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| 1 | Curative effect of heat-sensitive moxibustion on chronic persistent asthma: a multicenter randomized controlled trial显示文摘OBJECTIVE:To compare the curative effects of heat-sensitive moxibustion with conventional drugs on chronic persistent asthma and seek a valuable therapy to replaceWestern Medicine.METHODS:The participants in this multi-center,randomized,and controlled study were randomly divided into two groups:group A(n=144),treated with heat-sensitive moxibustion(50 sessions)and group B(n=144),treated with Seretide(salmeterol50μg/fluticasone 250μg,twice a day).The scores of asthma control test(ACT),forced expiratory volume in 1 second(FEV1),peak expiratory flow(PEF),and attack frequency were measured after 15,30,60,and 90 days of treatment.Patients followed up3 and 6 months after treatment.RESULTS:There was a significant difference(P=0.0002)in the ACT score and lung function between the two groups after 3 months of treatment and(P=0.000 03)during the follow-up visits.In addition,heat-sensitive moxibustion reduced attack frequency in the period from inclusion to the6-month follow-up visit.CONCLUSION:This study shows that heat-sensitive moxibustion may have a comparable curative effect toSeretide(salmeterol/fluticasone)on asthma. | Rixin Chen Mingren Chen Jun Xiong Zhenhai Chi B0 Zhang Ning Tian Zhenhua Xu Tangfa Zhang Wanyao Li Wei Zhang Xiaofeng Rong Zhen Wang Gang Sun Baohe Ge Guoxiong Yu Nanchang Song | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 20 |
| 2 | Formation and Variation of the Atmospheric Heat Source over the Tibetan Plateau and Its Climate Effects显示文摘To cherish the memory of the late Professor Duzheng YE on what would have been his 100 th birthday, and to celebrate his great accomplishment in opening a new era of Tibetan Plateau(TP) meteorology, this review paper provides an assessment of the atmospheric heat source(AHS) over the TP from different data resources, including observations from local meteorological stations, satellite remote sensing data, and various reanalysis datasets. The uncertainty and applicability of these heat source data are evaluated. Analysis regarding the formation of the AHS over the TP demonstrates that it is not only the cause of the atmospheric circulation, but is also a result of that circulation. Based on numerical experiments, the review further demonstrates that land–sea thermal contrast is only one part of the monsoon story. The thermal forcing of the Tibetan–Iranian Plateau plays a significant role in generating the Asian summer monsoon(ASM), i.e., in addition to pumping water vapor from sea to land and from the lower to the upper troposphere, it also generates a subtropical monsoon–type meridional circulation subject to the angular momentum conservation, providing an ascending-air large-scale background for the development of the ASM. | Guoxiong WU Bian HE Anmin DUAN Yimin LIU Wei YU | 2017 | Advances in Atmospheric Sciences2017，34，10： | 10 |
| 3 | Architecture of PtFe/C catalyst with high activity and durability for oxygen reduction reaction显示文摘PtFe/C 催化剂被列在后面由的受精和高温度的减小综合了酸沥滤。X 光检查衍射, X 光检查光电子光谱学和在边光谱学描述附近原子的 X 光检查揭示那磅 < 潜水艇 class= “ a-plus-plus ” > 3 Fe 合金形成发生在高温度的减小和那不稳定的 Fe 种期间被溶解进酸溶液。在到表面并且强壮的 O-Fe 结合的从核心区域的 Fe 集中的差别可以驾驶 Fe 的外面的散开到高度弄皱的磅骨骼,并且高度结果驱散表面 FeO <潜水艇class=“ a-plus-plus ”> x 在酸的媒介是稳定的,导致磅的构造<潜水艇class=“ a-plus-plus ”> 3 Fe@Pt-FeO <潜水艇class=“ a-plus-plus ”> x 建筑学。是准备了 PtFe/C 催化剂与 Pt/C 催化剂相比为氧减小反应表明一项更高的活动和可比较的耐久性,它可能在 PtFe/C 催化剂由于表面和表面下的 Fe 种类的合作效果。 | Jiayuan Li Guoxiong Wang Jing Wang Shu Miao Mingming Wei Fan Yang Liang Yu Xinhe Bao | 2014 | Nano Research2014，7，10： | 8 |
