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| 1 | Dihydromyricetin inhibits migration and invasion of hepatoma cells through regulation of MMP-9 expression显示文摘AIM:To investigate the effects of dihydromyricetin(DHM)on the migration and invasion of human hepatic cancer cells.METHODS:The hepatoma cell lines SK-Hep-1 and MHCC97L were used in this study.The cells were cultured in RPIM-1640 medium supplemented with 10%fetal bovine serum at 37℃in a humidified 5%CO2incubator.DHM was dissolved in dimethyl sulfoxide and diluted to various concentrations in medium before applying to cells.MTT assays were performed to measure the viability of the cells after DHM treatment.Wound healing and Boyden transwell assays were used to assess cancer cell motility.The invasive capacity of cancer cells was measured using Matrigel-coated transwell chambers.Matrix metalloproteinase(MMP)-2/9 activity was examined by fluorescence analysis.Western blot was carried out to analyze the expression of MMP-2,MMP-9,p-38,JNK,ERK1/2 and PKC-δproteins.All data were analyzed by Student’s t tests in GraphPad prism 5.0software and are presented as mean±SD.RESULTS:DHM was found to strongly inhibit the migration of the hepatoma cell lines SK-Hep-1(without DHM,24 h:120±8μmol/L vs 100μmol/L DHM,24h:65±10μmol/L,P<0.001)and MHCC97L(without DHM,24 h:126±7μmol/L vs 100μmol/L DHM,24h:74±6μmol/L,P<0.001).The invasive capacity of the cells was reduced by DHM treatment(SK-Hep-1cells without DHM,24 h:67±4μmol/L vs 100μmol/L DHM,24 h:9±3μmol/L,P<0.001;MHCC97L cells without DHM,24 h:117±8μmol/L vs 100μmol/L DHM,24 h:45±2μmol/L,P<0.001).MMP2/9 activity was also inhibited by DHM exposure(SK-Hep-1 cells without DHM,24 h:600±26μmol/L vs 100μmol/L DHM,24 h:100±6μmol/L,P<0.001;MHCC97L cells without DHM,24 h:504±32μmol/L vs 100μmol/L DHM 24 h:156±10μmol/L,P<0.001).Western blot analysis showed that DHM decreased the expression level of MMP-9 but had little effect on MMP-2.Further investigation indicated that DHM markedly reduced the phosphorylation levels of p38,ERK1/2 and JNK in a concentration-dependent manner but had no impact on the total protein levels.In addition,PKC-δprotein,a key protein in the regulation of MMP family protein expression,was up-regulated with DHM treatment.CONCLUSION:These findings demonstrate that DHM inhibits the migration and invasion of hepatoma cells and may serve as a potential candidate agent for the prevention of HCC metastasis. | Qing-Yu Zhang Ran Li Guo-Fang Zeng Bin Liu Jie Liu Yang Shu Zhong-Kao Liu Zhi-Dong Qiu Dong-Jun Wang Hui-Lai Miao Ming-Yi Li Run-Zhi Zhu | 2014 | World Journal of Gastroenterology2014，20，29： | 23 |
| 2 | A comparative analysis of five global cropland datasets in China显示文摘Accurate information of cropland area and spatial location is critical for studies of national food security, global environmental change, terrestrial ecosystem geophysics and the geochemical cycle. In this paper, we compared five global cropland datasets in circa 2010 of China from in terms of cropland area and spatial location, including Global Land30, FROM-GLC, Glob Cover, MODIS Collection 5, and MODIS Cropland. The results showed that the accuracies of cropland area and spatial location of Globe Land30 were higher than the other four products. The cropland areas of the five products varied in most of the provinces. Compared with the statistical data, the best goodness of fit was obtained using Globe Land30, followed by MODIS Collection 5 and FROM-GLC, with MODIS Cropland and Glob Cover having the poorer accuracies. Regarding the spatial