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| 1 | High-speed silicon photonic Mach–Zehnder modulator at 2 μm显示文摘Recently,2-μm wave band has gained increasing interest due to its potential application for next-generation optical communication.But the development of 2-μm optical communications is substantially hampered by the modulation speed due to the device bandwidth constraints.Thus,a high-speed modulator is highly demanded at 2μm.Motivated by this prospect,we demonstrate a high-speed silicon Mach–Zehnder modulator for a 2-μm wave band.The device is configured as a single-ended push–pull structure with waveguide electrorefraction via the free carrier plasma effect.The modulator was fabricated via a multiproject wafer shuttle run at a commercial silicon photonic foundry.The modulation efficiency of a single arm is measured to be 1.6 V·cm.The high-speed characterization is also performed,and the modulation speed can reach 80 Gbit/s with 4-level pulse amplitude modulation(PAM-4)formats. | Xi Wang Weihong Shen Wenxiang Li Yingjie Liu Yong Yao Jiangbing Du Qinghai Song Ke Xu | 2021 | Photonics Research2021，9，4： | 7 |
| 2 | Combining BPANN and wavelet analysis to simulate hydro-climatic processes a case study of the Kaidu River, North-west China显示文摘 | Jianhua XU Yaning CHEN Weihong LI Paul Y. PENG Yang YANG Chunan SONG Chunmeng-WEI Yulian HONG | 2013 | Frontiers of Earth Science2013，7，2： | 4 |
| 3 | Fabrication of superstable gold nanorod-carbon nanocapsule as a molecule loading material显示文摘In this work, we fabricated a monodisperse nanocomposite by coating gold nanorods(Au NRs) with a layer of biocompatible, stable carbon, obtaining Au NR@Carbon core–shell nanocapsules, which without any functionalization could be used as a molecule loading material due to its high surface areas. In this system, the Au NR core had a high-absorption cross section for conversion of near-infrared light to heat, which could be explored for local hyperthermia. The carbon shell, which was biocompatible and stable even under concentrated acidic and alkaline conditions, was able to adsorb molecules with p–p interactions or electrostatic interactions. In comparison with Au NR@Si O2, Au NR@Carbon nanocapsules demonstrate the following merits:(1) simple and green synthesis method,(2) far more stable with respect to high-temperature stability and(3) larger molecule loading capacity,which indicate great potential in the biomedical applications. | Wei Gao Xuewei Wang Huanhuan Fan Zhiling Song Xiaofang Lai Zhuo Chen Weihong Tan | 2015 | Science Bulletin2015，60，12： | 3 |
| 4 | Non-isothermal crystallization kinetics of wood-flour/polypropylene composites in the presence of b-nucleating agent显示文摘The influence of aryl amide compounds(TMB)as b-nucleating agents, on the non-isothermal crystallization of a wood-flour/polypropylene composite(WF/PP)prepared by compression molding was investigated by wide-angle X-ray diffraction and differential scanning calorimetry. TMB was proved to be an effective b-crystalline nucleating agent for WF/PP. The DSC data showed that the crystallization peak temperature(Tp) increased and the half-time(t1/2) decreased with the addition of TMB.Three theoretical models were used to analyze the nonisothermal crystallization process. The modified Avrami method and Mo method successfully explained the nonisothermal crystallization behavior of PP and its composites. Their activation energies for non-isothermal crystallization were determined basing on the Kissinger method. | Lang Huang Haigang Wang Weihong Wang Qingwen Wang Yongming Song | 2016 | Journal of Forestry Research2016，27，4： | 2 |
| 5 | Stable and unique graphitic Raman internal standard nanocapsules for surface-enhanced Raman spectroscopy quantitative analysis显示文摘Graphitic nanomaterials 有的独特、强壮、稳定的拉曼颤动广泛地在化学和 biomedicine 被使用了。然而,作为内部标准(ISs ) 利用他们改进提高表面的拉曼的精确性光谱学(重量的单位) 分析没被尝试。此处,我们报导设计一唯一是由很多金牌组成的 nanostructure nanoparticles (AuNPs ) 在 multilayered graphitic 上装饰了磁性的 nanocapsules (AGN ) 确定 analyte 并且消除与传统的 ISs 联系的问题。AGN 从 graphitic 部件表明了一个独特拉曼乐队,它在拉曼是局部性的 biomolecules 的沉默区域,没有任何背景干扰,使他们成为理想为量的拉曼分析。是从也显示的 AGN 的信号优异稳定性,甚至在严厉条件下面。与装饰 AuNPs 的改进, AGN nanostructures 极大地改进了重量的单位,特别地量的错误源于收集损失的排除和 analytes 的不一致的分发的量的精确性。AGN 进一步为房间染色和拉曼成像被利用,并且他们在 biomedicine 为应用显示出大诺言。 | Yuxiu Zou Long Chen Zhiling Song Ding Ding Yiqin Chen Yiting Xu Shanshan Wang Xiaofang Lai Yin Zhang Yang Sun Zhuo Chen Weihong Tan | 2016 | Nano Research2016，9，5： | 2 |
