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| 1 | Alcoholic liver disease and hepatitis C:A frequently underestimated combination显示文摘Alcoholic liver disease(ALD) and hepatitis C virus(HCV) infection represent, either alone or in combination, more than two thirds of all patients with liver disease in the Western world.This review discusses the epidemiology and combined impact of ALD and HCV on the progres sion of liver disease.ALD and HCV affect the progres sion of liver disease to liver cirrhosis and hepatocellular carcinoma(HCC) in a synergistic manner.Thus, the risk for HCC increases f ive times with a daily alcohol con sumption of 80 g;in the presence of HCV it is increased 20fold, and a combination of both risk factors leads to a more than 100fold risk for HCC development.Alcohol consumption also decreases the response to interferon treatment which is probably due to a lack of compliance than a direct effect on HCV replication.Several molecu lar mechanisms are discussed that could explain the synergistic interaction of alcohol and HCV on disease progression.They include modulation of the immune response and apoptosis, increased oxidative stress via induction of CYP2E1 and the hepatic accumulation of iron.Thus, both HCV and alcohol independently cause hepatic iron accumulation in > 50% of patients probably due to suppression of the liversecreted systemic iron hormone hepcidin.A better understanding of hepcidin regulation could help in developing novel therapeutic approaches to treat the chronic disease in the future.For now, it can be generally concluded that HCVinfect ed patients should abstain from alcohol and alcoholicsshould be encouraged to participate in detoxification programs. | Sebastian Mueller Gunda Millonig Helmut K Seitz | 2009 | World Journal of Gastroenterology2009，15，28： | 18 |
| 2 | Increased liver stiffness in alcoholic liver disease:Differentiating fibrosis from steatohepatitis显示文摘AIM:To test if inflammation also interferes with liver stiffness (LS) assessment in alcoholic liver disease (ALD) and to provide a clinical algorithm for reliable fibrosis assessment in ALD by FibroScan (FS).METHODS:We first performed sequential LS analysis before and after normalization of serum transaminases in a learning cohort of 50 patients with ALD admitted for alcohol detoxification. LS decreased in almost all patients within a mean observation interval of 5.3 d. Six patients (12%) would have been misdiagnosed with F3and F4 fibrosis but LS decreased below critical cut-off values of 8 and 12.5 kPa after normalization of trans-aminases. RESULTS:Of the serum transaminases,the decrease in LS correlated best with the decrease in glutamic oxaloacetic transaminase (GOT). No significant chang-es in LS were observed below GOT levels of 100 U/L. After establishing the association between LS and GOT levels,we applied the rule of GOT < 100 U/L for reliable LS assessment in a second validation cohort of 101 patients with histologically confi rmed ALD. By ex-cluding those patients with GOT > 100 U/L at the time of LS assessment from this cohort,the area under the receiver operating characteristic (AUROC) for cirrhosis detection by FS improved from 0.921 to 0.945 while specificity increased from 80% to 90% at a sensitivity of 96%. A similar AUROC could be obtained for lower F3 fibrosis stage if LS measurements were restricted to patients with GOT < 50 U/L. Histological grading of inflammation did not further improve the diagnostic accuracy of LS.CONCLUSION:Coexisting steatohepatitis markedly increases LS in patients with ALD independent of fibrosis stage. Postponing cirrhosis assessment by FS during alcohol withdrawal until GOT decreases to < 100 U/mL signif icantly improves the diagnostic accuracy. | Sebastian Mueller Gunda Millonig Lucie Sarovska Stefanie Friedrich Frank M Reimann Maria Pritsch Silke Eisele Felix Stickel Thomas Longerich Peter Schirmacher Helmut Karl Seitz | 2010 | World Journal of Gastroenterology2010，16，8： | 10 |
| 3 | Ionic liquids for extraction of metals and metal containing compounds from communal and industrial waste water显示文摘 | Lisa Fischer Thomas Falta Gunda Koellensperger Anja Stojanovic Daniel Kogelnig Markus Galanski Regina Krachler Bernhard K. Keppler Stephan Hann | 2011 | Water Research2011，，15： | 2 |
| 4 | Sneddon' s syndrome : ano- therMigaine-stroke assoeiation 显示文摘 | Tietjen GE Al-QasmiMM Gunda P | 2006 | Cephalalgia2006，26，3： | 1 |
| 5 | A potential role for immunotherapy in thyroid cancer by enhancing NY-ESO-1 cancer antigen expression 显示文摘 | Gunda V Frederick DT Bernasconi MJ | 2014 | Thyroid2014，24，8： | 1 |
| 6 | Understanding the Relationship Between Health Assessment Questionnaire-disability Indes(HAQDI),Psoriasis Area Severity Indes(PASI),And Quality of Life(QOL)and Its Influence on Cost-effectiveness in Psoriatic Arthritis(PSA)显示文摘 | Gunda P Syeda SS Jugl SM | 2015 | Value Health2015，18，7： | 1 |
