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| 1 | 周期性机械拉伸对类风湿关节炎和骨关节炎成纤维样滑膜细胞BMP-2表达的影响显示文摘目的研究周期性拉伸对类风湿关节炎(rheumatoid arthritis,RA)和骨关节炎(osteoarthritis,OA)成纤维样滑膜细胞(fibroblast-like synoviocytes,FLS)中骨形态发生蛋白-2(bone morphogenetic protein-2,BMP-2)表达的影响,探讨力学刺激在不同病理过程中对滑膜组织的作用。方法在正常条件和炎症条件下使用Flex cell 4000周期性力学加载系统,分别对正常、RA、OA来源的人膝关节FLS施加连续2 h和6 h的6%、0.5 Hz的拉应力,比较测定BMP-2 mRNA表达的差异性。结果 2 h的机械拉伸对3种FLS中BMP-2 mRNA的水平均无显著性影响6,h的机械拉伸能够显著升高RA FLS中BMP-2 mRNA的水平。炎症因子(IL-1β)作用2 h对正常FLS无显著影响,作用6 h使其中BMP-2 mRNA的水平显著升高;IL-1β作用2 h和6 h均使RA FLS中BMP-2 mRNA的水平显著升高,但只有作用2 h才使OA FLS中BMP-2 mRNA的水平显著升高,作用6 h对OA FLS中BMP-2 mRNA的水平无显著影响;炎症因子和力学刺激共同作用2 h使正常和RA FLS中BMP-2 mRNA的水平显著升高,作用6 h使正常、RA、OAFLS中BMP-2 mRNA水平均显著升高。结论正常、RA、OA FLS中BMP-2 mRNA对于力学刺激和炎症因子的响应不同,结果提示在RA和OA发病机制中,炎症因子的影响可能比力学刺激更强;力学刺激和IL-1β共同作用6 h后对OA FLS中BMP-2 mRNA产生协同效应,提示两者联合作用对OA病情发展具有一定作用。 | 周薇 吕永钢 Gurinder K Singh 颜艳 刘万钱 杨宁宁 张非飞 杨力 | 2011 | 医用生物力学2011，26，2： | 6 |
| 2 | Correlation between the proportion of breast volume involved by locally advanced tumors and invasion of the skin and posterior structures显示文摘AIM: To evaluate any differences between the percentages of involved breast volume, pathologic attributes,and tumor marker expression of T3 and T4a-c tumors in locally advanced breast cancers(BC).METHODS: All patients with T3 N > 0 and T4a-c BC without evidence of distant metastasis(M0), presenting to the Breast Clinic from 1980 to 2010, were examinedto determine whether their BC's involved ≥ 50% of their breast volumes, defined by gross replacement of at least one hemisphere. Core needle biopsy or postmastectomy specimens from tumors involving a known percent of breast volume were evaluated for:(1)pathological grades and lympho-vascular invasion(LVI);(2) hormone receptor(ER/PR) expression > 0; and(3)epidermoid growth factor 2(her2) over-expression(3+)by immune-histochemical staining or fluorescent in situ hybridization.RESULTS: The data base included 98 patients with T3N> 0 M0 and 120 with T4a-c, any N disease, M0 disease. T3 tumor masses involved 50% or more of the breast in 23/98(24%), and T4a-c tumors 65/120(54%)(P < 0.001). Only 1% of T3 tumors and 23% of T4a-c tumors presented with total breast replacement. There were no significant differences between the pathological attributes and marker expression of the T3 and T4a-c tumors.CONCLUSION: These data suggest that erosion of the overlying skin or underlying chest wall by some BC may be due to neglect and delay, rather than inherent biological aggressiveness. | Parastoo B Dahi Komal P Dhiran Constantine A Axiotis Jeremy Weedon Mahmoud El-Tamer Gurinder Sidhu Albert S Braverman | 2012 | World Journal of Clinical Oncology2012，3，3： | 2 |
| 3 | Simultaneous determination of nine flavonoids in Polygonum hydropiper L. samples using nanomagnetic powder three-phase hollow fibre-based liquid-phase microextraction combined with ultrahigh performance liquid chromatography–mass spectrometry显示文摘 | Xian Yang Bo-Chu Wang Xue Zhang Shui-Ping Yang Wei Li Qian Tang Gurinder K. Singh | 2010 | Journal of Pharmaceutical and Biomedical Analysis2010，，2： | 1 |
| 4 | Recent advances of resveratrol in nanostructured based delivery systems and in the management of HIV/AIDS显示文摘 | GURINDER S PAI S R | 2014 | Journal of Controlled Release2014，194，： | 1 |
| 5 | Investigation of structural,physical and optical proper-ties of CeO2-Bi2O3-B2O3 glasses显示文摘 | Gurinder Pal Singh Parvinder Kaur Simranpreet Kaur etal | 2012 | Physica B2012，407，： | 1 |
