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| 1 | Differential effects on apoptosis induction in hepatocyte lines by stable expression of hepatitis B virus X protein显示文摘瞄准:肝炎 B 蛋白质 X (HBx ) 被显示了是弱 oncogenic 在试管内。HBx 的转变活动与肿瘤的功能压制的几的抑制或 p53 被连接了。我们学习了 HBx 是否可以在取决于房间类型的 p53 上有不同效果。方法:我们使用了人的肝细胞瘤房间线 HepG2 和使不朽的鼠科的 hepatocyte 线 AML12 并且稳定地分析了表示了 HBx 的生理的数量的 transfected 克隆。P53 被紫外照耀导致。结果:由紫外照耀的 p53 正式就职由 HBx 的稳定的表示是未受影响的。然而,变得被 p53 激活的 cyclin 激酶禁止者 p21 (waf/cip/sdi ) 的表示在 HBx 被影响转变房间线 AML12-HBx9,然而并非在 HepG2。在 AML-HBx9,房间, p21 (waf/cip/sdi ) 蛋白质表示和 p21 (waf/cip/sdi ) 抄写是 deregulated。而且, apoptosis 的过程在调查的二根房间线以相反的方法被影响。当 HBx 的稳定的表示提高了紫外照耀在 HepG2 房间导致的 apoptosis 时, apoptosis 在 HBx 被减少转变 AML12-HBx9。P53 镇压了从 HBV enhancer 的抄写我,当由紫外照耀从表示向量或在内长的 p53 的正式就职以后表示了时。由内长的 p53 的压抑由在两根房间线的稳定地表示的 HBx 部分是可逆的。结论:HBx 的稳定的表示导致取决于使用的房间线的紫外照耀导致的 apoptosis 的解除管制。而在癌的表示导出 hepatocyte 线 HBx,在一根使不朽的 hepatocyte 线, HBx 扮演了 anti-apoptotic 提高的 apoptosis。 | Nicola Fiedler Ellen Quant Ludger Fink Jianguang Sun Ralph Schuster Wolfram H Gerlich Stephan Schaefer | 2006 | World Journal of Gastroenterology2006，12，29： | 8 |
| 2 | Use of shear wave elastography for the diagnosis and follow-up of biliary atresia: A meta-analysis显示文摘BACKGROUND Timely differentiation of biliary atresia(BA)from other infantile cholestatic diseases can impact patient outcomes.Additionally,non-invasive staging of fibrosis after Kasai hepatoportoenterostomy has not been widely standardized.Shear wave elastography is an ultrasound modality that detects changes in tissue stiffness.The authors propose that the utility of elastography in BA can be elucidated through meta-analysis of existing studies.AIM To assess the utility of elastography in:(1)BA diagnosis,and(2)post-Kasai fibrosis surveillance.METHODS A literature search identified articles that evaluated elastography for BA diagnosis and for post-Kasai follow-up.Twenty studies met criteria for meta-analysis:Eleven for diagnosis and nine for follow-up post-Kasai.Estimated diagnostic odds ratio(DOR),sensitivity,and specificity of elastography were calculated through a random-effects model using Meta-DiSc software.RESULTS Mean liver stiffness in BA infants at diagnosis was significantly higher than in non-BA,with overall DOR 24.61,sensitivity 83%,and specificity 79%.Post-Kasai,mean liver stiffness was significantly higher in BA patients with varices than in patients without,with DOR 16.36,sensitivity 85%,and specificity 76%.Elastography differentiated stage F4 fibrosis from F0-F3 with DOR of 70.03,sensitivity 96%,and specificity 89%.Elastography also differentiated F3-F4 fibrosis from F0-F2 with DOR of 24.68,sensitivity 85%,and specificity 81%.CONCLUSION Elastography has potential as a non-invasive modality for BA diagnosis and surveillance post-Kasai.This paper’s limitations include inter-study method heterogeneity and small sample sizes.Future,standardized,multi-center studies are recommended. | Ellen S Wagner Hussien Ahmed H Abdelgawad Meghan Landry Belal Asfour Mark B Slidell Ruba Azzam | 2022 | World Journal of Gastroenterology2022，28，32： | 5 |
| 3 | Photochemical internalization (PCI) of immunotoxins targeting CD133 is specific and highly potent at femtomolar levels in cells with cancer stem cell properties显示文摘 | Monica Bostad Kristian Berg Anders H?gset Ellen Skarpen Harald Stenmark P?l K. Selbo | 2013 | Journal of Controlled Release2013，，3： | 4 |