| 4 | Interannual Variability of Late-spring Circulation and Diabatic Heating over the Tibetan Plateau Associated with Indian Ocean Forcing显示文摘The thermal forcing of the Tibetan Plateau(TP) during boreal spring,which involves surface sensible heating,latent heating released by convection and radiation flux heat,is critical for the seasonal and subseasonal variation of the East Asian summer monsoon.Distinct from the situation in March and April when the TP thermal forcing is modulated by the sea surface temperature anomaly(SSTA) in the North Atlantic,the present study shows that it is altered mainly by the SSTA in the Indian Ocean Basin Mode(IOBM) in May,according to in-situ observations over the TP and MERRA reanalysis data.In the positive phase of the IOBM,a local Hadley circulation is enhanced,with its ascending branch over the southwestern Indian Ocean and a descending one over the southeastern TP,leading to suppressed precipitation and weaker latent heat over the eastern TP.Meanwhile,stronger westerly flow and surface sensible heating emerges over much of the TP,along with slight variations in local net radiation flux due to cancellation between its components.The opposite trends occur in the negative phase of the IOBM.Moreover,the main associated physical processes can be validated by a series of sensitivity experiments based on an atmospheric general circulation model,FAMIL.Therefore,rather than influenced by the remote SSTAs of the northern Atlantic in the early spring,the thermal forcing of the TP is altered by the Indian Ocean SSTA in the late spring on an interannual timescale. | Yu ZHAO Anmin DUAN Guoxiong WU | 2018 | Advances in Atmospheric Sciences2018，35，8： | 8 |
| 5 | Preface显示文摘The Climate System Model Development and Application Studies (CSMDA for short) is an International Partnership Program for Creative Research Teams that was started in October 2004 and is supported by | YU Rucong WU Guoxiong | 2008 | Advances in Atmospheric Sciences2008，25，4： | 7 |
| 6 | PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death显示文摘5-Fluorouracil(5-FU)is known as a first-line chemotherapeutic agent against colorectal cancer(CRC),but drug resistance occurs frequently and significantly limits its clinical success.Our previous study showed that the protocadherin 17(PCDH17)gene was frequently methylated and functioned as a tumor suppressor in CRC.However,the relationship between PCDH17 and 5-FU resistance in CRC remains unclear.Here,we revealed that PCDH17 was more highly expressed in 5-FU-sensitive CRC tissues than in 5-FU-resistant CRC tissues,and high expression of PCDH17 was correlated with high BECN1 expression.Moreover,this expression profile contributed to superior prognosis and increased survival in CRC patients.Restoring PCDH17 expression augmented the 5-FU sensitivity of CRC in vitro and in vivo by promoting apoptosis and autophagic cell death.Furthermore,autophagy played a dominant role in PCDH17-induced cell death,as an autophagy inhibitor blocked cell death to a greater extent than the pancaspase inhibitor Z-VAD-FMK.PCDH17 inhibition by siRNA decreased the autophagy response and 5-FU sensitivity.Mechanistically,we showed that c-Jun NH2-terminal kinase(JNK)activation was a key determinant in PCDH17-induced autophagy.The compound SP600125,an inhibitor of JNK,suppressed autophagy and 5-FU-induced cell death in PCDH17-reexpressing CRC cells.Taken together,our findings suggest for the first time that PCDH17 increases the sensitivity of CRC to 5-FU treatment by inducing apoptosis and JNK-dependent autophagic cell death.PCDH17 may be a potential prognostic marker for predicting 5-FU sensitivity in CRC patients. | Shuiping Liu Haoming Lin Da Wang Qiang Li Hong Luo Guoxiong Li Xiaohui Chen Yongqiang Li Peng Chen Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Mingming Zhang Xuemeng Han Qiujie Li Liuxi Chen Ying Liu Xiaying Chen Guohua Li Yu Xiang Ting Duan Jiao Feng Jianshu Lou Xingxing Huang Qin Zhang Ting Pan Lili Yan Ting Jin Wenzheng Zhang Lvjia Zhuo Yitian Sun Tian Xie Xinbing Sui | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 4 |
