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| 1 | Mild hypothermia for treatment of diffuse axonal injury: a quantitative analysis of diffusion tensor imaging显示文摘Fractional anisotropy values in diffusion tensor imaging can quantitatively reflect the consistency of nerve fibers after brain damage, where higher values generally indicate less damage to nerve fibers. Therefore, we hypothesized that diffusion tensor imaging could be used to evaluate the effect of mild hypothermia on diffuse axonal injury. A total of 102 patients with diffuse axonal injury were randomly divided into two groups: normothermic and mild hypothermic treatment groups. Patient's modified Rankin scale scores 2 months after mild hypothermia were significantly lower than those for the normothermia group. The difference in average fractional anisotropy value for each region of interest before and after mild hypothermia was 1.32–1.36 times higher than the value in the normothermia group. Quantitative assessment of diffusion tensor imaging indicates that mild hypothermia therapy may be beneficial for patients with diffuse axonal injury. | Guojie Jing Xiaoteng Yao Yiyi Li Yituan Xie Wang’an Li Kejun Liu Yingchao Jing Baisheng Li Yifan Lv Baoxin Ma | 2014 | Neural Regeneration Research2014，9，2： | 9 |
| 2 | Modeling permafrost properties in the Qinghai-Xizang(Tibet) Plateau显示文摘Water and heat dynamics in the active layer at a monitoring site in the Tanggula Mountains, located in the permafrost region of the Qinghai-Xizang(Tibet) Plateau(QXP), were studied using the physical-process-based COUPMODEL model, including the interaction between soil temperature and moisture under freeze-thaw cycles. Meteorological, ground temperature and moisture data from different depths within the active layer were used to calibrate and validate the model. The results indicate that the calibrated model satisfactorily simulates the soil temperatures from the top to the bottom of the soil layers as well as the moisture content of the active layer in permafrost regions. The simulated soil heat flux at depths of 0 to 20 cm was consistent with the monitoring data, and the simulations of the radiation balance components were reasonable. Energy consumed for phase change was estimated from the simulated ice content during the freeze/thaw processes from 2007 to 2008. Using this model, the active layer thickness and the energy consumed for phase change were predicted for future climate warming scenarios. The model predicts an increase of the active layer thickness from the current 330 cm to approximately 350–390 cm as a result of a 1–2°C warming. However, the effect active layer thickness of more precipitation is limited when the precipitation is increased by 20%–50%. The COUPMODEL provides a useful tool for predicting and understanding the fate of permafrost in the QXP under a warming climate. | HU GuoJie ZHAO Lin WU XiaoDong LI Ren WU TongHua XIE ChangWei PANG QiangQiang XIAO Yao LI WangPing QIAO YongPing SHI JianZong | 2015 | Science China Earth Sciences2015，58，12： | 7 |
| 3 | Modeling Hydrothermal Transfer Processes in Permafrost Regions of Qinghai-Tibet Plateau in China显示文摘Hydrothermal processes are key components in permafrost dynamics; these processes are integral to global warming. In this study the coupled heat and mass transfer model for(Coup Model) the soil-plant-atmosphere-system is applied in high-altitude permafrost regions and to model hydrothermal transfer processes in freeze-thaw cycles. Measured meteorological forcing and soil and vegetation properties are used in the Coup Model for the period from January 1, 2009 to December 31, 2012 at the Tanggula observation site in the Qinghai-Tibet Plateau. A 24-h time step is used in the model simulation. The results show that the simulated soil temperature and water content, as well as the frozen depth compare well with the measured data. The coefficient of determination(R2) is 0.97 for the mean soil temperature and 0.73 for the mean soil water content, respectively. The simulated soil heat flux at a depth of 0–20 cm is also consistent with the monitored data. An analysis is performed on the simulated hydrothermal transfer processes from the deep soil layer to the upper one during the freezing and thawing period. At the beginning of the freezing period, the water in the deep soil layer moves upward to the freezing front and releases heat during the freezing process. When the soil layer is completely frozen, there are no vertical water exchanges between the soil layers, and the heat exchange process is controlled by the vertical soil temperature gradient. During the thawing period, the downward heat process becomes more active due to increased incoming shortwave radiation at the ground surface. The melt water is quickly dissolved in the soil, and the soil water movement only changes in the shallow soil layer. Subsequently, the model was used to provide an evaluation of the potential response of the active layer to different scenarios of initial water content and climate warming at the Tanggula site. The results reveal that the soil water content and the organic layer provide protection against active layer deepening in summer, so climate warming will cause the permafrost active layer to become deeper and permafrost degradation. | HU Guojie ZHAO Lin LI Ren WU Tonghua WU Xiaodong PANG Qiangqiang XIAO Yao QIAO Yongping SHI Jianzong | 2015 | Chinese Geographical Science2015，25，6： | 4 |