location of cropland, Globe Land30 achieved the best accuracy, followed by FROM-GLC and MODIS Collection 5, with Glob Cover and MODIS Cropland having the poorer accuracies. In addition, the spatial agreement of the five datasets was reduced from agricultural production area to pastoral area and significantly affected by elevation and slope factors. Although the spatial resolution of MODIS Collection 5 was the lowest, accuracies of the cropland area and spatial location were better than those of Glob Cover and MODIS Cropland. Therefore, high spatial resolution remote sensing images can help to improve the accuracy of the dataset during land cover mapping, while it is also important to select a suitable classification method. Furthermore, in northwestern and southeastern China, spectral mixing pixels are universal because of the complicated landscape and fragmentized topography and result in uncertainty and poor consistency when using the five products. Therefore, these regions require additional attention in future cropland mapping studies. | LU Miao WU WenBin ZHANG Li LIAO AnPing PENG Shu TANG HuaJun | 2016 | Science China(Information Sciences)2016，59，12： | 15 |
| 3 | Numerical study of the effects of local atmospheric circulations on a pollution event over Beijing–Tianjin–Hebei, China显示文摘Currently, the Chinese central government is considering plans to build a trilateral economic sphere in the Bohai Bay area, including Beijing, Tianjin and Hebei(BTH), where haze pollution frequently occurs. To achieve sustainable development, it is necessary to understand the physical mechanism of the haze pollution there. Therefore, the pollutant transport mechanisms of a haze event over the BTH region from 23 to 24 September 2011 were studied using the Weather Research and Forecasting model and the FLEXible-PARTicle dispersion model to understand the effects of the local atmospheric circulations and atmospheric boundary layer structure. Results suggested that the penetration by sea-breeze could strengthen the vertical dispersion by lifting up the planetary boundary layer height(PBLH) and carry the local pollutants to the downstream areas; in the early night, two elevated pollution layers(EPLs) may be generated over the mountain areas: the pollutants in the upper EPL at the altitude of 2–2.5 km were favored to disperse by long-range transport, while the lower EPL at the altitude of 1 km may serve as a reservoir, and the pollutants there could be transported downward and contribute to the surface air pollution.The intensity of the sea–land and mountain–valley breeze circulations played an important role in the vertical transport and distribution of pollutants. It was also found that the diurnal evolution of the PBLH is important for the vertical dispersion of the pollutants,which is strongly affected by the local atmospheric circulations and the distribution of urban areas. | Yucong Miao Shuhua Liu Yijia Zheng Shu Wang Bicheng Chen Hui Zheng Jingchuan Zhao | 2015 | Journal of Environmental Sciences2015，27，4： | 14 |
