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| 1 | 世界家庭医生组织(WONCA)研究论文摘要汇编——如何改进欧洲国家的全科医学/家庭医学发展状况:来自30个欧洲国家专家的建议显示文摘背景对全科医学/家庭医学(GP/FM)的管理、GP/FM医务人员能力、GP/FM服务开展状况、GP/FM学术发展及地位在欧洲各国存在很大的差异。世界卫生组织鼓励各国政府为其国民提供高质量的GP/FM服务,因为这是实现'人人健康'目标的必要条件。本研究旨在调查欧洲家庭医师组织协会(EURACT)成员就如何改进其所在国家的GP/FM的地位而提出建议。方法本研究使用了混合方法及探索性序列设计方案。来自32个欧洲国家的EURACT成员首次参加了在欧洲举行的如何改进GP/FM发展状况的头脑风暴活动。随后,由来自37个欧洲国家的代表使用利克特量表(9个条目)就EURACT代表提出的建议在其所在国家是否可行进行评分并加权计算,同时对其所在国家的GP/FM发展状况以4个维度来进行评价。结果有来自30个欧洲国家的代表完成了所有调查。研究对象一致认为,不管GP/FM在其国家目前发展状况如何,非常有必要确保将GP/FM建立一门在教学和科研方面并举发展的学科。来自将GP/FM视为非常重要或重要的国家的研究对象认为,将GP/FM现有发展水平提高到其他学科同等水平,此举非常重要。来自不重视GP/FM的国家代表称,已强调了设立共同学习目标并规定了参考书目。结论为了改进欧洲的GP/FM发展状况,EURACT及其他专业机构必须设立共同目标,欧洲各国应共享GP/FM专业知识。此外,让决策者了解GP/FM服务体系的成本效益也非常重要。 | ZARBAILOV N WILM S TANDETER H 本刊编辑部 | 2017 | 中国全科医学2017，20，29： | 7 |
| 2 | 肠道菌群促进血管紧张素Ⅱ诱导的高血压和血管功能障碍显示文摘肠道微生物对宿主生理反应及对免疫功能的发展来说必不可少。肠道菌群对血压和全身血管功能等这些由免疫细胞功能决定的生理过程的影响知之甚少。方法:与常规饲养的小鼠(conventionally raised rats,CONV-R)比较,未受任何细菌影响的无菌小鼠(GF)表现出较为严重的全身性辅助性T细胞1型滞后。 | 刘莉 叶鹏 Karbach SH Schnfelder T Brandao I Wilms E Hrmann N Jckel S Schüler R Finger S Knorr M Lagrange J Brandt M Waisman A Kossmann S Schüfer K Münzel T Reinhardt C Wenzel P | 2016 | 中华高血压杂志2016，24，10： | 5 |
| 3 | Single-operator cholangioscopy for biliary complications in liver transplant recipients显示文摘AIM To evaluate cholangioscopy in addition to endoscopic retrograde cholangiopancreatography(ERCP) for management of biliary complications after liver transplantation(LT).METHODS Twenty-six LT recipients with duct-to-duct biliary reconstruction who underwent ERCP for suspected biliary complications between April and December2016 at the university hospital of Muenster were consecutively enrolled in this observational study. After evaluating bile ducts using fluoroscopy, cholangioscopy using a modern digital single-operator cholangioscopy s y s t e m(S py G la s s D S ?) wa s pe r fo r me d dur ing the same procedure with patients under conscious sedation. All patients received peri-interventional antibiotic prophylaxis and bile was collected during the intervention for microbial analysis and for antibiotic susceptibility testing.RESULTS Thirty-three biliary complications were found in a total of 22 patients, whereas four patients showed normal bile ducts. Anastomotic strictures were evident in 14(53.8%) patients, non-anastomotic strictures in seven(26.9%), biliary cast in three(11.5%), and stones in six(23.1%). A benefit of cholangioscopy was seen in 12(46.2%) patients. In four of them, cholangioscopy was crucial for selective guidewire placement prior to planned intervention. In six patients, biliary cast and/or stones failed to be diagnosed by ERCP and were only detectable through cholangioscopy. In one case, a bile duct ulcer due to fungal infection was diagnosed by cholangioscopy. In another case, signs of bile duct inflammation caused by acute cholangitis were evident. One patient developed post-interventional cholangitis. No further procedure-related complications occurred. Thirty-seven isolates were found in bile. Sixteen of these were gram-positive(43.2%), 12(32.4%) were gram-negative bacteria, and Candida species accounted for 24.3% of all isolated microorganisms. Interestingly, only 48.6% of specimens were sensitive to prophylactic antibiotics.CONCLUSION Single-operator cholangioscopy can provide important diagnostic information, helping endoscopists to plan and perform interventional procedures in LT-related biliary complications. | Anna Hüsing-Kabar Hauke Sebastian Heinzow Hartmut Hans-Jürgen Schmidt Carina Stenger Hans Ulrich Gerth Michele Pohlen Gerold Tholking Christian Wilms Iyad Kabar | 2017 | World Journal of Gastroenterology2017，23，22： | 4 |