| 4 | Isoflanvonic phytoestrogens-new prebiotic for farm animals:a review on research in China显示文摘 | Han Zhengkang Guojie Wang Wen Yao | 2006 | Curr Issues Intestinals Microbiol2006，，7： | 1 |
| 5 | The Surface Energy Budget and Its Impact on the Freeze-thaw Processes of Active Layer in Permafrost Regions of the Qinghai-Tibetan Plateau显示文摘The surface energy budget is closely related to freeze-thaw processes and is also a key issue for land surface process research in permafrost regions.In this study,in situ data collected from 2005 to 2015 at the Tanggula site were used to analyze surface energy regimes,the interaction between surface energy budget and freeze-thaw processes.The results confirmed that surface energy flux in the permafrost region of the Qinghai-Tibetan Plateau exhibited obvious seasonal variations.Annual average net radiation(R_(n))for 2010 was 86.5 W m^(-2),with the largest being in July and smallest in November.Surface soil heat flux(G_(0))was positive during warm seasons but negative in cold seasons with annual average value of 2.7 W m^(-2).Variations in R_(n) and G_(0) were closely related to freeze-thaw processes.Sensible heat flux(H)was the main energy budget component during cold seasons,whereas latent heat flux(LE)dominated surface energy distribution in warm seasons.Freeze-thaw processes,snow cover,precipitation,and surface conditions were important influence factors for surface energy flux.Albedo was strongly dependent on soil moisture content and ground surface state,increasing significantly when land surface was covered with deep snow,and exhibited negative correlation with surface soil moisture content.Energy variation was significantly related to active layer thaw depth.Soil heat balance coefficient K was>1 during the investigation time period,indicating the permafrost in the Tanggula area tended to degrade. | Junjie MA Ren LI Hongchao LIU Zhongwei HUANG Tonghua WU Guojie HU Yao XIAO Lin ZHAO Yizhen DU Shuhua YANG | 2022 | Advances in Atmospheric Sciences2022，39，1： | 1 |
| 6 | Isoflavonic phytoestrogens-new probioties for farm animals: a review on research in China 显示文摘 | Han Zhengkang Wang Guojie Yao Wen | 2006 | Curr Issues Intestinal Microbiol2006，7，： | 1 |
| 7 | Occludin and connexin 43 expression contribute to the pathogenesis of traumatic brain edema显示文摘The experimental model of traumatic brain injury was established in Sprague-Dawley rats according to Feeney’s free falling method.The brains were harvested at 2,6 and 24 hours,and at 3 and 5days after injury.Changes in brain water content were determined using the wet and dry weights.Our results showed that water content of tissue significantly increased after traumatic brain injury,and reached minimum at 24 hours.Hematoxylin-eosin staining revealed pathological impairment of brain tissue at each time point after injury,particularly at 3 days,with nerve cell edema,degeneration,and necrosis observed,and the apoptotic rate significantly increased.Immunohistochemistry and western blot analysis revealed that the expression of occludin at the injured site gradually decreased as injury time advanced and reached a minimum at 3 days after injury;the expression of connexin 43 gradually increased as injury time advanced and reached a peak at 24 hours after injury.The experimental findings indicate that changes in occludin and connexin 43 expression were consistent with the development of brain edema,and may reflect the pathogenesis of brain injury. | Wanyin Ren Guojie Jing Qin Shen Xiaoteng Yao Yingchao Jing Feng Lin Weidong Pan | 2013 | Neural Regeneration Research2013，8，29： | 1 |
| 8 | Evaluation and spatio-temporal analysis of surface energy flux in permafrost regions over the Qinghai-Tibet Plateau and Arctic using CMIP6 models显示文摘The surface energy budget over the Qinghai-Tibet Plateau(QTP)and the Arctic significantly influences the climate system with global consequences.The performances of 30 selected Coupled Model Intercomparison Project Phase 6(CMIP6)models were evaluated based on six sites in the QTP and Arctic.The simulation results for latent heat flux(LE)were more accurate in the QTP,where the correlation coefficient and root mean square error(RMSE)were 0.9 and 30 W m−2,respectively.The results for sensible heat flux(H)were more accurate in the Arctic,the correlation coefficient and RMSE were 0.8 and 24 W m−2,respectively.Furthermore,the multiple models mean results revealed that the surface energy flux had seasonal variation and regional differences over the QTP and the Arctic.In the QTP,H was the lowest in winter,increased in spring,and reached the maximum in summer.However,the transitional changes in spring and autumn were not apparent in the Arctic,mainly due to seasonal net radiation difference between the two places.LE was affected by precipitation and surface soil moisture content.This work is important for understanding land-atmosphere interactions and useful for improving the accuracy of land surface models simulations. | Junjie Ma Ren Li Zhongwei Huang Tonghua Wu Xiaodong Wu Lin Zhao Hongchao Liu Guojie Hu Yao Xiao Yizhen Du Shuhua Yang Wenhao Liu Yongliang Jiao Shenning Wang | 2022 | International Journal of Digital Earth2022，15，1： | 0 |
