3篇
您的检索式：作者名="Guoku Wang"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Exosomes derived from differentiated human ADMSC with the Schwann cell phenotype modulate peripheral nerve-related cellular functions显示文摘Peripheral nerve regeneration remains a significant clinical challenge due to the unsatisfactory functional recovery and public health burden.Exosomes,especially those derived from mesenchymal stem cells(MSCs),are promising as potential cell-free therapeutics and gene therapy vehicles for promoting neural regeneration.In this study,we reported the differentiation of human adipose derived MSCs(hADMSCs)towards the Schwann cell(SC)phenotype(hADMSC-SCs)and then isolated exosomes from hADMSCs with and without differentiation(i.e.,dExo vs uExo).We assessed and compared the effects of uExo and dExo on antioxidative,angiogenic,anti-inflammatory,and axon growth promoting properties by using various peripheral nerve-related cells.Our results demonstrated that hADMSC-SCs secreted more neurotrophic factors and other growth factors,compared to hADMSCs without differentiation.The dExo isolated from hADMSC-SCs protected rat SCs from oxidative stress and enhanced HUVEC migration and angiogenesis.Compared to uExo,dExo also had improved performances in downregulating pro-inflammatory gene expressions and cytokine secretions and promoting axonal growth of sensory neurons differentiated from human induced pluripotent stem cells.Furthermore,microRNA(miRNA)sequencing analysis revealed that exosomes and their parent cells shared some similarities in their miRNA profiles and exosomes displayed a distinct miRNA signature.Many more miRNAs were identified in dExo than in uExo.Several upregulated miRNAs,like miRNA-132-3p and miRNA-199b-5p,were highly related to neuroprotection,anti-inflammation,and angiogenesis.The dExo can effectively modulate various peripheral nerve-related cellular functions and is promising for cell-free biological therapeutics to enhance neural regeneration. | Bo Liu Yunfan Kong Wen Shi Mitchell Kuss Ke Liao Guoku Hu Peng Xiao Jagadesan Sankarasubramanian Chittibabu Guda Xinglong Wang Yuguo Lei Bin Duan | 2022 | Bioactive Materials2022，7，8： | 3 |
| 2 | Mineralization Patterns and Conditions of Lateritic Gibbsite Bauxite in Guinea显示文摘After the exploration and research of Lateritic-Gibbsite bauxite for years in Guinea, based on factors such as paleoclimate, paleogeography and parent rocks, the laterization and bauxite mineralization process of lateritic gibbsite bauxite in Guinea were analyzed. The mineralization conditions and topography were favorable for the formation of bauxite deposits on the West Africa craton of NW Africa, especially in Guinea. Through chemical and phase analysis for mineralogy and petrology of different mining area in BOKE-SANGAREDI of Guinea, the mineralization characters of different minerals were analyzed. Due to the paleoclimate and paleogeographical conditions, the parent rocks were leached of certain major elements, such as Si, K, Na, Ca and Mg. However, some elements, such as Al, Fe, and Ti, became relatively concentrated. Based on composition analyses of the bauxite and surrounding rocks, the laterization and bauxite mineralization processes are evaluated in the Boke-Sangaredi area of Guinea. | Rongliang Zhang Enpu Gong Guoku Wang Weiya Peng | 2018 | Advances in Geoscience2018，2，1： | 2 |
| 3 | Immobilization of Chiral Catalyst on Amorphous Al2O3 for the Selective Hydrogenation of Ethyl 1H-Indole-2-carboxylate显示文摘 | GUAN Ruqi CHAO Guoku YE Caiping WANG Yuxiang LIU Yanmei LI Haihua ZHAO Yajuan TAI Yulei | 2014 | Chemical Research in Chinese Universities2014，30，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员