| 7 | Impact of Surface Potential Vorticity Density Forcing over the Tibetan Plateau on the South China Extreme Precipitation in January 2008. Part Ⅰ:Data Analysis显示文摘The external source/sink of potential vorticity (PV) is the original driving force for the atmospheric circulation. The relationship between surface PV generation and surface PV density forcing is discussed in detail in this paper. Moreover, a case study of the extreme winter freezing rain/snow storm over South China in January 2008 is performed, and the surface PV density forcing over the eastern flank of the Tibetan Plateau (TP) has been found to significantly affect the precipitation over South China in this case. The TP generated PV propagated eastward in the middle troposphere. The associated zonal advection of positive absolute vorticity resulted in the increasing of cyclo-nic relative vorticity in the downstream region of the TP. Ascending air and convergence in the lower troposphere developed, which gave rise to the development of the southerly wind. This favored the increasing of negative meridio-nal absolute vorticity advection in the lower troposphere, which provided a large-scale circulation background conducive to ascending motion such that the absolute vorticity advection increased with height. Consequently, the ascending air further strengthened the southerly wind and the vertical gradient of absolute vorticity advection between the lower and middle troposphere in turn. Under such a situation, the enhanced ascending, together with the moist air transported by the southerly wind, formed the extreme winter precipitation in January 2008 over South China. | Tingting MA Guoxiong WU Yimin LIU Zhihong JIANG Jiahui YU | 2019 | Journal of Meteorological Research2019，33，3： | 4 |
| 8 | Single Nucleotide Polymorphism of FSHβ Gene Associated with Reproductive Traits in Japanese Flounder (Paralichthys olivaceus)显示文摘Follicle stimulating hormone β (FSHβ) of Japanese flounder (Paralichthys olivaceus) plays a key role in the regulation of gonadal development.This study aimed to investigate molecular genetic characteristics of the FSHβ gene and elucidate the effects of single nucleotide polymorphisms (SNPs) of FSHβ on reproductive traits in Japanese flounder.We used polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) and sequencing of the FSHβ gene in 60 individuals.We identified only an SNP (T/C) in the coding region of exon3 of FSHβ.The SNP (T/C) did not lead to amino acid changes at the position 340 bp of FSHβ gene.Statistical analysis showed that the SNP was significantly associated with testosterone (T) level and gonadosomatic index (GSI) (P<0.05).Individuals with genotype TC of the SNP had significantly higher serum T levels and GSI (P<0.05) than that of genotype CC.Therefore, FSHβ gene could be a useful molecular marker in selection for prominent reproductive trait in Japanese Flounder. | HE Feng WEN Haishen YU Dahui LI Jifang SHI Bao CHEN Caifang ZHANG Jiaren JIN Guoxiong CHEN Xiaoyan Shi Dan Yang Yanping | 2010 | Journal of Ocean University of China2010，9，4： | 4 |
