.Furthermore,upregulation of MKP-1 reduced Aβproduction and plaque formation and improved hippocampal long-term potentiation(LTP)and cognitive deficits in APP/PS1 transgenic mice.Our results demonstrate that MKP-1 impairment facilitates the pathogenesis of AD,whereas upregulation of MKP-1 plays a neuroprotective role to reduce Alzheimer-related phenotypes.Thus,this study suggests that MKP-1 is a novel molecule for AD treatment. | Yehong Du Yexiang Du Yun Zhang Zhilin Huang Min Fu Junjie Li Yayan Pang Peng Lei Yu Tian Wang Weihong Song Guiqiong He Zhifang Dong | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 2 |
| 11 | Characteristics of carotid artery disease (CAD) and presenting cerebrovascular symptoms in an aged group显示文摘 | Qingwei Chen Ying Liu Linlin Pei Dazhi Ke Guiqiong Li Wei Deng Wuwei Yao | 2009 | The International Journal of Cardiovascular Imaging2009，，2： | 1 |
| 12 | Distribution and expression of Pen-2 in the central nervous system of APP/PS1 double transgenic mice显示文摘-secretase 建筑群催化淀粉的蛋白质先锋应用软件的最后的劈开步产生淀粉的 A 肽,在 Alzheimer 的疾病广告病人的大脑的老年的匾的一个病原的部件。最近的研究显示出那 presenilin enhancer-2 1 是的 Pen-2, presenilin PS,包括的 PS1 和 PS2, nicastrin,和前面的咽有缺陷者 -secretase 的必要部件。在 vitro 的 Pen-2 的结构和功能是明确的。然而,很少在广告模型老鼠的中央神经系统 CNS 对 Pen-2 的神经解剖学的分发和表示被知道。我们这里报导,用象染色的 immunohistochemical 和 immunoblotting 那样的各种各样的方法,那 Pen-2 广泛地在广告模型老鼠在主要区域的特定的 neuronal 房间被表示包括嗅觉的灯泡,基础前脑, striatum ,外皮,马头鱼尾的怪兽,杏仁之类,丘脑,视下丘,小脑, brainstem ,并且针的绳索。它在老鼠大脑在特定的 neuronal 房间与 PS1 被共同表示。Pen-2 比细胞外的淀粉的存款广泛地更分布式,建议在局部性的淀粉的免职的另外的因素的重要性。Pen-2 在成年广告鼠标在房间膜和 cytoplasma 主要是局部性的,但是仅仅在控制在房间膜散布。在出生后的开发的早阶段, Pen-2 的表达式水平在 CNS 相对高,但是在成年鼠标逐渐地衰退。现在的学习作为一个关键部件为 Pen-2 提供一个解剖基础在发展和成年老鼠的大脑复杂的 -secretase,和 Pen-2 可能是仔细与在老化的负担有关神经系统。 | Yanan Chu Xuehua Peng Zhiming Long Kejian Wang Shifang Luo Akhilesh Sharma Guiqiong He | 2015 | Acta Biochimica et Biophysica Sinica2015，47，4： | 1 |
| 13 | Aquaporin-4 in the formation of cerebral edema following severe burns What role do arginine vasopressin levels play?显示文摘BACKGROUND: Aquaporin-4 (AQP-4), which is able to rapidly transport water within the brain, is highly expressed in brain tissue. It also plays an important role in the formation of cerebral edema following brain injury. However, the role of AQP-4 in the formation of cerebral edema following severe burns remains unknown. OBJECTIVE: To study changes in AQP-4 protein and mRNA expression during formation of cerebral edema following severe burns, and to explore the correlation between AQP-4 protein and mRNA expression with plasma levels of arginine vasopressin (AVP). DESIGN, TIME AND SETTING: A randomized, controlled, animal experiment was performed at the Research Center of Neuroscience, Chongqing Medical University from 2007 to 2008. MATERIALS: Biotin-labeled goat anti-rabbit antibody was provided by Beijing Zhongshan Biotechnology, China; in situ hybridization kit was provided by Wuhan Boster Biotechnology, China; rabbit anti-AQP-4 polyclonal antibody and horseradish peroxidase-labeled goat anti-rabbit IgG were provided by Chemicon, USA; AVP radioimmunoassay kit was provided by the Research Department of Neurobiology, the Second Military Medical University of Shanghai, China. METHODS: A total of 180 adult, healthy, Wistar rats were randomly assigned to control and burn groups with 30 rats in