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| 1 | ON SOME KEY SEDIMENTATION PROBLEMS OF THREE GORGES PROJECT (TGP)显示文摘This article addresses the problems of maintaining a useful life for the reservoir. flood stages to be anticipated at Chongqing, sedimentation in its region of fluctuating backwater. deposition of sediment in the vicinity of the dam and assessment of any possible impacts of the project on the estuary of the Yangtze River. | Lin Bingnan Dou Guoren Xie Jianheng Dai Dingzhong Chen Jisheng Tang Richang and Zhang Ren (Members of the Sedimentation Specialist Group. for the feasibility study of TGP.) | 1989 | International Journal of Sediment Research1989，4，1： | 12 |
| 2 | Virus-induced Phytoene Desaturase(PDS) Gene Silencing Using Tobacco Rattle Virus in Lilium × formolongi显示文摘Gene function analysis is challenging for Lilium due to the lack of an efficient method for stable genetic transformation. Virus-induced gene silencing(VIGS) is an attractive tool for determining gene function in plants. This study reported that Tobacco rattle virus(TRV)-based VIGS of a PHYTOENE DESATURASE(PDS) ortholog(LhPDS) can be achieved in Lilium × formolongi seedlings, with a survival rate of 92%, using the inoculation method of rubbing plus injection. Compared with untreated and mock-treated seedlings, the photobleached leaf phenotype of silenced plants significantly correlates with down-regulation of endogenous LhPDS(P ≤ 0.05). In addition, the silencing phenomenon can be observed in the growing points of plants, indicating that systemic viral infection was achieved using the protocol. The results indicate that TRV-based VIGS can be used to characterize gene function in Lilium × formolongi. This work lays the foundation for gene function analysis and molecular breeding in Lilium spp. | Hua Xu Leifeng Xu Panpan Yang Yuwei Cao Yuchao Tang Guoren He Suxia Yuan Jingyi Lei Jun Ming | 2019 | Horticultural Plant Journal2019，5，1： | 6 |
| 3 | Mining coterie patterns from Instagram photo trajectories for recommending popular travel routes显示文摘 | Yaxin YU Yuhai ZHAO Ge YU Guoren WANG | 2017 | Frontiers of Computer Science2017，11，6： | 5 |
| 4 | Research on cloud computing and services framework of marine environmental information management显示文摘Based on the features of marine environmental data and processing requirements,a cloud computing architecture of marine environment information is proposed,which provides a new cloud technology framework for the integration and sharing of marine environmental information resources.A physical layer,software platform layer and an application layer are illustrated systematically,at the same time,a corresponding solutions for many difficult technical problems such as parallel query processing of multi-dimensional,spatiotemporal information,data slice storage,software service flow customization,analysis,reorganization and so on.A prototype system is developed and many different data-size experiments and a comparative analysis are done based on it.The experiment results show that the cloud platform based on this framework can achieve high performance and scalability when dealing with large-scale marine data. | SHI Suixiang LIU Yang WEI Hongyu QIAO Baiyou WANG Guoren XU Lingyu | 2013 | Acta Oceanologica Sinica2013，32，10： | 3 |
| 5 | Effect of silver nanoparticles on an integrated fixed-film activated sludge–sequencing batch reactor: Performance and community structure显示文摘The effects of silver nanoparticles(AgNPs) on reactor performance, extracellular polymeric substances composition and microbial community structure and function in integrated fixed-film activated sludge–sequencing batch reactors(IFAS–SBRs) were investigated.Results showed that the addition of AgNPs from 0.1 to 10 mg/L exhibited no significant effects on nutrient removal. The average overall removal of COD, NH4+–N and PO43-–P was96.6%, 99.9% and 98.8%, respectively. The introduction of AgNPs caused an increase in extracellular polymeric substances content for the sludge and biofilm of IFAS–SBRs. The release of Ag+from Ag NPs and lactate dehydrogenase test implied the low toxicity of AgNPs to IFAS–SBRs. High-throughput sequencing revealed that microbial community structure showed significant shifts at phylum and genus levels after long-term exposure to AgNPs,but core functional groups responsible for nutrient removal remained at high abundance.Bacterial function prediction indicated that the metabolic categories showed no significant shifts under AgNPs stress, therefore good process performance could still be achieved. | Hexi Zhou Guoren Xu | 2019 | Journal of Environmental Sciences2019，31，6： | 2 |