| 9 | Impact of Surface Potential Vorticity Density Forcing over the Tibetan Plateau on the South China Extreme Precipitation in January 2008. Part Ⅱ:Numerical Simulation显示文摘The surface air convergence on the eastern flank of the Tibetan Plateau (TP) can increase the in situ surface potential vorticity density (PVD). Since the elevated TP intersects with the isentropic surfaces in the lower troposphere, the increased PVD on the eastern flank of TP thus forms a PVD forcing to the intersected isentropic surface in the boundary layer. The influence of surface PVD forcing over the TP on the extreme freezing rain/snow over South China in January 2008 is investigated by using numerical experiments based on the Finite-volume Atmospheric Model of the IAP/LASG (FAMIL). Compared with observations, the simulation results show that, by using a nudging method for assimilating observation data in the initial flow, this model can reasonably reproduce the distribution of precipitation, atmospheric circulation, and PVD propagation over and downstream of the TP during the extreme winter precipitation period. In order to investigate the impact of the increased surface PVD over the TP on the extreme precipitation in South China, a sensitivity experiment with surface PVD reduced over the TP region was performed. Compared with the control experiment, it is found that the precipitation in the TP downstream area, especially in Southeast China, is reduced. The rainband from Guangxi Region to Shandong Province has almost disappeared. In the lower troposphere, the increase of surface PVD over the TP region has generated an anomalous cyclonic circulation over southern China, which plays an important role in increasing southerly wind and the water vapor transport in this area;it also increases the northward negative absolute vorticity advection. In the upper troposphere, the surface PVD generated in eastern TP propagates on isentropic surface along westerly wind and results in positive absolute vorticity advection in the downstream areas. Consequently, due to the development of both ascending motion and water vapor transport in the downstream place of the TP, extremely heavy precipitation occurs over southern China. Thereby, a new mechanism concerning the influence of the increased surface PVD over the eastern TP slopes on the extreme weather event occurring over southern China is revealed. | Jiahui YU Yimin LIU Tingting MA Guoxiong WU | 2019 | Journal of Meteorological Research2019，33，3： | 3 |
| 10 | Investigation on the effect of Al-5Ti-1B master alloy on the near-eutectic Al-Si casting alloys modified with strontium显示文摘 | LIAO Hengcheng SUN Yu SUN Guoxiong | 2002 | J Mater Sci2002，37，16： | 1 |
| 11 | Restraining effect of strontium on the crystallization of Mg2Si phaseduring solidification in Al-Si-Mg casting alloys and mechanisms 显示文摘 | Liao Hengcheng Sun Yu Sun Guoxiong | 2003 | Materials Science and Engineering2003，358，： | 1 |
| 12 | Correlation between mechanical properties and amount of dendritic α-Al phase in as-cast near-eutectic Al–11.6% Si alloys modified with strontium显示文摘 | Hengcheng Liao Yu Sun Guoxiong Sun | 2002 | Materials Science & Engineering A2002，，1： | 1 |
| 13 | Reverse vaccinology approach identify an Echinococcus granulosus tegumental membrane protein enolase as vaccine candidate显示文摘 | Wenjia Gan Guoxiong Zhao Hongxu Xu Weihua Wu Wuying Du Jiang Huang Xinbing Yu Xuchu Hu | 2010 | Parasitology Research2010，，4： | 1 |