| 4 | Bedaquiline-containing regimens in patients with pulmonary multidrug-resistant tuberculosis in China:focus on the safety显示文摘Background:World Health Organization recommends countries introducing new drug and short treatment regimen for drug resistant tuberculosis(DR-TB)should develop and implement a system for active pharmacovigilance that allows for detection,reporting and management of adverse events.The aim of the study is to evaluate the frequency and severity of adverse events(AEs)of bedaquiline-containing regimen in a cohort of Chinese patients with multidrug-resistant(MDR)/extensively drug-resistant(XDR)-TB based on active drug safety monitoring(aDSM)system of New Drug Introduction and Protection Program(NDIP). | Jing-Tao Gao Juan Du Gui-Hui Wu Yi Pei Meng-Qiu Gao Leonardo Martinez Lin Fan Wei Chen Li Xie Yu Chen Hua Wang Long Jin Guo-Bao Li Pei-Lan Zong Yu Xiong Qian-Hong Wu Ming-Wu Li Xiao-Feng Yan Yan-Fang Miao Qing-Shan Cai Xin-Jie Li Da-Peng Bai Shu-Jun Geng Guo-Li Yang Pei-JunTang Yi Zeng Xiao-Hong Chen Tong-Xia Li Cui Cai Yun Zhou Ma Zhuo Jian-Yun Wang Wen-Long Guan Lin Xu Ji-Chan Shi Wei Shu Li-Li Cheng FeiTeng Yu-Jia Ning Shi-Heng Xie Yu-Xian Sun Li-Jie Zhang Yu-Hong Liu | 2021 | Infectious Diseases of Poverty2021，10，2： | 11 |
| 5 | Updated diagnosis, treatment and prevention of COVID-19 in children: experts' consensus statement (condensed version of the second edition)显示文摘In the early February,2020,we called up an experts' committee with more than 30 Chinese experts from 11 national medical academic organizations to formulate the first edition of consensus statement on diagnosis,treatment and prevention of coronavirus disease 2019 (COVID-19) in children,which has been published in this journal.With accumulated experiences in the diagnosis and treatment of COVID-19 in children,we have updated the consensus statement and released the second edition recently.The current version in English is a condensed version of the second edition of consensus statement on diagnosis,treatment and prevention of COVID-19 in children.In the current version,diagnosis and treatement criteria have been optimized,and early identification of severe and critical cases is highlighted.The early warning indicators for severe pediatric cases have been summarized which is utmost important for clinical practice.This version of experts consensus will be valuable for better prevention,diagnosis and treatment of COVID-19 in children worldwide. | Kun-Ling Shen Yong-Hong Yang Rong-Meng Jiang Tian-You Wang Dong-Chi Zhao Yi Jiang Xiao-Xia Lu Run-Ming Jin Yue-Jie Zheng Bao-Ping Xu Zheng-De Xie Zhi-sheng Liu Xing-wang Li Li-Kai Lin Yun-Xiao Shang Sai-Nan Shu Yan Bai Min Lu Gen Lu Ji-Kui Deng Wan-Jun Luo Li-Juan Xiong Miao Liu Yu-Xia Cui Le-Ping Ye Jia-Fu Li Jian-Bo Shao Li-Wei Gao Yong-Yan Wang Xue-Feng Wang | 2020 | World Journal of Pediatrics2020，16，3： | 9 |
| 6 | HDAC2 phosphorylation-dependent KIf5 deacetylation and RARa acetylation induced by RAR agonist switch the transcription regulatory programs of p21 in VSMCs显示文摘脉管的光滑的肌肉房间(VSMC ) 的反常增长在 angioplasty 以后发生在高血压,动脉粥样硬化和狭窄,导致 pathophysiological 脉管的改变。作为重要生长拘捕基因, p21 在脉管的改变起关键作用。由 retinoic 酸受体(RAR ) 和它的 ligand 的 p21 表示的规定为病理学的脉管的改变的控制有重要含意。不过,在 VSMC 遗体的调停 RAR 的 p21 表示的机制糟糕理解。这里,我们显示出那,在基础条件下面, RARα与 histone deacetylase 形成建筑群 2 (HDAC2 ) 并且 Krü象 ppel 一样因素 5 (Klf5 ) 在 p21 倡导者到禁止它的表示。在 RARα 之上;收缩筋刺激, HDAC2 是由 CK2α 的 phosphorylated;。在一方面, HDAC2 的 Phosphorylation 从 RARα 支持它的分离;,因此允许 liganded-RARα与激活剂交往;在另一方面,它与 Klf5 增加它的相互作用,因此导致 Klf5 的 deacetylation。Klf5 的 Deacetylation 从 p21 倡导者便于它的分离,减轻它 p21 倡导者上的压抑的效果。有由任何一个 CK2α 的 HDAC2 phosphorylation 的干扰;击倒或 HDAC2 的 phosphorylation 缺乏的异种的使用阻止 Klf5 的分离 p21 倡导者并且损害 RAR 导致收缩筋的 p21 激活。我们的结果揭示包含工作在 RAR 收缩筋处理之上把基础压抑建筑群从 p21 倡导者移开的 phosphorylation-deacetylation 串联的新奇机制,允许最佳导致收缩筋的 p21 表示。 | Bin Zheng Mei Han Ya-nan Shu Ying-jie Li Sui-bing Miao Xin-hua Zhang Hui-jing Shi Tian Zhang Jin-kun Wen | 2011 | Cell Research2011，21，10： | 9 |
