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| 1 | Progress in material removal mechanisms of surface polishing with ultra precision显示文摘Chemical mechanical polishing (CMP) process is commonly regarded as the best method for achieving global planarization in the field of surface finishing with ultra-precision. The development of investigation on material removal mechanisms for different materials used in com-puter hard disk and ultra-large scale integration fabrication are reviewed here. The mechanisms underlying the interac-tion between the abrasive particles and polished surfaces during CMP are addressed, and some ways to investigate the polishing mechanisms are presented. | XU Jin LUO Jianbin LU Xinchun ZHANG Chaohui PAN Guoshun | 2004 | Chinese Science Bulletin2004，49，16： | 25 |
| 2 | A comparative study between graphene oxide and diamond nanoparticles as water-based lubricating additives显示文摘The tribological properties of graphene oxide(GO) nanosheets and modified diamond(MD) nanoparticles with excellent water-solubility were investigated.GO nanosheets were synthesized using carbon fibers with a regular and uniform size,the lateral size being around 30 nm and the thickness being 2 or 3 nm,while MD nanoparticles were about 30 nm in the three dimensions.The friction properties of ceramics were improved by GO nanosheets or MD nanoparticles used as additives in water-based lubrication,though the effects of two nanoparticles were quite different.For GO nanosheets,the friction coefficient at the beginning decreased sharply from 0.6 to 0.1,as compared with the dionized water lubrication.At the same time,the running-in period was shortened from 2000 s to 250 s.A steady state characterized by ultralow friction(friction coefficient=0.01) was obtained after the running-in period.In the case of MD nanoparticles,the friction coefficient stayed at 0.1 without further decrease during the whole experiment.Based on the observation of wear scar and characterization of remains on the wear track,the positive effect of GO nanosheets was attributed to their lamellar structure and geometric size.MD nanoparticles reduced friction by forming the regularly grained surface on the mating surfaces,and prevented further reduction in steady-state friction coefficient owing to their larger size and hardness.In conclusion,GO nanosheets exhibited favorable potential as an effective additive for water-based lubrication. | LIU YuHong WANG XiaoKang PAN GuoShun LUO JianBin | 2013 | Science China(Technological Sciences)2013，56，1： | 21 |
| 3 | Modification on the tribological properties of ceramics lubricated by water using fullerenol as a lubricating additive显示文摘It is necessary to modify the running-in process for the application of ceramics using water as a lubricant in real conditions because ceramics sliding in water are characterized by a running-in period with severe friction and wear.Fullerenol,a kind of highly water-soluble nanoparticle,was synthesized and then used to ameliorate the tribological properties of Si 3 N 4 sliding against Al 2 O 3 in pure water.With the addition of fullerenol,the running-in period was shortened from 30 min to 100 s at a speed of 250 mm/s.The speed threshold above which ultralow friction can be obtained in a short time was expanded from 450 mm/s to 80 mm/s.Meanwhile,the load-carrying ability of water film was increased.The role of fullerenol was discussed based on observation of the wear scar by an optical interferometer and XPS characterization of the tribo-film on the wear track. | LIU YuHong WANG XiaoKang LIU PengXiao ZHENG JunPeng SHU ChunYing PAN GuoShun LUO JianBin | 2012 | Science China(Technological Sciences)2012，55，9： | 9 |
| 4 | Chemical mechanical polishing of computer hard dish substrate in colloidal SiO2 slurry 显示文摘 | Luo Jianbin Pan Guoshun | 2002 | Int J Nonlinear Sic2002，3，34： | 1 |