| 14 | Preface to special column on catalytic conversion of CO_(2)显示文摘With the increasing awareness of sustainable chemistry and green chemistry,catalytic conversion of carbon dioxide(CO_(2))into high value‐added and bulk chemicals is a promising tech‐nology that can utilize CO_(2) as an ideal C1 source while simulta‐neously storing renewable energy.Despite being frustrated with its thermodynamic stability and kinetic inertness,CO_(2) has been tamed for triggering catalytic constructions of highly‐valued entities like important hydrocarbon fuels and fine chemicals,mainly aiding by two scenarios:CO_(2) reduction and CO_(2)‐involved organic synthesis.Accordingly,science,industry and govern‐ment agencies have been devoted to leverage these synthetic tools in targeting the catalytic conversion of CO_(2).Therefore,it motivates us to organize the special column of“Catalytic Con‐version of CO_(2)”.The column contains 14 papers,including 4 reviews,4 communications and 6 articles,which cover the frontiers and most of the research aspects of catalytic con‐version of CO_(2). | Yanqiang Huang Da-Gang Yu Guoxiong Wang | 2022 | Chinese Journal of Catalysis2022，43，7： | 1 |
| 15 | Variation of second-phase morphology and its influence on fracture behavior of Al-Si alloy显示文摘 | Sun Yu Chen Jin Sun Guoxiong | 2004 | Journal of Southeast University2004，，20： | 1 |
| 16 | CAS FGOALS-f3-L参加CMIP6 DECK试验数据介绍显示文摘本文介绍了CAS FGOALS-f3-L参加CMIP6 DECK耦合试验数据。主要包括piControl,abrupt-4×CO2和1pctC02的试验设计,模式设置以及初步结果评估。piControl提供了561年的模拟结果,abrupt-4×CO2和1pctCO2分别提供了三组集合成员,每个成员包括160年的积分。初步评估结果表明,piControl试验中,耦合模式可以保证长期稳定积分。在气候态降水模拟上,piControl试验可以合理的再现全球海表温度和降水的基本分布型,相比上一代耦合模式,在ITCZ地区的降水有所改进。另一方面耦合模式的气候敏感度约为3.0℃,相比上一代的耦合模式更为合理。 | HE Bian YU Yongqiang BAO Qing LIN Pengfei LIU Hailong LI Jinxiao WANG Lei LIU Yimin WU Guoxiong CHEN Kangjun GUO Yuyang ZHAO Shuwen ZHANG Xiaoqi SONG Mirong XIE Jinbo | 2020 | Atmospheric and Oceanic Science Letters2020，13，6： | 0 |
| 17 | The Tibetan Plateau bridge:Influence of remote teleconnections from extratropical and tropical forcings on climate anomalies显示文摘本文回顾了青藏高原桥梁作用方面的最新研究进展,涉及北大西洋气候异常对春,夏亚洲季风和厄尔尼诺-南方涛动(ENSO)事件的遥相关影响,热带海洋异常和中国东部极端气候异常之间的联系以及华南春雨的季节内变化等.介绍了年际时间尺度上,冬-春季北大西洋海表温度强迫如何影响南亚季风的季节性转变以及随后ENSO事件的触发.5月份青藏高原上空显著的负感热斜压结构,为北大西洋影响亚洲季风和ENSO提供了桥梁效应,夏季北大西洋涛动与华东夏季降水变化显著相关,高原潜热在这一关系中起着桥梁作用.另一方面,这种高原桥梁效应也存在于从热带海洋异常到东亚夏季极端降水事件的连接中,以及从中纬度波列到华南春雨准双周振荡的联系中. | Yimin Liu Wei Yu Jilan Jiang Tingting Ma Jiangyu Mao Guoxiong Wu | 2024 | Atmospheric and Oceanic Science Letters2024，17，1： | 0 |
| 18 | Investigation of the seismic behavior of grouted sandy gravel foundations using shaking table tests显示文摘Sandy gravel foundations exhibit non-linear dynamic behavior when subjected to strong ground motions,which can have amplification effects on superstructures and can reveal insufficient lateral resistance of foundations.Grouting methods can be used to improve the seismic performance of natural sandy gravel foundations.The strength and stiffness of grouted sandy gravel foundations are different from those of natural foundations,which have unknown earthquake resistance.Few studies have investigated the seismic behavior of sandy gravel foundations before and after grouting.In this study,two shaking table tests were performed to evaluate the effect of grouting reinforcement on seismic performance.The natural frequency,acceleration amplification effect,lateral displacement,and vertical settlement of the non-grouted and grouted sandy gravel foundations were measured and compared.Additionally,the dynamic stress-strain relationships of the two foundations were obtained by a linear inversion method to evaluate the seismic energy dissipation.The test results indicated that the acceleration amplification,lateral displacement amplitude,and vertical settlement of the grouted sandy gravel foundation