| 9 | DEM simulations of tote blenders for enhanced axial mixing efficiency显示文摘The mixing performance of a multi-bladed tote blender is investigated using a graphics processing unit-based discrete element method program.The positioning,dimensions,and applicability of the baffles are systematically studied according to the axial mixing efficiency.The results indicate that the novel inclined multi-bladed baffles can break the symmetrical axial granular flow and introduce a more efficient convective flow into the granular mixing in the axial direction of the tote blender.Owing to the joint effects of convective mixing and asymmetrical granular flow,the axial mixing efficiency is increased by a factor of nearly 20.More importantly,the novel baffle placement approach exhibits excellent applicability to different operating conditions,particle shapes,and blender sizes.Additionally,the inclined baffles can prevent the segregation caused by shape discrepancies and improve the mixing homogeneity in the steady state.The novel baffle design is promising for applications in more complex industrial blenders for achieving a high axial mixing efficiency. | Fuhai Yu Zhihao Yao Guojie Chen Yun Zhang Yang Zheng | 2021 | Particuology2021，19，2： | 0 |
| 10 | Mapping the Brain-Wide Cholinergic Neurons Projecting to Skeletal Muscle in Mice by High-Throughput Light Sheet Tomography显示文摘Dear Editor,The cholinergic system plays an important role in regulating locomotion and motor functions by modulating neuronal activity[1].However,the anatomical relationships between the brain-wide cholinergic system and skeletal muscles remain unclear.To understand how this system modulates the activity of skeletal muscles,details of the pattern of cholinergic innervation and differences in the innervation of skeletal muscles are necessary.However,classical immunohistochemical methods are unable to test unequivocally whether a mapping exists in the connections from the brain to skeletal muscles. | Dayu Chen Xiaofeng Cheng Xiong Yang Yongsheng Zhang Zhigang He Qian Wang Guojie Yao Xiuli Liu Shaoqun Zeng Jincao Chen Hongbing Xiang | 2021 | Neuroscience Bulletin2021，37，2： | 0 |
| 11 | 单细胞技术揭示肝癌免疫图谱与动态特征显示文摘文章简介肝细胞癌是世界范围内死亡率排名第三的癌症,其中中国的肝癌发病率居世界之先。肿瘤存在多种免疫逃逸机制,提出了研究肿瘤微环境中不同免疫细胞状态的重要性。而不同类型的单细胞测序技术则是研究不同类型免疫细胞的状态和动态的有力手段。本研究结合了两种单细胞测序技术,充分发挥不同数据类型的优势,获得高分辨率的肝癌免疫图谱。肿瘤中的树突状细胞是重要的抗原呈递细胞,除传统的树突状细胞外。 | Qiming Zhang Yao He Nan Luo Shashank J.Patel Yanjie Han Ranran Gao Madhura Modak Sebastian Carotta Christian Haslinger David Kind Gregory W.Peet Guojie Zhong Shuangjia Lu Weihua Zhu Yilei Mao Mengmeng Xiao Michael Bergmann Xueda Hu Sid P.Kerkar Anne B.Vogt Stefan Pflanz Kang Liu 彭吉润 任仙文 张泽民 | 2020 | 科学新闻2020，，2： | 0 |
| 12 | Initiation of the Primate Genome Project显示文摘A crucial step for understanding human evolution is to identify the genomic changes that occurred during primate evolution,thus allowing investigators to reconstruct the ancestral states preceding the human condition.In the past several decades,the primate clade has been a research focus in genome sequencing due to its unique phylogenetic position and key importance. | Dong-Dong Wu Xiao-Guang Qi Li Yu Ming Li Zhi-Jin Liu Anne DYoder Christian Roos Takashi Hayakawa Jeffrey Rogers Tomas Marques-Bonet Bing Su Yong-Gang Yao Ya-Ping Zhang Guojie Zhang | 2022 | Zoological Research2022，43，2： | 0 |
| 13 | CAS Scientists Play an Important Role in National Basic Research Program显示文摘Of the 39 research projects that kicked off in 2005 with the support from the National Basic Research Program (dubbed the 973 Program) across the country, 12 are hosted by CAS scientists (including two under the joint leadership with other departments). Initiated in March 1997, the 973 Program is the national keystone basic research program organized by the Chinese government. Its strategic objectives are to strengthen the original innovations and to address the important scientific issues concerning the national economic and social development at a higher level and in a wider scope, so as to improve China’s capabilities of independent innovations and to provide scientific sup- port for the future development of the country. The followings are a brief account of some of the projects hosted by CAS in 2005. | XUE Yongbiao CHEN Zhiming YAO Tandong XIE Sishen LI Guojie PEI Gang GAO Fu | 2006 | Bulletin of the Chinese Academy of Sciences2006，20，2： | 0 |
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