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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | Orientation to learning context modulates retrieval processing for unrecognized words显示文摘Explicit memory errors may occur when individuals fail to retrieve information about items previously studied (item memory) or about the learning context (source memory). We examined electrophysiological measures during recognition failure in order to determine the influence of retrieval orientation for item versus source information. Recognition failure was associated with brain potentials distinct from those associated with success. Furthermore, source-memory failures were associated with earlier-onset brain potentials with a more anterior distribution compared to item-memory failures. Neurocognitive processing was thus modulated by retrieval orientation so as to differentially influence neural correlates of successful versus unsuccessful retrieval. | GUO ChunYan CHEN WenJun TIAN Tian Ken A PALLER Joel L VOSS | 2010 | Chinese Science Bulletin2010，55，26： | 6 |
| 3 | Easy MPE:Extraction of Quality Microplot Images for UAV-Based High-Throughput Field Phenotyping显示文摘Microplot extraction(PE)is a necessary image processing step in unmanned aerial vehicle-(UAV-)based research on breeding fields.At present,it is manually using ArcGIS,QGIS,or other GIS-based software,but achieving the desired accuracy is timeconsuming.We therefore developed an intuitive,easy-to-use semiautomatic program for MPE called Easy MPE to enable researchers and others to access reliable plot data UAV images of whole fields under variable field conditions.The program uses four major steps:(1)binary segmentation,(2)microplot extraction,(3)production of∗.shp files to enable further file manipulation,and(4)projection of individual microplots generated from the orthomosaic back onto the raw aerial UAV images to preserve the image quality.Crop rows were successfully identified in all trial fields.The performance of the proposed method was evaluated by calculating the intersection-over-union(IOU)ratio between microplots determined manually and by Easy MPE:the average IOU(±SD)of all trials was 91%(±3). | Léa Tresch Yue Mu Atsushi Itoh Akito Kaga Kazunori Taguchi Masayuki Hirafuji Seishi Ninomiya Wei Guo | 2019 | Plant Phenomics2019，1，1： | 3 |
| 4 | Active DNA or active histone triggering the production of antinuclear antibodies: inducing the generation of kidney iniury in mice显示文摘 | Wu H S Ma A N Guo L | 2000 | J Allergy Clin Immunol2000，105，1： | 2 |
| 5 | Dendritic cells loaded with XAGE-1b protein induce specific antitumor response against lung cancer显示文摘 | Zhou Q Wu Y L Guo A L | 2007 | ASCO Meeting Abstracts2007，25，18： | 1 |
| 6 | Tailoring properties of crosslinked polyimide aerogels for better moisture resistance, flexibility and strength显示文摘 | GUO H MEADOR M A B MCCORKLE L | 2012 | ACS Applied Mater & Interfaces2012，4，10： | 1 |
| 7 | Microbiological Transformation ofGinsenoside Rg1显示文摘 | DONG A L CUI Y J GUO H Z | 2001 | J Chin Pharm Sci2001，10，3： | 1 |
| 8 | Feature generation using genetic programming with application to fault classification显示文摘 | Guo H Jack L B Nandi A K | 2005 | IEEE Transaction on System Man and Cybernetics2005，35，1： | 1 |
| 9 | A randomized,double-blinded,placebo-controlled trial of oral alpha lipoic acid to prevent platinum-induced polyneuropathy显示文摘 | Guo Y Palmer J L Forman A | 2011 | J CIin Oncol2011，29，15： | 1 |
| 10 | Survival and reproduction of Liposcelis paeta ( Pearman ) (Psocoptera: Liposcelididae) when irradiated by electron beams 显示文摘 | Wang J J Guo D Q Fan J L Chen Y T Zhang J W Yang B A Li X Z | 2012 | Entomological Science2012，15，1： | 1 |
| 11 | Thinking Outside the Black Box: The Importance of Context in Understanding the Impact of a Preoperative Education Nursing Intervention among Chi- nese Cardiac Patients显示文摘 | Guo P East L Arthur A | 2014 | Patient Educ Couns2014，95，3： | 1 |
| 12 | In vitro assessment of the multifunctional bioactive potential of Alaska pollock skin collagen following simulated gastrointestinal digestion显示文摘 | GUO L HARNEDY P A ZHANG L | 2015 | J Sci Food Agric2015，95，7： | 1 |
| 13 | Effects of apoptosis-inducing nucleosides released from CD57^+ HLA DRbright natural suppressor cell line on human breast cancer cell death and growth 显示文摘 | Guo M W Jin A S Qi Y L | 2003 | Int J Oncol2003，23，1： | 1 |
| 14 | GP73, a novel Golgi - localized protein upregulated by viral infection显示文摘 | KLADNEY R D BULLA G A GUO L | 2000 | Gene2000，，： | 1 |
| 15 | Effects of dietary L-cami- tine and coenzyme Q10 supplementation on performance and ascites mortality of broilers显示文摘 | Geng A L Guo Y M Yuan J M | 2004 | Archives of Animal Nu- trition2004，58，： | 1 |
| 16 | A macro-scale and semidistributed monthly water balance model to predict climate change impacts in China显示文摘 | Guo S Wang J Xiong L Ying A and Li D | | 0，，： | 1 |
| 17 | Involvement of nuclei in the hypothalamus in cardiac sympathoexcitatory reflexes in cats显示文摘 | Guo Z L Moazzami A R | 2004 | Brain Res2004，1006，1： | 1 |
| 18 | Effects of dietary coenzyme Q10 supplementation on hepatic mitochondrial function and the activities of respiratory chainrelated enzymes in ascitic broiler chickens显示文摘 | Geng A L Guo Y M | 2005 | Br Poult Sci2005，46，5： | 1 |
| 19 | Preparation and characterization of chitosan-poly (acrylic acid) polymer magnetic microspheres 显示文摘 | Wu Y Guo J Yang W L et a I | 2006 | Polymer2006，47，： | 1 |
| 20 | A novel heterozygous nonsense mutation of keratin 5 in a Chinese family with Dowling-Degos disease显示文摘 | Guo L Luo X Zhao A | 2012 | J Eur Acad Dermatol Venereol2012，26，7： | 1 |
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