each group. The burn group was observed at five different time points: 2, 6, 12, 24, and 48 hours after burn. Hair on the mouse back was removed to expose skin on the back. After 1 day, skin with the hair removed was dipped into 100 °C water for 15 seconds to induce grade III burn injury that measures 30% of total burn surface area. MAIN OUTCOME MEASURES: Brain water content was measured using the dry-wet weight method. AQP-4 protein and mRNA expressions were detected using immunohistochemistry, in situ hybridization, Western blot, and reverse transcription-polymerase chain reaction; dynamic changes in plasma AVP were detected using radioimmunoassay. RESULTS: Brain water content gradually increased following severe burn injury. AQP-4 protein and mRNA expressions were upregulated in the supraoptic nucleus, suprachiasmatic nucleus, paraventricular nucleus, hippocampus, choroid plexus, and cerebral cortex. Plasma AVP levels increased following burn injury. AQP-4 protein and mRNA expressions positively correlated with brain water content and AVP levels during formation of cerebral edema (r = 0.870, 0.848, P < 0.01). CONCLUSION: AQP-4 participated in the formation of cerebral edema following burn injury. Plasma AVP upregulated AQP-4 expression in brain tissue, thereby promoting formation of cerebral edema. | Shifang Luo | 2010 | Neural Regeneration Research2010，5，7： | 1 |
| 14 | Indentation study of Z-pin reinforced polymer foam core sandwich structures 显示文摘 | Du Long Jiao Guiqiong | 2009 | Composites Part A2009，40，67： | 1 |
| 15 | Estrogen deficiency exacerbates learning and memory deficits associated with glucose metabolism disorder in APP/PS1 double transgenic female mice显示文摘Alterations in glucose metabolism occur in the brain in the early stage of Alzheimer's disease(AD),and menopausal women have more severe metabolic dysfunction and are more prone to dementia than men.Although estrogen deficiency-induced changes in glucose metabolism have been previously studied in animal models,their molecular mechanisms in AD remain elusive.To investigate this issue,double transgenic(APP/PS1)female mice were subjected to bilateral ovariectomy at 3 months of age and were sacrificed 1 week,1 month and 3 months after surgery to simulate early,middle and late postmenopause,respectively.Our analysis demonstrated that estrogen deficiency exacerbates learning and memory deficits in this mouse model of postmenopause.Estrogen deficiency impairs the function of mitochondria in glucose metabolism.It is possible that the occurrence of AD is associated with the aberrant mitochondrial ERβ-mediated IGF-1/IGF-1R/GSK-3βsignaling pathway.In this study,we established a potential mechanism for the increased risk of AD in postmenopausal women and proposed a therapeutic target for AD due to postmenopause. | Min Luo Qinghua Zeng Kai Jiang Yueyang Zhao Zhimin Long Yexiang Du Kejian Wang Guiqiong He | 2022 | Genes & Diseases2022，9，5： | 1 |
