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| 1 | Novel coumarin–benzimidazole derivatives as antioxidants and safer anti-inflammatory agents显示文摘Inspired from occurrence of anti-inflammatory activity of 3-substituted coumarins and antiulcer activity of various 2-substituted benzimidazoles,novel compounds have been designed by coupling coumarin derivatives at 3-position directly or through amide linkage with benzimidazole nucleus at 2-position.The resultant compounds are expected to exhibit both anti-inflammatory and antioxidant activities along with less gastric toxicity profile.Two series of coumarin–benzimidazole derivatives(4a–e and 5a–e)were synthesized and evaluated for anti-inflammatory activity and antioxidant activity.Compounds 4c,4d and 5a displayed good anti-inflammatory(45.45%,46.75%and 42.85%inhibition,respectively,versus 54.54% inhibition by indomethacin)and antioxidant(IC_(50) of 19.7,13.9 and 1.2 mmol/L,respectively,versus 23.4 mmol/L for butylatedhydroxytoluene)activities.Evaluation of ulcer index and in vivo biochemical estimations for oxidative stress revealed that compounds 4d and 5a remain safe on gastric mucosa and did not induce oxidative stress in tissues.Calculation of various molecular properties suggests the compounds to be sufficiently bioavailable. | Radha Krishan Arora Navneet Kaur Yogita Bansal Gulshan Bansal | 2014 | Acta Pharmaceutica Sinica B2014，4，5： | 6 |
| 2 | Absolute copy number differences of Y chromosomal genes between crossbred (Bos taurus×Bos indicus) and Indicine bulls显示文摘Background: The Y chromosome in mammal is paternally inherited and harbors genes related to male fertility and spermatogenesis. The unique intra-chromosomal recombination pattern of Y chromosome and morphological difference of this chromosome between Bos taurus and Bos indicus make it an ideal model for studying structural variation, especially in crossbred(Bos taurus × Bos indicus) bulls. Copy Number Variation(CNV) is a type of genomic structural variation that gives information complementary to SNP data. The purpose of this study was to find out copy number differences of four Y chromosomal spermatogenesis-related candidate genes in genomic DNA of crossbred and purebred Indicine bulls. Result: Four Y chromosomal candidate genes of spermatogenesis namely, sex determining gene on Y chromosome(SRY), DEAD box polypeptide 3-Y chromosome(DDX3Y), Ubiquitin specific peptidase 9, Y-linked(USP9Y), testis-specific protein on Y chromosome(TSPY) were evaluated. Absolute copy numbers of Y chromosomal genes were determined by standard curve-based quantitative real time PCR. Copy numbers of SRY and TSPY genes per unit amount of genomic DNA are higher in crossbred than Indicine bulls. However, no difference was observed in DDX3Y and USP9Y gene copy numbers between two groups. Conclusion: The present study demonstrates that the structural organization of Y chromosomes differs between crossbred and Indicine bulls which are reproductively healthy as observed from analysis of semen attributes. The absolute copy numbers of SRY and TSPY genes in unit mass of genomic DNA of crossbred bulls are significantly higher than Indicine bulls. No alteration in absolute copies of DDX3Y and USP9Y gene was found between the genome of crossbred and Indicine bulls. This study suggests that the DDX3Y and USP9Y are likely to be single copy genes in the genome of crossbred and Indicine bulls and variation in Y chromosome length between crossbred and Indicine bulls may be due to the copy number variation of SRY gene and TSPY array. | Ayan Mukherjee Gulshan Dass Jagan Mohanarao G Moloya Gohain Biswajit Brahma Tirtha Kumar Datta Sachinandan De | 2013 | Journal of Animal Science and Biotechnology2013，4，4： | 3 |
| 3 | 不同除草剂单独相继使用和混合使用防除小麦田虉草的效果比较(英文)显示文摘草是小麦田的主要杂草 ,尤其是水稻—小麦复种田块发生较为严重。用异丙隆防除 草已有 2 0多年的历史 ,防治效果十分显著。但近来有研究表明 草已具有对异丙隆的抗性。本试验研究了不同除草剂单独相继使用与混合使用对该杂草的防治效果。结果表明 ,播后 60 d,出苗前喷施氟乐灵和第一次灌水后喷施异丙隆的处理 ,除草效果最佳 ,而在成熟期 ,第一次灌水后喷施噻黄隆的处理具有与以上处理同样的防治效果。虽然使用异丙隆的处理产量最高 ,但一些除草剂单独相继使用也具有很好的杂草防治效果 ,小麦产量显著高于未用除草剂的对照。作者认为 ,在 草防治上存在有异丙隆抗性的地区 。 | Sardana Virender Brar LallSingh Mahajan Gulshan 张国平 | 2002 | 麦类作物学报2002，22，3： | 2 |