| 7 | Carbon dioxide tolerance in the single-stage liquid phase synthesis of dimethyl ether 显示文摘 | Sardesai A Gunda A Lee S | 2000 | Energy Sources2000，22，1： | 1 |
| 8 | Effect of Sliding Friction onthe Dynamics of Spur Gear Pair with Realistic Time--varying Stiffness显示文摘 | He S Gunda R Singh R | 2007 | Journal of Sound and Vibration2007，301，35： | 1 |
| 9 | Carbon Dioxide Tolerance in the Single-Stage Liquid-Phase Synthesis of Dimethyl Ether显示文摘 | Abhay Sardesai Arun Gunda Tim Tartamella Sunggyu Lee | 2000 | Energy Sources Part A: Recovery Utilization and Environmental Effects2000，，1： | 1 |
| 10 | A potential role for immunotherapy in thyroid cancer by enhancing NYESO-1 cancer antigen expression显示文摘 | Gunda V Frederick DT Bernasconi MJ | 2014 | Thyroid2014，24，8： | 1 |
| 11 | Nanostructure by design: solution-phase-processing poutes to nanocrystalline metals, ceramics, intermetallics, and composites显示文摘 | Gunda N V Buhro W E | 1998 | J Aerosol Sci1998，29，56： | 1 |
| 12 | Successful use of steroids and ureteric stents in 24 patients with idiopathic retroperitoneal fibrosis:a retrospective study显示文摘 | Fry AC Singh S Gunda SS | | 0，，03： | 1 |
| 13 | Synthesis of amino acid derived enaminones via wolff rearrangement using viny- logous amides as carbon nueleophiles 显示文摘 | Hajime Seki Gunda I Geog | 2010 | J Am Chem Soc2010，132，15： | 1 |
| 14 | Understanding the relationship between health assessment questionnaire- disability indes (HAQ-DI), psoriasis area severity indes( PASI), and qual- ity of life (QOL) and its influence on cost-effectiveness in psoriatic arthritis (PSA) 显示文摘 | Gunda P Syeda SS Jugl SM | 2015 | Value Health2015，18，7： | 1 |
| 15 | Long-term and non-invasive in vivo tracking of DiD dye-labeled human hepatic progenitors in chronic liver disease models显示文摘BACKGROUND Chronic liver diseases(CLD)are the major public health burden due to the continuous increasing rate of global morbidity and mortality.The inherent limitations of organ transplantation have led to the development of stem cell-based therapy as a supportive and promising therapeutic option.However,identifying the fate of transplanted cells in vivo represents a crucial obstacle.AIM To evaluate the potential applicability of DiD dye as a cell labeling agent for longterm,and non-invasive in vivo tracking of transplanted cells in the liver.METHODS Magnetically sorted,epithelial cell adhesion molecule positive(1×106 cells/mL)fetal hepatic progenitor cells were labeled with DiD dye and transplanted into the livers of CLD-severe combined immunodeficiency(SCID)mice.Near-infrared(NIR)imaging was performed for in vivo tracking of the DiD-labeled transplanted cells along with colocalization of hepatic markers for up to 80 d.The existence of human cells within mouse livers was identified using Alu polymerase chain reaction and sequencing.RESULTS NIR fluorescence imaging of CLD-SCID mice showed a positive fluorescence signal of DiD at days 7,15,30,45,60,and 80 post-transplantation.Furthermore,positive staining of cytokeratin,c-Met,and albumin colocalizing with DiD fluorescence clearly demonstrated that the fluorescent signal of hepatic markers emerged from the DiD-labeled transplanted cells.Recovery of liver function was also observed with serum levels of glutamic-oxaloacetic transaminase,glutamate-pyruvate transaminase,and bilirubin.The detection of human-specific Alu sequence from the transplanted mouse livers provided evidence for the survival of transplanted cells at day 80.CONCLUSION DiD-labeling is promising for long-term and non-invasive in vivo cell tracking,and understanding the regenerative mechanisms incurred by the transplanted cells. | Chaturvedula Tripura Srinivas Gunda Sandeep Kumar Vishwakarma Avinash Raj Thatipalli Jedy Jose Mahesh Kumar Jerald Aleem Ahmed Khan Gopal Pande | 2022 | World Journal of Hepatology2022，14，10： | 1 |
| 16 | Production of biodiesel fromsoybean oil on Ca0/Al203 solid base catalysts 显示文摘 | Pasupulety N Gunda K Liu Y Q | 2013 | Applied Cataly-sis A:General2013，452，15： | 1 |
| 17 | TIMI myocardial perfusion grade and ST segment res-olution: association with infarct size as assessed bysingle photon emission computed tomography imaging显示文摘 | ANGEJA B G GUNDA M MURPHY S A | 2002 | Circulation2002，105，： | 1 |
| 18 | Inferior rectus paresis and medial rectus overaction following retrobulbar anesthesia for cataract surgery显示文摘 | Muralidhar R Vijayalakshmi P Gunda AK | 2010 | Int Ophthalmol2010，30，4： | 1 |
| 19 | Genotoxicity assessment of an energetic propellant compound, 3-nitro-1,2,4-triazol-5-one (NTO) 显示文摘 | Gunda Reddya Jian Songb Paul Kirbyb | 2011 | Mutation Research/Genetic Toxicology and Environ- mental Mutagenesis2011，719，12： | 1 |
| 20 | Association of the arterial access site at angioplastywith transfusion and mortality: the MORTAL study显示文摘 | ANGEJA B G GUNDA M MURPHY S A | 2008 | Heart2008，94，： | 1 |
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