| 16 | Gender difference in valproic acid-induced neuroprotective effects on APP/PS1 double transgenic mice modeling Alzheimer's disease显示文摘Alzheimers 疾病(广告) 是在广告的特定的认知能力领域,病理,和风险与性差别引起进步记忆和认知缺陷的 neurodegenerative 混乱。自从 valproic 酸(VPA ) ,是广泛地使用的心情 stabilizer 和镇癫痫剂药,它在广告上展出多重 neuroprotective 活动,这研究打算在 APP/PS1 双转基因的老鼠建模上在 VPA 的效果调查性差别广告。行为的实验证明 VPA 减少了自治行为,学习改进并且存储器,和在广告鼠标的展出的性差别与控制鼠标相比。在老年的匾的减少,淀粉的(A) 40,并且 VPA 在男广告老鼠引起的 A42 在女广告老鼠是比那更著名的。同时, VPA 保护了大脑房间免受在女广告老鼠尤其是在男广告老鼠,但是仅仅稍微死的伤害,并且 VPA 处理变厚 postsynaptic 密度并且显著地在男、女的广告老鼠增加了 presynaptic 泡的数字和密度。然而, rescuing 的效果结构的早 synaptic 和由 VPA 的功能的赤字在雄的老鼠是更明显的。总的来说,这些结果支持了性差别显著地影响的假设广告并且如果基本生物差别和性特性谨慎地被考虑,显示 VPA 可以是为广告的有希望的疗法。 | Zhimin Long Qinghua Zeng Kejian Wang Akhilesh Sharma Guiqiong He | 2016 | Acta Biochimica et Biophysica Sinica2016，48，10： | 1 |
| 17 | Differential gene expression profile of Buyanghuanwu decoction in rats with ventricular remodeling post-myocardial infarction显示文摘OBJECTIVE: To investigate the effect of Buyanghuanwu decoction(BYHWD) on gene expression in ventricular remodeling post-myocardial infarction in rats.METHODS: Animal models of myocardial infarction were established by permanent ligation of the left anterior descending coronary artery. Echocardiography measurements were performed after the treatment of BYHWD(18 g·kg-1 collagen was observ·d-1) for 90 days.Myocardialed by mallory trichrome staining. Capillary density was quantified by using Factor rentially expⅧre immunohistochemical staining.Diffessed genes were explored by a short-read sequencing technology combined with a tag-based digital gene expression profiling(DGE)system. Real-time quantitative polymerase chain reaction detecting system(q PCR) was used to validate the sequencing results. After assembling the gene information from Sham, model and BYHWD groups, we constructed three DGE libraries based on each group. The sequencing of three libraries generated 66 000-73 000 unique tags, which were mapped to reference sequences for annotation of expressed genes.RESULTS: Among them, 511 and 352 differentially expressed genes were found in comparison with sham/model and model/BYHWD, respectively. Fifty-five genes exhibited reversed direction of gene expression differences between Sham/Model and Model/BYHWD groups. We found that transforming growth factor beta receptor-1, junctophilin-2,monocyte chemotactic protein 1, neuropeptide Y,arachidonate 5-Lipoxygenase, arachidonate 15-Lipoxygenase were significantly modulated, which suggested the involvement of these genes in BYHWD treatment.CONCLUSION: The DGE profiling data provide comprehensive gene expression information at the transcriptional level that could facilitate our understanding of the pharmacological mechanisms of BYHWD in ventricular remodeling post-myocardial infarction. | Zhang Tao Hua Yue Luo Hao Chen Hongmei Shao Meng Fu Xiuqiong John Man-Tak Chu Huang Guiqiong Liu Bin Zhou Yingchun | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 1 |
| 18 | Characteristics of carotid artery disease (CAD) and presenting cerebrovascular symptoms in an aged group显示文摘 | Qingwei Chen Ying Liu Linlin Pei Dazhi Ke Guiqiong Li Wei Deng Wuwei Yao | 2009 | The International Journal of Cardiovascular Imaging2009，，2： | 1 |
| 19 | Indentation study of Z-pin rein- forced polymer foam core sandwich structures显示文摘 | Du Long Jiao Guiqiong | 2009 | Composi- tes Part A2009，40，： | 1 |
| 20 | Exaet traveling wave solutions of the Whitham-Broer-Kaup and Broer-Kaup-Kupershmidt equations显示文摘 | Xu Guiqiong Li Zhibin | 2005 | Chaos Solitons and Fraetals2005，24，： | 1 |
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