| 7 | Architecture of PtFe/C catalyst with high activity and durability for oxygen reduction reaction显示文摘PtFe/C 催化剂被列在后面由的受精和高温度的减小综合了酸沥滤。X 光检查衍射, X 光检查光电子光谱学和在边光谱学描述附近原子的 X 光检查揭示那磅 < 潜水艇 class= “ a-plus-plus ” > 3 Fe 合金形成发生在高温度的减小和那不稳定的 Fe 种期间被溶解进酸溶液。在到表面并且强壮的 O-Fe 结合的从核心区域的 Fe 集中的差别可以驾驶 Fe 的外面的散开到高度弄皱的磅骨骼,并且高度结果驱散表面 FeO <潜水艇class=“ a-plus-plus ”> x 在酸的媒介是稳定的,导致磅的构造<潜水艇class=“ a-plus-plus ”> 3 Fe@Pt-FeO <潜水艇class=“ a-plus-plus ”> x 建筑学。是准备了 PtFe/C 催化剂与 Pt/C 催化剂相比为氧减小反应表明一项更高的活动和可比较的耐久性,它可能在 PtFe/C 催化剂由于表面和表面下的 Fe 种类的合作效果。 | Jiayuan Li Guoxiong Wang Jing Wang Shu Miao Mingming Wei Fan Yang Liang Yu Xinhe Bao | 2014 | Nano Research2014，7，10： | 8 |
| 8 | Switchable C02 electroreduction via engineering active phases of Pd nanoparticles显示文摘活跃阶段的工程定期被利用在异构的催化作用调节金属 nanoparticles (NP ) 的选择。然而,在 electrocatalysis 的活跃阶段的理解的缺乏为公司 2 electroreduction 妨碍了有效催化剂的发展。此处,我们报导 Pd NP 的活跃阶段的系统的工程,它被利用为公司 2 electroreduction 选择反应小径。在 situ X光检查吸收光谱学,在稀释的 situ 总计思考红外线的光谱学,并且密度功能的理论计算建议吸附氢的 Pd 的形成出现在混合物上-并且一个钯氢化物核心的阶段(在 0.2 V 上面的+ PdH x @PdH x )(对一个可逆的氢电极)经由 HCOO 便于甲酸盐生产*中间,而阶段 Pd 氢化物核心上的金属性的 Pd 表面的形成( PdH x @主要产品,是甲酸盐或公司,能有选择地与高 Faradaic 效率被生产(>90%) 并且在有可伸缩的申请的 0.05 ~ 0.9 V 的潜在的窗户中的集体活动示范。 | Dunfeng Gao Hu Zhou Fan Cai Dongniu Wang Yongfeng Hu Bei Jiang Wen-Bin Cai Xiaoqi Chen Rui Si Fan Yang Shu Miao Jianguo Wang Guoxiong wang Xinhe Bao | 2017 | Nano Research2017，10，6： | 8 |
| 9 | Autophagy activation by Jiang Zhi Granule protects against metabolic stress-induced hepatocyte injury显示文摘AIM To elucidate the potential role of autophagy and the protective effects of Jiang Zhi Granule(JZG) in metabolic stress-induced hepatocyte injury.METHODS An in vitro and in vivo approach was used in this study. Hep G2 cells were incubated in culture medium containing palmitate(PA; 0, 0.1, 0.2, 0.3, 0.4 or 0.5 mmol/L) and treated with or without JZG(100 μg/m L) for 24 h or 48 h, and the progression of autophagy was visualized by stable fluorescence-expressing cell lines LC3 and p62. Western blot analyses were performed to examine the expression of LC3-Ⅱ/LC3-Ⅰ, p62, m TOR and PI3 K, while mitochondrial integrity and oxidative stress were observed by fluorescence staining of JC-1 and reactive oxygen species. C57 BL/6 mice were divided into three groups: control group(n = 10), high fat(HF) group(n = 13) and JZG group(n = 13); and, histological staining was carried out to detect inflammation and lipid content in the liver.RESULTS The cell trauma induced by PA was aggravated in a dose-and time-dependent manner, and hepatic function was improved by JZG. PA had dual effects on autophagy by activating autophagy induction and blocking autophagic flux. The PI3 K-AKT-m TOR signaling pathway and the fusion of isolated hepatic autophagosomes and lysosomes were critically involved in this process. JZG activated autophagy progression by either induction of autophagosomes or co-localization of autophagosomes and lysosomes as well as degradation of autolysosomes to protect against PA-induced hepatocyte injury, and protected mitochondrial integrity against oxidative stress in PA-induced mitochondrial dysfunction. In addition, JZG ameliorated lipid droplets and inflammation induced by HF diet in vivo, leading to improved metabolic disorder and associated liver injury in a mouse model of non-alcoholic fatty liver disease(NAFLD).CONCLUSION Metabolic stress-induced hepatocyte injury exhibited dual effects on autophagy and JZG activated the entire process, resulting in beneficial effects in NAFLD. | Yi-Yuan Zheng Miao Wang Xiang-Bing Shu Pei-Yong Zheng Guang Ji | 2018 | World Journal of Gastroenterology2018，24，9： | 8 |
