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| 1 | T2期胆囊癌肿瘤位置和手术范围对预后的影响:一项国际多中心研究显示文摘T2期胆囊癌根据肿瘤位置不同,进一步细分为T2a(腹膜侧)或T2b期(肝脏侧)。既往有研究认为对于腹膜侧(T2a)肿瘤,在不影响预后的情况下可避免肝脏切除,但是目前仍然缺乏可靠的证据。为了探讨肿瘤位置对T2期胆囊癌的预后价值并明确手术切除的适当范围,该研究分析了韩国、日本、智利和美国的14家医院中937例接受胆囊癌手术患者的临床及病理资料。 | Kwon W Kim H Han Y 杨发才(编译) | 2020 | 中华医学杂志2020，100，39： | 21 |
| 2 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 3 | Power management unit chip design for automobile active-matrix organic light-emitting diode display module显示文摘A power management unit (PMU) chip supplying dual panel supply voltage, which has a low electro-magnetic interference (EMI) characteristic and is favorable for miniaturization, is designed. A two-phase charge pump circuit using external pumping capacitor increases its pumping current and works out the charge-loss problem by using bulk-potential biasing circuit. A low-power start-up circuit is also proposed to reduce the power consumption of the band-gap reference voltage generator. And the ring oscillator used in the ELVSS power circuit is designed with logic devices by supplying the logic power supply to reduce the layout area. The PMU chip is designed with MagnaChip’s 0.25 μm high-voltage process. The driving currents of ELVDD and ELVSS are more than 50 mA when a SPICE simulation is done. | KIM J H PARK J H KIM J H CAO T V LEE T Y BAN H J YANG K KIM H G HA P B KIM Y H | 2009 | Journal of Central South University2009，16，4： | 4 |
| 4 | 青年人群单纯收缩期或舒张期高血压的心血管病风险显示文摘根据2017年美国心脏病学院/美国心脏协会高血压指南定义,在1级高血压青年人群中,关于单纯收缩期高血压(isolated systolic hypertension,ISH)、单纯舒张期高血压(isolated diastolic hypertension,IDH)或收缩期和舒张期高血压(systolic and diastolic hypertension,SDH)相关的健康预后知之甚少。方法:在全国健康筛查数据库中. | 刘青(译) 刘莉(校) Lee H Yano Y Cho SMJ Park JH Park S Lloyd-Jones DM Kim HC | 2020 | 中华高血压杂志2020，28，8： | 3 |
| 5 | The growth of brain tumors can be suppressed by multiple transplantation of mesenchymal stem cells expressing cytosine deaminase显示文摘Suicide genes have recently emerged as an attractive alternative therapy for the treatment of various types of intractable cancers.The efficacy of suicide gene therapy relies on efficient gene delivery to target tissues and the localized concentration of final geneproducts. | Chang DY Yoo SW Hong Y Kim S Kim SJ Yoon SH Cho KG Paek SH Lee YD Kim SS Suh-Kim H | 2010 | 中国神经肿瘤杂志2010，8，2： | 3 |
| 6 | 干骺端固定解剖型非骨水泥柄结合陶瓷对陶瓷全髋关节置换治疗30岁以下患者的临床结果显示文摘年轻患者全髋关节置换手术方式还存在争议。作者分析了96例(127髋)30岁以下患者采用干骺端固定解剖型非骨水泥柄结合陶瓷对陶瓷全髋关节置换的治疗结果。随访10~16年,Harris评分、WOMAC评分、UCLA评分分别为95、16、8分。手术1年后,没有发生疼痛,所有股骨柄均未发现松动。无关节异响、陶瓷碎裂、松动以及骨溶解等并发症。因此作者认为, | Kim Y H Park J W Kim J S 胡孔足 | 2012 | 临床骨科杂志2012，15，5： | 3 |
| 7 | Fault detection method with PCA and LDA and its application to induction motor显示文摘A feature extraction and fusion algorithm was constructed by combining principal component analysis(PCA) and linear discriminant analysis(LDA) to detect a fault state of the induction motor.After yielding a feature vector with PCA and LDA from current signal that was measured by an experiment,the reference data were used to produce matching values.In a diagnostic step,two matching values that were obtained by PCA and LDA,respectively,were combined by probability model,and a faulted signal was finally diagnosed.As the proposed diagnosis algorithm brings only merits of PCA and LDA into relief,it shows excellent performance under the noisy environment.The simulation was executed under various noisy conditions in order to demonstrate the suitability of the proposed algorithm and showed more excellent performance than the case just using conventional PCA or LDA. | JUNG D Y LEE S M 王洪梅 KIM J H LEE S H | 2010 | Journal of Central South University2010，17，6： | 3 |
| 8 | 绝望中寻找希望:肿瘤多药耐药的新选择显示文摘【据《JMed Chem》2014年9月报道】题:水溶性与可裂解的槲皮素氨基酸偶联物可作为以P糖蛋白为基础的肿瘤多药耐药调节剂(作者Kim MK等) | 康晓征 Kim MK Choo H Chong Y | 2014 | 中华普通外科学文献(电子版)2014，8，6： | 2 |
| 9 | Methyloxime-substituted aminopyrrolidine: A new surrogate for 7-basic group of quinolone 显示文摘 | Hong C Y Kim Y K Lee Y H | 1998 | Bioorg Med Chem Lett1998，，8： | 2 |
| 10 | All-optical clock recovery from NRZ data with simple NRZ-to-PRZ converter based on self-modulation of semiconductor optical amplifier显示文摘 | Lee H J Kim H G Choi J Y | 1999 | Electronics Letters1999，35，12： | 2 |
| 11 | Expansion of Active Site Area and Improvement of Kinetic Reversibility in Electrochemical Pseudocapacitor Electrode显示文摘 | Lee H Y Kim S W | 2001 | Electrochemical and Solid-state Letters2001，4，3： | 2 |
| 12 | Learning approach to control of servomotors under disturbance torque dependent on time and staes 显示文摘 | KIM Y H HANS H CHO S H | 1998 | IEE Proc-D: Control Theory and Applications1998，145，3： | 2 |