| 6 | Fast track anesthesia for liver transplantation reduces postoperative ventilation time but not intensive care unit stay显示文摘 | James Y. Findlay Christopher J. Jankowski Gurinder M. Vasdev Robert C. Chantigian Bhargavi Gali Gerard S. Kamath Mark T. Keegan Brian A. Hall Keith A. Jones Christopher M. Burkle David J. Plevak | 2002 | Liver Transplantation2002，，8： | 1 |
| 7 | Structural and optical properties of WO3-PbO-B2O3 glass-ceramic显示文摘 | Gurinder Pal Singh Singh D P | | 0，，04： | 1 |
| 8 | Properties of a thermostable extracellular lipase from Bacillus megaterium AKG‐1显示文摘 | AnuragSekhon NeetuDahiya Ram P.Tiwari Gurinder S.Hoondal | 2005 | J Basic Microbiol2005，，2： | 1 |
| 9 | Biotechnological aspectsof chitinolytic enzymyces:a review显示文摘 | Neetu D?Rupinder T Gurinder S H | 2006 | Appl Microbiol Biotech-nol2006，71，： | 1 |
| 10 | Response surfacemethodology and process optimization of sustained release pellets using Taguchi orthogonal array design and central composite design 显示文摘 | Gurinder S Roopa S P Kusum V D | 2012 | J Adv Pharm Tech Res2012，3，1： | 1 |
| 11 | Evaluation of Lysimachia christinae Hance extracts as anticholecystitis and cholagogic agents in animals显示文摘 | Xian Yang Bo-Chu Wang Xue Zhang Wei-Qi Liu Jun-Zhen Qian Wei Li Jia Deng Gurinder K. Singh Hui Su | 2011 | Journal of Ethnopharmacology2011，，1： | 1 |
| 12 | Editorial:cataract surgery in the legally blind显示文摘In the United States,a patient is‘legally blind’if the best corrected vision in‘both eyes’is 20/200(0.1)or less or the peripheral visual field is less than 20°from the central fixation(1).It could be from advanced glaucoma,opaque cornea,amblyopia,cataract,macular degeneration,severe retinitis pigmentosa,retinal detachment,optic neuritis,conerod dystrophies,and/or chorio-retinal degenerations,etc.Legally blind are considered‘visually handicapped’.While some of these patients are‘functional’in their familiar surroundings,but most lose their‘independence’even in daily life activities.That has detrimental effect on their psychological wellbeing.They feel helpless and burden on their families and the society. | Gurinder Singh | 2022 | Annals of Eye Science2022，，3： | 0 |
| 13 | Impact of surgical incision on corneal curvature and corneal astigmatism in cataract surgery显示文摘This editorial in response to the published article titled“Changes in corneal curvature and aberrations after cataract surgery”by Dai,Ruan,and Wang et al.(1)is to reflect back on the evolution of cataract surgery.We started with the basic procedure of‘couching’to restore vision in blind eyes caused by mature or hypermature cataracts(2).Next came the procedure of‘intra-capsular cataract removal’with 180°corneo-scleral incision using von-Graefe’s knife,initially without any suture closure of the wound that followed by suturing the wound.Aphakic corrective glasses would suffice to restore‘functional vision’in those early days of cataract surgery. | Gurinder Singh | 2023 | Annals of Eye Science2023，，1： | 0 |
| 14 | 需求推动创新 基于USB的家电自动化设计显示文摘近年来,通用串行总线(Universal Serial Bus,USB)的使用为家电自动化引入了一种更为简单的实现途径。本文介绍了建立在USB基础之上的、创新的家电自动化应用,并以基于USB的照明控制为例,讲解了基于USB的家电自动化的基础知识。最后,本文比较了USB和其他用于家电自动化的主流无线技术(如ZigBee通信协议和Bluetooth无线通信协议等)的异同。 | Gurinder Singh | 2006 | 电子测试(新电子)2006，，12： | 0 |
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