| 4 | Interval Training Normalizes Cardiomyocyte Function, Diastolic Ca2+ Control, and SR Ca2+ Release Synchronicity in a Mouse Model of Diabetic Cardiomyopathy显示文摘 | Tomas O. St?len Morten Andre H?ydal Ole Johan Kemi Daniele Catalucci Marcello Ceci Ellen Aasum Terje Larsen Natale Rolim Gianluigi Condorelli Godfrey L. Smith Ulrik Wisl?ff | 2009 | Circulation Research2009，，6： | 2 |
| 5 | Post stroke depression: epidemiology, pathophysiology, and biological treatment显示文摘 | Ellen M Whyte Benoit H Mulsant | 2002 | Biological Psychiatry2002，，： | 2 |
| 6 | Post-stroke depression:epidemiology, pathophysiology, and biological treatment 显示文摘 | Ellen M Whyte Benoit H et al | 2002 | Society of Biological Psychiatry2002，52，： | 1 |
| 7 | Self - management program improves anticoaglation control and quality of life : A prospective randomized study 显示文摘 | Mohamed A Soliman H Ellen Van E | 2009 | Eur J Cardiothorac Surg2009，35，2： | 1 |
| 8 | Application of shrubs for den- drogeomorphological analysis显示文摘 | Ellen G Florin N Gartner H | 2001 | Geomorphology2001，125，： | 1 |
| 9 | Dental fear and anxiety levels of patients attending a dental clinic 显示文摘 | Ellen H Akarslan ZZ Bodrumlu E | 2006 | Quintessence Int2006，37，4： | 1 |
| 10 | Moral distress of staff nurses in a medical intensive care unit显示文摘 | Ellen H Elpern Barbara Covert | 2005 | American Journal of Critical Care2005，14，6： | 1 |
| 11 | Balloon kyphoplasty: continuing evidence of efficacy in treating vertebral collapse and fracture 显示文摘 | Ellen H | 2007 | J Bone Joint Surg (Am)2007，13，6： | 1 |
| 12 | Pl&tetet &lloimmuniz&tion &fter transf- usion显示文摘 | Ellen T Anne CS Erik H et &l | 1977 | Vox 9&ng1977，72，： | 1 |
| 13 | Rainfall Conditions for A- bundant Debris Avalanches in the San Francisco Bay Region显示文摘 | Cannon S H Ellen S D | 1985 | California Geol1985，38，12： | 1 |
| 14 | Evaluation of a fully covered self-ex- pandable metal stent in liver transplant patients with bile leaks : mid-term analysis 显示文摘 | Phillips M S Saue B Bonatti H Rehan M E Smith L A Ellen K | 2009 | Gastrointest Endosc2009，69，： | 1 |
| 15 | Physiological considerations in the design of particulate dosage forms for oral vaccine delivery显示文摘 | Yeh PY Ellens H Smith PL | 1998 | Adv Drug Deliv Rev1998，34，： | 1 |
| 16 | Membrane fusion: kinetics and mechanisms显示文摘 | Bentz J Ellens H | 1988 | Colloids Surfaces1988，30，： | 1 |
| 17 | Differential regulation of right and left ;entriculax β-adrenergic receptors in newborolambs with experimenntal cyanoticheart disease显示文摘 | Ellen V Shella H | 1990 | J Clin Invest1990，85，1： | 1 |
| 18 | 16 MDCT angiography of aortoiliac and lower extremity arteries:comparison with digital subtraction angiography显示文摘 | Thomas A Ellen F Robin H | 2007 | AmJ Roentgenol2007，189，3： | 1 |
| 19 | Quorum sensing and bio- film formation in streptococcal infections 显示文摘 | Cvitkovitch D G Li Y H Ellen R P | 2003 | J of Clinic Inves- tation2003，112，11： | 1 |
| 20 | Self - manage- ment program improves anticoaglation control and quality of life: A prospective randomized study显示文摘 | Mohamed A Soliman H Ellen Van E | 2009 | Eur J Cardiothorac Surg2009，35，2： | 1 |
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