| 4 | Variation in Antioxidants, Bioactive Compounds and Antioxidant Capacity in Germinated and Ungerminated Grains of Ten Rice Cultivars显示文摘Present study was conducted to characterise ten rice(Oryza sativa L.) cultivars viz. IET-23466, Dhan-201, IET-23448, MAS-946, IET-23445, IET-23463, IET-23455, PR-123, PR-115 and IET-23449 based on antioxidants(total phenolics, flavonols and tannins), bioactive compounds(phytic acid, gamma amino butyric acid, tocopherol and reduced ascorbate) and antioxidant activity(1,1-diphenyl-2-picrylhydrazyl radical scavenging activity, hydroxyl radical scavenging activity, free radical antioxidant power and total reducing power) with an aim to identify cultivars containing higher health promoting components after germination. Three cultivars IET-23466, IET-23463 and PR-123 performed better as revealed by higher level of antioxidants, bioactive compounds and antioxidant activity before and after germination. Three cultivars MAS-946, IET-23445 and IET-23449 had moderate level of antioxidants, bioactive compounds and antioxidant activity. Four cultivars Dhan-201, IET-23448, IET-23455 and PR-115 performed intermediately. Strong positive correlation was observed among total phenolics and the antioxidant activity. Phytic acid was found to be negatively correlated to the antioxidant activity. Our results highlighted that cultivars IET-23466, IET-23463 and PR-123 hold great potential after germination and would open up a useful opportunity for the functional food industry, and consumption of these cultivars after germination would afford health benefits to consumers since they contain higher level of antioxidants. | Maninder KAUR Bavita ASTHIR Gulshan MAHAJAN | 2017 | Rice science2017，24，6： | 2 |
| 5 | Guideline adherence in management of stable chronic obstructive pulmonary disease显示文摘 | Roozbeh Sharif Christel R. Cuevas Yue Wang Mohit Arora Gulshan Sharma | 2013 | Respiratory Medicine2013，，7： | 1 |
| 6 | TAT-mediated delivery oftousled protein to salivary glands protects against radiation-In-duced hypofunction显示文摘 | Gulshan Sunavala Dossabhoy | 2012 | Internat J Rad2012，5，15： | 1 |
| 7 | PhosphoruB fertil-izer response in an irrigated soybean-wheat production system on a sub-tropical, semiarid soil显示文摘 | Milkha S Aulakh Nanak S Pasricha Gulshan S Bahl | 2003 | Field Crops Research2003，80，2： | 1 |
| 8 | Studies on anther cultures of tomato —Lycopersicon esculentum Mill显示文摘 | Gulshan T. M. Varghese D. R. Sharma | 1981 | Biologia Plantarum1981，，6： | 1 |
| 9 | Studies on anther cultures of tomato-Lycopersicon esculentum Mill显示文摘 | GULSHAN T M V SHARMA D R | 1981 | Biologia Plantarum1981，23，： | 1 |
| 10 | An authorization mechanism for access control of resources in the web services paradigm显示文摘 | Rajender N Gulshan A | 2011 | Interna- tional Journal of Advanced Computer Science and Applications2011，2，6： | 1 |
| 11 | Studies on anther cultures of tomato-Lycopersicon esculentum Mill 显示文摘 | Gulshan T M V Sharma D R | 1981 | Biologia Plantarum1981，23，： | 1 |
| 12 | Modeling and parameter design of a laser shock peening process显示文摘 | Gulshan S Ramana V G David S S | 2011 | International Journal for Computational Methods in Engineering Science and Mechanics2011，12，5： | 1 |
| 13 | Four new degradation products of doxorubicin:An application of forced degradation study and hyphenated chromatographic techniques显示文摘Forced degradation study on doxorubicin(DOX) was carried out under hydrolytic condition in acidic,alkaline and neutral media at varied temperatures,as well as under peroxide,thermal and photolytic conditions in accordance with International Conference on Harmonization(ICH) guidelines Q1(R2).It was found extremely unstable to alkaline hydrolysis even at room temperature,unstable to acid hydrolysis at 80 ℃,and to oxidation at room temperature.It degraded to four products(O-I-O-IV) in oxidative condition,and to single product(A-I) in acid hydrolytic condition.These products were resolved on a C_8(150 mm × 4.6 mm,5 μm) column with isocratic elution using mobile phase consisting of HCOONH_4(10 mM,pH 2.5),acetonitrile and methanol(65:15:20,v/v/v).Liquid chromatography-photodiode array(LC-PDA) technique was used to ascertain the