| 10 | Detection of k-ras gene point mutation in fine needle aspiration and pancreatic juice by sequence special primer method and its clinical significance显示文摘INTRODUCTIONThe point mutation rate of k-ras gene at codon 12 inpancreatic adenocarcinoma is reported to be as highas 90%,and with no mutations in normalpancreas tissues or other pancreatic disorders.Wehave detected the presence of k-ras gene | Xun Liang Liu Cun Cai Dai Yi Miao Jing Hui Du Zhao Song Zhang Shu Zhen Chen | 2000 | World Journal of Gastroenterology2000，6，6： | 6 |
| 11 | Influence of fuel moisture, charge size, feeding rate and air ventilation conditions on the emissions of PM, OC, EC, parent PAHs, and their derivatives from residential wood combustion显示文摘Controlled combustion experiments were conducted to investigate the influence of fuel charge size, moisture, air ventilation and feeding rate on the emission factors (EFs) of carbonaceous particulate matter, parent polycyclic aromatic hydrocarbons (pPAHs) and their derivatives from residential wood combustion in a typical brick cooking stove. Measured EFs were found to be independent of fuel charge size, but increased with increasing fuel moisture. Pollution emissions from the normal burning under an adequate air supply condition were the lowest for most pollutants, while more pollutants were emitted when an oxygen deficient atmosphere was formed in the stove chamber during fast burning. The impacts of these factors on the size distribution of emitted particles was also studied. Modified combustion efficiency and the four investigated factors explained 68%, 72%, and 64% of total variations in EFs of PM, organic carbon, and oxygenated PAHs, respectively, but only 36%, 38% and 42% of the total variations in EFs of elemental carbon, pPAHs and nitro-PAHs, respectively. | Guofeng Shen Miao Xue Siye Wei Yuanchen Chen Qiuyue Zhao Bing Li Haisuo Wu Shu Tao | 2013 | Journal of Environmental Sciences2013，25，9： | 6 |
| 12 | Clinical practice guidelines for diagnosis and treatment of invasive breast cancer:Chinese Society of Breast Surgery(CSBrS)practice guidelines 2021显示文摘The survival of patients with breast cancer has been greatly improved by comprehensive treatment including surgery,radiotherapy,and systemic treatment,among which surgical treatment remains the mainstay.Breast surgeons must not only master surgical skills but also develop the ability to treat disease comprehensively.To improve the ability of breast surgeons in China to diagnose breast cancer early,perform reasonable surgical treatment,and provide comprehensive treatment orientation,the Chinese Society of Breast Surgery(CSBrS)has reported the key issues in the diagnosis and treatment of invasive breast cancer through opinion collection and expert discussion. | Miao Liu Chao-Bin Wang Fei Xie Yuan Peng Shu Wang Chinese Society of Breast Surgery | 2021 | Chinese Medical Journal2021，，9： | 6 |
| 13 | Enhanced recovery after surgery program in the patients undergoing hepatectomy for benign liver lesions显示文摘Background:Enhanced recovery after surgery(ERAS)has shown effectiveness in terms of reducing the hospital stay and cost.However,the benefit of ERAS in patients undergoing hepatectomy for benign liver lesions is still unclear.Methods:ERAS was implemented in our center since March 1st,2018.From September 2016 to Febru-ary 2018,109 patients were enrolled into the control group,and from March 2018 to June 2019,124 patients were enrolled into the ERAS group.All the indicators related to operation,liver functions,and postoperative outcomes were included in the analysis.Results:The clinicopathologic baselines were similar