| 13 | 在有煽动性、非煽动性的腹的疼痛显型的孩子的 interleukin-6 和桅杆房间的反的关系显示文摘 AIM: To investigate interleukin-6 (IL-6), mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P in the gastrointestinal mucosa of children with abdominal pain. METHODS: Formalin-fixed paraffin-embedded gas-trointestinal biopsy blocks from patients (n = 48) with non-inflammatory bowel disease (irritable bowel syndrome and functional abdominal pain) and inflammatory bowel disease were sectioned and stained for IL-6, mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P. All children had chronic abdominal pain as part of their presenting symptoms. Biopsy phenotype was confirmed by a pathologist, blinded to patient information. Descriptive statistics, chi-square, and independent sample t tests were used to compare differences between the inflammatory and non-inflammatory groups. RESULTS: The cohort (n = 48), mean age 11.9 years (SD = 2.9), 54.2% females, 90% Caucasian, was comprised of a non-inflammatory (n = 26) and an inflammatory (n = 22) phenotype. There was a significant negative correlation between substance P expression and mast cell count (P = 0.05, r = -0.373). Substance P was found to be expressed more often in female patient biopsies and more intensely in the upper gastrointestinal mucosa as compared to the lower mucosa. There were significantly increased gastrointestinal mucosal immunoreactivity to IL-6 (P = 0.004) in the inflammatory phenotype compared to non-inflammatory. Additionally, we found significantly increased mast cells (P = 0.049) in the mucosa of the non-inflammatory phenotype compared to the inflammatory group. This difference was particularly noted in the lower colon biopsies. CONCLUSION: The findings of this study yield preliminary evidence in identifying biomarkers of undiagnosed abdominal pain in children and may suggest candidate genes for future evaluation. | Wendy A Henderson Ravi Shankar Tara J Taylor Arseima Y Del Valle-Pinero David E Kleiner Kevin H Kim Nader N Youssef | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，6： | 2 |
| 14 | Design of logic process based low-power 512-bit EEPROM for UHF RFID tag chip显示文摘A 512-bit EEPROM IP was designed by using just logic process based devices.To limit the voltages of the devices within 5.5 V,EEPROM core circuits,control gate(CG) and tunnel gate(TG) driving circuits,DC-DC converters:positive pumping voltage(VPP=4.75 V) ,negative pumping voltage(VNN=4.75 V) ,and VNNL(=VNN/2) generation circuit were proposed.In addition,switching powers CG high voltage(CG_HV) ,CG low voltage(CG_LV) ,TG high voltage(TG_HV) ,TG low voltage(TG_LV) ,VNNL_CG and VNNL_TG switching circuit were supplied for the CG and TG driving circuit.Furthermore,a sequential pumping scheme and a new ring oscillator with a dual oscillation period were proposed.To reduce a power consumption of EEPROM in the write mode,the reference voltages VREF_VPP for VPP and VREE_VNN for VNN were used by dividing VDD(1.2 V) supply voltage supplied from the analog block in stead of removing the reference voltage generators.A voltage level detector using a capacitive divider as a low-power DC-DC converter design technique was proposed.The result shows that the power dissipation is 0.34μW in the read mode,13.76μW in the program mode,and 13.66μW in the erase mode. | 金丽妍 LEE J H KIM Y H | 2010 | Journal of Central South University2010，17，5： | 2 |
| 15 | A study on a platinum-silicon carbide Schottky diodes as a hydrogen gas sensor 显示文摘 | Kim C K Lee J H Lee Y H Cho N I and Kim D J | 2000 | Sensors and Actuators B2000，66，： | 2 |
| 16 | A problem reduction and decomposition approach for scheduling for a flowshop of batch processing machines 显示文摘 | Sung C S Kim Y H Yoon S H | 2000 | European Journal of Operational Research2000，121，： | 2 |
| 17 | Damage identification in beam-type structures: frequency-based method vs mode-shape-based method 显示文摘 | Kim J T Ryu Y S Cho H M | 2003 | Engineering Structures2003，25，1： | 2 |
| 18 | Melting and non-isothermal crystallization behaviors of poly(trimethylene terephthalate ) 显示文摘 | Kim Y H Lee K M | 1997 | Han''guk Somyu Konghakhoechi1997，34，12： | 2 |
| 19 | Artificial neural- network based feeder reconfiguration for loss reduction in distribution systems显示文摘 | Kim H Ko Y Jung K-H | 1993 | IEEE Trans onPowerDelivery1993，8，3： | 2 |
| 20 | The effect of pre-irradiation dose intense CHOP on anthracyline resistance in localized nasal NK/ T-cell lymphoma显示文摘 | Lee S H Ahn Y C Kim W S | 2006 | Haematologica2006，91，3： | 1 |
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