were lower than that of the non-grouted foundation under low-intensity earthquakes.However,a contrasting result was observed under high-intensity earthquakes.This demonstrated that different grouting reinforcement strategies are required for different sandy gravel foundations.In addition,the dynamic stress-strain relationship of the two foundations exhibited two different energy dissipation mechanisms.The results provide insights relating to the development of foundations for relevant engineering sites and to the dynamic behavior of grouted foundations prior to investigating soil-structure interaction problems. | Tiancheng WANG Yu LIANG Xiaoyong ZHANG Zhihuan RUAN Guoxiong MEI | 2022 | Frontiers of Structural and Civil Engineering2022，16，9： | 0 |
| 19 | VIBRATION MEASUREMENT OF DOUBLE-ENDED TUNING FORKS RESONATOR显示文摘提高调节叉(DETF ) 的双 ended 的连贯和可靠性共鸣器,共鸣器颤动的一个测量系统被介绍检查它的动态特征。激光 Doppler 技术被利用,在 DETF 颤动速度和光电探测器的产量电流之间的关系被获得。共鸣器颤动方程也被分析,它的开车力量仅仅取决于直接当前的偏爱电压和其他的电压的振幅。而且,基于测量驾驶控制电路的一个特殊共鸣器被设计。电路的振幅和频率被一台计算机控制以便 highlys 桌子和强壮的开车信号能是输出。驾驶并且测量 double-endedtuning 叉的实验被做了。驾驶信号的频率是 8 kHz,驾驶电压的 peak-to-peak 价值是 140 V。试验性的结果显示共鸣器能被驾驶控制电路稳定地驾驶, DETF 的动态特征可以在实时被测量。 | LENG Changlin ZHANG Guoxiong ZHONG Ying JIANG Chengzhi YU Fusheng | 2006 | Chinese Journal of Mechanical Engineering2006，19，1： | 0 |
| 20 | Spatiotemporal changes of typical glaciers and their responses to climate change in Xinjiang,Northwest China显示文摘Glaciers are highly sensitive to climate change and are undergoing significant changes in mid-latitudes.In this study,we analyzed the spatiotemporal changes of typical glaciers and their responses to climate change in the period of 1990-2015 in 4 different mountainous sub-regions in Xinjiang Uygur Autonomous Region of Northwest China:the Bogda Peak and Karlik Mountain sub-regions in the Tianshan Mountains;the Yinsugaiti Glacier sub-region in the Karakorum Mountains;and the Youyi Peak sub-region in the Altay Mountains.The standardized snow cover index(NDSI)and correlation analysis were used to reveal the glacier area changes in the 4 sub-regions from 1990 to 2015.Glacial areas in the Bogda Peak,Karlik Mountain,Yinsugaiti Glacier,and Youyi Peak sub-regions in the period of 1990-2015 decreased by 57.7,369.1,369.1,and 170.4 km^(2),respectively.Analysis of glacier area center of gravity showed that quadrant changes of glacier areas in the 4 sub-regions moved towards the origin.Glacier area on the south aspect of the Karlik Mountain sub-region was larger than that on the north aspect,while glacier areas on the north aspect of the other 3 sub-regions were larger than those on the south aspect.Increased precipitation in the Karlik Mountain sub-region inhibited the retreat of glaciers to a certain extent.However,glacier area changes in the Bogda Peak and Youyi Peak sub-regions were not sensitive to the increased precipitation.On a seasonal time scale,glacier area changes in the Bogda Peak,Karlik Mountain,Yinsugaiti Glacier,and Youyi Peak sub-regions were mainly caused by accumulated temperature in the wet season;on an annual time scale,the correlation coefficient between glacier area and annual average temperature was-0.72 and passed the significance test at P<0.05 level in the Karlik Mountain sub-region.The findings of this study can provide a scientific basis for water resources management in the arid and semi-arid regions of Northwest China in the context of global warming. | HUANG Xiaoran BAO Anming GUO Hao MENG Fanhao ZHANG Pengfei ZHENG Guoxiong YU Tao QI Peng Vincent NZABARINDA DU Weibing | 2022 | Journal of Arid Land2022，14，5： | 0 |
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