in these two groups.A significantly higher propor-tion of patients underwent laparoscopic surgery in the ERAS group.On the whole,intraoperative blood loss(100.00 mL vs.200.00 mL,P<0.001),blood transfusion(3.23%vs.10.09%,P=0.033),total bilirubin(17.10μmol/L vs.21.00μmol/L,P=0.041),D-dimer(2.08μg/mL vs.2.57μg/mL,P=0.031),postoperative hospital stay(5.00 d vs.6.00 d,P<0.001),and postoperative morbidity(16.13%vs.32.11%,P=0.008)were significantly shorter or less in the ERAS group than those in the control group.After stratified by operation methods,ERAS group showed significantly shorter postoperative hospital stay in both open and laparoscopic operation(both P<0.001).In patients underwent open surgery,ERAS group demonstrated significantly shorter operative duration(131.76±8.75 min vs.160.73±7.23 min,P=0.016),less intra-operative blood loss(200.00 mL vs.450.00 mL,P=0.008)and less postoperative morbidity(16.00%vs.44.44%,P=0.040).Conclusions:ERAS program may be safe and effective for the patients underwent hepatectomy,especially open surgery,for benign liver lesions. | Jia-Min Zhou Xi-Gan He Miao Wang Yi-Ming Zhao Lian Shu Long-Rong Wang Lu Wang An-Rong Mao | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，2： | 5 |
| 14 | Emissions of parent, nitrated, and oxygenated polycyclic aromatic hydrocarbons from indoor corn straw burning in normal and controlled combustion conditions显示文摘Emission factors(EFs) of parent polycyclic aromatic hydrocarbons(pPAHs), nitrated PAHs(nPAHs), and oxygenated PAHs(oPAHs)were measured for indoor corn straw burned in a brick cooking stove under diferent burning conditions. The EFs of total 28 pPAHs,6 nPAHs and 4 oPAHs were(7.9 ± 3.4),(6.5 ± 1.6)×10 3, and(6.1 ± 1.4)×10 1mg/kg, respectively. Fuel charge size had insignificant influence on the pollutant emissions. Measured EFs increased significantly in a fast burning due to the oxygen deficient atmosphere formed in the stove chamber. In both restricted and enhanced air supply conditions, the EFs of pPAHs, nPAHs and oPAHs were significantly higher than those measured in normal burning conditions. Though EFs varied among diferent burning conditions, the composition profiles and calculated isomer ratios were similar, without significant diferences. The results from the stepwise regression model showed that fuel burning rate, air supply amount, and modified combustion efciency were the three most significant influencing factors, explaining 72%–85% of the total variations. | Guofeng Shen Miao Xue Siye Wei Yuanchen Chen Bin Wang Rong Wang Yan Lv Huizhong Shen Wei Li Yanyan Zhang Ye Huang Han Chen Wen Wei Qiuyue Zhao Bing Li Haisuo Wu Shu Tao | 2013 | Journal of Environmental Sciences2013，25，10： | 5 |
| 15 | The influence of metabolic syndrome on atrial fibrillation recurrence: five-year outcomes after a single cryoballoon ablation procedure显示文摘BACKGROUND Metabolic syndrome(MetS)has been reported as a risk factor of atrial fibrillation(AF)recurrence after radi-ofrequency catheter ablation.This study aimed to investigate the long-term influence of MetS on paroxysmal AF recurrence after a single cryoballoon ablation procedure,which was scarcely investigated yet in Chinese population.METHODS In total,137 paroxysmal AF patients who had successfully completed a single cryoballoon ablation procedure at Fuwai Hospital,Beijing,China from December 2013 to October 2015 were enrolled.Excepting for patients with AF recurrence,all patients were followed up for no less than five years.Independent predictors of AF recurrence were determined by Cox propor-tional