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| 1 | Incidence and management of ZIv-aflibercept related toxicities in colorectal cancer显示文摘Ziv-afilbercept(Zaltrap, Ziv) is a humanized fusion protein constructed by joining the vascular endothelial growth factor(VEGF) binding portions of human VEGF receptors 1 and 2 to the Fc portion of human immunoglobulin IgG 1. Recently, a randomized, open-label, phase Ⅲ study compared 5-fluorouracil, leucovorin, irinotecan(FOLFIRI)/Ziv with FOLFIRI/placebo in patients who had been previously treated with oxaliplatin based chemotherapy for metastatic colon cancer(mC RC). Patients who had received prior bevacizumab therapy were also eligible. This study showed that the addition of Ziv improved overall survival with median survival time of 13.5 mo vs 12.06 mo in ziv vs placebo arm. Ziv also improved progression free survival from 4.67 mo to 6.9 mo with a response rate of 19.8% in the Ziv/FOLFIRI group vs 11.1% in FOLFIRI alone group. This led to the approval of Ziv in combination with FOLFIRI in metastatic colon cancer patients treated with prior oxaliplatin regimens. The mostcommon side effects were diarrhea, stomatitis, fatigue, hypertension, weight loss, loss of appetite, abdominal pain, and headache. As the use of Ziv has become more widespread in oncology practices, familiarity with the toxicity profile of the drug and the use of practice guidelines for their treatment has become increasing important. This review will address the toxicities noted in trials using Ziv for the treatment of mC RC, and will provide recommendations for toxicity management. | Muhammad Wasif Saif Valerie Relias Kostas Syrigos Krishna S Gunturu | 2014 | World Journal of Clinical Oncology2014，5，5： | 5 |
| 2 | FOLFIRINOX for locally advanced and metastatic pancreatic cancer: single institution retrospective review of efficacy and toxicity显示文摘 | Krishna S. Gunturu Xiaopan Yao Xiangyu Cong Jaykumar R. Thumar Howard S. Hochster Stacey M. Stein Jill Lacy | 2013 | Medical Oncology2013，，1： | 3 |
| 3 | Gastric cancer and trastuzumab: first biologic therapy in gastric cancer显示文摘 | Gunturu KS Woo Y Beaubier N | 2013 | Ther Adv Med Oncol2013，5，2： | 1 |
| 4 | Immunotherapy updates in pancreatic cancer: Are we there yet? 显示文摘 | Gunturu KS Rossi GR Sail MW | 2013 | Ther Adv Med On- col2013，5，1： | 1 |
| 5 | Immunotherapy updates in pancreatic cancer: are we there yet 显示文摘 | Gunturu KS Rossi GR Saif MW | 2013 | Ther Adv Med Oncol2013，5，1： | 1 |
| 6 | Pattern of pathogens and their sensitivity isolated from surgical site infections at the Aga Khan University Hospital,Nairobi,Kenya显示文摘 | Dinda V Gunturu R Kariuki S | 2013 | Ethiop J Health Sci2013，23，2： | 1 |
| 7 | Evaluation of SCSP over TC P/IP and SCSI over Fiber Channel Connections显示文摘 | Simitci H Malakapalli C Gunturu | 2001 | IEEE Hot Interconnects2001，，9： | 1 |
| 8 | Alzheimer' s Disease: A Health care Burden of Epidemic Proportion 显示文摘 | Dharmarajan TS Gunturu SG | 2009 | AHDB2009，2，1： | 1 |
| 9 | A Kinetic Model for the Synthesis of High-Molecular-Weight Alcohols over a Sulfided Co-K-Mo/C Catalyst显示文摘 | Gunturu A K Kugler E L Cropley J B | 1998 | Ind Eng Chem Res1998，37，： | 1 |
| 10 | A kinetic model for the synthesis of high-molecular-weight alcohols over a sulfided Co-K-Mo/C catalyst显示文摘 | Gunturu A K Kugler E L Cropley J B et a/ | 1998 | Ind Eng Chem Res1998，37，： | 1 |
| 11 | Evolving nonlinear time-series models of the hot metal silicon content in the blast furnace 显示文摘 | Saxen H Pettersson F Gunturu K | 2007 | Materials and Manufacturing Processes2007，22，5： | 1 |
| 12 | Henoch - Schonleinpurpura-a case report and review of the literature 显示文摘 | Amit B Sohagia Srinivas Guptha Gunturu | 2010 | Gastroenterol-ogy Research and Practice Volume 2010 Article ID 5976482010，7，： | 1 |
| 13 | Henoch- Sehonlein purpura-a case report and review of the literature 显示文摘 | SOHAGIA AB GUNTURU SG TONG TR | 2010 | Gastroenterol Res Pract2010，，： | 1 |
| 14 | A kinetic model for the synthesis of high-molecular-weight alcohols over a sulfided co-k-mo/c catalyst显示文摘 | Gunturu A K Kugler E L Cropley J B | 1998 | Industrial Engineering Chemical Resarch1998，37，6： | 1 |
| 15 | Henoch-Schonlein Purpura—A Case Report and Review of the Literature显示文摘 | Amit B. Sohagia Srinivas Guptha Gunturu Tommy R. Tong Hilary I. Hertan Nirmal S. Mann | 2010 | Gastroenterology Research and Practice2010，，： | 1 |
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