| 4 | Paclitaxel-eluting balloon dilation of biliary anastomotic stricture after liver transplantation显示文摘AIM:To investigate the safety and effectiveness of endoscopic therapy with a paclitaxel-eluting balloon(PEB) for biliary anastomotic stricture(AS) after liver transplantation(LT).METHODS:This prospective pilot study enrolled 13 consecutive eligible patients treated for symptomatic AS after LT at the University Hospital of Münster between January 2011 and March 2014.The patients were treated by endoscopic therapy with a PEB and followed up every 8 wk by endoscopic retrograde cholangiopancreatography(ERCP).In cases of re-stenosis,further balloon dilation with a PEB was performed.Follow-up was continued until 24 mo after the last intervention.RESULTS:Initial technical feasibility,defined as successful balloon dilation with a PEB during the initial ERCP procedure,was achieved in 100% of cases.Long-term clinical success(LTCS),defined as no need for further endoscopic intervention for at least 24 mo,was achieved in 12 of the 13 patients(92.3%).The mean number of endoscopic interventions required to achieve LTCS was only 1.7 ± 1.1.Treatment failure,defined as the need for definitive alternative treatment,occurred in only one patient,who developed recurrent stenosis with increasing bile duct dilatation that required stent placement.CONCLUSION:Endoscopic therapy with a PEB is very effective for the treatment of AS after LT,and seems to significantly shorten the overall duration of endoscopic treatment by reducing the number of interventions needed to achieve LTCS. | Anna Hüsing Holger Reinecke Vito R Cicinnati Susanne Beckebaum Christian Wilms Hartmut H Schmidt Iyad Kabar | 2015 | World Journal of Gastroenterology2015，21，3： | 4 |
| 5 | Orbitalcavernoushemangioma : findings on sequential Gd-enhanced MRI 显示文摘 | Wilms G Raat H Dom R | 1995 | J Comput Assist Tomogr1995，19，： | 1 |
| 6 | Inflammation in Parkinson's diseases and other neurodegenerative diseases: cause and therapeutic implications显示文摘 | Wilms H Zecca L Rosenstiel P | 2007 | Curr Pharm Des2007，13，18： | 1 |
| 7 | Orbital cavernous hemangioma: find- ings on sequential Gd-enhanced MRI 显示文摘 | Wilms G Raat H Dom R | 1995 | J Comput Assist Tomogr1995，19，4： | 1 |
| 8 | Activation of microglia by human neuromelanin is NF-kappaB dependent and involves p38 mitogen-activated protein kinase: implications for Parkinson' s disease 显示文摘 | Wilms H Rosenstiel P Sievers J | 2003 | FASEB J2003，17，3： | 1 |
| 9 | mRNA silencing in erythroid differentiation:hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3 'end显示文摘 | Ostareck D H Ostareck-Lederer A Wilm M | 1997 | Cell1997，89，： | 1 |
| 10 | Deep biosphere-related bacteria within the subsurface of tidal flat sediments 显示文摘 | Wilms R Kopke B Sass H | 2006 | Environ Microbiol2006，8，： | 1 |
| 11 | Pax1 and Pax9 syner- gistically regulate vertebral column development显示文摘 | Peters H Wilm B Sakai N | 1999 | De veloprnent1999，126，23： | 1 |
| 12 | Application of a wireless resonance frequency transducer to assess primary stability of orthodontic mini-implants: an in vitro study in pig ilia显示文摘 | Su YY Wilmes B Hö nscheid R | 2009 | Int J Oral Maxillofac Implants2009，24，4： | 1 |
| 13 | Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A显示文摘 | HARADA H BECKNELL B WILM M | 1999 | Mol Cell1999，3，4： | 1 |
| 14 | Activation of microglia by human neuromelanin is NF-kappaB dependent and involves p38 mitogen-activated protein kinase: implications for Parkinson's disease显示文摘 | Wilms H Rosentiel P Sievers J | 2003 | FASEB J2003，17，： | 1 |
| 15 | Echocontrast-enhanced transcranial ultrasound:frequency of use,diagnostic benefit,and validity of results compared with MRA显示文摘 | Zunker P Wilms H Brossmann J | 2002 | Stroke2002，33，11： | 1 |
| 16 | Editorial:Determinants of synaptic information transfer:from Ca2+binding proteins to Ca2+signaling domains显示文摘 | Isope P Wilms CD Schmidt H | 2016 | Front Cell Neurosci2016，10，： | 1 |
| 17 | Development of a European Combined Geodetic Network (ECGN) 显示文摘 | IHDE J T BAKER C BRUYNINX O FRANCIS M AMALVICT A KENYERES J MAKINEN S SHIPMAN J SIMEK H WILMES | 2005 | J Geodynamics2005，40，： | 1 |
| 18 | Involvement of benzodiazepine receptors in neuroinflammatory and neurodegenerative diseases:evidence from activated microglial cells in vitro显示文摘 | Wilms H Claasen J Rohl C | 2003 | Neurobiol Dis2003，14，3： | 1 |
| 19 | mRNA silencing in erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3' End 显示文摘 | Ostareck D H Ostareck-Lederer A Wilm M | 1997 | Cell1997，89，4： | 1 |
| 20 | Inflammation in Par- kinson's diseases and other neurodegenerative diseases: cause and therapeutic implications 显示文摘 | Wilms H Zecca L Rosenstie | 2007 | Curr Pharm Des2007，13，18： | 1 |
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