| 6 | Application of TruScreen in detecting ASCUS patients显示文摘Objective:To explore the application of cervical cancer screening system,TruScreen in detecting atypical squamous cell of undetermined significance(ASCIIS) patients.Methods:A total of 42 cases were selected,who were diagnosed as ASCIIS by thinprep cytologic test(TCT).Area from site 15 to 20,site 21 to 32 were detected by TruScreen.And the result was compared with those of cases which had positive pathological result of cervical biopsy.Results:There were 16 cases with abnormal pathological result in ASCUS cases,including 6 cases with cervical intraepithelial neoplasia(CIN)Ⅰ,6 cases with CINⅡ,3 cases with CINⅢand 1 case with infiltrating carcinoma. The consistency between TCT and pathological test was 38.10%(16/42).The positive rate of TruScreen at site 15-20 was 61.91%(26/42).There was significant difference in consistency with pathological test between TCT and TruScreen(x^2=4.762,P=0.029).The positive rate of TruScreen at site 21-32 was 66.67%(28/42)(Kappa=0.181,P=0.016).There was significant difference in consistency with pathological test between TCT and TruScreen(x^2=9.4919,P=0.002).And no case was missed when site 21-32 of patients with CINⅡand above were detected by TruScreen. Conclusions:TruScreen is effective in detecting ASCUS patients. | Weihong Li Yu Guo Haiyan Niu Song Jin Li Wang | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，8： | 2 |
| 7 | MKP-1 reduces Aβ generation and alleviates cognitive impairments in Alzheimer’s disease models显示文摘Mitogen-activated protein kinase(MAPK)phosphatase 1(MKP-1)is an essential negative regulator of MAPKs by dephosphorylating MAPKs at both tyrosine and threonine residues.Dysregulation of the MAPK signaling pathway has been associated with Alzheimer’s disease(AD).However,the role of MKP-1 in AD pathogenesis remains elusive.Here,we report that MKP-1 levels were decreased in the brain tissues of patients with AD and an AD mouse model.The reduction in MKP-1 gene expression appeared to be a result of transcriptional inhibition via transcription factor specificity protein 1(Sp1)cis-acting binding elements in the MKP-1 gene promoter.Amyloid-β(Aβ)-induced Sp1 activation decreased MKP-1 expression.However,upregulation of MKP-1 inhibited the expression of both Aβprecursor protein(APP)andβ-site APP-cleaving enzyme 1 by inactivating the extracellular signal-regulated kinase 1/2(ERK)/MAPK signaling pathway.Furthermore,upregulation of MKP-1 reduced Aβproduction and plaque formation and improved hippocampal long-term potentiation(LTP)and cognitive deficits in APP/PS1 transgenic mice.Our results demonstrate that MKP-1 impairment facilitates the pathogenesis of AD,whereas upregulation of MKP-1 plays a neuroprotective role to reduce Alzheimer-related phenotypes.Thus,this study suggests that MKP-1 is a novel molecule for AD treatment. | Yehong Du Yexiang Du Yun Zhang Zhilin Huang Min Fu Junjie Li Yayan Pang Peng Lei Yu Tian Wang Weihong Song Guiqiong He Zhifang Dong | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 2 |
| 8 | Biological function of Presenilin and its role in AD pathogenesis显示文摘Presenilins(PSs)are the catalytic core of γ-secretase complex.However,the mechanism of FAD-associated PS mutations in AD pathogenesis still remains elusive.Here we review the general biology and mechanism of γ-secretase and focus on the catalytic components–presenilins and their biological functions and contributions to the AD pathogenesis.The functions of presenilins are divided into γ-secretase dependent and γ-secretase independent ones.The γ-secretase dependent functions of presenilins are exemplified by the sequential cleavages in the processing of APP and Notch;the γ-secretase independent functions of presenilins include stabilizing β-catenin in Wnt signaling pathway,regulating calcium homeostasis and their interaction with synaptic transmission. | Shuting Zhang Mingming Zhang Fang Cai Weihong Song | 2013 | Translational Neurodegeneration2013，2，1： | 1 |