| 6 | Meiotic nuclear divisions 1(MND1)fuels cell cycle progression by activating a KLF6/E2F1 positive feedback loop in lung adenocarcinoma显示文摘Background:Considering the increase in the proportion of lung adenocarcinoma(LUAD)cases among all lung cancers and its considerable contribution to cancer-related deaths worldwide,we sought to identify novel oncogenes to provide potential targets and facilitate a better understanding of the malignant progression of LUAD.Methods:The results from the screening of transcriptome and survival analyses according to the integrated Gene Expression Omnibus(GEO)datasets and The Cancer Genome Atlas(TCGA)data were combined,and a promising risk biomarker called meiotic nuclear divisions 1(MND1)was selectively acquired.Cell viability assays and subcutaneous xenograftmodelswere used to validate the oncogenic role ofMND1 in LUADcell proliferation and tumor growth.Aseries of assays,including mass spectrometry,co-immunoprecipitation(Co-IP),and chromatin immunoprecipitation(ChIP),were performed to explore the underlying mechanism.Results:MND1 up-regulation was identified to be an independent risk factor for overall survival in LUAD patients evaluated by both tissue microarray staining and third party data analysis.In vivo and in vitro assays showed that MND1 promoted LUAD cell proliferation by regulating cell cycle.The results of the Co-IP,ChIP and dual-luciferase reporter assays validated that MND1 competitively bound to tumor suppressor Kruppel-like factor 6(KLF6),and thereby protecting E2F transcription factor 1(E2F1)from KLF6-induced transcriptional repression.Luciferase reporter and ChIP assays found that E2F1 activated MND1 transcription by binding to its promoter in a feedback manner.Conclusions:MND1,KLF6,and E2F1 form a positive feedback loop to regulate cell cycle and confer DDP resistance in LUAD.MND1 is crucial for malignant progression and may be a potential therapeutic target in LUAD patients. | Quanli Zhang Run Shi Yongkang Bai Lijuan Meng Jingwen Hu Hongyu Zhu Tongyan Liu Xiaomeng De Siwei Wang Jie Wang Lin Xu Guoren Zhou Rong Yin | 2021 | Cancer Communications2021，41，6： | 2 |
| 7 | MicroRNA-124a and microRNA-34b/c are frequently methylated in all histologicaltypes of colorectal cancer and polyps, and in the adjacent normal mucosa显示文摘 | Guoren Deng Sanjay Kakar Young Kim | 2011 | Oncology Letters2011，，1： | 2 |
| 8 | Preparation of superhydrophobic silver nano coatings with feather-like structures by electroless galvanic deposition显示文摘Superhydrophobic silver nanocoatings with feather-like morphology are fabricated on copper substrates by electroless galvanic deposition. The coating exhibit superhydrophobicity with a contact angle of 156.4° and glide angle of 4° without any further surface modification. Scanning electron microscope (SEM), X-ray diffraction (XRD) and contact angle measurements are used to investigate the morphology, crystal structure and superhydrophobicity, respectively, of the coatings. The coatings exhibit high thermal stability; their water contact angle did not change when the coatings were heated to 200°C for 2 h. The mechanism of superhydrophobicity of the silver coating is discussed based on the work of Amirfazli, Wenzel and Cassie. | FENG XiaoJuan SHI YanLong WANG YongSheng YUE GuoRen YANG Wu | 2013 | Chinese Science Bulletin2013，58，16： | 2 |
| 9 | A protein secondary structure prediction framework based on the extreme learning machine显示文摘 | Wang Guoren Zhao Yi Wang Di | 2008 | Neurocomputing2008，72，13： | 1 |
| 10 | Ceramsite made with water and wastewater sludge and its characteristics affected by SiO2 and A1203显示文摘 | Guoren Xu Jinlong Zou Guibai Li | 2008 | Environmental Science and Technology2008，42，19： | 1 |
| 11 | An uncertain skyline query algorithm based on state space searching 显示文摘 | Xin Junchang Huang Jianmei Wang Guoren | 2008 | Journal of Northeastern University2008，31，3： | 1 |
| 12 | Energy-ef- ficient reverse Skyline query processing over wireless sensor networks显示文摘 | Wang Guoren Xin Junchang Chen Lei | 2012 | IEEE Transactions on Knowledge and Data Engineering2012，24，7： | 1 |
| 13 | Optimal design of a name-your-own price channel显示文摘 | John G Wilson and Guoren Zhang | 2008 | Journal of Revenue and Pricing Management2008，7，3： | 1 |
| 14 | Quantitation of erbB-2gene copy number in breast cancer by an improved polymeragse chain reaction(PCR) technique,comprtitively differential PCR显示文摘 | Guoren Deng Young SK | 1999 | Breast Cancer Res Treat1999，58，： | 1 |
| 15 | 显示文摘 | Xie Guoren Shang Xiaoqin Liu Rufeng | 2011 | Polymers2011，84，1： | 1 |
| 16 | An unified law for various region of turbulent flow in open channels and pipes显示文摘 | Dou Guoren | 1980 | science in china (series A)1980，，11： | 1 |
| 17 | A survey of uncertain data management technology research显示文摘 | Zhou Aoying Jin Cheqing Wang Guoren | 2009 | Chinese Journal of Computers2009，32，1： | 1 |
| 18 | Investigation on the crystalline morphologies of polyphenylene sulfide and interfacial effect in its fibre composites显示文摘 | Zeng Hanmin He Guoren | 1984 | Die Angewandte Makromolekulare Chemie1984，127，： | 1 |
| 19 | Adhesion and surface analysis of carbon fibres electrochemically oxidized in aqueous potassium nitrate显示文摘 | S. F Waseem S. D Gardner Guoren He Wenbo Jiang U Pittman | 1998 | Journal of Materials Science1998，，12： | 1 |
| 20 | Utilization of dried sludge for making ceramsite显示文摘 | XU Guoren ZOU Jinlong DAI Yun | 2006 | Water Science and Technolegy2006，54，9： | 1 |
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