hazards regression analysis.RESULTS Among 137 paroxysmal AF patients,91 patients(66.4%)had successfully achieved overall five-year follow-up after a single cryoballoon ablation procedure,and 44 patients(32.1%)had MetS.Patients with MetS had a significant lower incidence of freedom from AF recurrence than those without MetS(50.0%vs.74.2%,log-rank P<0.01)during the five-year follow-up.MetS(HR=1.95,95%CI:1.069−3.551,P=0.030)was an independent predictor of AF recurrence after adjusting for multiple factors.After the second year post cryoballoon ablation procedure,the recurrence rate of AF gradually increased in patients with MetS,in con-trast,decreased recurrence rate of AF in patients without MetS.CONCLUSIONS MetS is an independent predictor for five-year AF recurrence after a single cryoballoon ablation procedure in paroxysmal AF patients.Combination therapy of AF and MetS may improve the long-term outcomes of AF patients. | Yu XIA Xiao-Feng LI Jun LIU Miao YU Pi-Hua FANG Shu ZHANG | 2021 | Journal of Geriatric Cardiology2021，18，12： | 5 |
| 16 | Parathyroid Hormone Contributes to Regulating Milk Calcium Content and Modulates Neonatal Bone Formation Cooperatively with Calcium显示文摘 | Cao, G. F. Gu, Z. Ren, Y. X. Shu, L. Tao, C. X. Karaplis, A. Gohzman, D. Miao, D. S. | 2009 | 南京医科大学学报(自然科学版)2009，29，3： | 4 |
| 17 | A Multi-Scale Urban Atmospheric Dispersion Model for Emergency Management显示文摘To assist emergency management planning and prevention in case of hazardous chemical release into the atmosphere, especially in densely built-up regions with large populations, a multi-scale urban atmospheric dispersion model was established.Three numerical dispersion experiments, at horizontal resolutions of 10 m, 50 m and 3000 m, were performed to estimate the adverse effects of toxic chemical release in densely built-up areas. The multi-scale atmospheric dispersion model is composed of the Weather Forecasting and Research(WRF) model, the Open Source Field Operation and Manipulation software package, and a Lagrangian dispersion model. Quantification of the adverse health effects of these chemical release events are given by referring to the U.S. Environmental Protection Agency's Acute Exposure Guideline Levels. The wind fields of the urban-scale case, with 3 km horizontal resolution, were simulated by the Beijing Rapid Update Cycle system, which were utilized by the WRF model. The sub-domain-scale cases took advantage of the computational fluid dynamics method to explicitly consider the effects of buildings. It was found that the multi-scale atmospheric dispersion model is capable of simulating the flow pattern and concentration distribution on different scales, ranging from several meters to kilometers, and can therefore be used to improve the planning of prevention and response programs. | MIAO Yucong LIU Shuhua ZHENG Hui ZHENG Yijia CHEN Bicheng WANG Shu | 2014 | Advances in Atmospheric Sciences2014，31，6： | 4 |
| 18 | Pharmacological actions of miltirone in the modulation of platelet function显示文摘Salvia miltiorrhiza Bunge contains various active constituents, some of which have been developed as commercially available medicine. Moreover, some other ingredients in Salvia miltiorrhiza play roles in anti-platelet activity. The aim of the present study was to investigate the effects and the underlying mechanism of miltirone, a lipophilic compound of Salvia miltiorrhiza Bunge. The ability of miltirone to modulate platelet function was investigated by a variety of in vitro and in vivo experiments. Platelet aggregation and dense