| 9 | The effect of combination therapy of allicin and fenofibrate on high fat diet-induced vascular endothelium dysfunction and liver damage in rats 显示文摘 | Li Weihong Wang Daxin Song Guohua | 2010 | Lipids Health Dis2010，9，1： | 1 |
| 10 | Effects of cypermethrin and methyl parathion mixtures on hormone levels and immune functions in Wistar rats 显示文摘 | PING LIU XIAOXIAO SONG WEIHONG YUAN | 2006 | Arch Toxieol2006，80，： | 1 |
| 11 | TIARA: Interactive, Topic-Based Visual Text Summarization and Analysis 显示文摘 | Shixia Liu Michelle X Zhou Shimei Pan Yangqiu Song Weihong Qima Weijia Cai Xiaoxiao Lima | 2012 | ACM Transactions on Intelligent Systems and Technology (TIST)2012，3，2： | 1 |
| 12 | 肿瘤坏死因子α致肝细胞凋亡效应及其机制的研究(英文)显示文摘Objective: To investigate the apoptosis effect of TNF-α on HepG2 cells and its mechanism in vitro. Methods: HepG2 cells were treated with TNF-α (400 U/mL). HepG2 cells treated with TNF-α for 24 h and apoptosis was proved by DNA fragments on gel electrophoresis. Fluorescent quantitative real-time PCR was used to detect Fas and FasL expression. HepG2 cells treated by TNF-α were co-cultivated with normal HepG2 cells. Apoptosis of HepG2 cells was determined by the method of FACS. Results: After 24 h TNF-α treatment, DNA was collapsed into fragments to form DNA ladder in gel elec- trophoresis; FasL expression increases and induces HepG2 cells apoptosis. By FACS, 98.4% of the co-cultivated cells were apoptosis, but 16.5% cells in control group were apoptosis. Conclusion: TNF-α can induce apoptosis of HepG2 cells in vitro. FasL expression on TNF-α pre-treated HepG2 cells increased and these cells can lead normal HepG2 cells to apoptosis. This may attribute to the cure of virus hepatitis and hepatoma. | Weiqing Song Weihong Lu Huabo Chen Huahui Li Jianmin Wu | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，2： | 1 |
| 13 | Numeric simulation for structure' s damage identification of space truss 显示文摘 | Ji Weihong Song Yupu Liang Bing | 2007 | Fron- tiers of Mechanical Engineering in China2007，2，4： | 1 |
| 14 | Do Buyouts (Still)Create Value-显示文摘 | Guo Shouron Edith Hotchkiss Weihong Song | 2011 | Journal of Finance2011，，2： | 1 |
| 15 | Fabrication of GO/magnetic graphitic nanocapsule/TiO_2 assemblies as efficient and recyclable photocatalysts显示文摘In this work, we fabricate an efficient and stable photocatalyst system which has superior recyclability even under concentrated acidic conditions. The photocatalyst is prepared by assembling magnetic graphitic nanocapsules, titania(Ti O2) and graphene oxide(GO) into a complex system through π-π stacking and electrostatic interactions. Such catalytic complex demonstrates very high stability. Even after dispersal into a concentrated acidic solution for one month, this photocatalyst could still be recycled and maintain its catalytic activity. With methyl orange as the model molecule, the photocatalyst is demonstrated to rapidly decompose the molecules with very high photocatalytic activity under both concentrated acidic and neutral condition. Moreover, this photocatalyst retains approximately 100 wt% of its original photocatalytic activity even after multiple experimental runs, of magnetic recycling. Finally, using different samples from natural water sources and different dyes, this GO/ magnetic graphitic nanocapsule/Ti O2 system also demonstrates its high efficiency and recyclability for practical application. | Zhenqian Cheng Ding Ding Xiangkun Nie Yiting Xu Zhiling Song Ting Fu Zhuo Chen Weihong Tan | 2015 | Science China Chemistry2015，58，7： | 1 |
| 16 | Novel pH-sensitive citrate cross-linked chitosan film for drug controlled release显示文摘 | Shu X Z Zhu K J Weihong Song | 2001 | International journal of pharmceutics2001，212，： | 1 |