purity of the products noted in LC-UV chromatogram.For their characterization,a six stage mass fragmentation(MS^6) pattern of DOX was outlined through mass spectral studies in positive mode of electrospray ionization(+ ESI) as well as through accurate mass spectral data of DOX and the products generated through liquid chromatography-time of flight mass spectrometry(LC-MS-TOF) on degraded drug solutions.Based on it,O-l-O-IV were characterized as 3-hydroxy-9-desacetyldoxorubicin-9-hydroperoxide,l-hydroxy-9-desacetyldoxorubicin-9-hydroperoxide,9-desacetyldoxorubicin-9-hydroperoxide and 9-desacetyldoxorubicin,respectively,whereas A-I was characterized as deglucosaminyl doxorubicin.While A-I was found to be a pharmacopoeial impurity,all oxidative products were found to be new degradation impurities.The mechanisms and pathways of degradation of doxorubicin were outlined and discussed. | Dheeraj Kaushik Gulshan Bansal | 2015 | Journal of Pharmaceutical Analysis2015，5，5： | 1 |
| 14 | Response of Greenhouse tomato to irrigationand fertigation显示文摘 | GULSHAN MAHAJAN SINGH K G | 2006 | Agricultural Water Management2006，84，12： | 1 |
| 15 | Effect of welding current on the structure and properties of resistance spot welded dissimilar(austenitic stainless steel and low carbon steel)metal joints显示文摘 | Shawon MRA Gulshan F Kumy ASW | 2015 | Journal of The Institution of Engineers(India):Series D2015，96，1： | 1 |
| 16 | Isolation and characterization of a degradation product in leflunomide and a validated selective stability-indicating HPLC-UV method for their quantification显示文摘Leflunomide(LLM) is subjected to forced degradation under conditions of hydrolysis,oxidation,dry heat,and photolysis as recommended by International Conference on Harmonization guideline Q1A(R2).In total,four degradation products(Ⅰ-Ⅳ) were formed under different conditions.Products Ⅰ,Ⅱ and Ⅳ were formed in alkaline hydrolytic,acidic hydrolytic and alkaline photolytic conditions.LLM and all degradation products were optimally resolved by gradient elution over a C18column.The major degradation product(Ⅳ) formed in hydrolytic alkaline conditions was isolated through column chromatography.Based on its 1H NMR,IR and mass spectral data,it was characterized as a British Pharmacopoeial impurity B.The HPLC method was found to be linear,accurate,precise,sensitive,specific,rugged and robust for quantification of LLM as well as product Ⅳ.Finally,the method was applied to stability testing of the commercially available LLM tablets. | Balraj Saini Gulshan Bansal | 2015 | Journal of Pharmaceutical Analysis2015，5，3： | 1 |
| 17 | Outcomes 15 years after valve replacement with a mechanical versus a bioprosthetic valve: Final report of the veterans affairs randomized trial 显示文摘 | Karl H Gulshan K William G | 2000 | J Am Coll Cardiol2000，36，： | 1 |
| 18 | Multi-detector computed tomography imaging of large airway pathology:A pictorial review显示文摘The tracheobronchial tree is a musculo-cartilagenous framework which acts as a conduit to aerate the lungs and consequently the entire body. A large spectrum of pathological conditions can involve the trachea and bronchial airways. These may be congenital anomalies, infections, post-intubation airway injuries, foreign body aspiration or neoplasms involving the airway. Appropriate management of airway disease requires an early and accurate diagnosis. In this pictorial essay review, we will comprehensively describe the various airway pathologies and their imaging findings by multi-detector computed tomography. | Tejeshwar Singh Jugpal Anju Garg Gulshan Rai Sethi Mradul Kumar Daga Jyoti Kumar | 2015 | World Journal of Radiology2015，7，12： | 1 |
| 19 | Modeling and parameter design of a laser shock peening process 显示文摘 | Gulshan S Ramana V G David S S | 2011 | International Journal for Computational Methods in Engineering Science and Mechan- ics2011，12，5： | 1 |
| 20 | Ferric reducing antioxidant power of essential oils extracted from Eucalyptus and Curcuma species显示文摘 | Durre Shahwar Muhammad Asam Raza Sana Bukhari Gulshan Bukhari | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，，3： | 1 |
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