| 5 | Discovery of an orally active VHL-recruiting PROTAC that achieves robust HMGCR degradation and potent hypolipidemic activity in vivo显示文摘HMG-CoA reductase(HMGCR) protein is usually upregulated after statin(HMGCR inhibitor) treatment, which inevitably diminishes its therapeutic efficacy, provoking the need for higher doses associated with adverse effects. The proteolysis targeting chimera(PROTAC) technology has recently emerged as a powerful approach for inducing protein degradation. Nonetheless, due to their bifunctional nature, developing orally bioavailable PROTACs remains a great challenge. Herein, we identified a powerful HMGCR-targeted PROTAC(21 c) comprising a VHL ligand conjugated to lovastatin acid that potently degrades HMGCR in Insig-silenced HepG2 cells(DC50 Z 120 nmol/L) and forms a stable ternary complex, as predicated by a holistic modeling protocol. Most importantly, oral administration of the corresponding lactone 21 b reveled favorable plasma exposures referring to both the parent 21 b and the conversed acid 21 c. Further in vivo studies of 21 b demonstrated robust HMGCR degradation and potent cholesterol reduction in mice with diet-induced hypercholesterolemia, highlighting a promising strategy for treating hyperlipidemia and associated diseases. | Guoshun Luo Zhenbang Li Xin Lin Xinyu Li Yu Chen Kun Xi Maoxu Xiao Hanlin Wei Lizhe Zhu Hua Xiang | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 1 |
| 6 | Structural and mechanical properties of nano-crystal TiN coatings显示文摘The structural and mechanical properties of TiN coatings prepared by ion beam assisted deposition (IBAD) were studied. The coatings have a polycrystal structure with grain size of ~10 nm or less. The hardness of the coatings increases with increasing grain size of TiN crystallites. The coating with grain size of 10.3 nm even has a superhardness of 44.7GPa. The relationship between the hardness and the grain size in the nano-crystalline coatings was discussed on the basis of grain-boundary triple junctions. | ZHANG Chenhui PAN Guoshun LUO Jianbin LI Wenzhi CHEN Darong | 2004 | Science China(Physics,Mechanics & Astronomy)2004，47，z1： | 0 |
| 7 | Synthesis of dual-doped non-precious metal electrocatalysts and their electrocatalytic activity for oxygen reduction reaction显示文摘The pyrolyzed carbon supported ferrum polypyrrole(Fe-N/C) catalysts are synthesized with or without selected dopants, p-toluenesulfonic acid(TsOH), by a facile thermal annealing approach at desired temperature for optimizing their activity for the oxygen reduction reaction(ORR) in O2-saturated 0.1 mol/L KOH solution. The electrochemical techniques such as cyclic voltammetry(CV) and rotating disk electrode(RDE) are employed with the Koutecky-Levich theory to quantitatively obtain the ORR kinetic constants and the reaction mechanisms. It is found that catalysts doped with TsOH show significantly improved ORR activity relative to the TsOH-free one. The average electron transfer numbers for the catalyzed ORR are determined to be 3.899 and 3.098, respectively, for the catalysts with and without TsOH-doping. The heat-treatment is found to be a necessary step for catalyst activity improvement, and the catalyst pyrolyzed at 600℃ gives the best ORR activity. An onset potential and the potential at the current density of-1.5 mA/cm2 for TsOH-doped catalyst after pyrolysis are 30 mV and 170 mV, which are more positive than those without pyrolized. Furthermore, the catalyst doped with TsOH shows higher tolerance to methanol compared with commercial Pt/C catalyst in 0.1 mol/L KOH. To understand this TsOH doping and pyrolyzed effect, X-ray diffraction(XRD), scanning electron microscope(SEM) and X-ray photoelectron spectroscopy(XPS) are used to characterize these catalysts in terms of their structure and composition. XPS results indicate that the pyrrolic-N groups are the most active sites, a finding that is supported by the correspondence between changes in pyridinic-N content and ORR activity that occur with changing temperature. Sulfur species are also structurally bound to carbon in the forms of C–Sn–C, an additional beneficial factor for the ORR. | Li Xu Guoshun Pan Xiaolu Liang Guihai Luo Chunli Zou Gaopan Chen | 2014 | Journal of Energy Chemistry2014，23，4： | 0 |
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