| 17 | Correlation of gut microbiota and neurotransmitters in a rat model of post-traumatic stress disorder显示文摘Objective:To determine the effect of gut microbiota on a rat model of post-traumatic stress disorder(PTSD)and explore the correlation of gut microbiota with behavior and neurotransmitters.Methods:We established a single prolonged stress(SPS)model to examine the pathogenesis of PTSD on rat behavior,gut microbiota,and neurotransmitter levels.Rats were separated into control and model groups,and neurotransmitter levels were measured using enzyme linked immunosorbent assay.Then,16 S rRNA sequencing was used to compare the gut microbiota between the control and model groups.Results:Compared with those in the control group,freezing time significantly increased,while number of standing upright,crossing frequency,time spent in the central arena,and total distance traveled were significantly reduced in the model group after exposure to SPS(all P<.05).Meanwhile,serotonin,or 5-hydroxytryptamine,levels in the brain in the model group were significantly lower than those the control group(P紏.0332).In addition,changes were observed in the gut microbiota diversity and relative abundances of bacterial phyla,orders,families,and genera in the model group.Especially,changes in Firmicutes,Bacteroidetes,Cyanobacteria,and Proteobacteria levels were most pronounced after SPS exposure.Correlation analysis showed that the strongest positive correlation was found between Bacteroidaceae and 5-HT(P?.0009).Moreover,RF32 abundance was the most negatively related to 5-HT(P?.0009),crossing frequency(P?.0007),and total distance(P?.0003).Conclusion:Our results suggest that SPS model rats showed differences in behavior,neurotransmitter levels,and gut microbiota with control rats.Moreover,Firmicutes,Bacteroidetes,Cyanobacteria,and Proteobacteria were most relevant to the exhibited fear-like and anxiety-like behaviors and significant serotonin content reduction in SPS model rats. | Qin Zhou Tianshi Sun Fengzhi Wu Feng Li Yan Liu Weihong Li Ning Dai Libo Tan Tenghui Li Yuehan Song | 2020 | Journal of Traditional Chinese Medical Sciences2020，7，4： | 1 |
| 18 | Quality control of daily meteorological data in China, 1951 -- 2000 : A new dataset显示文摘 | Song Feng Qi Hu Weihong Qian | 2004 | Int J Climatol2004，24，： | 1 |
| 19 | Recommendations for the diagnosis and treatment of paroxysmal kinesigemc dyskinesia: an expert consensus in China显示文摘Paroxysmal dyskinesias are a group of neurological diseases characterized by intermittent episodes of involuntary movements with different causes.Paroxysmal kinesigenic dyskinesia(PKD)is the most common type of paroxysmal dyskinesia and can be divided into primary and secondary types based on the etiology.Clinically,PKD is characterized by recurrent and transient attacks of involuntary movements precipitated by a sudden voluntary action.The major cause of primary PKD is genetic abnormalities,and the inheritance pattern of PKD is mainly autosomal-dominant with incomplete penetrance.The proline-rich transmembrane protein 2(PRRT2)was the first identified causative gene of PKD,accounting for the majority of PKD cases worldwide.An increasing number of studies has revealed the clinical and genetic characteristics,as well as the underlying mechanisms of PKD.By seeking the views of domestic experts,we propose an expert consensus regarding the diagnosis and treatment of PKD to help establish standardized clinical evaluation and therapies for PKD.In this consensus,we review the clinical manifestations,etiology,clinical diagnostic criteria and therapeutic recommendations for PKD,and results of genetic analyses in PKD patients performed in domestic hospitals. | Li Cao Xiaojun Huang Ning Wang Zhiying Wu Cheng Zhang Weihong Gu Shuyan Cong Jianhua Ma Ling Wei Yanchun Deng Qi Fang Qi Niu Jin Wang Zhaoxia Wang You Yin Jinyong Tian Shufen Tian Hongyan Bi Hong Jiang Xiaorong Liu Yang Lu Meizhen Sun Jianjun Wu Erhe Xu Tao Chen Tao Chen Xu Chen Wei Li Shujian Li Qinghua Li Xiaonan Song Ying Tang Ping Yang Yun Yang Min Zhang Xiong Zhang Yuhu Zhang Ruxu Zhang Yi Ouyang Jintai Yu Quanzhong Hu Qing Ke Yuanrong Yao Zhe Zhao Xiuhe Zhao Guohua Zhao Furu Liang Nan Cheng Jianhong Han Rong Peng Shengdi Chen Beisha Tang | 2021 | Translational Neurodegeneration2021，10，1： | 1 |
| 20 | Do buyouts (still) create value ? 显示文摘 | GUO SHOURUN EDITH S HOTCHKISS WEIHONG SONG | 2011 | The Journal of Finance2011，，2： | 1 |
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