granule secretion induced by various agonists were measured with platelet aggregometer. Clot retraction and spreading were imaged by digital camera and fluorescence microscope. Ferric chloride-induced carotid injury model and pulmonary thromboembolism model were used to check miltirone antithrombotic effect in vivo. To elucidate the mechanisms of anti-platelet activity of miltirone, flow cytometry and western blotting were performed. Miltirone (2, 4, 8μM) was shown to suppress platelet aggregation, dense granule, and α granule secretion in a dose-dependent manner. Meanwhile, miltirone inhibited the clot retraction and spreading of washed platelets. It reduced the phosphorylation of PLCγ2, PKC, Akt, GSK3β and ERK1/2 in the downstream signal pathway of collagen receptor. It also reduced the phosphorylation of Src and FAK in the integrin αIIbβ3-mediated “outside-in” signaling, while it did not suppress the phosphorylation of β3. In addition, miltirone prolonged the occlusion time and reduced collagen/epinephrine-induced pulmonary thrombi. Miltirone suppresses platelet “inside-out” and “outside-in” signaling by affecting PLCγ2/PKC/ERK1/2, PI3K/Akt, and Src/FAK signaling. Therefore, miltirone might represent a potential anti-platelet candidate for the prevention of thrombotic disorders. | Wei Song Yuan-yuan Ma Shuo Miao Ru-ping Yang Ying Zhu Dan Shu Meng Lu Rong Ma Zhang-yin Ming | 2019 | Acta Pharmacologica Sinica2019，40，2： | 3 |
| 19 | B/S Brace as an Alternative Treatment for Ingrown Toenails显示文摘 | Fei Miao Shu Nie Hong-Wei Wang | 2018 | Chinese Medical Journal2018，，19： | 3 |
| 20 | Influence of fuel mass load,oxygen supply and burning rate on emission factor and size distribution of carbonaceous particulate matter from indoor corn straw burning显示文摘The uncertainty in emission estimation is strongly associated with the variation in emission factor (EF),which could be influenced by a variety of factors such as fuel properties,stove type,fire management and even methods used in measurements.The impacts of these factors are complicated and often interact with each other.Controlled burning experiments were conducted to investigate the influences of fuel mass load,air supply and burning rate on the emissions and size distributions of carbonaceous particulate matter (PM) from indoor corn straw burning in a cooking stove.The results showed that the EFs of PM (EFPM),organic carbon (EFOC) and elemental carbon (EFEC) were independent of the fuel mass load.The differences among them under different burning rates or air supply amounts were also found to be insignificant (p > 0.05) in the tested circumstances.PM from the indoor corn straw burning was dominated by fine PM with diameter less than 2.1 μm,contributing 86.4%±3.9% of the total.The size distribution of PM was influenced by the burning rate and air supply conditions.On average,EF PM,EF OC and EF EC for corn straw burned in a residential cooking stove were (3.84±1.02),(0.846±0.895) and (0.391±0.350) g/kg,respectively.EF PM,EF OC and EF EC were found to be positively correlated with each other (p < 0.05),but they were not significantly correlated with the EF of co-emitted CO,suggesting that special attention should be paid to the use of CO as a surrogate for other incomplete combustion pollutants. | Guofeng Shen Miao Xue Siye Wei Yuanchen Chen Bin Wang Rong Wang Huizhong Shen Wei Li Yanyan Zhang Ye Huang Han Chen Wen Wei Qiuyue Zhao Bin Li Haisuo Wu Shu Tao | 2013 | Journal of Environmental Sciences2013，25，3： | 3 |
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